Oxidized low density lipoprotein induces the cyclin-dependent kinase inhibitor p21waf1 and the tumor suppressor Rb

Biochemical and Biophysical Research Communications

Volumn 293, Issue 5, 2002, Pages 1327-1332

  Mazière, Cécile ^a   Marcheux, Virginie ^a   Louandre, Christophe ^a   Mazière, Jean Claude ^a  

^a UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

Author keywords

Oxidative stress; Oxidized LDL; P21waf1; Rb

Indexed keywords

ALPHA TOCOPHEROL; CYCLIN DEPENDENT KINASE INHIBITOR; DNA; LIPID; LOW DENSITY LIPOPROTEIN; OKADAIC ACID; PROTEIN; PROTEIN P21; PROTEIN P53; REACTIVE OXYGEN METABOLITE; RETINOBLASTOMA PROTEIN; THYMIDINE; UNCLASSIFIED DRUG;

ARTICLE; CANCER INHIBITION; CELL CYCLE; CELL CYCLE G1 PHASE; CELL LEVEL; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS; DOSE RESPONSE; GENE EXPRESSION; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MEDIATOR; OXIDATION; OXIDATIVE STRESS; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INDUCTION; TUMOR SUPPRESSOR GENE;

ANTIOXIDANTS; CELL LINE; CELL NUCLEUS; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; CYCLOHEXIMIDE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FIBROBLASTS; G1 PHASE; GENES, P53; HUMANS; IMMUNOBLOTTING; LIPID PEROXIDATION; LIPOPROTEINS, LDL; OKADAIC ACID; OXIDATIVE STRESS; OXYGEN; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; TIME FACTORS; VITAMIN E;

EID: 0036073373     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00389-3     Document Type: Article

References (38)

1. The pathogenesis of atherosclerosis: A perspective for 1990's
2. Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid
3. Monocytes and neutrophils oxidize low density lipoprotein making it cytotoxic
4. Enhanced macrophages degradation of low density lipoprotein previously incubated with endothelial cells: Recognition by receptors for acetylated low density lipoproteins
5. Autooxidation of human low density lipoprotein: Loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes
6. Biochemical, structural and functional properties of oxidized low density lipoprotein
7. Macrophage and smooth muscle cell proliferation in atherosclerotic lesions of WHHL and comparably hypercholesterolemic fat fed animals
8. Lysophosphatidyl-choline transcriptionally induces growth factor gene expression in cultured human endothelial cells
9. Oxidized low density lipoprotein reduces thrombomodulin transcription in cultured human endothelial cells through degradation of the lipoprotein in lysosomes
10. Superoxide anion participation in human monocyte-mediated oxidation of low density lipoprotein and conversion of low density lipoprotein to a cytotoxin
11. 7 Beta-hydroperoxycholest-5-en-3-beta-ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidized low density lipoprotein
12. The E2F transcription factor is a cellular target for the RB protein
13. RB Kinases and RB-binding proteins: New points of view
14. Cancer cell cycles
15. Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases
16. Principles of CDK regulation
17. G1 phase progression: Cycling on cue
18. Direct interaction of p21 cyclin-dependent kinase inhibitor with the retinoblastoma tumor suppressor protein
19. p21 WAF1/Cip1: More than a break to the cell cycle?
20. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
21. Lipid peroxide and human diseases
22. A Simple method for the isolation and purification of total lipids from animal tissues
23. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
24. Quantitation of intracellular oxidation in a renal epithelial cell line
25. Toxicity determined in vitro by morphological alterations and neutral red absorption
26. Functional inactivation of the retinoblatoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
27. Specific enzymatic dephosphorylation of the retinoblastoma protein
28. Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatase
29. Oxidized LDL induces an oxidative stress and activates the tumor suppressor p53 in MRC5 human fibroblasts
30. The p21-cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
31. The retinoblastoma protein binds to a family of E2F transcription factors
32. The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner
33. Interaction of the p107 and Rb proteins with E2F during the cell proliferation response
34. E2F-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product
35. CyclinA-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint
36. Hypoxic stress induces reversible hypophosphorylation of pRB and reduction in cyclin A abundance independent of cell cycle progression
37. Protein phosphatase type 1-dependent dephosphorylation of the retinoblastoma tumor suppressor protein in ultraviolet-irradiated human skin and keratinocytes
38. Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence and apoptosis in human vascular smooth muscle cells from atherosclerotic plaques