Modulations of cell cycle checkpoints during HCV associated disease

BMC Infectious Diseases

Volumn 9, Issue , 2009, Pages 125-

  Sarfraz, Saira ^a   Hamid, Saeed ^a   Ali, Syed ^a   Jafri, Wasim ^a   Siddiqui, Anwar A ^a  

^a AGA KHAN UNIVERSITY   (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; MESSENGER RNA; PROTEIN KNTC1; PROTEIN MAD2; PROTEIN P15; PROTEIN P27; UNCLASSIFIED DRUG; CALCIUM BINDING PROTEIN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 2B; KNTC1 PROTEIN, HUMAN; MAD2L1 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; REPRESSOR PROTEIN;

ADULT; ARTICLE; CELL CYCLE REGULATION; CHROMOSOMAL INSTABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DNA DAMAGE; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE FUNCTION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER BIOPSY; LIVER FIBROSIS; MALE; PROTEIN EXPRESSION; UPREGULATION; CELL CYCLE; GENE EXPRESSION PROFILING; GENETICS; LIVER CIRRHOSIS; METABOLISM; MIDDLE AGED;

ADULT; CALCIUM-BINDING PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P27; GENE EXPRESSION PROFILING; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; LIVER CIRRHOSIS; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; REPRESSOR PROTEINS; RNA, MESSENGER; YOUNG ADULT;

EID: 70349773609     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-9-125     Document Type: Article

References (30)

1. Alter MJ. Epidemiology of hepatitis C virus infection. World J Gastroenterol 2007, 13(17):2436-2441.
2. Hamid S, Umar M, Alam A, Siddiqui A, Qureshi H, Butt J. PSG consensus statement on management of hepatitis C virus infection - 2003. Jpma 2004, 54(3):146-150.
3. Raza SA, Clifford GM, Franceschi S. Worldwide variation in the relative importance of hepatitis B and hepatitis C viruses in hepatocellular carcinoma: a systematic review. British journal of cancer 2007, 96(7):1127-1134. 10.1038/sj.bjc.6603649, 17406349.
4. Liang TJ, Heller T. Pathogenesis of hepatitis C-associated hepatocellular carcinoma. Gastroenterology 2004, 127(5 Suppl 1):S62-71. 10.1053/j.gastro.2004.09.017, 15508105.
5. Tillmann HL, Manns MP, Rudolph KL. Merging models of hepatitis C virus pathogenesis. Semin Liver Dis 2005, 25(1):84-92. 10.1055/s-2005-864784, 15732000.
6. Morgan DO. Principles of CDK regulation. Nature 1995, 374(6518):131-134. 10.1038/374131a0, 7877684.
7. Sherr CJ. Cancer cell cycles. Science 1996, 274(5293):1672-1677. 10.1126/science.274.5293.1672, 8939849.
8. Houtgraaf JH, Versmissen J, Giessen WJ. A concise review of DNA damage checkpoints and repair in mammalian cells. Cardiovasc Revasc Med 2006, 7(3):165-172. 10.1016/j.carrev.2006.02.002, 16945824.
9. Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999, 13(12):1501-1512. 10.1101/gad.13.12.1501, 10385618.
10. Molinari M. Cell cycle checkpoints and their inactivation in human cancer. Cell Prolif 2000, 33(5):261-274. 10.1046/j.1365-2184.2000.00191.x, 11063129.
11. Werling K, Szentirmay Z, Szepesi A, Schaff Z, Szalay F, Szabo Z, Telegdy L, David K, Stotz G, Tulassay Z. Hepatocyte proliferation and cell cycle phase fractions in chronic viral hepatitis C by image analysis method. Eur J Gastroenterol Hepatol 2001, 13(5):489-493. 10.1097/00042737-200105000-00005, 11396526.
12. Marshall A, Rushbrook S, Davies SE, Morris LS, Scott IS, Vowler SL, Coleman N, Alexander G. Relation between hepatocyte G1 arrest, impaired hepatic regeneration, and fibrosis in chronic hepatitis C virus infection. Gastroenterology 2005, 128(1):33-42. 10.1053/j.gastro.2004.09.076, 15633121.
13. Sarfraz S, Hamid S, Siddiqui A, Hussain S, Pervez S, Alexander G. Altered expression of cell cycle and apoptotic proteins in chronic hepatitis C virus infection. BMC microbiology 2008, 8:133. 2518161, 18680610, 10.1186/1471-2180-8-133.
14. Batts KP, Ludwig J. Chronic hepatitis. An update on terminology and reporting. The American journal of surgical pathology 1995, 19(12):1409-1417. 10.1097/00000478-199512000-00007, 7503362.
15. Asselah T, Bieche I, Laurendeau I, Paradis V, Vidaud D, Degott C, Martinot M, Bedossa P, Valla D, Vidaud M. Liver gene expression signature of mild fibrosis in patients with chronic hepatitis C. Gastroenterology 2005, 129(6):2064-2075. 10.1053/j.gastro.2005.09.010, 16344072.
16. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (San Diego, Calif) 2001, 25(4):402-408.
17. Farinati F, Cardin R, D'Errico A, De Maria N, Naccarato R, Cecchetto A, Grigioni W. Hepatocyte proliferative activity in chronic liver damage as assessed by the monoclonal antibody MIB1 Ki67 in archival material: the role of etiology, disease activity, iron, and lipid peroxidation. Hepatology 1996, 23(6):1468-1475. 10.1002/hep.510230625, 8675166.
18. Freeman A, Hamid S, Morris L, Vowler S, Rushbrook S, Wight DG, Coleman N, Alexander GJ. Improved detection of hepatocyte proliferation using antibody to the pre-replication complex: an association with hepatic fibrosis and viral replication in chronic hepatitis C virus infection. J Viral Hepat 2003, 10(5):345-350. 10.1046/j.1365-2893.2003.00454.x, 12969185.
19. Lake-Bakaar G, Mazzoccoli V, Ruffini L. Digital image analysis of the distribution of proliferating cell nuclear antigen in hepatitis C virus-related chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Dig Dis Sci 2002, 47(7):1644-1648. 10.1023/A:1015800126283, 12141830.
20. Okada T, Iizuka N, Yamada-Okabe H, Mori N, Tamesa T, Takemoto N, Tangoku A, Hamada K, Nakayama H, Miyamoto T. Gene expression profile linked to p53 status in hepatitis C virus-related hepatocellular carcinoma. FEBS Lett 2003, 555(3):583-590. 10.1016/S0014-5793(03)01345-0, 14675778.
21. Wurmbach E, Chen YB, Khitrov G, Zhang W, Roayaie S, Schwartz M, Fiel I, Thung S, Mazzaferro V, Bruix J. Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma. Hepatology 2007, 45(4):938-947. 10.1002/hep.21622, 17393520.
22. Lunz JG, Tsuji H, Nozaki I, Murase N, Demetris AJ. An inhibitor of cyclin-dependent kinase, stress-induced p21Waf-1/Cip-1, mediates hepatocyte mito-inhibition during the evolution of cirrhosis. Hepatology (Baltimore, Md) 2005, 41(6):1262-1271. 10.1002/hep.20709, 15880761.
23. Blain SW, Massague J. Breast cancer banishes p27 from nucleus. Nat Med 2002, 8(10):1076-1078. 10.1038/nm1002-1076, 12357238.
24. Sun D, Ren H, Oertel M, Sellers RS, Zhu L. Loss of p27Kip1 enhances tumor progression in chronic hepatocyte injury-induced liver tumorigenesis with widely ranging effects on Cdk2 or Cdc2 activation. Carcinogenesis 2007, 28(9):1859-1866. 10.1093/carcin/bgm079, 17434927.
25. Farazi PA, DePinho RA. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 2006, 6(9):674-687. 10.1038/nrc1934, 16929323.
26. Chan GK, Jablonski SA, Starr DA, Goldberg ML, Yen TJ. Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores. Nat Cell Biol 2000, 2(12):944-947. 10.1038/35046598, 11146660.
27. Fang G, Yu H, Kirschner MW. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes & development 1998, 12(12):1871-1883. 316912, 9637688, 10.1101/gad.12.12.1871.
28. Wang Z, Cummins JM, Shen D, Cahill DP, Jallepalli PV, Wang TL, Parsons DW, Traverso G, Awad M, Silliman N. Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer research 2004, 64(9):2998-3001. 10.1158/0008-5472.CAN-04-0587, 15126332.
29. Michel LS, Liberal V, Chatterjee A, Kirchwegger R, Pasche B, Gerald W, Dobles M, Sorger PK, Murty VV, Benezra R. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 2001, 409(6818):355-359. 10.1038/35053094, 11201745.
30. Wang X, Jin DY, Ng RW, Feng H, Wong YC, Cheung AL, Tsao SW. Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells. Cancer research 2002, 62(6):1662-1668.