High α-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma: Significance of hepatitis virus infection, age, p53 and β-catenin mutations

International Journal of Cancer

Volumn 112, Issue 1, 2004, Pages 44-50

  Peng, Shian Yang ^a   Chen, Wei J ^b   Lai, Po Lin ^c   Jeng, Yun Ming ^c,d   Sheu, Jin Chuan ^d   Hsu, Hey Chi ^c,d  

^a NATIONAL TAIPEI UNIVERSITY OF NURSING AND HEALTH SCIENCES   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

fetoprotein; catenin; Hepatocellular carcinoma; p53; Prognosis; Tumor stage

Indexed keywords

ALPHA FETOPROTEIN; BETA CATENIN; HEPATITIS B SURFACE ANTIGEN; MESSENGER RNA; PROTEIN P53;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CANCER INVASION; CANCER RECURRENCE; CANCER STAGING; CONCENTRATION (PARAMETERS); CONFIDENCE INTERVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HEPATITIS; HEPATITIS VIRUS; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; MUTATION; PATHOLOGY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REGRESSION ANALYSIS; RISK ASSESSMENT; SCHOOL CHILD; SERUM; SURVIVAL RATE; TUMOR VOLUME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; ALPHA-FETOPROTEINS; BETA CATENIN; CARCINOMA, HEPATOCELLULAR; CHILD; CYTOSKELETAL PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATITIS B; HEPATITIS B SURFACE ANTIGENS; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MUTATION; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; TRANS-ACTIVATORS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 4544301860     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.20279     Document Type: Article

References (45)

1. Nishio H, Heiskanen M, Palotie A, Belanger L, Dugaiczyk A. Tandem arrangement of the human serum albumin multigene family in the sub-centromeric region of 4q: evolution and chromosomal direction of transcription. J Mol Biol 1996;259:113-9.
2. Abelev GI. Alpha-fetoprotein in ontogenesis and its association with malignant tumors. Cancer Res 1971;14:295-358.
3. Tilghman SM, Belayew A. Transcriptional control of the murine albumin/alpha-fetoprotein locus during development. Proc Natl Acad Sci USA 1982;79:5254-7.
4. Marchio A, Meddeb M, Pineau P, Danglot G, Tiollais P, Bernheim A, Dejean A. Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer 1997;18:59-65.
5. Kusano N, Shiraishi K, Kubo K, Oga A, Okita K, Sasaki K. Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: their relationship to clinicopathological features. Hepatology 1999;29:1858-62.
6. Wong N, Lai P, Pang E, Fung LF, Sheng Z, Wong V, Wang W, Hayashi Y, Perlman E, Yuna S, Lau JW, Johnson PJ. Genomic aberrations in human hepatocellular carcinomas of differing etiologies. Clin Cancer Res 2000;6:4000-9.
7. Guan XY, Fang Y. Sham JS, Kwong DL, Zhang Y, Liang Q, Li H, Zhou H, Trent JM. Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer 2000;29:110-6.
8. Belayew A, Tilghman SM. Genetic analysis of alpha-fetoprotein synthesis in mice. Mol Cell Biol 1982;2:1427-35.
9. Chen DS, Sung JL. Serum alphafetoprotein in hepatocellular carcinoma. Cancer 1977;40:779-83.
10. Peng SY, Lai PL, Chu JS, Lee PH, Tsung PT, Chen DS, Hsu HC. Expression and hypomethylation of alpha-fetoprotein gene in unicentric and multicentric human hepatocellular carcinomas. Hepatology 1993;17:35-41.
11. Nomura F, Ohnishi K, Tanabe Y. Clinical features and prognosis of hepatocellular carcinoma with reference to serum alpha-fetoprotein levels: analysis of 606 patients. Cancer 1989;64:1700-7.
12. Imamura H, Matsuyama Y, Tanaka E, Ohkubo T, Hasegawa K, Miyagawa S, Sugawara Y, Minagawa M, Takayama T, Kawasaki S, Makuuchi M. Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol 2003;38:200-7.
13. Matsumoto K, Yoshimoto J, Sugo H, Kojima K, Futagawa S. Matsumoto T. Relationship between the histological degrees of hepatitis and the postoperative recurrence of hepatocellular carcinoma in patients with hepatitis C. Hepatol Res 2002;23:196-201.
14. Toder V, Blank M, Gold-Gefter L, Nebel L. The effect of alpha-fetoprotein on the growth of placental cells in vitro. Placenta 1983;4:79-86.
15. Dudich E, Semenkova L, Gorbatova E, Dudich I, Khromykh L, Tatulov E, Grechko G, Sukhikh G. Growth-regulative activity of human α-fetoprotein for different types of tumor and normal cells. Tumour Biol 1998;19:30-40.
16. Li MS, Li PF, Yang FY, He SP, Du GG, Li G. The intracellular mechanism of alpha-fetoprotein promoting the proliferation of NIH 3T3 cells. Cell Res 2002;12:151-6.
17. Wang XW, Xie H. Alpha-fetoprotein enhances the proliferation of human hepatoma cell in vitro. Life Sci 1999;64:17-23.
18. Li MS, Li PF, He SP, Du GG, Li G. The promoting molecular mechanism of alpha-fetoprotein on the growth of human hepatoma Bel7402 cell line. World J Gastroenterol 2002;8:469-75.
19. Mizejewski GJ. Biological role of alpha-fetoprotein in cancer: prospects for anticancer therapy. Expert Rev Anticancer Ther 2002;2:709-35.
20. Takahashi Y, Mai M, Ogino T, Ueda H, Sawaguchi K, Ueno M. Clinicopathological study of AFP producing gastric cancer: significance of AFP in gastric cancer. Nippon Geka Gakkai Zasshi 1987;88:696-700.
21. Koide N, Nishio A, Igarashi J, Kajikawa S, Adachi W, Amano J. Alpha-fetoprotein-producing gastric cancer: histochemical analysis of cell proliferation, apoptosis, and angiogenesis. Am J Gastroenterol 1999;94:1658-63.
22. Li Y, Tang ZY, Ye SL, Liu YK, Chen J, Xue Q, Chen J, Gao DM, Bao WH. Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97. World J Gastroenterol 2001;7:630-6.
23. Feuerman MH, Godbout R, Ingram RS, Tilghman SM. Tissue-specific transcription of the mouse alpha-fetoprotein gene promoter is dependent on HNF-1. Mol Cell Biol 1989;9:4204-12.
24. Wen P, Groupp ER, Buzard G, Crawford N, Locker J. Enhancer, repressor, and promoter specificities combine to regulate the rat α-fetoprotein Gene. DNA Cell Biol 1991;10:525-36.
25. Lee KC, Crowe AJ, Barton MC. p53-mediated repression of alpha-fetoprotein gene expression by specific DNA binding. Mol Cell Biol 1999;19:1279-88.
26. Ogden SK, Lee KC, Wernke-Dollries K, Stratton SA, Aronow B, Barton MC. p53 targets chromatin structure alteration to repress α-fetoprotein gene expression. J Biol Chem 2001;276:42057-62.
27. Damalas A, Kahan S, Shtutman M, Ben-Ze'ev A, Oren M. Deregulated β-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation. EMBO J 2001;20:4912-22.
28. Hsu HC, Tseng HJ, Lai PL, Lee PH, Peng SY. Expression of p53 gene in 184 unifocal hepatocellular carcinomas: association with tumor growth and invasiveness. Cancer Res 1993;53:4691-4.
29. Hsu HC, Peng SY, Lai PL, Chu JS, Lee PH. Mutations of p53 gene in hepatocellular carcinoma (HCC) correlate with tumor progression and patient prognosis: a study of 138 patients with unifocal HCC. Int J Oncol 1994;4:1341-7.
30. Hsu HC, Jeng YM, Mao TL, Chu JS, Lai PL, Peng SY. β-catenin mutations are associated with a subset of low stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis. Am J Pathol 2000;157:763-70.
31. Huang H, Fuji H, Sankila A, Mahler-Araujo BM, Matsuda M, Cathomas G, Ohgaki H. β-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection. Am J Pathol 1999;155:1795-801.
32. Legoix P. Bluteau O. Bayer J, Perret C, Balabaud C, Belghiti J, Franco D, Thomas G, Laurent Puig P, Zucman-Rossi J. Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity. Oncogene 1999;18:4044-6.
33. Devereux TR, Stern MC, Flake GP, Yu MC, Zhang ZQ, London SJ, Taylor JA. CTNNBI mutations and β-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin BI. Mol Carcinog 2001;31:68-73.
34. Hsu HC, Wu TT, Wu MZ, Sheu JC, Lee CS, Chen DS. Tumor Invasiveness and prognosis in resected hepatocellular carcinoma: clinical and pathogenetic implications. Cancer 1988;61:2095-9.
35. Hsu HC, Chiou TJ, Chen ZY, Lee CS, Lee PH, Peng SY. Clonality and clonal evolution of hepatocellular carcinoma with multiple nodules. Hepatology 1991;13:923-8.
36. Hu RH, Lee PH, Yu SC, Dai HC, Sheu JC, Lai MY, Hsu HC, Chen DS. Surgical resection of recurrent hepatocellular carcinoma: prognosis and analysis of risk factors. Surgery 1996;120:23-9.
37. Grandchamp B, De Verneuil H, Beaumont C, Chretien S, Walter O, Nordmann Y. Tissue-specific expression of porphobilinogen deaminase: two isoenzymes from a single gene. Eur J Biochem 1987;162:105-10.
38. Don RH, Cox PT, Wainwright BJ, Baker K, Mattick JS. "Touch- down" PCR to circumvent spurious priming during gene amplification. Nucl Acids Res 1991;19:4008.
39. Pan HW, Ou YH, Peng SY, Liu SH, Lai PL, Lee PH, Sheu JC, Chen CL, Hsu HC. Overexpression of osteopontin is associated with intrahepatic metastasis, early recurrence, and poorer prognosis of surgically resected hepatocellular carcinoma. Cancer 2003;98:119-27.
40. Wang XW, Gibson MK, Vermeulen W, Yen H, Forrester K, Sturzbecher HW, Hoeijmakers JH, Harris CC, Abrogation of p53-induced apoptosis by the hepatitis B virus X gene. Cancer Res 1995;55:6012-6.
41. Truant R, Antunovic J, Greenblatt J, Prives C, Cromlish JA. Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation. J Virol 1995;69:1851-9.
42. Ogden SK, Lee KC, Barton MC. Hepatitis B viral transactivator HBx alleviates p53-mediated repression of α-fetoprotein gene expression. J Biol Chem 2000;275:27806-14.
43. Arima T, Nakao K, Nakata K, Ishikawa H, Ichikawa T, Hamasaki K, Ishii N, Eguchi K. Transactivation of human alpha-fetoprotein gene by X-gene product of hepatitis B virus in human hepatoma cells. Int J Mol Med 2002;9:397-400.
44. Otsuka M, Aizaki H, Kato N, Suzuki T, Miyamura T, Omata M, Seki N. Differential cellular gene expression induced by hepatitis B and C viruses. Biochem Biophys Res Commun 2003;300:443-7.
45. Torres JM, Laborda J, Naval J, Darracq N, Calvo M, Mishal Z, Uriel J. Expression of alpha-fetoprotein receptors by human T-lymphocytes during blastic transformation. Mol Immunol 1989;26:851-7.