Inhibition of hepatitis C virus (HCV) core protein-induced cell growth by non-structural protein 4A (NS4A) is mediated by mitochondrial dysregulation

Bosnian Journal of Basic Medical Sciences

Volumn 8, Issue 1, 2008, Pages 4-11

  Selimovic, Denis ^a   Hassan, Mohamed ^b  

^a INSERM   (France)

^b Clinics of Vascular Surgery   (Germany)

Author keywords

Cell growth; HCV core; NS4A

Indexed keywords

CARRIER PROTEIN; CORE PROTEIN; NS4A COFACTOR PEPTIDE, HEPATITIS C VIRUS; PROTEIN SYNTHESIS INHIBITOR; TETRACYCLINE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CELL PROLIFERATION; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HEPATITIS C VIRUS; HUMAN; LIVER CELL CARCINOMA; LIVER MITOCHONDRION; LIVER TUMOR; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

CARCINOMA, HEPATOCELLULAR; CARRIER PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, VIRAL; HEPACIVIRUS; HUMANS; LIVER NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, LIVER; PROTEIN SYNTHESIS INHIBITORS; TETRACYCLINE; VIRAL CORE PROTEINS; VIRAL PROTEINS;

EID: 42449088547     PISSN: 15128601     EISSN: None     Source Type: Journal    
DOI: 10.17305/bjbms.2008.2988     Document Type: Article

References (32)

1. Anonymous. World Health Organization-Hepatitis C: global prevalence. Wkly. Epidemiol. Rec. 1997; 72:341-344.
2. Alberti A., Chemello L., Benvegnú L. Natural history of hepatitis C.J Hepatol. 1999;1:17-24
3. Fried M.W., Shiff man ML, Reddy K.R., Smith C, Marinos G, Gonçales F.L Jr., Häussinger D., Diago M., Carosi G, Dhumeaux D., Craxi A, Lin A, Hoff man J., Yu J. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N. Engl. J. Med. 2002; 347:975-982.
4. Takamizawa A, Mori C, Fuke I, Manabe S., Murakami S., Fujita, J., Onishi, E, Andoh, T., Yoshida, I., and Okayama, H Structure and organization of the hepatitis C virus genome isolated from human carriers. J. Virol. 1991;65:1105-1113.
5. Ray R.B., Lagging L.M., Meyer K., Steele R, Ray R Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein. Virus Res. 1995; 37: 209-220.
6. Ray R.B., Lagging L.M., Meyer K., Ray R Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype. J. Virol. 1996;70: 4438-4443.
7. Ray R.B., Steele R, Meyer K., Ray R Transcriptional repression of p53 promoter by hepatitis C virus core protein. J. Biol. Chem. 1997; 272:10983-10986.
8. Srinivas R.V., Ray R.B., Meyer K., Ray, R Hepatitis C virus core protein inhibits human immunodefi ciency virus type 1 replication. Virus Res. 1996; 45: 87-92.
9. Erhardt A, Hassan M., Heintges T., Haussinger D. Hepatitis C virus core protein induces cell proliferation and activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-i in a HepG2 Tet-Off cell line. Virology 2002; 292: 272-284
10. Hassan M., Ghozlan H, Abdel-Kader O. Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells. Cell Signal. 2004;16:1375-1385
11. Moriya K., Yotsuyanagi H, Shintani Y, Fujie H, Ishibashi K., Mat-suura Y, Miyamura T., Koike K. Hepatitis C virus core protein induces hepatic steatosis in transgenic mice. J. Gen. Virol. 1997; 78:1527-1531.
12. Failla C, Tomei L., De Francesco R Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins. J. Virol. 1994;68: 3753-3760.
13. Neddermann P., Clementi A., De Francesco R Hyperphospho-rylation of the hepatitis C virus NS5 A protein requires an active NS3 protease, NS4A, NS4B, and NS5A encoded on the same polyprotein. J. Virol. 1999; 73:9984-9991.
14. Hassan M., Ghozlan H. , Abdel-Kader, O. Activation of c-Jun NH2-terminal kinase (JNK) signaling pathway is essential for the modulation of Hepatitis C Virus (HCV) non-structural protein 3 (NS3)- mediated cell growth in hepatocyte and non-hepatocyte derived cells. Virology 2005; 333: 324-336.
15. Kato J., Kato N, Yoshida H, Ono-Nita S.K., Shiratori Y, Omata M. Hepatitis C virus NS4A and NS4B proteins suppress translation in vivo. J. Med. Virol. 2002; 66:187-199.
16. Nomura-Takigawa Y, Nagano-Fujii M., Deng L., Kitazawa S., Ishido S., Sada K., Hotta H Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis. J. Gen. Virol. 2006; 87:1935-1945.
17. Hassan M., Selimovic D., Ghozlan H, Abdel-Kader O. Induction of high-molecular-weight (HMW) tumor necrosis factor (TNF) alpha by hepatitis C virus (HCV non-structural protein 3 (NS3) in liver cells is AP-i and NF-kappaB-dependent activation. Cell Signal. 2007;19: 301-311.
18. Selimovic D., Hassan M., Haikel Y, Hengge U.R Taxol-induced mitochondrial stress in melanoma cells is mediated by activation of c-Jun N-terminal kinase (JNK) and p38 pathways via uncoupling protein 2. Cell. Signal 2007; (In press).
19. Hassan M., Mirmohammadsadegh A, Selimovic D., Nambiar S., Tannapfel A, Hengge U.R. Identifi cation of functional genes during Fas-mediated apoptosis using a randomly fragmented cDNA library.Cell Mol Life Sci. 2005; 62(17):2015-2026
20. Sacco R., Tsutsumi T., Suzuki R., Otsuka M., Aizaki H, Sakamoto S., Matsuda M., Seki N, Matsuura Y., Miyamura T., Suzuki T. An-tiapoptotic regulation by hepatitis C virus core protein through up-regulation of inhibitor of caspase-activated DNase.Virology. 2003; 317: 24-35.
21. Fujita T., Ishido S., Muramatsu S., Itoh M., Hotta H. Suppression of actinomycin D-induced apoptosis by the NS3 protein of hepatitis C virus. Biochem. Biophys. Res. Commun. 1996; 229:825-831.
22. He Y., Nakao H., Tan S.L., Polyak S.J., Neddermann P., Vijaysri S., Jacobs B.L., Katze M.G. Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase. J. Virol. 76: 9207-9217.
23. Lan K.H., Sheu M.L, Hwang S.J., Yen S.H., Chen S.Y, Wu J.C., Wang Y.J., Kato N, Omata M., Chang FY., Lee S.D. HCV NS5A interacts with p53 and inhibits ps3-mediated apoptosis. Oncogene. 2002; 21(31):4801-4811.
24. Hahn C.S., Cho Y.G., Kang B.S., Lester I.M., Hahn YS. The HCV core protein acts as a positive regulator of fas-mediated apoptosis in a human. Virology. 2000; 276(1):127-137
25. Moorman J.P., Prayther D., McVay D., Hahn CS. The C-terminal region of hepatitis C core protein is required for Fas-ligand independent apoptosis in Jurkat cells by facilitating Fas oligmeriza-tion. Virology 2003; 312:320-329.
26. Ruggieri A, Murdolo M., Rapicetta M. Induction of Fas ligand expression in a human heptoblastoma cell line by HCV core protein. Virus Res. 2003; 97:103-110.
27. Ruggieri A, Harada T., Matsuura Y, and Miyamura T. Sensitization to fas-mediated apoptosis by hepatitis C virus core protein. Virology 1997; 229,68-76. (Pubitemid 27243489)
28. Ciccaglione AR, Marcantonio C, Tritarelli E., Equestre M., Magurano F., Costantino A, Nicoletti L, Rapicetta M. The transmembrane domain of hepatitis C virus E1 glycoprotein induces cell death. Virus Res. 2004; 104:1-9.
29. Ciccaglione A.R., Marcantonio C, Costantino A, Equestre M., Rapicetta M. Expression of HCV E1 protein in baculovirus-in-fected cells: effects on cell viability and apoptosis induction. Inter-virology 2003; 46:121-126
30. Hsu EC, Hsi B., Hiro-Tsuchihara M., Ruland J., Iorio C, Sarangi F., Diao J., Migliaccio G, Tyrrell D.L., Kneteman N, Richardson CD. Modifi ed apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers. Nat Biotechnol. 2003; 21: 519-525.
31. Nomura-Takigawa Y, Nagano-Fujii M., Deng L., Kitazawa S., Ishido S, Sada K., Hotta H Non-structural protein4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis. J. Gen. Virol. 2006; 87:1935-1945.
32. Siavoshian S., Abraham J.D., Thumann C, Kieny M.P., Schuster C Hepatitis C virus core, NS3, NS5A, NS5B proteins induce apoptosis in mature dendritic cells J. Med Virol. 2005; 75;402-411.