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Volumn 14, Issue 7, 2013, Pages 15029-15058

DNA methylation and cancer diagnosis

Author keywords

Biomarkers; Cancer diagnosis; Clinical trials; DNA methylation; DNA methylation inhibitors

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; BRCA1 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE INHIBITOR; DOCETAXEL; ENTINOSTAT; FLAVONOID; FLUCYTOSINE DEOXYRIBOSIDE; GLUTATHIONE TRANSFERASE P1; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDRALAZINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MG 98; MICRORNA; N PHTHALOYLTRYPTOPHAN; PANOBINOSTAT; PEGINTERFERON; PREDNISONE; PROCAINAMIDE; PROTEIN MLH1; SEPTIN 9; SGI 110; TEMOZOLOMIDE; TETRAHYDROURIDINE; TUMOR MARKER; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROATE MAGNESIUM; ZEBULARINE;

EID: 84880731892     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms140715029     Document Type: Review
Times cited : (132)

References (156)
  • 1
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird, A. DNA methylation patterns and epigenetic memory. Genes Dev. 2002, 16, 6-21.
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 3
    • 84863986133 scopus 로고    scopus 로고
    • Functions of DNA methylation: Islands, start sites, gene bodies and beyond
    • Jones, P.A. Functions of DNA methylation: Islands, start sites, gene bodies and beyond. Nat. Rev. Genet. 2012, 13, 484-492.
    • (2012) Nat. Rev. Genet , vol.13 , pp. 484-492
    • Jones, P.A.1
  • 4
    • 2642551522 scopus 로고    scopus 로고
    • Structure and function of eukaryotic DNA methyltransferases
    • Chen, T.; Li, E. Structure and function of eukaryotic DNA methyltransferases. Curr. Top. Dev. Biol. 2004, 60, 55-89.
    • (2004) Curr. Top. Dev. Biol , vol.60 , pp. 55-89
    • Chen, T.1    Li, E.2
  • 5
    • 79955060261 scopus 로고    scopus 로고
    • Regulation of expression and activity of DNA (cytosine-5) methyltransferases in mammalian cells
    • Kinney, S.R.M.; Pradhan, S. Regulation of expression and activity of DNA (cytosine-5) methyltransferases in mammalian cells. Prog. Mol. Biol. Transl. Sci. 2011, 101, 311-333.
    • (2011) Prog. Mol. Biol. Transl. Sci , vol.101 , pp. 311-333
    • Kinney, S.R.M.1    Pradhan, S.2
  • 6
    • 0035943709 scopus 로고    scopus 로고
    • Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin
    • Bachman, K.E.; Rountree, M.R.; Baylin, S.B. Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin. J. Biol. Chem. 2001, 276, 32282-32287.
    • (2001) J. Biol. Chem , vol.276 , pp. 32282-32287
    • Bachman, K.E.1    Rountree, M.R.2    Baylin, S.B.3
  • 8
    • 79952258043 scopus 로고    scopus 로고
    • Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance
    • Sharma, S.; de Carvalho, D.D.; Jeong, S.; Jones, P.A.; Liang, G. Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance. PLoS Genet. 2011, 7, e1001286.
    • (2011) PLoS Genet , vol.7
    • Sharma, S.1    de Carvalho, D.D.2    Jeong, S.3    Jones, P.A.4    Liang, G.5
  • 9
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano, M.; Bell, D.W.; Haber, D.A.; Li, E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999, 99, 247-257.
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 10
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • Li, E.; Bestor, T.H.; Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 1992, 69, 915-926.
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 11
    • 0037168587 scopus 로고    scopus 로고
    • The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a
    • Chedin, F.; Lieber, M.R.; Hsieh, C.L. The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. Proc. Natl. Acad. Sci. USA 2002, 99, 16916-16921.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 16916-16921
    • Chedin, F.1    Lieber, M.R.2    Hsieh, C.L.3
  • 12
    • 0032102949 scopus 로고    scopus 로고
    • Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells
    • Okano, M.; Xie, S.; Li, E. Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. Nucleic Acids Res. 1998, 26, 2536-2540.
    • (1998) Nucleic Acids Res , vol.26 , pp. 2536-2540
    • Okano, M.1    Xie, S.2    Li, E.3
  • 15
    • 84861894312 scopus 로고    scopus 로고
    • Mapping the tRNA binding site on the surface of human DNMT2 methyltransferase
    • Jurkowski, T.P.; Shanmugam, R.; Helm, M.; Jeltsch, A. Mapping the tRNA binding site on the surface of human DNMT2 methyltransferase. Biochemistry 2012, 51, 4438-4444.
    • (2012) Biochemistry , vol.51 , pp. 4438-4444
    • Jurkowski, T.P.1    Shanmugam, R.2    Helm, M.3    Jeltsch, A.4
  • 16
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones, P.A.; Baylin, S.B. The epigenomics of cancer. Cell 2007, 128, 683-692.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 17
    • 78149478781 scopus 로고    scopus 로고
    • Aberrant epigenetic landscape in cancer: How cellular identity goes awry
    • Berdasco, M.; Esteller, M. Aberrant epigenetic landscape in cancer: How cellular identity goes awry. Dev. Cell 2010, 19, 698-711.
    • (2010) Dev. Cell , vol.19 , pp. 698-711
    • Berdasco, M.1    Esteller, M.2
  • 18
    • 77955700020 scopus 로고    scopus 로고
    • Genome-wide hypomethylation in cancer may be a passive consequence of transformation
    • Wild, L.; Flanagan, J.M. Genome-wide hypomethylation in cancer may be a passive consequence of transformation. Biochim. Biophys. Acta 2010, 1806, 50-57.
    • (2010) Biochim. Biophys. Acta , vol.1806 , pp. 50-57
    • Wild, L.1    Flanagan, J.M.2
  • 19
    • 84878260646 scopus 로고    scopus 로고
    • TETonic shift: Biological roles of TET proteins in DNA demethylation and transcription
    • Pastor, W.A.; Aravind, L.; Rao, A. TETonic shift: Biological roles of TET proteins in DNA demethylation and transcription. Nat. Rev. Mol. Cell Biol. 2013, 14, 341-356.
    • (2013) Nat. Rev. Mol. Cell Biol , vol.14 , pp. 341-356
    • Pastor, W.A.1    Aravind, L.2    Rao, A.3
  • 21
    • 33847055935 scopus 로고    scopus 로고
    • Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1
    • Valinluck, V.; Sowers, L.C. Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. Cancer Res. 2007, 67, 946-950.
    • (2007) Cancer Res , vol.67 , pp. 946-950
    • Valinluck, V.1    Sowers, L.C.2
  • 22
    • 80052495940 scopus 로고    scopus 로고
    • Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
    • He, Y.-F.; Li, B.-Z.; Li, Z.; Liu, P.; Wang, Y.; Tang, Q.; Ding, J.; Jia, Y.; Chen, Z.; Li, L.; et al. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 2011, 333, 1303-1307.
    • (2011) Science , vol.333 , pp. 1303-1307
    • He, Y.-F.1    Li, B.-Z.2    Li, Z.3    Liu, P.4    Wang, Y.5    Tang, Q.6    Ding, J.7    Jia, Y.8    Chen, Z.9    Li, L.10
  • 26
    • 84877336241 scopus 로고    scopus 로고
    • Decrease of 5-Hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1
    • Liu, C.; Liu, L.; Chen, X.; Shen, J.; Shan, J.; Xu, Y.; Yang, Z.; Wu, L.; Xia, F.; Bie, P.; et al. Decrease of 5-Hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1. PLoS One 2013, 8, e62828.
    • (2013) PLoS One , vol.8
    • Liu, C.1    Liu, L.2    Chen, X.3    Shen, J.4    Shan, J.5    Xu, Y.6    Yang, Z.7    Wu, L.8    Xia, F.9    Bie, P.10
  • 27
    • 77955964086 scopus 로고    scopus 로고
    • AID and somatic hypermutation
    • Maul, R.W.; Gearhart, P.J. AID and somatic hypermutation. Adv. Immunol. 2010, 105, 159-191.
    • (2010) Adv. Immunol , vol.105 , pp. 159-191
    • Maul, R.W.1    Gearhart, P.J.2
  • 28
    • 77649104794 scopus 로고    scopus 로고
    • Reprogramming towards pluripotency requires AID-dependent DNA demethylation
    • Bhutani, N.; Brady, J.J.; Damian, M.; Sacco, A.; Corbel, S.Y.; Blau, H.M. Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature 2010, 463, 1042-1047.
    • (2010) Nature , vol.463 , pp. 1042-1047
    • Bhutani, N.1    Brady, J.J.2    Damian, M.3    Sacco, A.4    Corbel, S.Y.5    Blau, H.M.6
  • 30
    • 77957350610 scopus 로고    scopus 로고
    • Identification of driver and passenger DNA methylation in cancer by epigenomic analysis
    • Kalari, S.; Pfeifer, G.P. Identification of driver and passenger DNA methylation in cancer by epigenomic analysis. Adv. Genet. 2010, 70, 277-308.
    • (2010) Adv. Genet , vol.70 , pp. 277-308
    • Kalari, S.1    Pfeifer, G.P.2
  • 31
    • 23844472366 scopus 로고    scopus 로고
    • Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas
    • Peng, D.F.; Kanai, Y.; Sawada, M.; Ushijima, S.; Hiraoka, N.; Kosuge, T.; Hirohashi, S. Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas. Cancer Sci. 2005, 96, 403-408.
    • (2005) Cancer Sci , vol.96 , pp. 403-408
    • Peng, D.F.1    Kanai, Y.2    Sawada, M.3    Ushijima, S.4    Hiraoka, N.5    Kosuge, T.6    Hirohashi, S.7
  • 32
    • 0030006213 scopus 로고    scopus 로고
    • Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer
    • Belinsky, S.A.; Nikula, K.J.; Baylin, S.B.; Issa, J.P. Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer. Proc. Natl. Acad. Sci. USA 1996, 93, 4045-4050.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4045-4050
    • Belinsky, S.A.1    Nikula, K.J.2    Baylin, S.B.3    Issa, J.P.4
  • 33
    • 0031719311 scopus 로고    scopus 로고
    • Elevated expression and altered pattern of activity of DNA methyltransferase in liver tumors of rats fed methyl-deficient diets
    • Lopatina, N.G.; Vanyushin, B.F.; Cronin, G.M.; Poirier, L.A. Elevated expression and altered pattern of activity of DNA methyltransferase in liver tumors of rats fed methyl-deficient diets. Carcinogenesis 1998, 19, 1777-1781.
    • (1998) Carcinogenesis , vol.19 , pp. 1777-1781
    • Lopatina, N.G.1    Vanyushin, B.F.2    Cronin, G.M.3    Poirier, L.A.4
  • 34
    • 39749128967 scopus 로고    scopus 로고
    • CpG island methylation profile of pancreatic intraepithelial neoplasia
    • Sato, N.; Fukushima, N.; Hruban, R.H.; Goggins, M. CpG island methylation profile of pancreatic intraepithelial neoplasia. Mod. Pathol. 2007, 21, 238-244.
    • (2007) Mod. Pathol , vol.21 , pp. 238-244
    • Sato, N.1    Fukushima, N.2    Hruban, R.H.3    Goggins, M.4
  • 36
    • 0037328351 scopus 로고    scopus 로고
    • Molecular progression of promoter methylation in intraductal papillary mucinous neoplasms (IPMN) of the pancreas
    • House, M.G.; Guo, M.; Iacobuzio-Donahue, C.; Herman, J.G. Molecular progression of promoter methylation in intraductal papillary mucinous neoplasms (IPMN) of the pancreas. Carcinogenesis 2003, 24, 193-198.
    • (2003) Carcinogenesis , vol.24 , pp. 193-198
    • House, M.G.1    Guo, M.2    Iacobuzio-Donahue, C.3    Herman, J.G.4
  • 39
    • 0033153303 scopus 로고    scopus 로고
    • The human DNA methyltransferases (DNMTs) 1, 3a and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors
    • Robertson, K.D.; Uzvolgyi, E.; Liang, G.; Talmadge, C.; Sumegi, J.; Gonzales, F.A.; Jones, P.A. The human DNA methyltransferases (DNMTs) 1, 3a and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res. 1999, 27, 2291-2298.
    • (1999) Nucleic Acids Res , vol.27 , pp. 2291-2298
    • Robertson, K.D.1    Uzvolgyi, E.2    Liang, G.3    Talmadge, C.4    Sumegi, J.5    Gonzales, F.A.6    Jones, P.A.7
  • 40
    • 0026317881 scopus 로고
    • High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer
    • El-Deiry, W.S.; Nelkin, B.D.; Celano, P.; Yen, R.-W.C.; Falco, J.P.; Hamilton, S.R.; Baylin, S.B. High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer. Proc. Natl. Acad. Sci. USA 1991, 88, 3470-3474.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 3470-3474
    • El-Deiry, W.S.1    Nelkin, B.D.2    Celano, P.3    Yen, R.-W.C.4    Falco, J.P.5    Hamilton, S.R.6    Baylin, S.B.7
  • 41
    • 0141995080 scopus 로고    scopus 로고
    • Expression Analysis of DNA Methyltransferases 1, 3A, and 3B in Sporadic Breast Carcinomas
    • Girault, I.; Tozlu, S.; Lidereau, R.; Bièche, I. Expression Analysis of DNA Methyltransferases 1, 3A, and 3B in Sporadic Breast Carcinomas. Clin. Cancer Res. 2003, 9, 4415-4422.
    • (2003) Clin. Cancer Res , vol.9 , pp. 4415-4422
    • Girault, I.1    Tozlu, S.2    Lidereau, R.3    Bièche, I.4
  • 42
    • 0035283201 scopus 로고    scopus 로고
    • Expression of DNA methyltransferases DNMT1,3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia
    • Mizuno, S.; Chijiwa, T.; Okamura, T.; Akashi, K.; Fukumaki, Y.; Niho, Y.; Sasaki, H. Expression of DNA methyltransferases DNMT1,3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Blood 2001, 97, 1172-1179.
    • (2001) Blood , vol.97 , pp. 1172-1179
    • Mizuno, S.1    Chijiwa, T.2    Okamura, T.3    Akashi, K.4    Fukumaki, Y.5    Niho, Y.6    Sasaki, H.7
  • 43
    • 0035962631 scopus 로고    scopus 로고
    • DNA methylation, methyltransferases, and cancer
    • Robertson, K.D. DNA methylation, methyltransferases, and cancer. Oncogene 2001, 20, 3139-3155.
    • (2001) Oncogene , vol.20 , pp. 3139-3155
    • Robertson, K.D.1
  • 45
    • 79955648677 scopus 로고    scopus 로고
    • DNMT3B gene amplification predicts resistance to DNA demethylating drugs
    • Simó-Riudalbas, L.; Melo, S.A.; Esteller, M. DNMT3B gene amplification predicts resistance to DNA demethylating drugs. Genes Chromosomes Cancer 2011, 50, 527-534.
    • (2011) Genes Chromosomes Cancer , vol.50 , pp. 527-534
    • Simó-Riudalbas, L.1    Melo, S.A.2    Esteller, M.3
  • 48
    • 0017727698 scopus 로고
    • 5-Methylcytosine content of rat hepatoma DNA substituted with bromodeoxyuridine
    • Singer, J.; Stellwagen, R.H.; Roberts-Ems, J.; Riggs, A.D. 5-Methylcytosine content of rat hepatoma DNA substituted with bromodeoxyuridine. J. Biol. Chem. 1977, 252, 5509-5513.
    • (1977) J. Biol. Chem , vol.252 , pp. 5509-5513
    • Singer, J.1    Stellwagen, R.H.2    Roberts-Ems, J.3    Riggs, A.D.4
  • 49
    • 0033817101 scopus 로고    scopus 로고
    • Rapid quantification of DNA methylation by high performance capillary electrophoresis
    • Fraga, M.F.; Rodríguez, R.; Cañal, M.J. Rapid quantification of DNA methylation by high performance capillary electrophoresis. Electrophoresis 2000, 21, 2990-2994.
    • (2000) Electrophoresis , vol.21 , pp. 2990-2994
    • Fraga, M.F.1    Rodríguez, R.2    Cañal, M.J.3
  • 50
    • 0036372376 scopus 로고    scopus 로고
    • Nearest-neighbor analysis
    • Ramsahoye, B.H. Nearest-neighbor analysis. Methods Mol. Biol. 2002, 200, 9-15.
    • (2002) Methods Mol. Biol , vol.200 , pp. 9-15
    • Ramsahoye, B.H.1
  • 51
    • 39749084733 scopus 로고    scopus 로고
    • Global DNA hypomethylation in liver cancer cases and controls: A phase I preclinical biomarker development study
    • Guerrero-Preston, R.; Santella, R.M.; Blanco, A.; Desai, M.; Berdasco, M.; Fraga, M. Global DNA hypomethylation in liver cancer cases and controls: A phase I preclinical biomarker development study. Epigenetics 2007, 2, 223-226.
    • (2007) Epigenetics , vol.2 , pp. 223-226
    • Guerrero-Preston, R.1    Santella, R.M.2    Blanco, A.3    Desai, M.4    Berdasco, M.5    Fraga, M.6
  • 52
    • 0036311364 scopus 로고    scopus 로고
    • Restriction landmark genome scanning
    • Costello, J.F.; Smiraglia, D.J.; Plass, C. Restriction landmark genome scanning. Methods 2002, 27, 144-149.
    • (2002) Methods , vol.27 , pp. 144-149
    • Costello, J.F.1    Smiraglia, D.J.2    Plass, C.3
  • 53
    • 18844465619 scopus 로고    scopus 로고
    • Methylome profiling of cancer cells by amplification of inter-methylated sites (AIMS)
    • Frigola, J.; Ribas, M.; Risques, R.-A.; Peinado, M.A. Methylome profiling of cancer cells by amplification of inter-methylated sites (AIMS). Nucleic Acids Res. 2002, 30, e28.
    • (2002) Nucleic Acids Res , vol.30
    • Frigola, J.1    Ribas, M.2    Risques, R.-A.3    Peinado, M.A.4
  • 57
    • 84857911910 scopus 로고    scopus 로고
    • Detection of aberrant promoter methylation of GSTP1, RASSF1A, and RARβ2 in serum DNA of patients with breast cancer by a newly established one-step methylation-specific PCR assay
    • Yamamoto, N.; Nakayama, T.; Kajita, M.; Miyake, T.; Iwamoto, T.; Kim, S.J.; Sakai, A.; Ishihara, H.; Tamaki, Y.; Noguchi, S. Detection of aberrant promoter methylation of GSTP1, RASSF1A, and RARβ2 in serum DNA of patients with breast cancer by a newly established one-step methylation-specific PCR assay. Breast Cancer Res. Treat. 2012, 132, 165-173.
    • (2012) Breast Cancer Res. Treat , vol.132 , pp. 165-173
    • Yamamoto, N.1    Nakayama, T.2    Kajita, M.3    Miyake, T.4    Iwamoto, T.5    Kim, S.J.6    Sakai, A.7    Ishihara, H.8    Tamaki, Y.9    Noguchi, S.10
  • 58
    • 0030825309 scopus 로고    scopus 로고
    • A sensitive and quantitative DNA methylation assay
    • Xiong, Z.; Laird, P.W. COBRA: A sensitive and quantitative DNA methylation assay. Nucleic Acids Res. 1997, 25, 2532-2534.
    • (1997) Nucleic Acids Res , vol.25 , pp. 2532-2534
    • Xiong, Z.1    Laird, P.W.C.2
  • 60
    • 38449113853 scopus 로고    scopus 로고
    • DNA methylation analysis by pyrosequencing
    • Tost, J.; Gut, I.G. DNA methylation analysis by pyrosequencing. Nat. Protoc. 2007, 2, 2265-2275.
    • (2007) Nat. Protoc , vol.2 , pp. 2265-2275
    • Tost, J.1    Gut, I.G.2
  • 62
    • 34548734299 scopus 로고    scopus 로고
    • Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing
    • Taylor, K.H.; Kramer, R.S.; Davis, J.W.; Guo, J.; Duff, D.J.; Xu, D.; Caldwell, C.W.; Shi, H. Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing. Cancer Res. 2007, 67, 8511-8518.
    • (2007) Cancer Res , vol.67 , pp. 8511-8518
    • Taylor, K.H.1    Kramer, R.S.2    Davis, J.W.3    Guo, J.4    Duff, D.J.5    Xu, D.6    Caldwell, C.W.7    Shi, H.8
  • 66
    • 77957377060 scopus 로고    scopus 로고
    • Detection of DNA methylation changes in body fluids
    • Liloglou, T.; Field, J.K. Detection of DNA methylation changes in body fluids. Adv. Genet. 2010, 71, 177-207.
    • (2010) Adv. Genet , vol.71 , pp. 177-207
    • Liloglou, T.1    Field, J.K.2
  • 68
    • 56849133040 scopus 로고    scopus 로고
    • Laird-Offringa I.A.DNA.Methylation-based biomarkers for early detection of non-small cell lung cancer: An update
    • Anglim, P.P.; Alonzo, T.A.; Laird-Offringa, I.A. DNA methylation-based biomarkers for early detection of non-small cell lung cancer: An update. Mol. Cancer 2008, 7, 81.
    • (2008) Mol. Cancer , vol.7 , pp. 81
    • Anglim, P.P.1    Alonzo, T.A.2
  • 72
    • 0035835818 scopus 로고    scopus 로고
    • P16(MTS-1/CDKN2/INK4a) in cancer progression
    • Rocco, J.W.; Sidransky, D. p16(MTS-1/CDKN2/INK4a) in cancer progression. Exp. Cell Res. 2001, 264, 42-55.
    • (2001) Exp. Cell Res , vol.264 , pp. 42-55
    • Rocco, J.W.1    Sidransky, D.2
  • 76
    • 78149469118 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy
    • Kaina, B.; Margison, G.P.; Christmann, M.; Targeting, O. 6-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy. Cell. Mol. Life Sci. 2010, 67, 3663-3681.
    • (2010) Cell. Mol. Life Sci , vol.67 , pp. 3663-3681
    • Kaina, B.1    Margison, G.P.2    Christmann, M.3    Targeting, O.4
  • 79
    • 0642374221 scopus 로고    scopus 로고
    • The role of glutathione-S-transferase in anti-cancer drug resistance
    • Townsend, D.M.; Tew, K.D. The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene 2003, 22, 7369-7375.
    • (2003) Oncogene , vol.22 , pp. 7369-7375
    • Townsend, D.M.1    Tew, K.D.2
  • 82
    • 61749084094 scopus 로고    scopus 로고
    • GSTP1 determines cis-platinum cytotoxicity in gastric adenocarcinoma MGC803 cells: Regulation by promoter methylation and extracellular regulated kinase signaling
    • Zhang, Y.; Qu, X.; Jing, W.; Hu, X.; Yang, X.; Hou, K.; Teng, Y.; Zhang, J.; Liu, Y. GSTP1 determines cis-platinum cytotoxicity in gastric adenocarcinoma MGC803 cells: Regulation by promoter methylation and extracellular regulated kinase signaling. Anticancer Drugs 2009, 20, 208-214.
    • (2009) Anticancer Drugs , vol.20 , pp. 208-214
    • Zhang, Y.1    Qu, X.2    Jing, W.3    Hu, X.4    Yang, X.5    Hou, K.6    Teng, Y.7    Zhang, J.8    Liu, Y.9
  • 83
    • 0037364371 scopus 로고    scopus 로고
    • Quantitative Gstp1 methylation clearly distinguishes benign prostatic tissue and limited prostate adenocarcinoma
    • Harden, S.V.; Guo, Z.; Epstein, J.I.; Sidransky, D. Quantitative Gstp1 methylation clearly distinguishes benign prostatic tissue and limited prostate adenocarcinoma. J. Urol. 2003, 169, 1138-1142.
    • (2003) J. Urol , vol.169 , pp. 1138-1142
    • Harden, S.V.1    Guo, Z.2    Epstein, J.I.3    Sidransky, D.4
  • 85
    • 80054683472 scopus 로고    scopus 로고
    • Role of glutathione-S-transferase P1 hypermethylation in molecular detection of prostate cancer
    • Hashad, D.I.; Hashad, M.M.E.I.; Talaat, I.M.; Ibrahim, M.A. Role of glutathione-S-transferase P1 hypermethylation in molecular detection of prostate cancer. Genet Test Mol. Biomark. 2011, 15, 667-670.
    • (2011) Genet Test Mol. Biomark , vol.15 , pp. 667-670
    • Hashad, D.I.1    Hashad, M.M.E.I.2    Talaat, I.M.3    Ibrahim, M.A.4
  • 86
    • 79955739303 scopus 로고    scopus 로고
    • DNA Mismatch Repair in Eukaryotes and Bacteria
    • Fukui, K. DNA Mismatch Repair in Eukaryotes and Bacteria. J. Nucleic Acids 2010, 2010, 1-16.
    • (2010) J. Nucleic Acids , vol.2010 , pp. 1-16
    • Fukui, K.1
  • 91
    • 0035870248 scopus 로고    scopus 로고
    • A gene hypermethylation profile of human cancer
    • Esteller, M.; Corn, P.G.; Baylin, S.B.; Herman, J.G. A gene hypermethylation profile of human cancer. Cancer Res. 2001, 61, 3225-3229.
    • (2001) Cancer Res , vol.61 , pp. 3225-3229
    • Esteller, M.1    Corn, P.G.2    Baylin, S.B.3    Herman, J.G.4
  • 92
    • 0037169354 scopus 로고    scopus 로고
    • Cancer susceptibility and the functions of BRCA1 and BRCA2
    • Venkitaraman, A.R. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 2002, 108, 171-182.
    • (2002) Cell , vol.108 , pp. 171-182
    • Venkitaraman, A.R.1
  • 94
    • 0030843274 scopus 로고    scopus 로고
    • Methylation of the BRCA1 gene in sporadic breast cancer
    • Dobrovic, A.; Simpfendorfer, D. Methylation of the BRCA1 gene in sporadic breast cancer. Cancer Res. 1997, 57, 3347-3350.
    • (1997) Cancer Res , vol.57 , pp. 3347-3350
    • Dobrovic, A.1    Simpfendorfer, D.2
  • 101
    • 34248217444 scopus 로고    scopus 로고
    • Methylation of human microRNA genes in normal and neoplastic cells
    • Weber, B.; Stresemann, C.; Brueckner, B.; Lyko, F. Methylation of human microRNA genes in normal and neoplastic cells. Cell Cycle 2007, 6, 1001-1005.
    • (2007) Cell Cycle , vol.6 , pp. 1001-1005
    • Weber, B.1    Stresemann, C.2    Brueckner, B.3    Lyko, F.4
  • 102
    • 33744805399 scopus 로고    scopus 로고
    • Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
    • Saito, Y.; Liang, G.; Egger, G.; Friedman, J.M.; Chuang, J.C.; Coetzee, G.A.; Jones, P.A. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 2006, 9, 435-443.
    • (2006) Cancer Cell , vol.9 , pp. 435-443
    • Saito, Y.1    Liang, G.2    Egger, G.3    Friedman, J.M.4    Chuang, J.C.5    Coetzee, G.A.6    Jones, P.A.7
  • 104
    • 84865566726 scopus 로고    scopus 로고
    • DNA methylation of microRNA genes in multiple myeloma
    • Wong, K.Y.; Huang, X.; Chim, C.S. DNA methylation of microRNA genes in multiple myeloma. Carcinogenesis 2012, 33, 1629-1638.
    • (2012) Carcinogenesis , vol.33 , pp. 1629-1638
    • Wong, K.Y.1    Huang, X.2    Chim, C.S.3
  • 105
    • 84878857160 scopus 로고    scopus 로고
    • MicroRNAs in Pancreatic Cancer: Potential Interests as Biomarkers and Therapeutic Tools
    • Cho, W.C.S., Ed.; Springer: Dordrecht, The Netherlands
    • Cordelier, P.; Torrisani, J. MicroRNAs in Pancreatic Cancer: Potential Interests as Biomarkers and Therapeutic Tools. In MicroRNAs in Cancer Translational Research; Cho, W.C.S., Ed.; Springer: Dordrecht, The Netherlands, 2011; pp. 287-307.
    • (2011) MicroRNAs In Cancer Translational Research , pp. 287-307
    • Cordelier, P.1    Torrisani, J.2
  • 106
    • 1542636969 scopus 로고    scopus 로고
    • Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling
    • Sato, N.; Fukushima, N.; Matsubayashi, H.; Goggins, M. Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling. Oncogene 2004, 23, 1531-1538.
    • (2004) Oncogene , vol.23 , pp. 1531-1538
    • Sato, N.1    Fukushima, N.2    Matsubayashi, H.3    Goggins, M.4
  • 109
    • 77952202346 scopus 로고    scopus 로고
    • Genomic imprinting-an epigenetic gene-regulatory model
    • Koerner, M.V.; Barlow, D.P. Genomic imprinting-an epigenetic gene-regulatory model. Curr. Opin. Genet. Develop. 2010, 20, 164-170.
    • (2010) Curr. Opin. Genet. Develop , vol.20 , pp. 164-170
    • Koerner, M.V.1    Barlow, D.P.2
  • 110
    • 33846581497 scopus 로고    scopus 로고
    • Loss of imprinting and cancer
    • Jelinic, P.; Shaw, P. Loss of imprinting and cancer. J. Pathol. 2007, 211, 261-268.
    • (2007) J. Pathol , vol.211 , pp. 261-268
    • Jelinic, P.1    Shaw, P.2
  • 111
    • 48449090298 scopus 로고    scopus 로고
    • Epigenetic biomarkers for human cancer: The time is now
    • Mulero-Navarro, S.; Esteller, M. Epigenetic biomarkers for human cancer: The time is now. Crit. Rev. Oncol. Hematol. 2008, 68, 1-11.
    • (2008) Crit. Rev. Oncol. Hematol , vol.68 , pp. 1-11
    • Mulero-Navarro, S.1    Esteller, M.2
  • 113
  • 115
    • 76249112147 scopus 로고    scopus 로고
    • Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options
    • Stumpel, D.J.P.M.; Schneider, P.; van Roon, E.H.J.; Boer, J.M.; de Lorenzo, P.; Valsecchi, M.G.; de Menezes, R.X.; Pieters, R.; Stam, R.W. Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options. Blood 2009, 114, 5490-5498.
    • (2009) Blood , vol.114 , pp. 5490-5498
    • Stumpel, D.J.P.M.1    Schneider, P.2    van Roon, E.H.J.3    Boer, J.M.4    de Lorenzo, P.5    Valsecchi, M.G.6    de Menezes, R.X.7    Pieters, R.8    Stam, R.W.9
  • 120
    • 1942438016 scopus 로고    scopus 로고
    • Rules of evidence for cancer molecular-marker discovery and validation
    • Ransohoff, D.F. Rules of evidence for cancer molecular-marker discovery and validation. Nat. Rev. Cancer 2004, 4, 309-314.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 309-314
    • Ransohoff, D.F.1
  • 121
    • 84862535291 scopus 로고    scopus 로고
    • DNA methylation biomarkers in cancer: Progress towards clinical implementation
    • Mikeska, T.; Bock, C.; Do, H.; Dobrovic, A. DNA methylation biomarkers in cancer: Progress towards clinical implementation. Expert Rev. Mol. Diagn. 2012, 12, 473-487.
    • (2012) Expert Rev. Mol. Diagn , vol.12 , pp. 473-487
    • Mikeska, T.1    Bock, C.2    Do, H.3    Dobrovic, A.4
  • 123
    • 0000418476 scopus 로고
    • Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine
    • Santi, D.V.; Norment, A.; Garrett, C.E. Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine. Proc. Natl. Acad. Sci. USA 1984, 81, 6993-6997.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 6993-6997
    • Santi, D.V.1    Norment, A.2    Garrett, C.E.3
  • 125
    • 0034105545 scopus 로고    scopus 로고
    • DNA methylation inhibitors in the treatment of leukemias, myelodysplastic syndromes and hemoglobinopathies: Clinical results and possible mechanisms of action
    • Lübbert, M. DNA methylation inhibitors in the treatment of leukemias, myelodysplastic syndromes and hemoglobinopathies: Clinical results and possible mechanisms of action. Curr. Top. Microbiol. Immunol. 2000, 249, 135-164.
    • (2000) Curr. Top. Microbiol. Immunol , vol.249 , pp. 135-164
    • Lübbert, M.1
  • 126
    • 79951620932 scopus 로고    scopus 로고
    • New nucleoside analogs for patients with hematological malignancies
    • Robak, T. New nucleoside analogs for patients with hematological malignancies. Expert Opin. Investig. Drugs 2011, 20, 343-359.
    • (2011) Expert Opin. Investig. Drugs , vol.20 , pp. 343-359
    • Robak, T.1
  • 127
    • 84863337757 scopus 로고    scopus 로고
    • Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
    • Tsai, H.-C.; Li, H.; Van Neste, L.; Cai, Y.; Robert, C.; Rassool, F.V.; Shin, J.J.; Harbom, K.M.; Beaty, R.; Pappou, E.; et al. Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell 2012, 21, 430-446.
    • (2012) Cancer Cell , vol.21 , pp. 430-446
    • Tsai, H.-C.1    Li, H.2    van Neste, L.3    Cai, Y.4    Robert, C.5    Rassool, F.V.6    Shin, J.J.7    Harbom, K.M.8    Beaty, R.9    Pappou, E.10
  • 129
    • 84879471312 scopus 로고    scopus 로고
    • Prospective phase II study on 5-days azacitidine for treatment of symptomatic and/or erythropoietin unresponsive patients with low/INT-1-risk myelodysplastic syndromes
    • Filì, C.; Malagola, M.; Follo, M.Y.; Finelli, C.; Iacobucci, I.; Martinelli, G.; Cattina, F.; Clissa, C.; Candoni, A.; Fanin, R.; et al. Prospective phase II study on 5-days azacitidine for treatment of symptomatic and/or erythropoietin unresponsive patients with low/INT-1-risk myelodysplastic syndromes. Clin. Cancer Res. 2013, 19, 3297-3308.
    • (2013) Clin. Cancer Res , vol.19 , pp. 3297-3308
    • Filì, C.1    Malagola, M.2    Follo, M.Y.3    Finelli, C.4    Iacobucci, I.5    Martinelli, G.6    Cattina, F.7    Clissa, C.8    Candoni, A.9    Fanin, R.10
  • 131
    • 84879565439 scopus 로고    scopus 로고
    • A multivariate analysis of the relationship between response and survival among patients with higher-risk myelodysplastic syndromes treated within azacitidine or conventional care regimens in the randomized AZA-001 trial
    • doi:10.3324/haematol.2012.074831
    • Gore, S.D.; Fenaux, P.; Santini, V.; Bennett, J.M.; Silverman, L.R.; Seymour, J.F.; Hellstrom-Lindberg, E.; Swern, A.S.; Beach, C.L.; List, A.F.; et al. A multivariate analysis of the relationship between response and survival among patients with higher-risk myelodysplastic syndromes treated within azacitidine or conventional care regimens in the randomized AZA-001 trial. Haematologica 2013, doi:10.3324/haematol.2012.074831.
    • (2013) Haematologica
    • Gore, S.D.1    Fenaux, P.2    Santini, V.3    Bennett, J.M.4    Silverman, L.R.5    Seymour, J.F.6    Hellstrom-Lindberg, E.7    Swern, A.S.8    Beach, C.L.9    List, A.F.10
  • 133
    • 79958714414 scopus 로고    scopus 로고
    • 2'-deoxy-5,6-dihydro-5-azacytidine-a less toxic alternative of 2'-deoxy-5-azacytidine: A comparative study of hypomethylating potential
    • Matoušová, M.; Votruba, I.; Otmar, M.; Tloušťová, E.; Günterová, J.; Mertlíková-Kaiserová, H. 2'-deoxy-5,6-dihydro-5-azacytidine-a less toxic alternative of 2'-deoxy-5-azacytidine: A comparative study of hypomethylating potential. Epigenetics 2011, 6, 769-776.
    • (2011) Epigenetics , vol.6 , pp. 769-776
    • Matoušová, M.1    Votruba, I.2    Otmar, M.3    Tloušťová, E.4    Günterová, J.5    Mertlíková-Kaiserová, H.6
  • 134
    • 77952203695 scopus 로고    scopus 로고
    • S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth
    • Chuang, J.C.; Warner, S.L.; Vollmer, D.; Vankayalapati, H.; Redkar, S.; Bearss, D.J.; Qiu, X.; Yoo, C.B.; Jones, P.A. S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth. Mol. Cancer Ther. 2010, 9, 1443-1450.
    • (2010) Mol. Cancer Ther , vol.9 , pp. 1443-1450
    • Chuang, J.C.1    Warner, S.L.2    Vollmer, D.3    Vankayalapati, H.4    Redkar, S.5    Bearss, D.J.6    Qiu, X.7    Yoo, C.B.8    Jones, P.A.9
  • 135
    • 84865117517 scopus 로고    scopus 로고
    • Flight of a cytidine deaminase complex with an imperfect transition state analogue inhibitor: Mass spectrometric evidence for the presence of a trapped water molecule
    • Schroeder, G.K.; Zhou, L.; Snider, M.J.; Chen, X.; Wolfenden, R. Flight of a cytidine deaminase complex with an imperfect transition state analogue inhibitor: Mass spectrometric evidence for the presence of a trapped water molecule. Biochemistry 2012, 51, 6476-6486.
    • (2012) Biochemistry , vol.51 , pp. 6476-6486
    • Schroeder, G.K.1    Zhou, L.2    Snider, M.J.3    Chen, X.4    Wolfenden, R.5
  • 136
    • 0036965821 scopus 로고    scopus 로고
    • Zebularine: A novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases
    • Zhou, L.; Cheng, X.; Connolly, B.A.; Dickman, M.J.; Hurd, P.J.; Hornby, D.P. Zebularine: A novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. J. Mol. Biol. 2002, 321, 591-599.
    • (2002) J. Mol. Biol , vol.321 , pp. 591-599
    • Zhou, L.1    Cheng, X.2    Connolly, B.A.3    Dickman, M.J.4    Hurd, P.J.5    Hornby, D.P.6
  • 137
    • 33846362233 scopus 로고    scopus 로고
    • Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression
    • Scott, S.A.; Lakshimikuttysamma, A.; Sheridan, D.P.; Sanche, S.E.; Geyer, C.R.; DeCoteau, J.F. Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression. Exp. Hematol. 2007, 35, 263-273.
    • (2007) Exp. Hematol , vol.35 , pp. 263-273
    • Scott, S.A.1    Lakshimikuttysamma, A.2    Sheridan, D.P.3    Sanche, S.E.4    Geyer, C.R.5    Decoteau, J.F.6
  • 139
    • 67349200930 scopus 로고    scopus 로고
    • The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells
    • Flotho, C.; Claus, R.; Batz, C.; Schneider, M.; Sandrock, I.; Ihde, S.; Plass, C.; Niemeyer, C.M.; Lübbert, M. The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia 2009, 23, 1019-1028.
    • (2009) Leukemia , vol.23 , pp. 1019-1028
    • Flotho, C.1    Claus, R.2    Batz, C.3    Schneider, M.4    Sandrock, I.5    Ihde, S.6    Plass, C.7    Niemeyer, C.M.8    Lübbert, M.9
  • 140
    • 79251557812 scopus 로고    scopus 로고
    • Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors
    • Chik, F.; Szyf, M. Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors. Carcinogenesis 2011, 32, 224-232.
    • (2011) Carcinogenesis , vol.32 , pp. 224-232
    • Chik, F.1    Szyf, M.2
  • 141
    • 84869850999 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors in cancer: A chemical and therapeutic patent overview and selected clinical studies
    • Fahy, J.; Jeltsch, A.; Arimondo, P.B. DNA methyltransferase inhibitors in cancer: A chemical and therapeutic patent overview and selected clinical studies. Expert Opin. Ther. Pat. 2012, 22, 1427-1442.
    • (2012) Expert Opin. Ther. Pat , vol.22 , pp. 1427-1442
    • Fahy, J.1    Jeltsch, A.2    Arimondo, P.B.3
  • 142
    • 0023936754 scopus 로고
    • Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity
    • Cornacchia, E.; Golbus, J.; Maybaum, J.; Strahler, J.; Hanash, S.; Richardson, B. Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J. Immunol. 1988, 140, 2197-2200.
    • (1988) J. Immunol , vol.140 , pp. 2197-2200
    • Cornacchia, E.1    Golbus, J.2    Maybaum, J.3    Strahler, J.4    Hanash, S.5    Richardson, B.6
  • 145
    • 27644597195 scopus 로고    scopus 로고
    • Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine
    • Chuang, J.C.; Yoo, C.B.; Kwan, J.M.; Li, T.W.H.; Liang, G.; Yang, A.S.; Jones, P.A. Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine. Mol. Cancer Ther. 2005, 4, 1515-1520.
    • (2005) Mol. Cancer Ther , vol.4 , pp. 1515-1520
    • Chuang, J.C.1    Yoo, C.B.2    Kwan, J.M.3    Li, T.W.H.4    Liang, G.5    Yang, A.S.6    Jones, P.A.7
  • 146
    • 0020557283 scopus 로고
    • Conversion of atrial fibrillation to sinus rhythm by acute intravenous procainamide infusion
    • Fenster, P.E.; Comess, K.A.; Marsh, R.; Katzenberg, C.; Hager, W.D. Conversion of atrial fibrillation to sinus rhythm by acute intravenous procainamide infusion. Am. Heart J. 1983, 106, 501-504.
    • (1983) Am. Heart J , vol.106 , pp. 501-504
    • Fenster, P.E.1    Comess, K.A.2    Marsh, R.3    Katzenberg, C.4    Hager, W.D.5
  • 147
    • 0041939756 scopus 로고    scopus 로고
    • Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells
    • Villar-Garea, A.; Fraga, M.F.; Espada, J.; Esteller, M. Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res. 2003, 63, 4984-4989.
    • (2003) Cancer Res , vol.63 , pp. 4984-4989
    • Villar-Garea, A.1    Fraga, M.F.2    Espada, J.3    Esteller, M.4
  • 148
    • 28844497663 scopus 로고    scopus 로고
    • Procainamide is a specific inhibitor of DNA methyltransferase 1
    • Lee, B.H.; Yegnasubramanian, S.; Lin, X.; Nelson, W.G. Procainamide is a specific inhibitor of DNA methyltransferase 1. J. Biol. Chem. 2005, 280, 40749-40756.
    • (2005) J. Biol. Chem , vol.280 , pp. 40749-40756
    • Lee, B.H.1    Yegnasubramanian, S.2    Lin, X.3    Nelson, W.G.4
  • 149
    • 33645086120 scopus 로고    scopus 로고
    • Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines
    • Stresemann, C.; Brueckner, B.; Musch, T.; Stopper, H.; Lyko, F. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res. 2006, 66, 2794-2800.
    • (2006) Cancer Res , vol.66 , pp. 2794-2800
    • Stresemann, C.1    Brueckner, B.2    Musch, T.3    Stopper, H.4    Lyko, F.5
  • 152
    • 26444451123 scopus 로고    scopus 로고
    • Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy
    • Fang, M.Z.; Chen, D.; Sun, Y.; Jin, Z.; Christman, J.K.; Yang, C.S. Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy. Clin. Cancer Res. 2005, 11, 7033-7041.
    • (2005) Clin. Cancer Res , vol.11 , pp. 7033-7041
    • Fang, M.Z.1    Chen, D.2    Sun, Y.3    Jin, Z.4    Christman, J.K.5    Yang, C.S.6
  • 153
    • 25144507259 scopus 로고    scopus 로고
    • Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids
    • Lee, W.J.; Shim, J.-Y.; Zhu, B.T. Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol. Pharmacol. 2005, 68, 1018-1030.
    • (2005) Mol. Pharmacol , vol.68 , pp. 1018-1030
    • Lee, W.J.1    Shim, J.-Y.2    Zhu, B.T.3
  • 154
    • 84880711984 scopus 로고    scopus 로고
    • Genetic and epigenetic studies for determining molecular targets of natural product anticancer agents
    • Wang, Y.; Li, Y.; Liu, X.; Cho, W.C. Genetic and epigenetic studies for determining molecular targets of natural product anticancer agents. Curr. Cancer Drug Targets 2013, 13, 506-518.
    • (2013) Curr. Cancer Drug Targets , vol.13 , pp. 506-518
    • Wang, Y.1    Li, Y.2    Liu, X.3    Cho, W.C.4
  • 155
    • 65649152375 scopus 로고    scopus 로고
    • Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors
    • Plummer, R.; Vidal, L.; Griffin, M.; Lesley, M.; de Bono, J.; Coulthard, S.; Sludden, J.; Siu, L.L.; Chen, E.X.; Oza, A.M.; et al. Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors. Clin. Cancer Res. 2009, 15, 3177-3183.
    • (2009) Clin. Cancer Res , vol.15 , pp. 3177-3183
    • Plummer, R.1    Vidal, L.2    Griffin, M.3    Lesley, M.4    de Bono, J.5    Coulthard, S.6    Sludden, J.7    Siu, L.L.8    Chen, E.X.9    Oza, A.M.10
  • 156
    • 42249104213 scopus 로고    scopus 로고
    • A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia
    • Klisovic, R.B.; Stock, W.; Cataland, S.; Klisovic, M.I.; Liu, S.; Blum, W.; Green, M.; Odenike, O.; Godley, L.; Burgt, J.V. et al. A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia. Clin. Cancer Res. 2008, 14, 2444-2449.
    • (2008) Clin. Cancer Res , vol.14 , pp. 2444-2449
    • Klisovic, R.B.1    Stock, W.2    Cataland, S.3    Klisovic, M.I.4    Liu, S.5    Blum, W.6    Green, M.7    Odenike, O.8    Godley, L.9    Burgt, J.V.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.