Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients

Cancer Research

Volumn 59, Issue 1, 1999, Pages 71-73

  Wong, Ivy H N ^a   Lo, Y M Dennis ^a   Zhang, Jun ^a   Liew, Choong Tsek ^a   Ng, Margaret H L ^a   Wong, Nathalie ^a   Lai, Paul B S ^a   Lau, Wan Y ^a   Hjelm, N Magnus ^a   Johnson, Philip J ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P16;

ADULT; AGED; AMINO ACID SEQUENCE; ARTICLE; BLOOD LEVEL; CANCER CELL CULTURE; CANCER DIAGNOSIS; CANCER STAGING; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DNA METHYLATION; FEMALE; HUMAN; LIVER CELL CARCINOMA; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROGNOSIS;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; DNA, NEOPLASM; FEMALE; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; TUMOR MARKERS, BIOLOGICAL;

EID: 0032893755     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Chen, C. J., Yu, M. W., and Liaw, Y. F. Epidemiological characteristics and risk factors of hepatocellular carcinoma. J. Gastroenterol. Hepatol., 12: S294-S308, 1997.
2. Sheu, J. C. Molecular mechanism of hepatocarcinogenesis. J. Gastroenterol. Hepatol., 12: S309-S313, 1997.
3. INK4 (MTS1) gene occur in a subset of patients with hepatocellular carcinoma. Hepatology, 25: 1376-1381, 1997.
4. Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E., Burger, P. C., Baylin, S. B., and Sidransky, D. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med., 1: 686-692, 1995.
5. Nawroz, H., Koch, W., Anker, P., Stroun, M., and Sidransky, D. Microsatellite alterations in serum DNA of head and neck cancer patients. Nat. Med., 2: 1035-1037, 1996.
6. Hibi, K., Robinson, R., Booker, S., Wu. L., Hamilton, S. R., Sidransky, D., and Jen, J. Molecular detection of genetic alterations in the serum of colorectal cancer patients. Cancer Res., 58: 1405-1407, 1998.
7. Herman, J. G., Graff, J. R., Myohanen, S., Nelkin, B. D., and Baylin, S. B. Methylation-specific PCR. A novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA, 91: 9821-9826, 1996.
8. Lo, Y. M. D., Tein, M. S. C., Lau, T. K., Haines, C. J., Leung, T. N., Poon, P. M. K., Wainscoat, J. S., Johnson, P. J., Chang, A. M. Z., and Hjelm, N. M. Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis. Am. J. Hum. Genet., 62: 768-775, 1998.
9. Wong, I. H. N., Leung, T., Ho. S., Lau, W. Y., Chan, M., and Johnson, P. J. Semiquantitation of circulating hepatocellular carcinoma cells by reverse transcriptase polymerase chain reaction. Br. J. Cancer, 76: 628-633, 1997.
10. Wong, I. H. N., Ng, M. H. L., Lee, J. C. K., Lo, K. W., Chung, Y. F., and Huang, D. P. Transcriptional silencing of the p16 gene in human myeloma-derived cell lines by hypermethylation. Br. J. Haematol., 103: 168-175, 1998.
11. Laird, P. W. Oncogenic mechanisms mediated by DNA methylation. Mol. Med. Today, 3: 223-229, 1997.
12. Gonzalez-Zulueta, M., Bender, C. M., Yang, A. S., Nguyen, T., Bean, R. W., Van Tomout, J. M., and Jones, P. A. Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res., 55: 4531-4535, 1995.
13. Graff, J. R., Herman, J. G., Lapidus, R. G., Chopra, H., Xu, R., Jarrard, D. F., Isaacs, W. B., Pitha, P. M., Davidson, N. E., and Baylin, S. B. E-Cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res., 55: 5195-5199, 1995.
14. Herman, J. G., Latif, F., Weng, W., Lerman, M. I., Zbar, B., Liu, S., Samid, D., Duan, D. S. R., Gnarra, J. R., Linehan, W. M., and Baylin, S. B. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc. Natl. Acad. Sci. USA. 91: 9700-9704, 1994.
15. Mancini, D. N., Rodenhiser, D. I., Ainsworth, P. J., O'Malley, F. P., Singh, S. M., Xing, W., and Archer, T. K. CpG methylation within the 5′ regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site. Oncogene, 16: 1161-1169, 1998.
16. Chelly, J., Concordet, J. P., Kaplan, J. C., and Kalm, A. Illegitimate transcription: transcription of any gene in any cell type. Proc. Natl. Acad. Sci. USA, 86: 2617-2621, 1989.
17. Hainaut, P., Hernandez, T., Robinson, A., Rodriguez-Tome, P., Flores, T., Hollstein, M., Harris, C. C., and Montesano, R. IARC database of p53 mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools. Nucleic Acids Res., 26: 205-213, 1998.
18. Beahrs, O. H., Henson, D. E., Hutter, R. V. P., and Kennedy, B. J. (eds.). Handbook for Staging of Cancer. Philadelphia: J. B. Lippincott, 1993.