Flight of a cytidine deaminase complex with an imperfect transition state analogue inhibitor: Mass spectrometric evidence for the presence of a trapped water molecule

Biochemistry

Volumn 51, Issue 32, 2012, Pages 6476-6486

  Schroeder, Gottfried K ^a,c   Zhou, Li ^a   Snider, Mark J ^b   Chen, Xian ^a   Wolfenden, Richard ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b The College of Wooster   (United States)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ADDED MASS; AMMONIUM IONS; CYTIDINE DEAMINASE; DIMERIC COMPLEXES; DIMERIC SPECIES; ENZYME-INHIBITOR COMPLEX; FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETRY; FREE ENERGY OF BINDING; FT-ICR MS; INHIBITORY COMPLEX; SUBUNIT INTERFACES; TRANSITION-STATE ANALOGUES; VAPOR PHASE; WATER MOLECULE;

ENZYMES; HYDRATES; HYDRATION; ZINC;

MOLECULES;

CYTIDINE DEAMINASE; CYTIDINE DEAMINASE INHIBITOR; ENZYME INHIBITOR; UNCLASSIFIED DRUG; WATER; ZEBULARINE;

ARTICLE; ENERGY; ENTROPY; ENZYME ANALYSIS; ENZYME INHIBITOR COMPLEX; ENZYME STABILITY; ENZYME SUBSTRATE; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; ISOTOPE LABELING; PRIORITY JOURNAL; THERMODYNAMICS;

CALORIMETRY; CYTIDINE; CYTIDINE DEAMINASE; DEAMINATION; DIMERIZATION; ENZYME INHIBITORS; FOURIER ANALYSIS; HYDROLYSIS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; MASS SPECTROMETRY; PROTEIN BINDING; PYRIMIDINE NUCLEOSIDES; THERMODYNAMICS; WATER;

EID: 84865117517     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300516u     Document Type: Article

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