Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia

Blood

Volumn 97, Issue 5, 2001, Pages 1172-1179

  Mizuno, Shin Ichi ^a   Chijiwa, Takahito ^b   Okamura, Takashi ^b   Akashi, Koichi ^b   Fukumaki, Yasuyuki ^b   Niho, Yoshiyuki ^b   Sasaki, Hiroyuki ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; BONE MARROW CELL; CARCINOGENESIS; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; GENE EXPRESSION; HEMATOPOIESIS; HUMAN; MAJOR CLINICAL STUDY; MONOCYTE; MYELOID LEUKEMIA; NEUTROPHIL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR SUPPRESSOR GENE;

EID: 0035283201     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.5.1172     Document Type: Article

References (56)

1. DNA methylation
2. How does DNA methylation repress transcription?
3. Genomic imprinting in mammals
4. Genomic imprinting: Significance in development and diseases and the molecular mechanisms
5. RNA and the epigenetic regulation of X chromosome inactivation
6. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
7. DNA methylation and cancer
8. Cancer epigenetics comes of age
9. DNA hypermethylation in tumorigenesis: Epigenetics joins genetics
10. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns
11. Allele-specific hypermethylarian of the retinoblastoma tumor-suppressor gene
12. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
13. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
14. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
15. p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing
16. DNA methylation changes in hematologic malignancies: Biologic and clinical implications
17. Progressive de nova DNA methylation at the bcr-abl locus in the course of chronic myelogenous leukemia
18. ABL1 methylation is a distinct molecular event associated with clonal evolution of chronic myeloid leukemia
19. Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B
20. Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies
21. Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression
22. Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia
23. Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain
24. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
25. The human DNA methyltransferases (DNMTs) 1, 3a and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors
26. Cloning, expression and chromosome locations of the human DNMT3 gene family
27. Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila
28. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
29. High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer
30. Increased cytosine DNA-methyltransferase activity during colon cancer progression
31. Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer
32. Increased DNA methyltransferase expression in leukaemia
33. Basic local alignment search tool
34. Persistence of multipotent progenitors expressing AML1/ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia
35. - blasts from acute myelogenous leukemia
36. Single-step method of RNA isolation by acid guanidinium thiocyanatephenol-chloroform extraction
37. Analysis of cytokine mRNA and DNA: Detection and quantitation by competitive polymerase chain reaction
38. Comparison of bisulfite modification of 5-methyldeoxycytidine and deoxycytidine residues
39. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
40. A commentary on the practical applications of competitive PCR
41. Quantitative RT-PCR: Pitfalls and potential
42. Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation
43. CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression
44. Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells
45. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
46. Changes of DNA methylation and chromatin structure in the human myeloperoxidase gene during myeloid differentiation
47. Developmental programs of human erythroleukemia cells: Globin gene expression and methylation
48. Lineage-specific methylation of the c-fms gene in blood cells and macrophages
49. Cell lineage specificity in G-CSF receptor gene methylation
50. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
51. Immunodeficiency, centromeric heterochromatin instability of chromosomes 1.9, and 16, and facial anomalies: The ICF syndrome
52. ICF syndrome: A new case and review of the literature
53. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene
54. The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome
55. Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1
56. Tying it all together: Epigenetics, genetics, cell cycle, and cancer