Methylation pattern of different regions of the MLH1 promoter and silencing of gene expression in hereditary and sporadic colorectal cancer

Genes Chromosomes and Cancer

Volumn 31, Issue 4, 2001, Pages 357-361

  Menigatti, Mirco ^a   Gregorio, Carmela Di ^b   Borghi, Francesca ^a   Sala, Elisa ^a   Scarselli, Alessandra ^a   Pedroni, Monica ^a   Foroni, Moira ^a   Benatti, Piero ^a   Roncucci, Luca ^a   De Leon, Maurizio Ponz ^a   Percesepe, Antonio ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b Ospedale B Ramazzini   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ADULT; ARTICLE; BASE MISPAIRING; CANCER CLASSIFICATION; CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; DNA METHYLATION; FEMALE; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; GENE SILENCING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; TUMOR SUPPRESSOR GENE;

BASE PAIR MISMATCH; CARRIER PROTEINS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA METHYLATION; DNA REPAIR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS);

EID: 0034946935     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.1154     Document Type: Article

References (15)

1. Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression
2. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
3. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective humar tumor cell lines
4. Germ-line MSH6 mutations in colorectal cancer families
5. Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers
6. Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer
7. Mutations predisposing to hereditary nonpolyposis colorectal cancer
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9. Mismatch repair genes and mono-nucleotide tracts as mutation targets in colorectal tumors with different degrees of microsatellite instability
10. CpG island methylator phenotype in colorectal cancer
11. The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)
12. Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
13. Characterization of MSH2 and MLH1 mutations in Italian families with hereditary nonpolyposis colorectal cancer
14. MSH2 and MLH1 mutations in sporadic replication error-positive colorectal carcinoma as assessed by two-dimensional DNA electrophoresis
15. Conversion of diploidy to haploidy