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Volumn 20, Issue 3, 2011, Pages 343-359

New nucleoside analogs for patients with hematological malignancies

Author keywords

azacitidine; capecitabine; clofarabine; CNDAC; decitabine; forodesine; gemcitabine; leukemia; lymphoma; nelarabine; sapacitabine; troxacitabine; zebularine

Indexed keywords

2 AMINO 6 CHLORO 9 [5(DIHYDROXYBORYL)PENTYL]PURINE; 5 AZA 2' DEOXYCYTIDINE; ANTILEUKEMIC AGENT; ANTINEOPLASTIC AGENT; AZACITIDINE; BENDAMUSTINE; CISPLATIN; CLADRIBINE; CLOFARABINE; CYC 682; CYTARABINE; FLUDARABINE; FODOSINE; FORODESINE; GEMCITABINE; HISTONE DEACETYLASE INHIBITOR; IDARUBICIN; IMMUCILIN H; LMP 420; NELARABINE; OSI 7836; PACLITAXEL; PENTOSTATIN; PURINE NUCLEOSIDE DERIVATIVE; PYRIMIDINE NUCLEOSIDE DERIVATIVE; RITUXIMAB; SAPACITABINE; SPD 758; SR 9025; THIARABINE; TOCLADESINE; TROXACITABINE; UNCLASSIFIED DRUG; VALPROIC ACID; ZEBULARINE;

EID: 79951620932     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.2011.554822     Document Type: Review
Times cited : (32)

References (99)
  • 1
    • 63449116519 scopus 로고    scopus 로고
    • Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases
    • Robak T, Korycka A, Lech-Maranda E, Robak P. Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases. Molecules 2009;14:1183-226
    • (2009) Molecules , vol.14 , pp. 1183-226
    • Robak, T.1    Korycka, A.2    Lech-Maranda, E.3    Robak, P.4
  • 2
    • 48949117194 scopus 로고    scopus 로고
    • Cytotoxic nucleoside analogues: Different strategies to improve their clinical efficacy
    • DOI 10.2174/092986708784221449
    • Galmarini CM, Popowycz F, Joseph B. Cytotoxic nucleoside analogues: different strategies to improve their clinical efficacy. Curr Med Chem 2008;15:1072-82 (Pubitemid 352002976)
    • (2008) Current Medicinal Chemistry , vol.15 , Issue.11 , pp. 1072-1082
    • Galmarini, C.M.1    Popowycz, F.2    Joseph, B.3
  • 3
    • 40049109232 scopus 로고    scopus 로고
    • Potential role of novel nucleoside analogs in the treatment of acute myeloid leukemia
    • DOI 10.1097/MOH.0b013e3282f46e94, PII 0006275220080300000006
    • Faderl S, Gandhi V, Kantarjian HM. Potential role of novel nucleoside analogs in the treatment of acute myeloid leukemia. Curr Opin Hematol 2008;15:101-7 (Pubitemid 351323149)
    • (2008) Current Opinion in Hematology , vol.15 , Issue.2 , pp. 101-107
    • Faderl, S.1    Gandhi, V.2    Kantarjian, H.M.3
  • 4
    • 77951628255 scopus 로고    scopus 로고
    • Comparison of cladribine plus cyclophosphamide with fludarabine plus cyclophosphamide as first-line therapy for chronic lymphocytic leukemia: A phase III randomized study by the Polish Adult Leukemia Group (PALG-CLL3 Study)
    • Robak T, Jamroziak K, Gora-Tybor J, et al. Comparison of cladribine plus cyclophosphamide with fludarabine plus cyclophosphamide as first-line therapy for chronic lymphocytic leukemia: a phase III randomized study by the Polish Adult Leukemia Group (PALG-CLL3 Study). J Clin Oncol 2010;28:1863-9
    • (2010) J Clin Oncol , vol.28 , pp. 1863-9
    • Robak, T.1    Jamroziak, K.2    Gora-Tybor, J.3
  • 5
    • 67650685040 scopus 로고    scopus 로고
    • Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer
    • Parker WB. Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer. Chem Rev 2009;109:2880-93
    • (2009) Chem Rev , vol.109 , pp. 2880-93
    • Parker, W.B.1
  • 7
    • 33646550489 scopus 로고    scopus 로고
    • Pharmacological and clinical studies on purine nucleoside analogs- new anticancer agents
    • Lech-Maranda E, Korycka A, Robak T. Pharmacological and clinical studies on purine nucleoside analogs- new anticancer agents. Mini Rev Med Chem 2006;6:575-81
    • (2006) Mini Rev Med Chem , vol.6 , pp. 575-81
    • Lech-Maranda, E.1    Korycka, A.2    Robak, T.3
  • 8
    • 33750601477 scopus 로고    scopus 로고
    • Purine nucleoside analogs as immunosuppressive and antineoplastic agents: Mechanism of action and clinical activity
    • Robak T, Lech-Maranda E, Korycka A, Robak E. Purine nucleoside analogs as immunosuppressive and antineoplastic agents: mechanism of action and clinical activity. Curr Med Chem 2006;13:3165-89 (Pubitemid 44680862)
    • (2006) Current Medicinal Chemistry , vol.13 , Issue.26 , pp. 3165-3189
    • Robak, T.1    Lech-Maranda, E.2    Korycka, A.3    Robak, E.4
  • 9
    • 68849122744 scopus 로고    scopus 로고
    • Clofarabine as a novel nucleoside analogue approved to treat patients with haematological malignancies: Mechanism of action and clinical activity
    • Lech-Maranda E, Korycka A, Robak T. Clofarabine as a novel nucleoside analogue approved to treat patients with haematological malignancies: mechanism of action and clinical activity. Mini Rev Med Chem 2009;9:805-12
    • (2009) Mini Rev Med Chem , vol.9 , pp. 805-12
    • Lech-Maranda, E.1    Korycka, A.2    Robak, T.3
  • 12
    • 33646337195 scopus 로고    scopus 로고
    • Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia
    • Jeha S, Gaynon PS, Razzouk BI, et al. Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia. J Clin Oncol 2006;24:917-23
    • (2006) J Clin Oncol , vol.24 , pp. 917-23
    • Jeha, S.1    Gaynon, P.S.2    Razzouk, B.I.3
  • 13
    • 35148869073 scopus 로고    scopus 로고
    • Effectiveness of clofarabine in elderly AML patients with adverse cytogenetics unfit for intensive chemotherapy [abstract1985]
    • Burnett AK, Baccarani M, Johnson P, et al. Effectiveness of clofarabine in elderly AML patients with adverse cytogenetics unfit for intensive chemotherapy [abstract 1985]. Blood 2006;108(Suppl):562a
    • (2006) Blood , vol.108 , Issue.SUPPL.
    • Burnett, A.K.1    Baccarani, M.2    Johnson, P.3
  • 15
    • 52649154001 scopus 로고    scopus 로고
    • A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome
    • Faderl S, Ravandi F, Huang X, et al. A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome. Blood 2008;112:1638-45
    • (2008) Blood , vol.112 , pp. 1638-45
    • Faderl, S.1    Ravandi, F.2    Huang, X.3
  • 17
    • 66749161188 scopus 로고    scopus 로고
    • Oral (po) and Intravenous (iv) Clofarabine for Patients (pts) with Myelodysplastic Syndrome (MDS)
    • ASH Annual Meeting Abstracts
    • Faderl S, Garcia-Manero G, Ravandi F, et al. Oral (po) and Intravenous (iv) Clofarabine for Patients (pts) with Myelodysplastic Syndrome (MDS). ASH Annual Meeting Abstracts. Blood 2008;112:222
    • (2008) Blood , vol.112 , pp. 222
    • Faderl, S.1    Garcia-Manero, G.2    Ravandi, F.3
  • 18
    • 33748114785 scopus 로고    scopus 로고
    • Nelarabine: Efficacy in the treatment of clinical malignancies
    • DOI 10.2217/14796694.2.4.441
    • Roecker AM, Allison JC, Kisor DF. Nelarabine: efficacy in the treatment of clinical malignancies. Future Oncol 2006;2:441-8 (Pubitemid 44304602)
    • (2006) Future Oncology , vol.2 , Issue.4 , pp. 441-448
    • Roecker, A.M.1    Allison, J.C.2    Kisor, D.F.3
  • 19
    • 0036606777 scopus 로고    scopus 로고
    • Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase
    • Rodriguez COJ, Mitchell BS, Ayres M, et al. Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. Cancer Res 2002;62:3100-5 (Pubitemid 34602401)
    • (2002) Cancer Research , vol.62 , Issue.11 , pp. 3100-3105
    • Rodriguez Jr., C.O.1    Mitchell, B.S.2    Ayres, M.3    Eriksson, S.4    Gandhi, V.5
  • 20
    • 33748885763 scopus 로고    scopus 로고
    • Clofarabine and nelarabine: Two new purine nucleoside analogs
    • DOI 10.1097/01.cco.0000245326.65152.af, PII 0000162220061100000007
    • Ghandi V, Plunkett W. Clofarabine and nelarabine: two new purine nucleoside analogs. Curr Opini Oncol 2006;18:584-90 (Pubitemid 44427632)
    • (2006) Current Opinion in Oncology , vol.18 , Issue.6 , pp. 584-590
    • Gandhi, V.1    Plunkett, W.2
  • 21
    • 41949097313 scopus 로고    scopus 로고
    • Phase i trial of nelarabine in indolent Leukemias
    • Gandhi V, Tam C, O'Brien S, et al. Phase I trial of nelarabine in indolent Leukemias. J Clin Oncol 2008;26:1098-105
    • (2008) J Clin Oncol , vol.26 , pp. 1098-105
    • Gandhi, V.1    Tam, C.2    O'Brien, S.3
  • 22
    • 46149095502 scopus 로고    scopus 로고
    • FDA drug approval summary: Nelarabine (Arranon®) for the treatment of T-cell lymphoblastic leukemia/lymphoma
    • DOI 10.1634/theoncologist.2006-0017
    • Cohen MH, Johnson JR, Justice R, Pazdur R. FDA drug approval summary: nelarabine (Arranon) for the treatment of T-cell lymphoblastic leukemia/ lymphoma. Oncologist 2008;13:709-14 (Pubitemid 351904915)
    • (2008) Oncologist , vol.13 , Issue.6 , pp. 709-714
    • Cohen, M.H.1    Johnson, J.R.2    Justice, R.3    Pazdur, R.4
  • 23
    • 20644435369 scopus 로고    scopus 로고
    • Phase i study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies
    • Kurtzberg J, Ernst TJ, Keating MJ, et al. Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies. J Clin Oncol 2005;23:3396-403
    • (2005) J Clin Oncol , vol.23 , pp. 3396-403
    • Kurtzberg, J.1    Ernst, T.J.2    Keating, M.J.3
  • 24
    • 20644464975 scopus 로고    scopus 로고
    • Phase II study of nelarabine (compound 506U78) in children and young adults with refractory T-cell malignancies: A report from the children's oncology group
    • Berg SL, Blaney SM, Devidas M, et al. Phase II study of nelarabine (compound 506U78) in children and young adults with refractory T-cell malignancies: a report from the children's oncology group. J Clin Oncol 2005;23:3376-403
    • (2005) J Clin Oncol , vol.23 , pp. 3376-403
    • Berg, S.L.1    Blaney, S.M.2    Devidas, M.3
  • 25
    • 34250003760 scopus 로고    scopus 로고
    • Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801
    • DOI 10.1182/blood-2006-11-056754
    • DeAngelo DJ, Yu D, Johnson JL, et al. Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: cancer and leukemia Group B study 19801. Blood 2007;109:5136-42 (Pubitemid 46890527)
    • (2007) Blood , vol.109 , Issue.12 , pp. 5136-5142
    • DeAngelo, D.J.1    Yu, D.2    Johnson, J.L.3    Coutre, S.E.4    Stone, R.M.5    Stopeck, A.T.6    Gockerman, J.P.7    Mitchell, B.S.8    Appelbaum, F.R.9    Larson, R.A.10
  • 27
    • 33746361377 scopus 로고    scopus 로고
    • Phase II study of compound GW506U78 (araG) for patients with indolent B-cell or peripheral T-cell lymphoma previously treated with chemotherapy [abstract 2359]
    • Goy A, Bleyer A, Hagemeister F, et al. Phase II study of compound GW506U78 (araG) for patients with indolent B-cell or peripheral T-cell lymphoma previously treated with chemotherapy [abstract 2359]. Blood 2003;102:639a
    • (2003) Blood , vol.102
    • Goy, A.1    Bleyer, A.2    Hagemeister, F.3
  • 28
    • 35048849848 scopus 로고    scopus 로고
    • Forodesine (BCX-1777, immucillin H) - A new purine nucleoside analogue: Mechanism of action and potential clinical application
    • DOI 10.2174/138955707781662636
    • Korycka A, Błonski JZ, Robak T. Forodesine (BCX-1777, Immucillin H)- a new purine nucleoside analogue: mechanism of action and potential clinical application. Mini Rev Med Chem 2007;7:976-83 (Pubitemid 47554785)
    • (2007) Mini-Reviews in Medicinal Chemistry , vol.7 , Issue.9 , pp. 976-983
    • Korycka, A.1    Blonski, J.Z.2    Robak, T.3
  • 30
    • 0038730672 scopus 로고    scopus 로고
    • Mechanism of inhibition of T-acute lymphoblastic leukemia cells by PNP inhibitor - BCX-1777
    • DOI 10.1016/S1567-5769(03)00076-6
    • Bantia S, Ananth SL, Parker CD, et al. Mechanism of inhibition of T-acute lymphoblastic leukemia cells by PNP inhibitor- BCX- 1777. Int Immunopharmacol 2003;3:879-87 (Pubitemid 36629453)
    • (2003) International Immunopharmacology , vol.3 , Issue.6 , pp. 879-887
    • Bantia, S.1    Ananth, S.L.2    Parker, C.D.3    Horn, L.L.4    Upshaw, R.5
  • 31
    • 0036479245 scopus 로고    scopus 로고
    • Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase
    • DOI 10.1074/jbc.M105906200
    • Kicska GA, Tyler PC, Evans GB, et al. Purine-less death in plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase. J Biol Chem 2002;277:3226-31 (Pubitemid 34953185)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.5 , pp. 3226-3231
    • Kicska, G.A.1    Tyler, P.C.2    Evans, G.B.3    Furneaux, R.H.4    Schramm, V.L.5    Kim, K.6
  • 32
    • 33749365341 scopus 로고    scopus 로고
    • Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells
    • DOI 10.1182/blood-2006-03-007468
    • Balakrishnan K, Nimmanapalli R, Ravandi F, et al. Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells. Blood 2006;108:2392-8 (Pubitemid 44497524)
    • (2006) Blood , vol.108 , Issue.7 , pp. 2392-2398
    • Balakrishnan, K.1    Nimmanapalli, R.2    Ravandi, F.3    Keating, M.J.4    Gandhi, V.5
  • 33
    • 70349567556 scopus 로고    scopus 로고
    • Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM
    • Alonso R, Lopez-Guerra M, Upshaw R, et al. Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM. Blood 2009;114:1563-75
    • (2009) Blood , vol.114 , pp. 1563-75
    • Alonso, R.1    Lopez-Guerra, M.2    Upshaw, R.3
  • 34
    • 77956319533 scopus 로고    scopus 로고
    • Forodesine: Review of preclinical and clinical data
    • Al-Kali A, Gandhi V, Ayoubi M, et al. Forodesine: review of preclinical and clinical data. Future Oncol 2010;6:1211-17
    • (2010) Future Oncol , vol.6 , pp. 1211-17
    • Al-Kali, A.1    Gandhi, V.2    Ayoubi, M.3
  • 35
    • 77956307784 scopus 로고    scopus 로고
    • Influence of bone marrow stromal microenvironment on forodesine-induced responses in CLL primary cells
    • Balakrishnan K, Burger JA, Quiroga MP, et al. Influence of bone marrow stromal microenvironment on forodesine-induced responses in CLL primary cells. Blood 2010;116:1083-91
    • (2010) Blood , vol.116 , pp. 1083-91
    • Balakrishnan, K.1    Burger, J.A.2    Quiroga, M.P.3
  • 36
    • 77956299127 scopus 로고    scopus 로고
    • Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia
    • Balakrishnan K, Verma D, O'Brien S, et al. Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia. Blood 2010;116:886-92
    • (2010) Blood , vol.116 , pp. 886-92
    • Balakrishnan, K.1    Verma, D.2    O'Brien, S.3
  • 37
    • 48249122554 scopus 로고    scopus 로고
    • Response to oral forodesine in refractory cutaneous T-cell lymphoma: Interim results of a phase I/II study [abstract 122]
    • Duvic M, Forero-Torres A, Foss F, et al. Response to oral forodesine in refractory cutaneous T-cell lymphoma: interim results of a phase I/II study [abstract 122]. Blood 2007;110:44a
    • (2007) Blood , vol.110
    • Duvic, M.1    Forero-Torres, A.2    Foss, F.3
  • 38
    • 37049003122 scopus 로고    scopus 로고
    • Forodesine IV (Bcx-1777) is clinically active in relapsed/refractory T-cell leukemia: Results of a phase II study (Interim Report) [abstract 1851]
    • Furman RR, Lia Gore L, Ravandi F, Hoelzer D. Forodesine IV (Bcx-1777) is clinically active in relapsed/refractory T-cell leukemia: results of a phase II study (Interim Report) [abstract 1851]. Blood 2006;108:524a
    • (2006) Blood , vol.108
    • Furman, R.R.1    Lia Gore, L.2    Ravandi, F.3    Hoelzer, D.4
  • 39
    • 78349273651 scopus 로고    scopus 로고
    • The effects of forodesine in murine and human multiple myeloma cells
    • 2010
    • Bieghs L, Caers J, De Bruyne E, et al. The effects of forodesine in murine and human multiple myeloma cells. Adv Hematol 2010;2010:131895
    • (2010) Adv Hematol , pp. 131895
    • Bieghs, L.1    Caers, J.2    De Bruyne, E.3
  • 40
    • 65349161620 scopus 로고    scopus 로고
    • Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part II
    • Kamath VP, Xue J, Juarez-Brambila JJ. Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part II. Bioorg Med Chem Lett 2009;19:2627-9
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 2627-9
    • Kamath, V.P.1    Xue, J.2    Juarez-Brambila, J.J.3
  • 42
    • 0345275863 scopus 로고    scopus 로고
    • RNA-Directed Actions of 8-Chloro-Adenosine in Multiple Myeloma Cells
    • Stellrecht CM, Rodriguez CO Jr, Ayres M, Gandhi V. RNA-directed actions of 8-chloro-adenosine in multiple myeloma cells. Cancer Res 2003;63:7968-74 (Pubitemid 37466734)
    • (2003) Cancer Research , vol.63 , Issue.22 , pp. 7968-7974
    • Stellrecht, C.M.1    Rodriguez Jr., C.O.2    Ayres, M.3    Gandhi, V.4
  • 43
    • 4644355516 scopus 로고    scopus 로고
    • Chain termination and inhibition of Saccharomyces cerevisiae poly(A) polymerase by C-8-modified ATP analogs
    • DOI 10.1074/jbc.M401752200
    • Chen LS, Sheppard TL. Chain termination and inhibition of saccharomyces cerevisiae poly(A) polymerase by C-8-modified ATP analogs. J Biol Chem 2004;279:40405-11 (Pubitemid 39287629)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.39 , pp. 40405-40411
    • Chen, L.S.1    Sheppard, T.L.2
  • 44
    • 19344378925 scopus 로고    scopus 로고
    • Cell death of bioenergetically compromised and transcriptionally challenged CLL lymphocytes by chlorinated ATP
    • DOI 10.1182/blood-2004-05-1699
    • Balakrishnan K, Stellrecht CM, Genini D, et al. Cell death of bioenergetically compromised and transcriptionally challenged CLL lymphocytes by chlorinated ATP. Blood 2005;105:4455-62 (Pubitemid 40720794)
    • (2005) Blood , vol.105 , Issue.11 , pp. 4455-4462
    • Balakrishnan, K.1    Stellrecht, C.M.2    Genini, D.3    Ayres, M.4    Wierda, W.G.5    Keating, M.J.6    Leoni, L.M.7    Gandhi, V.8
  • 45
    • 35448969250 scopus 로고    scopus 로고
    • Multiple myeloma cell killing by depletion of the MET receptor tyrosine kinase
    • DOI 10.1158/0008-5472.CAN-07-0770
    • Stellrecht CM, Phillip CJ, Cervantes-Gomez F, Gandhi V. Multiple myeloma cell killing by depletion of the MET receptor tyrosine kinase. Cancer Res 2007;67:9913-20 (Pubitemid 47621240)
    • (2007) Cancer Research , vol.67 , Issue.20 , pp. 9913-9920
    • Stellrecht, C.M.1    Phillip, C.J.2    Cervantes-Gomez, F.3    Gandhi, V.4
  • 46
    • 70349925289 scopus 로고    scopus 로고
    • Preclinical activity of 8-chloroadenosine with mantle cell lymphoma: Roles of energy depletion and inhibition of DNA and RNA synthesis
    • Dennison JB, Balakrishnan K, Gandhi V. Preclinical activity of 8-chloroadenosine with mantle cell lymphoma: roles of energy depletion and inhibition of DNA and RNA synthesis. Br J Haematol 2009;147:297-307
    • (2009) Br J Haematol , vol.147 , pp. 297-307
    • Dennison, J.B.1    Balakrishnan, K.2    Gandhi, V.3
  • 48
    • 77956426657 scopus 로고    scopus 로고
    • LMP-420: A novel purine nucleoside analog with potent cytotoxic effects for CLL cells and minimal toxicity for normal hematopoietic cells
    • Mowery YM, Weinberg JB, Kennedy MN, et al. LMP-420: a novel purine nucleoside analog with potent cytotoxic effects for CLL cells and minimal toxicity for normal hematopoietic cells. Leukemia 2010;24:1580-7
    • (2010) Leukemia , vol.24 , pp. 1580-7
    • Mowery, Y.M.1    Weinberg, J.B.2    Kennedy, M.N.3
  • 49
    • 42249101239 scopus 로고    scopus 로고
    • Treatment of experimental colitis in mice with LMP-420, an inhibitor of TNF transcription
    • Hale LP, Cianciolo G. Treatment of experimental colitis in mice with LMP-420, an inhibitor of TNF transcription. J Inflamm (Lond) 2008;5:4
    • (2008) J Inflamm (Lond) , vol.5 , pp. 4
    • Hale, L.P.1    Cianciolo, G.2
  • 50
    • 33748169679 scopus 로고    scopus 로고
    • LMP-420, a small-molecule inhibitor of TNF-alpha, reduces replication of HIV-1 and Mycobacterium tuberculosis in human cells
    • Haraguchi S, Day NK, Kamchaisatian W, et al. LMP-420, a small-molecule inhibitor of TNF-alpha, reduces replication of HIV-1 and Mycobacterium tuberculosis in human cells. AIDS Res Ther 2006;3:8
    • (2006) AIDS Res Ther , vol.3 , pp. 8
    • Haraguchi, S.1    Day, N.K.2    Kamchaisatian, W.3
  • 52
    • 55749110754 scopus 로고    scopus 로고
    • Demethylating agents in myeloid malignancies
    • Garcia-Manero G. Demethylating agents in myeloid malignancies. Curr Opin Oncol 2008;20:705-10
    • (2008) Curr Opin Oncol , vol.20 , pp. 705-10
    • Garcia-Manero, G.1
  • 54
    • 14844313747 scopus 로고    scopus 로고
    • WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia
    • DOI 10.1002/ijc.20797
    • Schmelz K, Wagner M, Dorken B, Tamm I. 5-Aza-2¢-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia. Int J Cancer 2005;114:683-95 (Pubitemid 40344429)
    • (2005) International Journal of Cancer , vol.114 , Issue.5 , pp. 683-695
    • Schmelz, K.1    Wagner, M.2    Dorken, B.3    Tamm, I.4
  • 55
    • 77749302093 scopus 로고    scopus 로고
    • A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines
    • Hollenbach PW, Nguyen AN, Brady H, et al. A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines. LoS One 2010;5:e9001
    • (2010) LoS One , vol.5
    • Hollenbach, P.W.1    Nguyen, A.N.2    Brady, H.3
  • 56
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study
    • Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 2009;10:223-32
    • (2009) Lancet Oncol , vol.10 , pp. 223-32
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3
  • 58
    • 77955176936 scopus 로고    scopus 로고
    • Azacytidine (Aza) as first line therapy in AML: Results of the French ATU program [abstract 843]
    • Thepot S, Itzykson R, Seegers V, et al. Azacytidine (Aza) as first line therapy in AML: results of the French ATU program [abstract 843]. Blood 2009;114:347
    • (2009) Blood , vol.114 , pp. 347
    • Thepot, S.1    Itzykson, R.2    Seegers, V.3
  • 60
    • 33750530675 scopus 로고    scopus 로고
    • Phase 1/2 study of the combination of 5-aza-2¢-deoxycytidine with valproic acid in patients with leukemia
    • Garcia-Manero G, Kantarjian HM, Sanchez-Gonzalez B, et al. Phase 1/2 study of the combination of 5-aza-2¢-deoxycytidine with valproic acid in patients with leukemia. Blood 2006;108:3271-9
    • (2006) Blood , vol.108 , pp. 3271-9
    • Garcia-Manero, G.1    Kantarjian, H.M.2    Sanchez-Gonzalez, B.3
  • 61
    • 79951622591 scopus 로고    scopus 로고
    • pressReleaseId=896
    • Available from http://www.supergen. com/investors/pressrelease.html? pressReleaseId=896.
  • 62
    • 45549100917 scopus 로고    scopus 로고
    • Repair of 2¢-C-cyano-2¢-deoxy-1-beta-D-arabino- pentofuranosylcytosine-induced DNA single-strand breaks by transcription-coupled nucleotide excision repair
    • Wang Y, Liu X, Matsuda A, Plunkett W. Repair of 2¢-C-cyano-2¢- deoxy-1-beta-D-arabino-pentofuranosylcytosine-induced DNA single-strand breaks by transcription-coupled nucleotide excision repair. Cancer Res 2008;68:3881-9
    • (2008) Cancer Res , vol.68 , pp. 3881-9
    • Wang, Y.1    Liu, X.2    Matsuda, A.3    Plunkett, W.4
  • 64
    • 0034744725 scopus 로고    scopus 로고
    • 2 arrest
    • Azuma A, Huang P, Matsuda A, Plunkett W. 2¢-C-cyano-2¢-deoxy-1- beta-D-arabino-pentofuranosylcytosine:a novel anticancer nucleoside analog that causes both DNA strand breaks and G(2) arrest. Mol Pharmacol 2001;59:725-31 (Pubitemid 32279610)
    • (2001) Molecular Pharmacology , vol.59 , Issue.4 , pp. 725-731
    • Azuma, A.1    Huang, P.2    Matsuda, A.3    Plunkett, W.4
  • 65
    • 38349177265 scopus 로고    scopus 로고
    • Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2¢-C-cyano-2¢-deoxy-1-beta-D-arabino-pentofuranosylcytosine
    • Liu X, Matsuda A, Plunkett W. Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2¢-C-cyano-2¢-deoxy-1-beta-D- arabino-pentofuranosylcytosine. Mol Cancer Ther 2008;7:133-42
    • (2008) Mol Cancer Ther , vol.7 , pp. 133-42
    • Liu, X.1    Matsuda, A.2    Plunkett, W.3
  • 66
    • 23044441597 scopus 로고    scopus 로고
    • 2 arrest induced by 2′-C-cyano- 2′-deoxy-1-β-D-arabino-pentofuranosylcytosine and consequences of checkpoint abrogation
    • DOI 10.1158/0008-5472.CAN-05-0288
    • Liu X, Guo Y, Li Y, et al. Molecular basis for G2 arrest induced by 2¢-C-cyano-2¢-deoxy-1-beta-D-arabino-pentofuranosylcytosine and consequences of checkpoint abrogation. Cancer Res 2005;65:6874-81 (Pubitemid 41060726)
    • (2005) Cancer Research , vol.65 , Issue.15 , pp. 6874-6881
    • Liu, X.1    Guo, Y.2    Li, Y.3    Jiang, Y.4    Chubb, S.5    Azuma, A.6    Huang, P.7    Matsuda, A.8    Hittelman, W.9    Plunkett, W.10
  • 68
    • 78049254408 scopus 로고    scopus 로고
    • Combination of sapacitabine and HDAC inhibitors stimulates cell death in AML and other tumour types
    • Green SR, Choudhary AK, Fleming IN. Combination of sapacitabine and HDAC inhibitors stimulates cell death in AML and other tumour types. Br J Cancer 2010;103:1391-9
    • (2010) Br J Cancer , vol.103 , pp. 1391-9
    • Green, S.R.1    Choudhary, A.K.2    Fleming, I.N.3
  • 69
    • 74949124273 scopus 로고    scopus 로고
    • Phase i clinical and pharmacokinetic study of oral sapacitabine in patients with acute leukemia and myelodysplastic syndrome
    • Kantarjian H, Garcia-Manero G, O'Brien S, et al. Phase I clinical and pharmacokinetic study of oral sapacitabine in patients with acute leukemia and myelodysplastic syndrome. J Clin Oncol 2010;28:285-91
    • (2010) J Clin Oncol , vol.28 , pp. 285-91
    • Kantarjian, H.1    Garcia-Manero, G.2    O'Brien, S.3
  • 70
    • 34250633985 scopus 로고    scopus 로고
    • Troxacitabine in acute leukemia
    • DOI 10.1080/10245330701406881, PII 779391419
    • Swords R, Giles F. Troxacitabine in acute leukemia. Hematology 2007;12:219-27 (Pubitemid 46930248)
    • (2007) Hematology , vol.12 , Issue.3 , pp. 219-227
    • Swords, R.1    Giles, F.2
  • 72
    • 0031016944 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics of β-L-dioxolane-cytidine, a novel anticancer agent, in rats
    • DOI 10.1007/s002800050609
    • Moore LE, Boudinot FD, Chu CK. Preclinical pharmacokinetics of beta-L-dioxolane-cytidine, a novel anticancer agent, in rats. Cancer Chemother Pharmacol 1997;39:532-6 (Pubitemid 27096769)
    • (1997) Cancer Chemotherapy and Pharmacology , vol.39 , Issue.6 , pp. 532-536
    • Moore, L.E.1    Boudinot, F.D.2    Chu, C.K.3
  • 78
    • 0034672617 scopus 로고    scopus 로고
    • Metabolism of 4¢-thio-beta-D-arabinofuranosylcytosine in CEM cells
    • Parker WB, Shaddix SC, Rose LM, Waud WR. Metabolism of 4¢-thio-beta-D-arabinofuranosylcytosine in CEM cells. Biochem Pharmacol 2000;60:1925-32
    • (2000) Biochem Pharmacol , vol.60 , pp. 1925-32
    • Parker, W.B.1    Shaddix, S.C.2    Rose, L.M.3    Waud, W.R.4
  • 80
    • 4243221788 scopus 로고    scopus 로고
    • OSI-7836 (4¢-thio-beta-D-arabinofuranosylcytosine: A novel anticancer nucleoside analog that inhibits DNA polymerases and induces G2 arrest
    • Abstract 4779
    • Blajeski AL, Richardson KA, Emerson DL, et al. OSI-7836 (4¢-thio-beta-D-arabinofuranosylcytosine: a novel anticancer nucleoside analog that inhibits DNA polymerases and induces G2 arrest. Proc Am Assoc Cancer Res 2002;43:abstract 4779
    • (2002) Proc Am Assoc Cancer Res , vol.43
    • Blajeski, A.L.1    Richardson, K.A.2    Emerson, D.L.3
  • 81
    • 8844232440 scopus 로고    scopus 로고
    • Polymerization of the triphosphates of AraC, 2-,2-difluorodeoxycytidine (dFdC) and OSI-7836 (T-araC) by human DNA polymerase alpha and DNA primase
    • Richardson KA, Vega TP, Richardson FC, et al. Polymerization of the triphosphates of AraC, 2-,2-difluorodeoxycytidine (dFdC) and OSI-7836 (T-araC) by human DNA polymerase alpha and DNA primase. Biochem Pharmacol 2004;68:2337-46
    • (2004) Biochem Pharmacol , vol.68 , pp. 2337-46
    • Richardson, K.A.1    Vega, T.P.2    Richardson, F.C.3
  • 82
    • 12444330217 scopus 로고    scopus 로고
    • The antitumor activity of GS7836 (4¢-thio-araC), a nucleoside analog, in mouse xenografts: Comparison to standard cytotoxic agents and schedule dependence [abstract 5418]
    • Tomkinson B, Brown E, Henninger D, et al. The antitumor activity of GS7836 (4¢-thio-araC), a nucleoside analog, in mouse xenografts: comparison to standard cytotoxic agents and schedule dependence [abstract 5418]. Proc Am Assoc Cancer Res 2002;43:1094
    • (2002) Proc Am Assoc Cancer Res , vol.43 , pp. 1094
    • Tomkinson, B.1    Brown, E.2    Henninger, D.3
  • 84
    • 67349186631 scopus 로고    scopus 로고
    • Enhancement of the in vivo antitumor activity of clofarabine by 1-beta-D-[4-thio-arabinofuranosyl] - Cytosine
    • Parker WB, Shaddix SC, Gilbert KS, et al. Enhancement of the in vivo antitumor activity of clofarabine by 1-beta-D-[4-thio-arabinofuranosyl]- cytosine. Cancer Chemother Pharmacol 2009;64:253-61
    • (2009) Cancer Chemother Pharmacol , vol.64 , pp. 253-61
    • Parker, W.B.1    Shaddix, S.C.2    Gilbert, K.S.3
  • 86
    • 33646721128 scopus 로고    scopus 로고
    • A phase i study of a new nucleoside analogue, OSI-7836, using two administration schedules in patients with advanced solid malignancies
    • Lee CP, de Jonge MJ, O'Donnell AE, et al. A phase I study of a new nucleoside analogue, OSI-7836, using two administration schedules in patients with advanced solid malignancies. Clin Cancer Res 2006;12:2841-8
    • (2006) Clin Cancer Res , vol.12 , pp. 2841-8
    • Lee, C.P.1    De Jonge, M.J.2    O'Donnell, A.E.3
  • 87
    • 0036965821 scopus 로고    scopus 로고
    • Zebularine: A novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases
    • DOI 10.1016/S0022-2836(02)00676-9
    • Zhou L, Cheng X, Connolly BA, et al. Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. J Mol Biol 2002;321:591-9 (Pubitemid 36124798)
    • (2002) Journal of Molecular Biology , vol.321 , Issue.4 , pp. 591-599
    • Zhou, L.1    Cheng, X.2    Connolly, B.A.3    Dickman, M.J.4    Hurd, P.J.5    Hornby, D.P.6
  • 89
    • 33846362233 scopus 로고    scopus 로고
    • Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression
    • DOI 10.1016/j.exphem.2006.10.005, PII S0301472X06006540
    • Scott SA, Lakshimikuttysamma A, Sheridan DP, et al. Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression. Exp Hematol 2007;35:263-73 (Pubitemid 46135814)
    • (2007) Experimental Hematology , vol.35 , Issue.2 , pp. 263-273
    • Scott, S.A.1    Lakshimikuttysamma, A.2    Sheridan, D.P.3    Sanche, S.E.4    Geyer, C.R.5    DeCoteau, J.F.6
  • 90
    • 67349200930 scopus 로고    scopus 로고
    • The DNA methyltransferas inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells
    • Flotho C, Claus R, Batz C, et al. The DNA methyltransferas inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia 2009;23:1019-28
    • (2009) Leukemia , vol.23 , pp. 1019-28
    • Flotho, C.1    Claus, R.2    Batz, C.3
  • 95
    • 33846796029 scopus 로고    scopus 로고
    • Zebularine reactivates silenced E- adherin but unlike 5-Azacytidine does not induce switching from latent to lytic pstein-Barr virus nfection in Burkitt's lymphoma Akata cells
    • Rao SP, Rechsteiner MP, Berger C, et al. Zebularine reactivates silenced E- adherin but unlike 5-Azacytidine does not induce switching from latent to lytic pstein-Barr virus nfection in Burkitt's lymphoma Akata cells. Mol Cancer 2007;6:3
    • (2007) Mol Cancer , vol.6 , pp. 3
    • Rao, S.P.1    Rechsteiner, M.P.2    Berger, C.3
  • 97
    • 77950867869 scopus 로고    scopus 로고
    • Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells
    • Madhavi Billam M, Sobolewski MD, Davidson NE. Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells. Breast Cancer Res Treat 2010;120:581-92
    • (2010) Breast Cancer Res Treat , vol.120 , pp. 581-92
    • Madhavi Billam, M.1    Sobolewski, M.D.2    Davidson, N.E.3
  • 98
    • 74549195798 scopus 로고    scopus 로고
    • Current and emerging therapies for acute myeloid leukemia
    • Robak T, Wierzbowska A. Current and emerging therapies for acute myeloid leukemia. Clin Ther 2009;31(Pt 2):2349-70
    • (2009) Clin Ther , vol.31 , Issue.PART 2 , pp. 2349-70
    • Robak, T.1    Wierzbowska, A.2
  • 99
    • 39049180806 scopus 로고    scopus 로고
    • Nucleosides as anticancer agents: From concept to the clinic
    • Secrist JA III. Nucleosides as anticancer agents: from concept to the clinic. Nucleic Acids Symp Ser(Oxf) 2005;49:15-6
    • (2005) Nucleic Acids Symp Ser(Oxf) , vol.49 , pp. 15-6
    • Secrist Iii, J.A.1


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