Toxicogenomic approaches for understanding molecular mechanisms of heavy metal mutagenicity and carcinogenicity

International Journal of Hygiene and Environmental Health

Volumn 216, Issue 5, 2013, Pages 587-598

  Koedrith, Preeyaporn ^a,b   Kim, HyeLim ^a   Weon, Jong Il ^c   Seo, Young Rok ^a  

^a Dongguk University   (South Korea)

^b MAHIDOL UNIVERSITY   (Thailand)

^c Dongguk University   (South Korea)

Author keywords

Carcinogenicity; Environment; Heavy metal; Mutagenicity; Toxicogenomics

Indexed keywords

CARCINOGEN; HEAVY METAL; MUTAGENIC AGENT;

ANIMAL; ARTICLE; CARCINOGENICITY; CHEMICALLY INDUCED DISORDER; ENVIRONMENT; ENVIRONMENTAL EXPOSURE; GENETICS; GENOMICS; HUMAN; MUTAGENICITY; NEOPLASM; TOXICOGENOMICS;

CARCINOGENICITY; ENVIRONMENT; HEAVY METAL; MUTAGENICITY; TOXICOGENOMICS;

ANIMALS; CARCINOGENS; ENVIRONMENTAL EXPOSURE; GENOMICS; HUMANS; METALS, HEAVY; MUTAGENS; NEOPLASMS;

EID: 84880047017     PISSN: 14384639     EISSN: 1618131X     Source Type: Journal    
DOI: 10.1016/j.ijheh.2013.02.010     Document Type: Article

References (186)

1. Adorján P., Distler J., Lipscher E., Model F., Müller J., Pelet C., Braun A., Florl A.R., Gütig D., Grabs G., Howe A., Kursar M., Lesche R., Leu E., Lewin A., Maier S., Müller V., Otto T., Scholz C., Schulz W.A., Seifert H.H., Schwope I., Ziebarth H., Berlin K., Piepenbrock C., Olek A. Tumour class prediction and discovery by microarray-based DNA methylation analysis. Nucleic Acids Res. 2002, 30:e21.
2. Almadori G., Bussu F., Galli J., Rigante M., Lauriola L., Michetti F., Maggiano N., Schafer B.W., Heizmann C.W., Ranelletti F.O., Paludetti G. Diminished expression of S100A2, a putative tumour suppressor, is an independent predictive factor of neck node relapse in laryngeal squamous cell carcinoma. J. Otolaryngol. Head Neck Surg. 2009, 38:16-22.
3. Altenburger R., Scholz S., Schmitt-Jansen M., Busch W., Escher B.I. Mixture toxicity revisited from a toxicogenomic perspective. Environ. Sci. Technol. 2012, 46:2508-2522.
4. Anderson N.L., Matheson A.D., Steiner S. Proteomics: applications in basic and applied biology. Curr. Opin. Biotechnol. 2000, 11:408-412.
5. Andrew A.S., Warren A.J., Barchowsky A., Temple K.A., Klei L., Soucy N.V., O'Hara K.A., Hamilton J.W. Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ. Health Perspect. 2003, 111:825-835.
6. Argos M., Kibriya M.G., Parvez F., Jasmine F., Rakibuz-Zaman M., Ahsan H. Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population. Cancer Epidemiol. Biomarkers Prev. 2006, 15:1367-1375.
7. Arita A., Niu J., Qu Q., Zhao N., Ruan Y., Nadas A., Chervona Y., Wu F., Sun H., Hayes R.B., Costa M. Global levels of histone modifications in peripheral blood mononuclear cells of subjects with exposure to nickel. Environ. Health Perspect. 2012, 120:198-203.
8. Ayensu W.K., Tchounwou P.B. Microarray analysis of mercury-induced changes in gene expression in human liver carcinoma (HepG2) cells: importance in immune responses. Int. J. Environ. Res. Public Health 2006, 3:141-173.
9. Badisa V.L., Latinwo L.M., Odewumi C.O., Ikediobi C.O., Badisa R.B., Brooks-Walter A., Lambert A.T., Nwoga J. Cytotoxicity and stress gene microarray analysis in cadmium-exposed CRL-1439 normal rat liver cells. Int. J. Mol. Med. 2008, 22:213-219.
10. Bae D.S., Gennings C., Carter W.H., Yang R.S., Campain J.A. Toxicological interactions among arsenic, cadmium, chromium, and lead in human keratinocytes. Toxicol. Sci. 2001, 63:132-142.
11. Balkwill F., Mantovani A. Inflammation and cancer: back to Virchow?. Lancet 2001, 357:539-545.
12. Benbrahim-Tallaa L., Waterland R.A., Styblo M., Achanzar W.E., Webber M.M., Waalkes M.P. Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation. Toxicol. Appl. Pharmacol. 2005, 206:288-298.
13. Benton M.A., Rager J.E., Smeester L., Fry R.C. Comparative genomic analyses identify common molecular pathways modulated upon exposure to low doses of arsenic and cadmium. BMC Genomics 2011, 12:173.
14. Beranova-Giorgianni S. Proteome analysis by two-dimensional gel electrophoresis and mass spectrometry: strengths and limitations. Trends Anal. Chem. 2003, 22:273-281.
15. Besaratinia A., Kim S.I., Hainaut P., Pfeifer G.P. In vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure. Gastroenterology 2009, 137:1127-1137.
16. Besaratinia A., Li H., Yoon J.I., Zheng A., Gao H., Tommasi S. A high-throughput next-generation sequencing-based method for detecting the mutational fingerprint of carcinogens. Nucleic Acids Res. 2012, 26:1-13.
17. Beyersmann D., Hartwig A. Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms. Arch. Toxicol. 2008, 82:493-512.
18. Binet F., Antoine F., Girard D. Interaction between arsenic trioxide and human primary cells: emphasis on human cells of myeloid origin. Inflamm. Allergy Drug Targets 2009, 8:21-27.
19. Birdsall R.E., Kiley M.P., Segu Z.M., Palmer C.D., Madera M., Gump B.B., MacKenzie J.A., Parsons P.J., Mechref Y., Novotny M.V., Bendinskas K.G. Effects of lead and mercury on the blood proteome of children. J. Proteome Res. 2010, 9:4443-4453.
20. Boonchai W., Walsh M., Cummings M., Chenevix-Trench G. Expression of p53 in arsenic-related and sporadic basal cell carcinoma. Arch. Dermatol. 2000, 136:195-198.
21. Bouton C.M., Pevsner J. Effects of lead on gene expression. Neurotoxicology 2000, 21:1045-1055.
22. Bridgewater L.C., Manning F.C., Patierno S.R. Arrest of replication by mammalian DNA polymerases alpha and beta caused by chromium-DNA lesions. Mol. Carcinog. 1998, 23:201-206.
23. Broday L., Peng W., Kuo M.H., Salnikow K., Zoroddu M., Costa M. Nickel compounds are novel inhibitors of histone H4 acetylation. Cancer Res. 2000, 60:238-241.
24. Bulk E., Sargin B., Krug U., Hascher A., Jun Y., Knop M., Kerkhoff C., Gerke V., Liersch R., Mesters R.M., Hotfilder M., Marra A., Koschmieder S., Dugas M., Berdel W.E., Serve H., Müller-Tidow C. S100A2 induces metastasis in non-small cell lung cancer. Clin. Cancer Res. 2009, 15:22-29.
25. Burchell J., Poulsom R., Hanby A., Whitehouse C., Cooper L., Clausen H., Miles D., Taylor-Papadimitriou J. An alpha2,3 sialyltransferase (ST3 Gal I) is elevated in primary breast carcinomas. Glycobiology 1999, 9:1307-1311.
26. Callinan P.A., Feinberg A.P. The emerging science of epigenomics. Hum. Mol. Genet. 2006, 15:R95-R101.
27. Cao Y., Yu S.L., Wang Y., Guo G.Y., Ding Q., An R.H. MicroRNA-dependent regulation of PTEN after arsenic trioxide treatment in bladder cancer cell line T24. Tumour Biol. 2011, 32:179-188.
28. Chai C.Y., Huang Y.C., Hung W.C., Kang W.Y., Chen W.T. Arsenic salts induced autophagic cell death and hypermethylation of DAPK promoter in SV-40 immortalized human uroepithelial cells. Toxicol. Lett. 2007, 173:48-56.
29. Chakraborti T., Kim K.A., Goldstein G.G., Bressler J.P. Increased AP-1 DNA binding activity in PC12 cells treated with lead. J. Neurochem. 1999, 73:187-194.
30. Chen D.S., Chan K.M. Changes in the protein expression profiles of the Hepa-T1 cell line when exposed to Cu2+. Aquat. Toxicol. 2009, 94:163-176.
31. Chen H., Ke Q., Kluz T., Yan Y., Costa M. Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing. Mol. Cell. Biol. 2006, 26:3728-3737.
32. Chen H., Li S., Liu J., Diwan B.A., Barrett J.C., Waalkes M.P. Chronic inorganic arsenic exposure induces hepatic global and individual gene hypomethylation: implications for arsenic hepatocarcinogenesis. Carcinogenesis 2004, 25:1779-1786.
33. Combes R., Balls M., Curren R., Fischbach M., Fusenig N., Kirkland D., Lasne C., Landolph J., LeBoeuf R., Marquardt H., McCormick J., Müller L., Rivedal E., Sabbioni E., Tanaka N., Vasseur P., Yamasaki H. Cell transformation assays as predictors of human carcinogenicity. ECVAM Workshop Report 39. Altern. Lab. Anim. 1999, 27:745-767.
34. Conolly R.B. Biologically motivated quantitative models and the mixture toxicity problem. Toxicol. Sci. 2001, 63:1-2.
35. Coppin J.F., Qu W., Waalkes M.P. Interplay between cellular methyl metabolism and adaptive efflux during oncogenic transformation from chronic arsenic exposure in human cells. J. Biol. Chem. 2008, 283:19342-19350.
36. Cronin M.T., Jaworska J.S., Walker J.D., Comber M.H., Watts C.D., Worth A.P. Use of QSARs in international decision-making frameworks to predict health effects of chemical substances. Environ. Health Perspect. 2003, 111:1391-1401.
37. Cunha I.W., Carvalho K.C., Martins W.K., Marques S.M., Muto N.H., Falzoni R., Rocha R.M., Aguiar S., Simoes A.C., Fahham L., Neves E.J., Soares F.A., Rei s.L.F. Identification of genes associated with local aggressiveness and metastatic behavior in soft tissue tumors. Transl. Oncol. 2010, 3:23-32.
38. Danchenko M., Skultety L., Rashydov N.M., Berezhna V.V., Mátel L., Salaj T., Pret'ová A., Hajduch M. Proteomic analysis of mature soybean seeds from the Chernobyl area suggests plant adaptation to the contaminated environment. J. Proteome Res. 2009, 8:2915-2922.
39. Dangi-Garimella S., Yun J., Eves E.M., Newman M., Erkeland S.J., Hammond S.M., Minn A.J., Rosner M.R. Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7. EMBO J. 2009, 28:347-358.
40. Díaz-Barriga F., Llamas E., Mejía J.J., Carrizales L., Santoyo M.E., Vega-Vega L., Yáñez L. Arsenic-cadmium interaction in rats. Toxicology 1990, 64:191-203.
41. Dix D.J., Houck K.A., Martin M.T., Richard A.M., Setzer R.W., Kavlock R.J. The ToxCast program for prioritizing toxicity testing of environmental chemicals. Toxicol. Sci. 2007, 95:5-12.
42. Dorman D.C., Struve M.F., Norris A., Higgins A.J. Metabolomic analyses of body fluids after subchronic manganese inhalation in rhesus monkeys. Toxicol. Sci. 2008, 106:46-54.
43. Dubrovskaya V.A., Wetterhahn K.E. Effects of Cr(VI) on the expression of the oxidative stress genes in human lung cells. Carcinogenesis 1998, 19:1401-1407.
44. Fowler B.A., Conner E.A., Yamauchi H. Metabolomic and proteomic biomarkers for III-V semiconductors: chemical-specific porphyrinurias and proteinurias. Toxicol. Appl. Pharmacol. 2005, 206:121-130.
45. Fu H.Y., Shen J.Z. Hypermethylation of CpG island of p16 gene and arsenic trioxide induced p16 gene demethylation in multiple myeloma. Zhonghua Neike Zazhi 2005, 44:411-414.
46. Fujiwaki R., Iida K., Nakayama K., Kanasaki H., Hata K., Katabuchi H., Okamura H., Miyazaki K. Clinical significance of interleukin-1 receptor antagonist in patients with cervical carcinoma. Gynecol. Oncol. 2003, 89:77-83.
47. Fukuda T., Saito A., Wasaki J., Shinano T., Osaki M. Metabolic alterations proposed by proteome in rice roots grown under low P and high Al concentration under low pH. Plant Sci. 2007, 172:1157-1165.
48. Galaris D., Evangelou A. The role of oxidative stress in mechanisms of metal-induced carcinogenesis. Crit. Rev. Oncol. Hematol. 2002, 42:93-103.
49. Garcia-Reyero N., Perkins E.J. Systems biology: leading the revolution in ecotoxicology. Environ. Toxicol. Chem. 2011, 30:265-273.
50. Garrisi V.M., Abbate I., Quaranta M., Mangia A., Tommasi S., Paradiso A. SELDI-TOF serum proteomics and breast cancer: which perspective?. Expert. Rev. Proteomics 2008, 5:779-785.
51. Gatzidou E.T., Zira A.N., Theocharis S.E. Toxicogenomics: a pivotal piece in the puzzle of toxicological research. J. Appl. Toxicol. 2007, 27:302-309.
52. Ge F., Lu X.P., Zeng H.L., He Q.Y., Xiong S., Jin L., He Q.Y. Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J. Proteome Res. 2009, 8:3006-3019.
53. Gianazza E., Wait R., Sozzi A., Regondi S., Saco D., Labra M., Agradi E. Growth and protein profile changes in Lepidium sativum L. plantlets exposed to cadmium. Environ. Exp. Bot. 2007, 59:159-187.
54. Goering P.L., Fowler B.A. Regulation of lead inhibition of delta-aminolevulinic acid dehydratase by a low molecular weight, high affinity renal lead-binding protein. J. Pharmacol. Exp. Ther. 1984, 231:66-71.
55. Goering P.L., Fowler B.A. Mechanism of renal lead-binding protein reversal of delta-aminolevulinic acid dehydratase inhibition by lead. J. Pharmacol. Exp. Ther. 1985, 234:365-371.
56. Goering P.L., Mistry P., Fowler B.A. A low molecular weight lead-binding protein in brain attenuates lead inhibition of delta-aminolevulinic acid dehydratase: comparison with a renal lead-binding protein. J. Pharmacol. Exp. Ther. 1986, 237:220-225.
57. Govindarajan B., Klafter R., Miller M.S., Mansur C., Mizesko M., Bai X., LaMontagne K., Arbiser J.L. Reactive oxygen-induced carcinogenesis causes hypermethylation of p16(Ink4a) and activation of MAP kinase. Mol. Med. 2002, 8:1-8.
58. Griffin J.L., Walker L.A., Shore R.F., Nicholson J.K. Metabolic profiling of chronic cadmium exposure in the rat. Chem. Res. Toxicol. 2001, 14:1428-1434.
59. Grossmann J., Roschitzki B., Panse C., Fortes C., Barkow-Oesterreicher S., Rutishauser D., Schlapbach R. Implementation and evaluation of relative and absolute quantification in shotgun proteomics with label-free methods. J. Proteomics 2010, 7:1740-1746.
60. Hamadeh H.K., Amin R.P., Paules R.S., Afshari C.A. An overview of toxicogenomics. Curr. Issues Mol. Biol. 2002, 4:45-56.
61. Han X., Amar S. Secreted frizzled-related protein 1 (SFRP1) protects fibroblasts from ceramide-induced apoptosis. J. Biol. Chem. 2004, 279:2832-2840.
62. Hayes K.R., Bradfield C.A. Advances in toxicogenomics. Chem. Res. Toxicol. 2005, 18:403-414.
63. He Q.Y., Yip T.T., Li M., Chiu J.F. Proteomic analyses of arsenic-induced cell transformation with SELDI-TOF ProteinChip technology. J. Cell. Biochem. 2003, 88:1-8.
64. Hemdan N.Y., Emmrich F., Faber S., Lehmann J., Sack U. Alterations of TH1/TH2 reactivity by heavy metals: possible consequences include induction of autoimmune diseases. Ann. N. Y. Acad. Sci. 2007, 1109:129-137.
65. Hochadel J.F., Waalkes M.P. Sequence of exposure to cadmium and arsenic determines the extent of toxic effects in male Fischer rats. Toxicology 1997, 116:89-98.
66. Hou L., Zhang X., Wang D., Baccarelli A. Environmental chemical exposures and human epigenetics. Int. J. Epidemiol. 2012, 41:79-105.
67. Hsiao C.J., Stapleton S.R. Early sensing and gene expression profiling under a low dose of cadmium exposure. Biochimie 2009, 91:329-343.
68. Hu J., Dong A., Fernandez-Ruiz V., Shan J., Kawa M., Martínez-Ansó E., Prieto J., Qian C. Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma. Cancer Res. 2009, 69:6951-6959.
69. Huang D., Zhang Y., Qi Y., Chen C., Ji W. Global DNA hypomethylation, rather than reactive oxygen species (ROS), a potential facilitator of cadmium-stimulated K562 cell proliferation. Toxicol. Lett. 2008, 179:43-47.
70. Hussain S.P., Schwank J., Staib F., Wang X.W., Harris C.C. TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer. Oncogene 2007, 26:2166-2176.
71. Izzotti A., Cartiglia C., Balansky R., D'Agostini F., Longobardi M., De Flora S. Selective induction of gene expression in rat lung by hexavalent chromium. Mol. Carcinog. 2002, 35:75-84.
72. Jensen T.J., Novak P., Eblin K.E., Gandolfi A.J., Futscher B.W. Epigenetic remodeling during arsenical-induced malignant transformation. Carcinogenesis 2008, 29:1500-1508.
73. Jo W.J., Ren X., Chu F., Aleshin M., Wintz H., Burlingame A., Smith M.T., Vulpe C.D., Zhang L. Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure. Toxicol. Appl. Pharmacol. 2009, 241:294-302.
74. Jomova K., Valko M. Advances in metal-induced oxidative stress and human disease. Toxicology 2011, 283:65-87.
75. Jones P.A., Baylin S.B. The epigenomics of cancer. Cell 2007, 128:683-692.
76. Jones P.A., Baylin S.B., Bernsten B.E., Feinberg A.P., Greally J.M., Jenuwein T., Jirtle R., Ushijima T., Pierotta V., Allis C.D., Elgin S.C., Rine J., Wu C. Moving AHEAD with an international human epigenome project. Nature 2008, 454:711-715.
77. Judson R.S., Houck K.A., Kavlock R.J., Knudsen T.B., Martin M.T., Mortensen H.M., Reif D.M., Rotroff D.M., Shah I., Richard A.M., Dix D.J. In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project. Environ. Health Perspect. 2010, 118:485-492.
78. Kaltreider R.C., Pesce C.A., Ihnat M.A., Lariviere J.P., Hamilton J.W. Differential effects of arsenic(III) and chromium(VI) on nuclear transcription factor binding. Mol. Carcinog. 1999, 25:219-229.
79. Karaczyn A., Ivanov S., Reynolds M., Zhitkovich A., Kasprzak K.S., Salnikow K. Ascorbate depletion mediates up-regulation of hypoxia-associated proteins by cell density and nickel. J. Cell. Biochem. 2006, 97:1025-1035.
80. Karaczyn A.A., Golebiowski F., Kasprzak K.S. Truncation, deamidation, and oxidation of histone H2B in cells cultured with nickel(II). Chem. Res. Toxicol. 2005, 18:1934-1942.
81. Ke Q., Li Q., Ellen T.P., Sun H., Costa M. Nickel compounds induce phosphorylation of histone H3 at serine 10 by activating JNK-MAPK pathway. Carcinogenesis 2008, 29:1276-1281.
82. Kellermann J. ICPL-isotope-coded protein label. Methods Mol. Biol. 2008, 424:113-123.
83. Kennedy S. The role of proteomics in toxicology: identification of biomarkers of toxicity by protein expression analysis. Biomarkers 2002, 7:269-290.
84. Keyvanshokooh S., Vaziri B., Gharaei A., Mahboudi F., Esmaili-Sari A., Shahriari-Moghadam M. Proteome modifications of juvenile beluga (Huso huso) brain as an effect of dietary methylmercury. Comp. Biochem. Physiol. Part D Genomics Proteomics 2009, 4:243-248.
85. Kim H.L., Seo Y.R. Synergistic genotoxic effect between gene and environmental pollutant: oxidative DNA damage induced by thioredoxin reductase 1 silencing under nickel treatment. Mol. Cell. Toxicol. 2011, 7:251-257.
86. Kim H.L., Seo Y.R. Identification of potential molecular biomarkers in response to thioredoxin reductase 1 deficiency under nickel exposure. BioChip J. 2012, 6:157-164.
87. Kim H.L., Seo Y.R. Molecular and genomic approach for understanding the gene-environment interaction between Nrf2 deficiency and carcinogen nickel-induced DNA damage. Oncol. Rep. 2012, 28:1959-1967.
88. Klein C.B., Conway K., Wang X.W., Bhamra R.K., Lin X.H., Cohen M.D., Annab L., Barrett J.C., Costa M. Senescence of nickel-transformed cells by an X chromosome: possible epigenetic control. Science 1991, 251:796-799.
89. Koedrith P., Seo Y.R. Advances in carcinogenic metal toxicity and potential molecular markers. Int. J. Mol. Sci. 2011, 12:9576-9595.
90. Koizumi S., Yamada H. DNA microarray analysis of altered gene expression in cadmium-exposed human cells. J. Occup. Health 2003, 45:331-334.
91. Kudo T., Ikehara Y., Togayachi A., Morozumi K., Watanabe M., Nakamura M., Nishihara S., Narimatsu H. Up-regulation of a set of glycosyltransferase genes in human colorectal cancer. Lab. Invest. 1998, 78:797-811.
92. Kuo C.H., Wang K.C., Tian T.F., Tsai M.H., Chiung Y.M., Hsiech C.M., Tsai S.J., Wang S.Y., Tsai D.M., Huang C.C., Tseng Y.J. Metabolomic characterization of laborers exposed to welding fumes. Chem. Res. Toxicol. 2012, 25:676-686.
93. Lafaye A., Junot C., Ramounet-Le Gall B., Fritsch P., Tabet J.C., Ezan E. Metabolite profiling in rat urine by liquid chromatography/electrospray ion trap mass spectrometry. Application to the study of heavy metal toxicity. Rapid Commun. Mass Spectrom. 2003, 17:2541-2549.
94. Lee B.K., Lee S.J., Joo J.S., Cho K.S., Kim N.S., Kim H.J. Association of glutathione S-transferase genes (GSTM1 and GSTT1) polymorphisms with hypertension in lead-exposed workers. Mol. Cell. Toxicol. 2012, 8:203-208.
95. Lee K.H., Chung E.K., Moon J.S., Nam S.W., Lee M.Y., Son B.S. Assessment of human biomonitoring and DNA microarray analysis in the vicinity population on an industrial complex. Mol. Cell. Toxicol. 2011, 7:207-219.
96. Lee S.W., Tomasetto C., Swisshelm K., Keyomarsi K., Sager R. Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment. Proc. Natl. Acad. Sci. U. S. A. 1992, 89:2504-2508.
97. Lee Y.W., Klein C.B., Kargacin B., Salnikow K., Kitahara J., Dowjat K., Zhitkovich A., Christie N.T., Costa M. Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens. Mol. Cell. Biol. 1995, 15:2547-2557.
98. Leonard S.S., Bower J.J., Shi X. Metal-induced toxicity, carcinogenesis, mechanisms and cellular responses. Mol. Cell. Biochem. 2004, 255:3-10.
99. Lettieri T. Recent applications of DNA microarray technology to toxicology and ecotoxicology. Environ. Health Perspect. 2006, 114:4-9.
100. Li J., Chen P., Sinogeeva N., Gorospe M., Wersto R.P., Chrest F.J., Barnes J., Liu Y. Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells. J. Biol. Chem. 2002, 277:49504-49510.
101. Li J., Gorospe M., Barnes J., Liu Y. Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts. J. Biol. Chem. 2003, 278:13183-13191.
102. Liu J., Liu Y., Habeebu S.M., Waalkes M.P., Klaassen C.D. Chronic combined exposure to cadmium and arsenic exacerbates nephrotoxicity, particularly in metallothionein-I/II null mice. Toxicology 2000, 147:157-166.
103. Lueking A., Horn M., Eickhoff H., Büssow K., Lehrach H., Walter G. Protein microarrays for gene expression and antibody screening. Anal. Biochem. 1999, 270:103-111.
104. Luque-Garcia J.L., Cabezas-Sanchez P., Camara C. Proteomics as a tool for examining the toxicity of heavy metals. Trends Anal. Chem. 2011, 30:703-716.
105. Madden E.F., Akkerman M., Fowler B.A. A comparison of 60, 70, and 90kDa stress protein expression in normal rat NRK-52 and human HK-2 kidney cell lines following in vitro exposure to arsenite and cadmium alone or in combination. J. Biochem. Mol. Toxicol. 2002, 16:24-32.
106. Majumdar S., Chanda S., Ganguli B., Mazumder D.N., Lahiri S., Dasgupta U.B. Arsenic exposure induces genomic hypermethylation. Environ. Toxicol. 2010, 25:315-318.
107. Mann M. Functional and quantitative proteomics using SILAC. Nat. Rev. Mol. Cell Biol. 2006, 7:952-958.
108. Marsit C.J., Eddy K., Kelsey K.T. MicroRNA responses to cellular stress. Cancer Res. 2006, 66:10843-10848.
109. Mass M.J., Wang L. Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis. Mutat. Res. 1997, 386:263-277.
110. Matés J.M., Segura J.A., Alonso F.J., Márquez J. Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis. Arch. Toxicol. 2008, 82:273-299.
111. Matés J.M., Pérez-Gómez C., Núñez de Castro I., Asenjo M., Márquez J. Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death. Int. J. Biochem. Cell Biol. 2002, 34:439-458.
112. Maurici D., Aardema M., Corvi R., Kleber M., Krul C., Laurent C., Loprieno N., Pasanen M., Pfuhler S., Phillips B., Prentice D., Sabbioni E., Sanner T., Vanparys P. Carcinogenicity. Altern. Lab. Anim. 2005, 33:177-182.
113. Minden J.S., Dowd S.R., Meyer H.E., Stühler K. Difference gel electrophoresis. Electrophoresis 2009, 30:S156-S161.
114. Mistry P., Lucier G.W., Fowler B.A. High-affinity lead binding proteins in rat kidney cytosol mediate cell-free nuclear translocation of lead. J. Pharmacol. Exp. Ther. 1985, 232:462-469.
115. Mistry P., Mastri C., Fowler B.A. Influence of metal ions on renal cytosolic lead-binding proteins and nuclear uptake of lead in the kidney. Biochem. Pharmacol. 1986, 35:711-713.
116. Monks T.J., Xie R., Tikoo K., Lau S.S. Ros-induced histone modifications and their role in cell survival and cell death. Drug Metab. Rev. 2006, 38:755-767.
117. Müller L., Kikuchi Y., Probst G., Schechtman L., Shimada H., Sofuni T., Tweats D. ICH-harmonised guidances on genotoxicity testing of pharmaceuticals: evolution, reasoning and impact. Mutat. Res. 1999, 436:195-225.
118. Neal R., Aykin-Burns N., Ercal N., Zigler J.S. Pb2+ exposure alters the lens alpha A-crystallin protein profile in vivo and induces cataract formation in lens organ culture. Toxicology 2005, 212:1-9.
119. Nieboer E., Fletcher G.G., Thomassen Y. Relevance of reactivity determinants to exposure assessment and biological monitoring of the elements. J. Environ. Monit. 1999, 1:1-14.
120. Nuwaysir E.F., Bittner M., Trent J., Barrett J.C., Afshari A.J. Microarrays and toxicology: the advent of toxicogenomics. Mol. Carcinog. 1999, 24:153-159.
121. Oesch S., Gertsch J. Cannabinoid receptor ligands as potential anticancer agents-high hopes for new therapies?. J. Pharm. Pharmacol. 2009, 61:839-853.
122. Okoji R.S., Yu R.C., Maronpot R.R., Froines J.R. Sodium arsenite administration via drinking water increases genome-wide and Ha-ras DNA hypomethylation in methyl-deficient C57BL/6J mice. Carcinogenesis 2002, 23:777-785.
123. Oskarsson A., Squibb K.S., Fowler B.A. Intracellular binding of lead in the kidney: the partial isolation and characterization of postmitochondrial lead binding components. Biochem. Biophys. Res. Commun. 1982, 104:290-298.
124. Page M.J., Amess B., Rohlff C., Stubberfield C., Parekh R. Proteomics: a major new technology for the drug discovery process. Drug Discovery Today 1999, 4:55-62.
125. Park J.Y., Lee Y.J., Koedrith P., Seo Y.R. Protective role of thioredoxin reductase 1 in cadmium-induced DNA damage. Mol. Cell. Toxicol. 2012, 8:289-295.
126. Park J.Y., Seo Y.R. The protective role of Nrf2 in cadmium-induced DNA damage. Mol. Cell. Toxicol. 2011, 7:61-66.
127. Pilsner J.R., Liu X., Ahsan H., Ilievski V., Slavkovich V., Levy D., Factor-Litvak P., Graziano J.H., Gamble M.V. Genomic methylation of peripheral blood leukocyte DNA: influences of arsenic and folate in Bangladeshi adults. Am. J. Clin. Nutr. 2007, 86:1179-1186.
128. Poli G., Leonarduzzi G., Biasi F., Chiarpotto E. Oxidative stress and cell signalling. Curr. Med. Chem. 2004, 11:1163-1182.
129. Qian Y., Harris E.D., Zheng Y., Tiffany-Castiglioni E. Lead targets GRP78, a molecular chaperone, in C6 rat glioma cells. Toxicol. Appl. Pharmacol. 2000, 163:260-266.
130. Rahman K. Studies on free radicals, antioxidants, and co-factors. Clin. Interv. Aging 2007, 2:219-236.
131. Ramirez T., Brocher J., Stopper H., Hock R. Sodium arsenite modulates histone acetylation, histone deacetylase activity and HMGN protein dynamics in human cells. Chromosoma 2008, 117:147-157.
132. Ramos-Fernández A., López-Ferrer D., Vázquez J. Improved method for differential expression proteomics using trypsin-catalyzed 18O labeling with a correction for labeling efficiency. Mol. Cell. Proteomics 2007, 6:1274-1286.
133. Reichard J.F., Schnekenburger M., Puga A. Long term low-dose arsenic exposure induces loss of DNA methylation. Biochem. Biophys. Res. Commun. 2007, 352:188-192.
134. Ren X., McHale C.M., Skibola C.F., Smith A.H., Smith M.T., Zhang L. An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis. Environ. Health Perspect. 2011, 119:11-19.
135. Requejo R., Tena M. Proteome analysis of maize roots reveals that oxidative stress is a main contributing factor to plant arsenic toxicity. Phytochemistry 2005, 66:1519-1528.
136. Robertson D.G. Metabonomics in toxicology: a review. Toxicol. Sci. 2005, 85:809-822.
137. Robertson K.D. DNA methylation and human disease. Nat. Rev. Genet. 2005, 6:597-610.
138. Rubin R.B., Merchant M. A rapid protein profiling system that speeds study of cancer and other diseases. Am. Clin. Lab. 2000, 19:28-29.
139. Schirmer K., Fischer B.B., Madureira D.J., Pillai S. Transcriptomics in ecotoxicology. Anal. Bioanal. Chem. 2010, 397:917-923.
140. Schneider F., Kemmner W., Haensch W., Franke G., Gretschel S., Karsten U., Schlag P.M. Overexpression of sialyltransferase CMP-sialic acid:Galbeta1,3GalNAc-R alpha6-Sialyltransferase is related to poor patient survival in human colorectal carcinomas. Cancer Res. 2001, 61:4605-4611.
141. Shelton K.R., Egle P.M. The proteins of lead-induced intranuclear inclusion bodies. J. Biol. Chem. 1982, 257:11802-11807.
142. Shelton K.R., Todd J.M., Egle P.M. The induction of stress-related proteins by lead. J. Biol. Chem. 1986, 261:1935-1940.
143. Shi L., Reid L.H., Jones W.D., Shippy R., Warrington J.A., Baker S.C., Collins P.J., de Longueville F., Kawasaki E.S., Lee K.Y., Luo Y., Sun Y.A., Willey J.C., Setterquist R.A., Fischer G.M., Tong W., Dragan Y.P., Dix D.J., Frueh F.W., Goodsaid F.M., Herman D., Jensen R.V., Johnson C.D., Lobenhofer E.K., Puri R.K., Schrf U., Thierry-Mieg J., Wang C., Wilson M., Wolber P.K., Zhang L., Amur S., Bao W., Barbacioru C.C., Lucas A.B., Bertholet V., Boysen C., Bromley B., Brown D., Brunner A., Canales R., Cao X.M., Cebula T.A., Chen J.J., Cheng J., Chu T.M., Chudin E., Corson J., Corton J.C., Croner L.J., Davies C., Davison T.S., Delenstarr G., Deng X., Dorris D., Eklund A.C., Fan X.H., Fang H., Fulmer-Smentek S., Fuscoe J.C., Gallagher K., Ge W., Guo L., Guo X., Hager J., Haje P.K., Han J., Han T., Harbottle H.C., Harris S.C., Hatchwell E., Hauser C.A., Hester S., Hong H., Hurban P., Jackson S.A., Ji H., Knight C.R., Kuo W.P., LeClerc J.E., Levy S., Li Q.Z., Liu C., Liu Y., Lombardi M.J., Ma Y., Magnuson S.R., Maqsodi B., McDaniel T., Mei N., Myklebost O., Ning B., Novoradovskaya N., Orr M.S., Osborn T.W., Papallo A., Patterson T.A., Perkins R.G., Peters E.H., Peterson R., Philips K.L., Pine P.S., Pusztai L., Qian F., Ren H., Rosen M., Rosenzweig B.A., Samaha R.R., Schena M., Schroth G.P., Shchegrova S., Smith D.D., Staedtler F., Su Z., Sun H., Szallasi Z., Tezak Z., Thierry-Mieg D., Thompson K.L., Tikhonova I., Turpaz Y., Vallanat B., Van C., Walker S.J., Wang S.J., Wang Y., Wolfinger R., Wong A., Wu J., Xiao C., Xie Q., Xu J., Yang W., Zhang L., Zhong S., Zong Y., Slikker W. The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat. Biotechnol. 2006, 24:1151-1161.
144. Shinkai Y., Yamamoto C., Kaji T. Lead induces the expression of endoplasmic reticulum chaperones GRP78 and GRP94 in vascular endothelial cells via the JNK-AP-1 pathway. Toxicol. Sci. 2010, 114:378-386.
145. Simpson A.J., McNally D.J., Simpson M.J. NMR spectroscopy in environmental research: from molecular interactions to global processes. Prog. Nucl. Magn. Reson. Spectrosc. 2011, 58:97-175.
146. Singh J., Carlisle D.L., Pritchard D.E., Patierno S.R. Chromium-induced genotoxicity and apoptosis: relationship to chromium carcinogenesis. Oncol. Rep. 1998, 5:1307-1318. (Review).
147. Skordi E., Yap I.K., Claus S.P., Martin F.P., Cloarec O., Lindberg J., Schuppe-Koistinen I., Holmes E., Nicholson J.K. Analysis of time-related metabolic fluctuations induced by ethionine in the rat. J. Proteome Res. 2007, 6:4572-4581.
148. Solis-Heredia M.J., Quintanilla-Vega B., Sierra-Santoyo A., Hernández J.M., Brambila E., Cebrián M.E., Albores A. Chromium increases pancreatic metallothionein in the rat. Toxicology 2000, 142:111-117.
149. Strahl B.D., Allis C.D. The language of covalent histone modifications. Nature 2000, 403:41-45.
150. Suganuma T., Workman J.L. Crosstalk among histone modifications. Cell 2008, 135:604-607.
151. Takiguchi M., Achanzar W.E., Qu W., Li G., Waalkes M.P. Effects of cadmium on DNA-(cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation. Exp. Cell Res. 2003, 286:355-365.
152. Theodoridis G., Gika H.G., Wilson I.D. Mass spectrometry-based holistic analytical approaches for metabolite profiling in systems biology studies. Mass Spectrom. Rev. 2011, 30:884-904.
153. Tong W., Fang H., Mendrick D. Toxicogenomics and cell-based assays for toxicology. Interdisciplinary Bio Central 2009, 1:1-10.
154. Tsang T.M., Haselden J.N., Holmes E. Metabonomic characterization of the 3-nitropropionic acid rat model of Huntington's disease. Neurochem. Res. 2009, 34:1261-1271.
155. Uthus E.O., Davis C. Dietary arsenic affects dimethylhydrazine-induced aberrant crypt formation and hepatic global DNA methylation and DNA methyltransferase activity in rats. Biol. Trace Elem. Res. 2005, 103:133-145.
156. Valko M., Izakovic M., Mazur M., Rhodes C.J., Telser J. Role of oxygen radicals in DNA damage and cancer incidence. Mol. Cell. Biochem. 2004, 266:37-56.
157. Valko M., Rhodes C.J., Moncol J., Izakovic M., Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol. Interact. 2006, 160:1-40.
158. Vannini C., Marsoni M., Domingo G., Antognoni F., Biondi S., Bracale M. Proteomic analysis of chromate-induced modifications in Pseudokirchneriella subcapitata. Chemosphere 2009, 76:1372-1379.
159. Vendrell I., Carrascal M., Campos F., Abián J., Suñol C. Methylmercury disrupts the balance between phosphorylated and non-phosphorylated cofilin in primary cultures of mice cerebellar granule cells. A proteomic study. Toxicol. Appl. Pharmacol. 2010, 242:109-118.
160. Vendrell I., Carrascal M., Vilaró M.T., Abián J., Rodríguez-Farré E., Suñol C. Cell viability and proteomic analysis in cultured neurons exposed to methylmercury. Hum. Exp. Toxicol. 2007, 26:263-272.
161. Viant M.R. Recent developments in environmental metabolomics. Mol. Biosyst. 2008, 4:980-986.
162. Videira P.A., Ligeiro D., Correia M., Trindade H. Gene expression analysis in superficial bladder cancer: comparison of two suitable endogenous reference genes. Curr. Urol. 2007, 1:145-150.
163. Vido K., Spector D., Lagniel G., Lopez S., Toledano M.B., Labarre J. A proteome analysis of the cadmium response in Saccharomyces cerevisiae. J. Biol. Chem. 2001, 276:8469-8474.
164. Visioli G., Marmiroli M., Marmiroli N. Two-dimensional liquid chromatography technique coupled with mass spectrometry analysis to compare the proteomic response to cadmium stress in plants. J. Biomed. Biotechnol. 2010, 2010:567510.
165. Wang G., Chen X.-Q., Lipsky M.M., Whittaker M.H., Fowler B.A. Effect of combined lead, cadmium and arsenic exposure on the expression of cellular protective factors in rat kidneys at LOEL dose levels. Toxicologist 2005, 84:237.
166. Wang G., Fowler B.A. Roles of biomarkers in evaluating interactions among mixtures of lead, cadmium and arsenic. Toxicol. Appl. Pharmacol. 2008, 233:92-99.
167. Wang P.H., Lee W.L., Juang C.M., Yang Y.H., Lo W.H., Lai C.R., Hsieh S.L., Yuan C.C. Altered mRNA expressions of sialyltransferases in ovarian cancers. Gynecol. Oncol. 2005, 99:631-639.
168. Wang Z., Yang J., Fisher T., Xiao H., Jiang Y., Yang C. Akt activation is responsible for enhanced migratory and invasive behavior of arsenic-transformed human bronchial epithelial cells. Environ. Health Perspect. 2012, 120:92-97.
169. Weisburger E.K. History of the Bioassay Program of the National Cancer Institute. Prog. Exp. Tumor Res. 1983, 26:187-201.
170. Wicki R., Franz C., Scholl F.A., Heizmann C.W., Schäfer B.W. Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation. Cell Calcium 1997, 22:243-254.
171. Wildes D., Wells J.A. Sampling the N-terminal proteome of human blood. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:4561-4566.
172. Williams A.E., Perry M.M., Moschos S.A., Larner-Svensson H.M., Lindsay M.A. Role of miRNA-146a in the regulation of the innate immune response and cancer. Biochem. Soc. Trans. 2008, 36:1211-1215.
173. Witzmann F.A., Fultz C.D., Grant R.A., Wright L.S., Kornguth S.E., Siegel F.L. Regional protein alterations in rat kidneys induced by lead exposure. Electrophoresis 1999, 20:943-951.
174. Xie Y., Trouba K.J., Liu J., Waalkes M.P., Germolec D.R. Biokinetics and subchronic toxic effects of oral arsenite, arsenate, monomethylarsonic acid, and dimethylarsinic acid in v-Ha-ras transgenic (Tg.AC) mice. Environ. Health Perspect. 2004, 112:1255-1263.
175. Yamada H., Koizumi S. DNA microarray analysis of human gene expression induced by a non-lethal dose of cadmium. Ind. Health 2002, 40:159-166.
176. Yan P.S., Wei S.H., Huang T.H. Methylation-specific oligonucleotide microarray. Methods Mol. Biol. 2004, 287:251-260.
177. Ye J., Shi X. Gene expression profile in response to chromium-induced cell stress in A549 cells. Mol. Cell. Biochem. 2001, 222:189-197.
178. Yoon S., Han S.S., Rana S.V. Molecular markers of heavy metal toxicity-a new paradigm for health risk assessment. J. Environ. Biol. 2008, 29:1-14.
179. Zhai R., Su S., Lu X., Liao R., Ge X., He M., Huang Y., Mai S., Lu X., Christiani D. Proteomic profiling in the sera of workers occupationally exposed to arsenic and lead: identification of potential biomarkers. Biometals 2005, 18:603-613.
180. Zhang A.H., Bin H.H., Pan X.L., Xi X.G. Analysis of p16 gene mutation, deletion and methylation in patients with arseniasis produced by indoor unventilated-stove coal usage in Guizhou, China. J. Toxicol. Environ. Health Part A 2007, 70:970-975.
181. Zhang H., Lian C., Shen Z. Proteomic identification of small, copper-responsive proteins in germinating embryos of Oryza sativa. Ann. Bot. 2009, 103:923-930.
182. Zhao C.Q., Young M.R., Diwan B.A., Coogan T.P., Waalkes M.P. Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:10907-10912.
183. Zheng Y.G., Wu J., Chen Z., Goodman M. Chemical regulation of epigenetic modifications: opportunities for new cancer therapy. Med. Res. Rev. 2008, 28:645-687.
184. Zhou X., Li Q., Arita A., Sun H., Costa M. Effects of nickel, chromate, and arsenite on histone 3 lysine methylation. Toxicol. Appl. Pharmacol. 2009, 236:78-84.
185. Zhou X., Sun H., Ellen T.P., Chen H., Costa M. Arsenite alters global histone H3 methylation. Carcinogenesis 2008, 29:1831-1836.
186. Zieske L.R. A perspective on the use of iTRAQ reagent technology for protein complex and profiling studies. J. Exp. Bot. 2006, 57:1501-1508.