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Volumn 111, Issue 10, 2003, Pages 1391-1401

Use of QSARs in international decision-making frameworks to predict health effects of chemical substances

Author keywords

Chemical substances; Human health effects; Prediction; QSAR; Regulatory agencies; Toxicity

Indexed keywords

ENVIRONMENTAL CHEMICAL;

EID: 0003302467     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.5760     Document Type: Review
Times cited : (241)

References (88)
  • 1
    • 0031822868 scopus 로고    scopus 로고
    • A quantitative structure-activity relationship (QSAR) for a Draize eye irritation database
    • Abraham MH, Kumarsingh R, Cometto-Muniz JE, Cain WS. 1998a. A quantitative structure-activity relationship (QSAR) for a Draize eye irritation database. Toxicol In Vitro 12:201-207.
    • (1998) Toxicol. In Vitro , vol.12 , pp. 201-207
    • Abraham, M.H.1    Kumarsingh, R.2    Cometto-Muniz, J.E.3    Cain, W.S.4
  • 2
    • 0031877290 scopus 로고    scopus 로고
    • Draize eye scores and eye irritation thresholds in man combined into one quantitative structure-activity relationship
    • Abraham MH, Kumarsingh R, Cometto-Muniz JE, Cain WS. 1998b. Draize eye scores and eye irritation thresholds in man combined into one quantitative structure-activity relationship Toxicol In Vitro 12:403-408.
    • (1998) Toxicol. In Vitro , vol.12 , pp. 403-408
    • Abraham, M.H.1    Kumarsingh, R.2    Cometto-Muniz, J.E.3    Cain, W.S.4
  • 3
    • 0043095658 scopus 로고    scopus 로고
    • TOPKAT
    • Accelrys Inc. Cambridge, UK: Accelrys Inc. Available: [accessed 9 October 2002]
    • Accelrys Inc. 2002. TOPKAT. Cambridge, UK: Accelrys Inc. Available: http://www.accelrys.com/products/topkat/index.html [accessed 9 October 2002].
    • (2002)
  • 4
    • 0000973407 scopus 로고
    • Definitive relationships among chemical-structure, carcinogenicity and mutagenicity for 301 chemicals tested by the United States NTP
    • Ashby J, Tennant RW. 1991. Definitive relationships among chemical-structure, carcinogenicity and mutagenicity for 301 chemicals tested by the United States NTP. Mutat Res 257:229-306.
    • (1991) Mutat. Res. , vol.257 , pp. 229-306
    • Ashby, J.1    Tennant, R.W.2
  • 5
    • 0002022798 scopus 로고    scopus 로고
    • Validation and development of the DEREK skin sensitisation rulebase by analysis of the BgVV list of contact allergens
    • (Balls M, van Zeller A-M, Halder ME, eds). Amsterdam: Elsevier Science BV
    • Barratt M, Langowski J. 2000. Validation and development of the DEREK skin sensitisation rulebase by analysis of the BgVV list of contact allergens. In: Progress in the Reduction, Refinement, and Replacement of Animal Experimentation (Balls M, van Zeller A-M, Halder ME, eds). Amsterdam: Elsevier Science BV, 493-512.
    • (2000) Progress in the Reduction, Refinement, and Replacement of Animal Experimentation , pp. 493-512
    • Barratt, M.1    Langowski, J.2
  • 6
    • 0026644007 scopus 로고
    • The value of the local lymph node assay in quantitative structure activity investigations
    • Basketter DA, Roberts DW, Cronin MTD, Scholes EW. 1992. The value of the local lymph node assay in quantitative structure activity investigations. Contact Dermatitis 27:137-142.
    • (1992) Contact Dermatitis , vol.27 , pp. 137-142
    • Basketter, D.A.1    Roberts, D.W.2    Cronin, M.T.D.3    Scholes, E.W.4
  • 9
    • 0042093845 scopus 로고    scopus 로고
    • Council of Ministers. Report of the 2355th session of the Council "Environment," Luxembourg, 7 June 2001. Luxembourg:Council of Ministers. Available: [accessed 9 October 2002)
    • Council of Ministers. 2001. Report of the 2355th session of the Council "Environment," Luxembourg, 7 June 2001. Luxembourg:Council of Ministers. Available: http://www.health.fgov.be/WHI3/krant/krantarch2001/ kranttekstjune1/010611m05whi.htm [ccessed 9 October 2002).
    • (2001)
  • 10
    • 0033946802 scopus 로고    scopus 로고
    • Computational methods for the prediction of drug toxicity
    • Cronin MTD. 2000. Computational methods for the prediction of drug toxicity. Curr Opin Drug Discov Devel 3:292-297.
    • (2000) Curr. Opin. Drug Discov. Devel. , vol.3 , pp. 292-297
    • Cronin, M.T.D.1
  • 11
    • 0028191789 scopus 로고
    • A multivariate QSAR analysis of a skin sensitization database
    • Cronin MTD, Basketter DA. 1994. A multivariate QSAR analysis of a skin sensitization database. SAR QSAR Environ Res 2:159-179.
    • (1994) SAR QSAR Environ. Res. , vol.2 , pp. 159-179
    • Cronin, M.T.D.1    Basketter, D.A.2
  • 12
    • 0028839283 scopus 로고
    • QSAR in toxicology. 3. Prediction of chronic toxicities
    • Cronin MTD, Dearden JC. 1995a. QSAR in toxicology. 3. Prediction of chronic toxicities. Guant Struct-Act Relat14:329-334.
    • (1995) Guant. Struct-Act Relat. , vol.14 , pp. 329-334
    • Cronin, M.T.D.1    Dearden, J.C.2
  • 13
    • 0029586108 scopus 로고
    • QSAR in toxicology. 4. Prediction of non-lethal mammalian toxicological endpoints, and expert systems for toxicity prediction
    • Cronin MTD, Dearden JC. 1995b QSAR in toxicology. 4. Prediction of non-lethal mammalian toxicological endpoints, and expert systems for toxicity prediction. Duant Struct-Act Rel 14:518-523.
    • (1995) Duant. Struct-Act Rel. , vol.14 , pp. 518-523
    • Cronin, M.T.D.1    Dearden, J.C.2
  • 15
    • 0012959393 scopus 로고    scopus 로고
    • Use of DSARs in international decision-making frameworks to predict ecological effects and environmental fate of chemical substances
    • Cronin MTD, Walker JD, Jaworska JS, Comber MHI, Watts CD, Worth AP. 2003. Use of DSARs in international decision-making frameworks to predict ecological effects and environmental fate of chemical substances. Environ Health Perspect 111:1376-1390.
    • (2003) Environ. Health Perspect. , vol.111 , pp. 1376-1390
    • Cronin, M.T.D.1    Walker, J.D.2    Jaworska, J.S.3    Comber, M.H.I.4    Watts, C.D.5    Worth, A.P.6
  • 16
    • 0043095655 scopus 로고    scopus 로고
    • Commission Directive 2001/59/EC of 6 August 2001 adapting to technical progress for the 28th time Council Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances
    • Commission of the European Communities
    • Commission of the European Communities. 2001. Commission Directive 2001/59/EC of 6 August 2001 adapting to technical progress for the 28th time Council Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances. Off J Eur Communities L225:1-333.
    • (2001) Off. J. Eur. Communities , vol.L225 , pp. 1-333
  • 17
    • 0042093843 scopus 로고    scopus 로고
    • Preliminary Comments and Suggestions for Task 8: Use of QSAR
    • (Working Group: Testing, Registration and Evaluation). Copenhagen:Danish Environmental Protection Agency
    • Danish EPA. 2001. Preliminary Comments and Suggestions for Task 8: Use of QSAR. (Working Group: Testing, Registration and Evaluation). Copenhagen:Danish Environmental Protection Agency.
    • (2001)
    • Danish, E.P.A.1
  • 18
    • 0001383515 scopus 로고    scopus 로고
    • The development and validation of expert systems for predicting toxicity - The report and recommendations of an ECVAM/ECB workshop (ECVAM workshop 24)
    • Dearden JC, Barratt MD, Benigni R, Bristol DW, Combes RD, Cronin MTD et al. 1997. The development and validation of expert systems for predicting toxicity - the report and recommendations of an ECVAM/ECB workshop (ECVAM workshop 24). Altern Lab Anim 25:223-252.
    • (1997) Altern. Lab. Anim. , vol.25 , pp. 223-252
    • Dearden, J.C.1    Barratt, M.D.2    Benigni, R.3    Bristol, D.W.4    Combes, R.D.5    Cronin, M.T.D.6
  • 19
    • 0042093842 scopus 로고    scopus 로고
    • In Vitro Models for the Prediction of Dermal Absorption of Chemicals
    • Contract Research Report 178/1197. Newcastle upon Tyne, UK:HSE Books, 168. Available: [accessed 1 May 2002]
    • Dick IP, Williams FM, 1998, In Vitro Models for the Prediction of Dermal Absorption of Chemicals. Contract Research Report 178/1197. Newcastle upon Tyne, UK:HSE Books, 168. Available: http://www.hse.gov.uk/research/crr_pdf/1998/crr98178.pdf [accessed 1 May 2002].
    • (1998)
    • Dick, I.P.1    Williams, F.M.2
  • 20
    • 0041592825 scopus 로고    scopus 로고
    • Technical Guidance Document in Support of Commission Directive 93/67/EEC on Risk Assessment for New Notified Substances and Commission Regulation (EC) No. 1488/94 on Risk Assessment for Existing Substances
    • EC (European Community). Luxembourg:Office for Official Publications of the European Communities
    • EC (European Community). 1996. Technical Guidance Document in Support of Commission Directive 93/67/EEC on Risk Assessment for New Notified Substances and Commission Regulation (EC) No. 1488/94 on Risk Assessment for Existing Substances. Part III. Luxembourg:Office for Official Publications of the European Communities.
    • (1996) , Issue.PART III
  • 21
    • 0041592823 scopus 로고    scopus 로고
    • White Paper on the Strategy for a Future Chemicals Policy
    • EC. Brussels:European Commission. Available: [accessed 9 October 2002]
    • EC. 2002. White Paper on the Strategy for a Future Chemicals Policy. Brussels:European Commission. Available: http://europa.eu.int/comm/environment/chemicals/whitepaper.htm [accessed 9 October 2002].
    • (2002)
  • 22
    • 0003188910 scopus 로고
    • Council Directive 67/548/EEC of 27 June 1967 on the approximation of laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances
    • EEC (European Economic Community)
    • EEC (European Economic Community). 1967 Council Directive 67/548/EEC of 27 June 1967 on the approximation of laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances. Off J Eur Communities 196:1-5.
    • (1967) Off. J. Eur. Communities , vol.196 , pp. 1-5
  • 23
    • 0041592822 scopus 로고
    • Council Directive 76/769/EEC of 27 July 1976 on the approximation of the laws, regulations and administrative provisions of the Member States relating to restrictions on the marketing and use of certain dangerous substances and preparations
    • EEC (European Economic Community)
    • EEC (European Economic Community). 1976a. Council Directive 76/769/EEC of 27 July 1976 on the approximation of the laws, regulations and administrative provisions of the Member States relating to restrictions on the marketing and use of certain dangerous substances and preparations. Off J Eur Communities L262.
    • (1976) Off. J. Eur. Communities , vol.L262
  • 24
    • 0003188912 scopus 로고
    • Council Directive 79/831/EEC of 18 September 1979 amending for the sixth time Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances
    • EEC (European Economic Community)
    • EEC (European Economic Community). 1976b. Council Directive 79/831/EEC of 18 September 1979 amending for the sixth time Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances. Off J Eur Communities L 259:10-28.
    • (1976) Off. J. Eur. Communities , vol.L259 , pp. 10-28
  • 25
    • 0041592819 scopus 로고
    • Council Directive 67/548/EEC of 27 June 1967 on the approximation of laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances (as amended by Council Directive 92/32/EEC of 30 April 1992 amending for the seventh time
    • EEC (European Economic Commity) L154
    • EEC (European Economic Commity). 1992. Council Directive 67/548/EEC of 27 June 1967 on the approximation of laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances (as amended by Council Directive 92/32/EEC of 30 April 1992 amending for the seventh time. Off J Eur Communities L154.
    • (1992) Off. J. Eur. Communities
  • 26
    • 0043095651 scopus 로고
    • Laying down the principles for assessment of risks to man and the environment of substances notified in accordance with Council Directive 67/458/EEC
    • EEC (European Economic Community). Commission Directive 93/67/EEC of 20 July 1993 L227/9
    • EEC (European Economic Community). 1993a. Commission Directive 93/67/EEC of 20 July 1993. Laying down the principles for assessment of risks to man and the environment of substances notified in accordance with Council Directive 67/458/EEC. Off J Eur Communities L227/9.
    • (1993) Off. J. Eur. Communities
  • 27
    • 84988625967 scopus 로고
    • Council Regulation (EEC) No 793/93 of 23 March 1993 on the evaluation and control of the risks of existing substances
    • EEC (European Economic Community) L84/76
    • EEC (European Economic Community). 1993b. Council Regulation (EEC) No 793/93 of 23 March 1993 on the evaluation and control of the risks of existing substances. Off J Eur Communities L84/76.
    • (1993) Off. J. Eur. Communities
  • 28
    • 0042093838 scopus 로고
    • Laying down the principles for assessment of risks to man and the environment of existing substances in accordance with Council Regulation (EEC) No. 793/93
    • EEC (European Economic Community). Commission Regulation (EC) No. 1488/94 L161/3
    • EEC (European Economic Community). 1994. Commission Regulation (EC) No. 1488/94 laying down the principles for assessment of risks to man and the environment of existing substances in accordance with Council Regulation (EEC) No. 793/93. Off J Eur Communities L161/3.
    • (1994) Off. J. Eur. Communities
  • 30
    • 0042594731 scopus 로고    scopus 로고
    • Existing Chemicals
    • European Chemicals Bureau Ispra, Italy: European Chemical Bureau, European Commission. Available: [accessed 9 October 2002]
    • European Chemicals Bureau 2002. Existing Chemicals. Ispra, Italy: European Chemical Bureau, European Commission. Available: http://ecb.jrc.it/existing-chomicals/ [accessed 9 October 2002].
    • (2002)
  • 31
    • 0034807089 scopus 로고    scopus 로고
    • Prediction of rodent carcinogenicity of aromatic amines: A quantitative structure-activity relationships model
    • Franke R, Gruska A, Giuliani A, Benigni R. 2001. Prediction of rodent carcinogenicity of aromatic amines: a quantitative structure-activity relationships model. Carcinogenesis 22:1561-1571.
    • (2001) Carcinogenesis , vol.22 , pp. 1561-1571
    • Franke, R.1    Gruska, A.2    Giuliani, A.3    Benigni, R.4
  • 32
    • 0035999509 scopus 로고    scopus 로고
    • A random walk model of skin permeation
    • Frasch HF. 2002. A random walk model of skin permeation. Risk Anal 22:265-276.
    • (2002) Risk Anal. , vol.22 , pp. 265-276
    • Frasch, H.F.1
  • 33
    • 0033970279 scopus 로고    scopus 로고
    • Development of a decision support system for the introduction of alternative methods into local irritancy/corrosivity testing strategies. Development of a relational database
    • Garner I, Graetschel G, Kahl J, Schlede E. 2000a. Development of a decision support system for the introduction of alternative methods into local irritancy/corrosivity testing strategies. Development of a relational database. Altern Lab Anim 28:11-28.
    • (2000) Altern. Lab. Anim. , vol.28 , pp. 11-28
    • Garner, I.1    Graetschel, G.2    Kahl, J.3    Schlede, E.4
  • 34
    • 0033739877 scopus 로고    scopus 로고
    • Development of a decision support system for the introduction of alternative methods into local irritancy/corrosivity testing strategies. Creation of fundamental rules for a decision support system
    • Garner I, Zinke S, Graetschel G, Schlede E. 2000b. Development of a decision support system for the introduction of alternative methods into local irritancy/corrosivity testing strategies. Creation of fundamental rules for a decision support system. Altern Lab Anim 28:665-698.
    • (2000) Altern. Lab. Anim. , vol.28 , pp. 665-698
    • Garner, I.1    Zinke, S.2    Graetschel, G.3    Schlede, E.4
  • 35
    • 0035687627 scopus 로고    scopus 로고
    • Extended quantitative structure-activity relationships for 80 aromatic and heterocyclic amines: Structural, electronic, and hydropathic factors affecting mutagenic potency
    • Hatch FT, Knize MG, Colvin ME. 2001. Extended quantitative structure-activity relationships for 80 aromatic and heterocyclic amines: structural, electronic, and hydropathic factors affecting mutagenic potency. Environ Mol Mutagen 38:268-291.
    • (2001) Environ. Mol. Mutagen. , vol.38 , pp. 268-291
    • Hatch, F.T.1    Knize, M.G.2    Colvin, M.E.3
  • 37
    • 0038682208 scopus 로고    scopus 로고
    • Verification of literature-derived SARs for skin irritation and corrosion
    • Hulzebos EM, Maslankiewicz L, Walker JD. 2003. Verification of literature-derived SARs for skin irritation and corrosion. QSAR Comb Sci 22:351-363.
    • (2003) QSAR Comb. Sci. , vol.22 , pp. 351-363
    • Hulzebos, E.M.1    Maslankiewicz, L.2    Walker, J.D.3
  • 38
    • 0041592811 scopus 로고    scopus 로고
    • (Q)SARs for human toxicological endpoints: A literature search
    • RIVM Report 601516.00. A report by RIVM (Research for Man and Environment). Bilthoven:RIVM
    • Hulzebos EM, Schielen PCJI, Wijkhuizen-Maslankiewicz L. 1999. (Q)SARs for human toxicological endpoints: a literature search. RIVM Report 601516.00. A report by RIVM (Research for Man and Environment). Bilthoven:RIVM.
    • (1999)
    • Hulzebos, E.M.1    Schielen, P.C.J.I.2    Wijkhuizen-Maslankiewicz, L.3
  • 39
    • 0029823285 scopus 로고    scopus 로고
    • A RASH analysis of national toxicity program data: Predictions for 30 compounds to be tested in rodent carcinogenesis experiments
    • Jones TD, Easterly CE. 1996. A RASH analysis of national toxicity program data: predictions for 30 compounds to be tested in rodent carcinogenesis experiments. Environ Health Perspect 104(suppl 5):1017-1030.
    • (1996) Environ. Health Perspect. , vol.104 , Issue.SUPPL. 5 , pp. 1017-1030
    • Jones, T.D.1    Easterly, C.E.2
  • 41
    • 0026778110 scopus 로고
    • MULTICASE: A hierarchical computer automated structure evaluation program
    • Klopman G. 1992. MULTICASE: a hierarchical computer automated structure evaluation program. Quant Struct-Act Relat 11:176-184.
    • (1992) Quant. Struct-Act Relat. , vol.11 , pp. 176-184
    • Klopman, G.1
  • 42
    • 0026324580 scopus 로고
    • Structure-activity relations: Maximizing the usefulness of mutagenicity and carcinogenicity databases
    • Klopman G, Rosenkranz HS. (1991). Structure-activity relations: maximizing the usefulness of mutagenicity and carcinogenicity databases. Environ Health Perspect 96:67-75.
    • (1991) Environ. Health Perspect. , vol.96 , pp. 67-75
    • Klopman, G.1    Rosenkranz, H.S.2
  • 43
    • 0035124369 scopus 로고    scopus 로고
    • Prediction of eye irritation from organic chemicals using membrane-interaction QSAR analysis
    • Kulkarni A, Hopfinger AJ, Osborne R, Bruner LH, Thompson ED. 2001. Prediction of eye irritation from organic chemicals using membrane-interaction QSAR analysis. Toxicol Sci 59:335-345.
    • (2001) Toxicol. Sci. , vol.59 , pp. 335-345
    • Kulkarni, A.1    Hopfinger, A.J.2    Osborne, R.3    Bruner, L.H.4    Thompson, E.D.5
  • 44
    • 0043095644 scopus 로고    scopus 로고
    • Laboratory of Mathematical Chemistry. Bourgas, Bulgaria:University of Bourgas. Available: [accessed 29 October 2002]
    • Laboratory of Mathematical Chemistry. 2002. Bourgas, Bulgaria:University of Bourgas. Available: http://omega.btu.bg/netscape/software.htm [accessed 29 October 2002].
    • (2002)
  • 45
    • 0036490186 scopus 로고    scopus 로고
    • Uses and limitations of quantitative structure-activity relationships (QSARs) to categorize substances on the Canadian Domestic Substance List as persistent and/or bioaccumulative, and inherently toxic to non-human organisms
    • MacDonald D, Breton R, Sutcliffe R, Walker J. 2002. Uses and limitations of quantitative structure-activity relationships (QSARs) to categorize substances on the Canadian Domestic Substance List as persistent and/or bioaccumulative, and inherently toxic to non-human organisms. SAR QSAR Environ Res 13: 43-55.
    • (2002) SAR QSAR Environ. Res. , vol.13 , pp. 43-55
    • MacDonald, D.1    Breton, R.2    Sutcliffe, R.3    Walker, J.4
  • 48
    • 0032458218 scopus 로고    scopus 로고
    • A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software
    • Matthews EJ, Contrera JF. 1998. A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software. Regul Toxicol Pharmacol 28:242-264.
    • (1998) Regul. Toxicol. Pharmacol. , vol.28 , pp. 242-264
    • Matthews, E.J.1    Contrera, J.F.2
  • 50
    • 0025658802 scopus 로고
    • The microcomputer OASIS system for predicting of the biological activity of chemical compounds
    • Mekenyan OG, Karabunarliev S, Bonchev D. 1990. The microcomputer OASIS system for predicting of the biological activity of chemical compounds. Comput Chem 14:193-200.
    • (1990) Comput. Chem. , vol.14 , pp. 193-200
    • Mekenyan, O.G.1    Karabunarliev, S.2    Bonchev, D.3
  • 51
    • 0000489034 scopus 로고
    • A new development of the OASIS computer system for modelling of molecular properties
    • Mekenyan OG, Karabunarliev S, Ivanov J, Dimitrov D. 1994. A new development of the OASIS computer system for modelling of molecular properties. Comput Chem 18:173-187.
    • (1994) Comput. Chem. , vol.18 , pp. 173-187
    • Mekenyan, O.G.1    Karabunarliev, S.2    Ivanov, J.3    Dimitrov, D.4
  • 52
    • 0036096659 scopus 로고    scopus 로고
    • Quantitative structure-permeability relationships (QSPRs) for percutaneous absorption
    • Moss GP, Dearden JC, Patel H, Cronin MTD. 2002. Quantitative structure-permeability relationships (QSPRs) for percutaneous absorption. Toxicol In Vitro 16:299-317.
    • (2002) Toxicol. In Vitro , vol.16 , pp. 299-317
    • Moss, G.P.1    Dearden, J.C.2    Patel, H.3    Cronin, M.T.D.4
  • 53
    • 0038355985 scopus 로고
    • U.S. EPA/EC Joint Project on the Evaluation of (Quantitative) Structure Activity Relationships
    • OECD. OECD Report No. OECD/GD/(94) 28. Paris:Organisation for Economic Cooperation and Development
    • OECD. 1994. U.S. EPA/EC Joint Project on the Evaluation of (Quantitative) Structure Activity Relationships, OECD Report No. OECD/GD/(94) 28. Paris:Organisation for Economic Cooperation and Development.
    • (1994)
  • 54
    • 0041592808 scopus 로고    scopus 로고
    • OECD. Paris:Organisation for Economic Co-operation and Development. Available: [accessed 9 October 2002]
    • OECD. 2002a. Manual for Investigation of HPV Chemicals. Paris:Organisation for Economic Co-operation and Development. Available: http://webnet1.oecd.org/EN/document/ 0,,EN-document-525-14-no-5-33255-0,00.html http://webnet1.oecd.org/EN/document/ [accessed 9 October 2002].
    • (2002) Manual for Investigation of HPV Chemicals
  • 55
    • 0042594766 scopus 로고    scopus 로고
    • OECD's Database on Chemical Risk Assessment Models
    • OECD. Paris:Organisation for Economic Co-operation and Development. Available: [accessed 9 October 2002]
    • OECD. 2002b. OECD's Database on Chemical Risk Assessment Models. Paris:Organisation for Economic Co-operation and Development. Available: http://webdomino1.oecd.org/comnet/env/models.nsf [accessed 9 October 2002].
    • (2002)
  • 56
    • 0003472952 scopus 로고    scopus 로고
    • Briefing Document on the Work of DYNAMEC and the DYNAMEC Mechanism for the Selection and Prioritisation of Hazardous Substances
    • OSPAR Commission. London:OSPAR Commission
    • OSPAR Commission. 2000. Briefing Document on the Work of DYNAMEC and the DYNAMEC Mechanism for the Selection and Prioritisation of Hazardous Substances. London:OSPAR Commission.
    • (2000)
  • 59
    • 0026606514 scopus 로고
    • Predicting skin permeability
    • Potts RO, Guy R. 1992. Predicting skin permeability. Pharm Res 9:663-669.
    • (1992) Pharm. Res. , vol.9 , pp. 663-669
    • Potts, R.O.1    Guy, R.2
  • 60
    • 0035144211 scopus 로고    scopus 로고
    • Evaluation of the TOPKAT system for predicting the carcinogenicity of chemicals
    • Prival MJ. 2001. Evaluation of the TOPKAT system for predicting the carcinogenicity of chemicals. Environ Mol Mutagen 37:55-69.
    • (2001) Environ. Mol. Mutagen. , vol.37 , pp. 55-69
    • Prival, M.J.1
  • 61
    • 0029850983 scopus 로고    scopus 로고
    • A mechanism-mediated model for carcinogenicity: Model content and prediction of the outcome of rodent carcinogenicity bioassays currently being conducted on 25 organic chemicals
    • Purdy R. 1996. A mechanism-mediated model for carcinogenicity: model content and prediction of the outcome of rodent carcinogenicity bioassays currently being conducted on 25 organic chemicals. Environ Health Perspect 104(suppl 5):1085-1094.
    • (1996) Environ. Health Perspect. , vol.104 , Issue.SUPPL. 5 , pp. 1085-1094
    • Purdy, R.1
  • 62
    • 0032435458 scopus 로고    scopus 로고
    • Commercial toxicology prediction systems: A regulatory perspective
    • Richard AM. 1998. Commercial toxicology prediction systems: a regulatory perspective. Toxicol Lett 102-103:611-616.
    • (1998) Toxicol. Lett. , vol.102-103 , pp. 611-616
    • Richard, A.M.1
  • 63
    • 0036491315 scopus 로고    scopus 로고
    • Al and SAR approaches for predicting chemical carcinogenicity: Survey and status report
    • Richard AM, Benigni R. 2002. Al and SAR approaches for predicting chemical carcinogenicity: survey and status report. SAR QSAR Environ Res 13:1-19.
    • (2002) SAR QSAR Environ. Res. , vol.13 , pp. 1-19
    • Richard, A.M.1    Benigni, R.2
  • 65
    • 0038261010 scopus 로고    scopus 로고
    • Identification of potential PBTs and vPvBs by use of QSARs
    • Copenhagen:Danish Environmental Protection Agency
    • Tyle H, Larsen HS, Wedebye EB, Niemela J. 2001. Identification of potential PBTs and vPvBs by use of QSARs. Copenhagen:Danish Environmental Protection Agency.
    • (2001)
    • Tyle, H.1    Larsen, H.S.2    Wedebye, E.B.3    Niemela, J.4
  • 66
    • 0003417276 scopus 로고
    • Dermal Exposure Assessment: Principles and Applications
    • U.S. EPA. EPA/600/8-91-011B. Washington, DC:U.S. Environmental Protection Agency
    • U.S. EPA. 1992. Dermal Exposure Assessment: Principles and Applications. EPA/600/8-91-011B. Washington, DC:U.S. Environmental Protection Agency.
    • (1992)
  • 67
    • 0041592848 scopus 로고    scopus 로고
    • High Production Volume (HPV) Challenge Program
    • U.S. EPA. Washington, DC:U.S. Environmental Protection Agency. Available: [accessed 9 October 2002]
    • U.S. EPA. 2002a. High Production Volume (HPV) Challenge Program. Washington, DC:U.S. Environmental Protection Agency. Available: http://www.epa.gov/chemrtk/sarfinl1.htm [accessed 9 October 2002].
    • (2002)
  • 68
    • 0042594758 scopus 로고    scopus 로고
    • High Production Volume (HPV) Challenge Program
    • U.S. EPA. Washington, DC:U.S. Environmental Protection Agency. Available: [accessed 9 October 2002]
    • U.S. EPA. 2002b. High Production Volume (HPV) Challenge Program. Washington, DC:U.S. Environmental Protection Agency. Available: http://www.epa.gov/chemrtk/volchall.htm [accessed 9 October 2002].
    • (2002)
  • 69
    • 0043095633 scopus 로고    scopus 로고
    • Interagency Testing Committee under the Toxic Substances Control Act (TSCA)
    • U.S. EPA. Washington, DC:U.S. Environmental Protection Agency. Available: [accessed 9 October 2002]
    • U.S. EPA. 2002c. Interagency Testing Committee under the Toxic Substances Control Act (TSCA). Washington, DC:U.S. Environmental Protection Agency. Available: http://www.epa.gov/opptintr/itc/ [accessed 9 October 2002].
    • (2002)
  • 70
    • 0043095677 scopus 로고    scopus 로고
    • Minimum Pre-Market Data/Structure Activity Relationships Study
    • U.S. EPA. Washington, DC:U.S. Environmental Protection Agency. Available: [accessed 9 October 2002]
    • U.S. EPA. 2002d. Minimum Pre-Market Data/Structure Activity Relationships Study. Washington, DC:U.S. Environmental Protection Agency. Available: http://www.epa.gov/opptintr/MPD-SAR/ [accessed 9 October 2002].
    • (2002)
  • 71
    • 0012164128 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research
    • U.S. FDA. Rockville, MD:U.S. Food and Drug Administration. Available: [accessed 9 October 2002]
    • U.S. FDA. 2002. Center for Drug Evaluation and Research. Rockville, MD:U.S. Food and Drug Administration. Available: http://www.fda.gov/cder [accessed 9 October 2002].
    • (2002)
  • 72
    • 0026355090 scopus 로고
    • Chemical selection by the TSCA Interagency Testing Committee: Use of computerized substructure searching to identify chemical groups for health effects, chemical fate and ecological effects testing
    • Walker JD. 1991. Chemical selection by the TSCA Interagency Testing Committee: use of computerized substructure searching to identify chemical groups for health effects, chemical fate and ecological effects testing. Sci Total Environ 109/110:691-700.
    • (1991) Sci. Total Environ. , vol.109 , Issue.110 , pp. 691-700
    • Walker, J.D.1
  • 73
    • 0027884494 scopus 로고
    • 1977 to 1992: Creation, structure, functions and contributions
    • The TSCA Interagency Testing Committee (Gorsuch JW, Dwyer FJ, Ingersoll CG, La Pointe TW, eds). ASTM STP 1216. Philadelphia:American Society for Testing and Materials
    • Walker JD. 1993a. The TSCA Interagency Testing Committee, 1977 to 1992: creation, structure, functions and contributions. In: Environmental Toxicology and Risk Assessment, Vol 2 (Gorsuch JW, Dwyer FJ, Ingersoll CG, La Pointe TW, eds). ASTM STP 1216. Philadelphia:American Society for Testing and Materials, 451-509.
    • (1993) Environmental Toxicology and Risk Assessment , vol.2 , pp. 451-509
    • Walker, J.D.1
  • 74
    • 0038599860 scopus 로고
    • The TSCA Interagency Testing Committee's approaches to screening and scoring chemicals and chemical groups: 1977-1983
    • (Lu PY, ed). Oak Ridge, TN:Oak Ridge National Laboratories
    • Walker JD. 1993b. The TSCA Interagency Testing Committee's approaches to screening and scoring chemicals and chemical groups: 1977-1983. In: Access and Use of Information Resources in Assessing Health Risks from Chemical Exposure (Lu PY, ed). Oak Ridge, TN:Oak Ridge National Laboratories, 77-93.
    • (1993) Access and Use of Information Resources in Assessing Health Risks from Chemical Exposure , pp. 77-93
    • Walker, J.D.1
  • 75
    • 0029535029 scopus 로고
    • Estimation methods used by the TSCA Interagency Testing Committee to prioritize chemicals for testing: Exposure and biological effects scoring and structure activity relationships
    • Walker JD. 1995. Estimation methods used by the TSCA Interagency Testing Committee to prioritize chemicals for testing: exposure and biological effects scoring and structure activity relationships. Toxicol Mod 1:123-141.
    • (1995) Toxicol. Mod. , vol.1 , pp. 123-141
    • Walker, J.D.1
  • 76
    • 0037424620 scopus 로고    scopus 로고
    • Applications of QSARs in toxicology: A perspective of government. A US Government perspective
    • Walker JD. 2003, Applications of QSARs in toxicology: a perspective of government. a US Government perspective. J Mol Struct-Theochem 622:167-184.
    • (2003) J. Mol. Struct-Theochem. , vol.622 , pp. 167-184
    • Walker, J.D.1
  • 78
    • 0000256362 scopus 로고
    • New cost-effective, computerized approaches to selecting chemicals for priority testing consideration
    • (Suter GW II, Lewis MA, eds). ASTM STP 1007,07-536. Philadelphia:American Society for Testing and Materials
    • Walker JD, Brink RH. 1989. New cost-effective, computerized approaches to selecting chemicals for priority testing consideration. In: Aquatic Toxicology and Environmental Fate, Vol 11 (Suter GW II, Lewis MA, eds). ASTM STP 1007,07-536. Philadelphia:American Society for Testing and Materials.
    • (1989) Aquatic Toxicology and Environmental Fate , vol.11
    • Walker, J.D.1    Brink, R.H.2
  • 80
    • 0036780044 scopus 로고    scopus 로고
    • Global government applications of analogues, SARs and QSARs to predict aquatic toxicity, chemical or physical properties, environmental fate parameters and health effects of organic chemicals
    • Walker JD, Carlsen L, Hulzebos E, Simon-Hettich B. 2002. Global government applications of analogues, SARs and QSARs to predict aquatic toxicity, chemical or physical properties, environmental fate parameters and health effects of organic chemicals. SAR QSAR Environ Res 13:607-616.
    • (2002) SAR QSAR Environ. Res. , vol.13 , pp. 607-616
    • Walker, J.D.1    Carlsen, L.2    Hulzebos, E.3    Simon-Hettich, B.4
  • 81
    • 0038176322 scopus 로고    scopus 로고
    • Using HPV chemical data to develop QSARs for non-HPV chemicals: Opportunities to promote more efficient use of chemical testing resources
    • Walker JD, Dimitrov S, Mekenyan O. 2003, Using HPV chemical data to develop QSARs for non-HPV chemicals: opportunities to promote more efficient use of chemical testing resources. QSAR Comb Sci 22:386-395.
    • (2003) QSAR Comb. Sci. , vol.22 , pp. 386-395
    • Walker, J.D.1    Dimitrov, S.2    Mekenyan, O.3
  • 83
    • 0042594710 scopus 로고    scopus 로고
    • In Vitro Dermal Absorption of Liquids
    • Contract Research Report 350/2001. Newcastle upon Tyne, UK:HSE Books. Available: [accessed 1 May 2002]
    • Wilkinson SC, Williams FM 2001. In Vitro Dermal Absorption of Liquids. Contract Research Report 350/2001. Newcastle UponTyne, UK:HSE Books. Available: http://www.hse.gov.uk/research/crr_pdf/2001/crr01350.pdf [accessed 1 May 2002].
    • (2001)
    • Wilkinson, S.C.1    Williams, F.M.2
  • 84
    • 0029153221 scopus 로고
    • Development of structure-activity relationship rules for predicting carcinogenic potential of chemicals
    • Woo YT, Lai DY, Argus MF, Arcos JC. 1995. Development of structure-activity relationship rules for predicting carcinogenic potential of chemicals. Toxicol Lett 79:219-228.
    • (1995) Toxicol. Lett. , vol.79 , pp. 219-228
    • Woo, Y.T.1    Lai, D.Y.2    Argus, M.F.3    Arcos, J.C.4
  • 86
    • 0032856748 scopus 로고    scopus 로고
    • Embedded cluster modelling - A novel method for analysing embedded data sets
    • Worth AP, Cronin MTD. 1999. Embedded cluster modelling - a novel method for analysing embedded data sets. Quant Struct-Act Relat 18:229-235.
    • (1999) Quant. Struct-Act Relat. , vol.18 , pp. 229-235
    • Worth, A.P.1    Cronin, M.T.D.2
  • 87
    • 0033974388 scopus 로고    scopus 로고
    • Local irritation/corrosion testing strategies: Development of a decision support system for the introduction of alternative methods
    • Zinke S, Garner I, Graetschel G, Schlede E. 2000. Local irritation/corrosion testing strategies: development of a decision support system for the introduction of alternative methods. Altern Lab Anim 28:29-40.
    • (2000) Altern. Lab. Anim. , vol.28 , pp. 29-40
    • Zinke, S.1    Garner, I.2    Graetschel, G.3    Schlede, E.4
  • 88
    • 0036323878 scopus 로고    scopus 로고
    • Evaluation of a rule base for identifying contact allergens by using a regulatory database: Comparison of data on chemicals notified in the European Union with "structural alerts" used in the DEREK expert system
    • Available: [accessed 1 May 2002]
    • Zinke S, Garner I, Schlede E. 2002. Evaluation of a rule base for identifying contact allergens by using a regulatory database: comparison of data on chemicals notified in the European Union with "structural alerts" used in the DEREK expert system. Altern Lab Anim 30:285-298. Available: http://www.hse.gov.uk/research/crr_pdf/2001/crr01350.pdf [accessed 1 May 2002].
    • (2002) Altern. Lab. Anim. , vol.30 , pp. 285-298
    • Zinke, S.1    Garner, I.2    Schlede, E.3


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