-
1
-
-
33144480327
-
Cannabinoid receptors as therapeutic targets
-
Mackie K. Cannabinoid receptors as therapeutic targets. Annu Rev Pharmacol Toxicol 2006; 46: 101-122.
-
(2006)
Annu Rev Pharmacol Toxicol
, vol.46
, pp. 101-122
-
-
Mackie, K.1
-
2
-
-
0025325535
-
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
-
Matsuda LA et al. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 1990; 346: 561-564.
-
(1990)
Nature
, vol.346
, pp. 561-564
-
-
Matsuda, L.A.1
-
3
-
-
0027515373
-
Molecular characterization of a peripheral receptor for cannabinoids
-
Munro S et al. Molecular characterization of a peripheral receptor for cannabinoids. Nature 1993; 365: 61-65.
-
(1993)
Nature
, vol.365
, pp. 61-65
-
-
Munro, S.1
-
4
-
-
35748973885
-
Novel cannabinoid receptors
-
Brown AJ. Novel cannabinoid receptors. Br J Pharmacol 152: 567-575.
-
Br J Pharmacol
, vol.152
, pp. 567-575
-
-
Brown, A.J.1
-
5
-
-
35649015179
-
The orphan receptor GPR55 is a novel cannabinoid receptor
-
Ryberg E et al. The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol 2007; 152: 1092-1101.
-
(2007)
Br J Pharmacol
, vol.152
, pp. 1092-1101
-
-
Ryberg, E.1
-
6
-
-
40349114501
-
GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity
-
Overton et al. GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity. Br J Pharmacol 2008; 153: 76-81.
-
(2008)
Br J Pharmacol
, vol.153
, pp. 76-81
-
-
Overton1
-
7
-
-
33646814424
-
Cannabinoid receptors and endocannabinoids: Evidence for new players
-
Mackie K, Stella N. Cannabinoid receptors and endocannabinoids: evidence for new players. AAPS J 2006; 8: E298-E306.
-
(2006)
AAPS J
, vol.8
-
-
Mackie, K.1
Stella, N.2
-
8
-
-
64249138218
-
The therapeutic potential of novel cannabinoid receptors
-
Kreitzer FR, Stella N. The therapeutic potential of novel cannabinoid receptors. Pharmacol Ther 2009; 122: 83-96.
-
(2009)
Pharmacol Ther
, vol.122
, pp. 83-96
-
-
Kreitzer, F.R.1
Stella, N.2
-
9
-
-
48249097797
-
Endocannabinoids: Synthesis and degradation
-
Di Marzo V. Endocannabinoids: synthesis and degradation. Rev Physiol Biochem Pharmacol 2008; 160: 1-24.
-
(2008)
Rev Physiol Biochem Pharmacol
, vol.160
, pp. 1-24
-
-
Di Marzo, V.1
-
10
-
-
34548500793
-
Discovery and isolation of anandamide and other endocannabinoids
-
Hanus LO. Discovery and isolation of anandamide and other endocannabinoids. Chem Biodivers 2007; 4: 1828-1841.
-
(2007)
Chem Biodivers
, vol.4
, pp. 1828-1841
-
-
Hanus, L.O.1
-
11
-
-
0344873175
-
Anandamide and vanilloid TRPV1 receptors
-
Ross RA. Anandamide and vanilloid TRPV1 receptors. Br J Pharmacol 2003; 140: 790-801.
-
(2003)
Br J Pharmacol
, vol.140
, pp. 790-801
-
-
Ross, R.A.1
-
12
-
-
34547881031
-
Interaction of ligands for the peroxisome proliferator-activated receptor gamma with the endocannabinoid system
-
Lenman A, Fowler CJ. Interaction of ligands for the peroxisome proliferator-activated receptor gamma with the endocannabinoid system. Br J Pharmacol 2007; 151: 1343-1351.
-
(2007)
Br J Pharmacol
, vol.151
, pp. 1343-1351
-
-
Lenman, A.1
Fowler, C.J.2
-
13
-
-
53049084435
-
Anandamide effects on 5-HT(3) receptors in vivo
-
Racz I et al. Anandamide effects on 5-HT(3) receptors in vivo. Eur J Pharmacol 2008; 596: 98-101.
-
(2008)
Eur J Pharmacol
, vol.596
, pp. 98-101
-
-
Racz, I.1
-
14
-
-
61349143694
-
The enigmatic pharmacology of GPR55
-
Ross RA. The enigmatic pharmacology of GPR55. Trends Pharmacol Sci 2009; 30: 156-163.
-
(2009)
Trends Pharmacol Sci
, vol.30
, pp. 156-163
-
-
Ross, R.A.1
-
15
-
-
42349086864
-
Endocannabinoids and the regulation of bone metabolism
-
Bab I et al. Endocannabinoids and the regulation of bone metabolism. J Neuroendocrinol 2008; 20(Suppl 1): 69-74.
-
(2008)
J Neuroendocrinol
, vol.20
, Issue.SUPPL. 1
, pp. 69-74
-
-
Bab, I.1
-
16
-
-
0041411118
-
The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis
-
Maccarrone M, Finazzi-Agro A. The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis. Cell Death Differ 2003; 10: 946-955.
-
(2003)
Cell Death Differ
, vol.10
, pp. 946-955
-
-
Maccarrone, M.1
Finazzi-Agro, A.2
-
17
-
-
52049093883
-
Endocannabinoids as positive or negative factors in hematopoietic cell migration and differentiation
-
Patinkin D et al. Endocannabinoids as positive or negative factors in hematopoietic cell migration and differentiation. Eur J Pharmacol 2008; 595: 1-6.
-
(2008)
Eur J Pharmacol
, vol.595
, pp. 1-6
-
-
Patinkin, D.1
-
18
-
-
0013779962
-
The isolation and structure of cannabinolic cannabidiolic and cannabigerolic acids
-
Mechoulam R, Gaoni Y, Hashish IV. The isolation and structure of cannabinolic cannabidiolic and cannabigerolic acids. Tetrahedron 1965; 21: 1223-1229.
-
(1965)
Tetrahedron
, vol.21
, pp. 1223-1229
-
-
Mechoulam, R.1
Gaoni, Y.2
Hashish, I.V.3
-
19
-
-
0024263922
-
Determination and characterization of a cannabinoid receptor in rat brain
-
Devane WA et al. Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol 1988; 34: 605-613.
-
(1988)
Mol Pharmacol
, vol.34
, pp. 605-613
-
-
Devane, W.A.1
-
20
-
-
43249100162
-
Targeting the endocannabinoid system: To enhance or reduce?
-
Di Marzo V. Targeting the endocannabinoid system: to enhance or reduce? Nat Rev Drug Discov 2008; 7: 438-455.
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 438-455
-
-
Di Marzo, V.1
-
21
-
-
48249106686
-
Cannabinoid CB1 receptor antagonists in therapeutic and structural perspectives
-
Lange JH, Kruse CG. Cannabinoid CB1 receptor antagonists in therapeutic and structural perspectives. Chem Rec 2008; 8: 156-168.
-
(2008)
Chem Rec
, vol.8
, pp. 156-168
-
-
Lange, J.H.1
Kruse, C.G.2
-
22
-
-
50349086035
-
Therapeutic use of Cannabis sativa on chemotherapy-induced nausea and vomiting among cancer patients: Systematic review and meta-analysis
-
Machado Rocha FC et al. Therapeutic use of Cannabis sativa on chemotherapy-induced nausea and vomiting among cancer patients: systematic review and meta-analysis. Eur J Cancer Care (Engl) 2008; 17: 431-443.
-
(2008)
Eur J Cancer Care (Engl)
, vol.17
, pp. 431-443
-
-
Machado Rocha, F.C.1
-
23
-
-
18844400058
-
Cannabinoid-based drugs as anti-inflammatory therapeutics
-
Klein TW. Cannabinoid-based drugs as anti-inflammatory therapeutics. Nat Rev Immunol 2005; 5: 400-411.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 400-411
-
-
Klein, T.W.1
-
24
-
-
34248219556
-
Cannabinoids for the treatment of inflammation
-
Ashton JC. Cannabinoids for the treatment of inflammation. Curr Opin Investig Drugs 2007; 8: 373-384.
-
(2007)
Curr Opin Investig Drugs
, vol.8
, pp. 373-384
-
-
Ashton, J.C.1
-
25
-
-
63449105700
-
Role of cannabinoids in chronic liver disease
-
Parfienuk A et al. Role of cannabinoids in chronic liver disease. World J Gastroenterol 2008; 14: 6109-6114.
-
(2008)
World J Gastroenterol
, vol.14
, pp. 6109-6114
-
-
Parfienuk, A.1
-
26
-
-
52949090419
-
CNS immune surveillance and neuroinflammation: Endocannabinoids keep control
-
Wolf SA et al. CNS immune surveillance and neuroinflammation: endocannabinoids keep control. Curr Pharm Des 2008; 14: 2266-2278.
-
(2008)
Curr Pharm Des
, vol.14
, pp. 2266-2278
-
-
Wolf, S.A.1
-
27
-
-
33749165439
-
Endocannabinoid overactivity and intestinal inflammation
-
Di Marzo V, Izzo AA. Endocannabinoid overactivity and intestinal inflammation. Gut 2006; 55: 1371-1376.
-
(2006)
Gut
, vol.55
, pp. 1371-1376
-
-
Di Marzo, V.1
Izzo, A.A.2
-
28
-
-
34250209535
-
Attenuation of allergic contact dermatitis through the endocannabinoid system
-
Karsak M et al. Attenuation of allergic contact dermatitis through the endocannabinoid system. Science 2007; 316: 1494-1497.
-
(2007)
Science
, vol.316
, pp. 1494-1497
-
-
Karsak, M.1
-
29
-
-
38349119137
-
Biology and therapeutic potential of cannabinoid CB2 receptor inverse agonists
-
Lunn CA et al. Biology and therapeutic potential of cannabinoid CB2 receptor inverse agonists. Br J Pharmacol 2008; 153: 226-239.
-
(2008)
Br J Pharmacol
, vol.153
, pp. 226-239
-
-
Lunn, C.A.1
-
30
-
-
38349099590
-
The peripheral cannabinoid receptor knockout mice: An update
-
Buckley NE. The peripheral cannabinoid receptor knockout mice: an update. Br J Pharmacol 2008; 153: 309-318.
-
(2008)
Br J Pharmacol
, vol.153
, pp. 309-318
-
-
Buckley, N.E.1
-
31
-
-
22544439953
-
Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors
-
Idris AI et al. Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors. Nat Med 2005; 11: 774-779.
-
(2005)
Nat Med
, vol.11
, pp. 774-779
-
-
Idris, A.I.1
-
32
-
-
27944510259
-
Cannabinoid receptor type 2 gene is associated with human osteoporosis
-
Karsak M et al. Cannabinoid receptor type 2 gene is associated with human osteoporosis. Hum Mol Genet 2005; 14: 3389-3396.
-
(2005)
Hum Mol Genet
, vol.14
, pp. 3389-3396
-
-
Karsak, M.1
-
33
-
-
31444437185
-
Peripheral cannabinoid receptor, CB2, regulates bone mass
-
Ofek O et al. Peripheral cannabinoid receptor, CB2, regulates bone mass. Proc Natl Acad Sci USA 2006; 103: 696-701.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 696-701
-
-
Ofek, O.1
-
34
-
-
38349132542
-
Cannabinoid receptors and the regulation of bone mass
-
Bab I, Zimmer A. Cannabinoid receptors and the regulation of bone mass. Br J Pharmacol 2008; 153: 182-188.
-
(2008)
Br J Pharmacol
, vol.153
, pp. 182-188
-
-
Bab, I.1
Zimmer, A.2
-
35
-
-
34548181608
-
The cannabinoid CB(2) receptor: A good friend in the gut
-
Izzo AA. The cannabinoid CB(2) receptor: a good friend in the gut. Neurogastroenterol Motil 2007; 19: 704-708.
-
(2007)
Neurogastroenterol Motil
, vol.19
, pp. 704-708
-
-
Izzo, A.A.1
-
36
-
-
34347397535
-
The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration
-
Ashton JC, Glass M. The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration. Curr Neuropharmacol 2007; 5: 73-80.
-
(2007)
Curr Neuropharmacol
, vol.5
, pp. 73-80
-
-
Ashton, J.C.1
Glass, M.2
-
37
-
-
17144400758
-
Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice
-
Steffens S et al. Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature 2005; 434: 782-786.
-
(2005)
Nature
, vol.434
, pp. 782-786
-
-
Steffens, S.1
-
38
-
-
42349116948
-
The role of the endocannabinoid system in atherosclerosis
-
Mach F, Steffens S. The role of the endocannabinoid system in atherosclerosis. J Neuroendocrinol 2008; 20(Suppl 1): 53-57.
-
(2008)
J Neuroendocrinol
, vol.20
, Issue.SUPPL. 1
, pp. 53-57
-
-
Mach, F.1
Steffens, S.2
-
39
-
-
35648999552
-
Endocannabinoid metabolism and uptake: Novel targets for neuropathic and inflammatory pain
-
Jhaveri MD et al. Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain. Br J Pharmacol 2007; 152: 624-632.
-
(2007)
Br J Pharmacol
, vol.152
, pp. 624-632
-
-
Jhaveri, M.D.1
-
40
-
-
0037709942
-
The endocannabinoid system as a target for the development of new drugs for cancer therapy]
-
Bifulco M, Di Marzo V. [The endocannabinoid system as a target for the development of new drugs for cancer therapy]. Recenti Prog Med 2003; 94: 194-198.
-
(2003)
Recenti Prog Med
, vol.94
, pp. 194-198
-
-
Bifulco, M.1
Di Marzo, V.2
-
41
-
-
33745013193
-
Cannabinoids and cancer: Pros and cons of an antitumour strategy
-
Bifulco M et al. Cannabinoids and cancer: pros and cons of an antitumour strategy. Br J Pharmacol 2006; 148: 123-135.
-
(2006)
Br J Pharmacol
, vol.148
, pp. 123-135
-
-
Bifulco, M.1
-
42
-
-
43049127845
-
The endocannabinoid system in cancer-potential therapeutic target?
-
Flygare J, Sander B. The endocannabinoid system in cancer-potential therapeutic target? Semin Cancer Biol 2008; 18: 176-189.
-
(2008)
Semin Cancer Biol
, vol.18
, pp. 176-189
-
-
Flygare, J.1
Sander, B.2
-
43
-
-
39049104489
-
Cannabinoids for cancer treatment: Progress and promise
-
Sarfaraz S et al. Cannabinoids for cancer treatment: progress and promise. Cancer Res 2008; 68: 339-342.
-
(2008)
Cancer Res
, vol.68
, pp. 339-342
-
-
Sarfaraz, S.1
-
44
-
-
0016804266
-
Antineoplastic activity of cannabinoids
-
Munson AE et al. Antineoplastic activity of cannabinoids. J Natl Cancer Inst 1975; 55: 597-602.
-
(1975)
J Natl Cancer Inst
, vol.55
, pp. 597-602
-
-
Munson, A.E.1
-
45
-
-
54249155522
-
Network pharmacology: The next paradigm in drug discovery
-
Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 2008; 4: 682-690.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 682-690
-
-
Hopkins, A.L.1
-
46
-
-
33846474121
-
G-protein-coupled receptors and cancer
-
Dorsam RT, Gutkind JS. G-protein-coupled receptors and cancer. Nat Rev Cancer 2007; 7: 79-94.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 79-94
-
-
Dorsam, R.T.1
Gutkind, J.S.2
-
47
-
-
23044517184
-
Cannabinoids and ceramide: Two lipids acting hand-by-hand
-
Velasco G et al. Cannabinoids and ceramide: two lipids acting hand-by-hand. Life Sci 2005; 77: 1723-1731.
-
(2005)
Life Sci
, vol.77
, pp. 1723-1731
-
-
Velasco, G.1
-
48
-
-
0032566430
-
Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells
-
Sanchez C et al. Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells. FEBS Lett 1998; 436: 6-10.
-
(1998)
FEBS Lett
, vol.436
, pp. 6-10
-
-
Sanchez, C.1
-
49
-
-
0031724645
-
Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol- induced stimulation of glucose metabolism in primary astrocytes
-
Sanchez C et al. Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol- induced stimulation of glucose metabolism in primary astrocytes. Mol Pharmacol 1998; 54: 834-843.
-
(1998)
Mol Pharmacol
, vol.54
, pp. 834-843
-
-
Sanchez, C.1
-
50
-
-
33645763253
-
The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
-
Carracedo A et al. The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. Cancer Cell 2000; 9: 301-312.
-
(2000)
Cancer Cell
, vol.9
, pp. 301-312
-
-
Carracedo, A.1
-
51
-
-
0036534724
-
De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis
-
Gomez del Pulgar T et al. De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis. Biochem J 2002; 363: 183-188.
-
(2002)
Biochem J
, vol.363
, pp. 183-188
-
-
Gomez del Pulgar, T.1
-
52
-
-
40949083594
-
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression
-
Blazquez C et al. Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Res 2008; 68: 1945-1952.
-
(2008)
Cancer Res
, vol.68
, pp. 1945-1952
-
-
Blazquez, C.1
-
53
-
-
37349095918
-
Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: A new marker of cannabinoid antitumoral activity?
-
Blazquez C et al. Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity? Neuropharmacology 2008; 54: 235-243.
-
(2008)
Neuropharmacology
, vol.54
, pp. 235-243
-
-
Blazquez, C.1
-
54
-
-
59449111015
-
Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells
-
Cianchi F et al. Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells. Clin Cancer Res 2008; 14: 7691-7700.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7691-7700
-
-
Cianchi, F.1
-
55
-
-
2942729530
-
Ceramide sensitizes astrocytes to oxidative stress: Protective role of cannabinoids
-
Carracedo A et al. Ceramide sensitizes astrocytes to oxidative stress: protective role of cannabinoids. Biochem J 2004; 380: 435-440.
-
(2004)
Biochem J
, vol.380
, pp. 435-440
-
-
Carracedo, A.1
-
57
-
-
36249002916
-
PKB and the mitochondria: AKTing on apoptosis
-
Parcellier A et al. PKB and the mitochondria: AKTing on apoptosis. Cell Signal 2008; 20: 21-30.
-
(2008)
Cell Signal
, vol.20
, pp. 21-30
-
-
Parcellier, A.1
-
58
-
-
35148860072
-
PI3K class IB pathway
-
Andrews S et al. PI3K class IB pathway. Sci STKE 2007: cm2.
-
(2007)
Sci STKE
-
-
Andrews, S.1
-
59
-
-
0028334738
-
A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits
-
Stephens L et al. A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits. Cell 1994; 77: 83-93.
-
(1994)
Cell
, vol.77
, pp. 83-93
-
-
Stephens, L.1
-
60
-
-
0037184060
-
Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway
-
Gomez Del Pulgar T et al. Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 2002; 277: 36527-36533.
-
(2002)
J Biol Chem
, vol.277
, pp. 36527-36533
-
-
Gomez Del Pulgar, T.1
-
61
-
-
0034654660
-
The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt
-
Gomez del Pulgar T et al. The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt. Biochem J 2000; 347: 369-373.
-
(2000)
Biochem J
, vol.347
, pp. 369-373
-
-
Gomez del Pulgar, T.1
-
62
-
-
34547484379
-
Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain
-
Ozaita A et al. Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain. J Neurochem 2007; 102: 1105-1114.
-
(2007)
J Neurochem
, vol.102
, pp. 1105-1114
-
-
Ozaita, A.1
-
63
-
-
34948815127
-
PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis
-
Fang J et al. PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis. Cell Signal 2007; 19: 2487-2497.
-
(2007)
Cell Signal
, vol.19
, pp. 2487-2497
-
-
Fang, J.1
-
64
-
-
1542510624
-
Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor
-
Hart S et al. Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor. Cancer Res 2004; 64: 1943-1950.
-
(2004)
Cancer Res
, vol.64
, pp. 1943-1950
-
-
Hart, S.1
-
65
-
-
35348910284
-
The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells
-
Greenhough A et al. The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells. Int J Cancer 2007; 121: 2172-2180.
-
(2007)
Int J Cancer
, vol.121
, pp. 2172-2180
-
-
Greenhough, A.1
-
66
-
-
33845973763
-
Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest
-
Sarfaraz S et al. Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest. J Biol Chem 2006; 281: 39480-39491.
-
(2006)
J Biol Chem
, vol.281
, pp. 39480-39491
-
-
Sarfaraz, S.1
-
67
-
-
33845627660
-
Cannabinoid receptors as novel targets for the treatment of melanoma
-
Blazquez C et al. Cannabinoid receptors as novel targets for the treatment of melanoma. FASEB J 2006; 20: 2633-2635.
-
(2006)
FASEB J
, vol.20
, pp. 2633-2635
-
-
Blazquez, C.1
-
68
-
-
17344380844
-
Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extra-cellular signal-regulated kinase activation
-
Galve-Roperh I et al. Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extra-cellular signal-regulated kinase activation. Nat Med 2000; 6: 313-319.
-
(2000)
Nat Med
, vol.6
, pp. 313-319
-
-
Galve-Roperh, I.1
-
69
-
-
0033405883
-
Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells
-
Melck D et al. Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells. FEBS Lett 1999; 463: 235-240.
-
(1999)
FEBS Lett
, vol.463
, pp. 235-240
-
-
Melck, D.1
-
70
-
-
38049143945
-
Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
-
Preet A et al. Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Oncogene 2008; 27: 339-346.
-
(2008)
Oncogene
, vol.27
, pp. 339-346
-
-
Preet, A.1
-
71
-
-
56549091431
-
The complexity of mitogen-activated protein kinases (MAPKs) made simple
-
Krishna M, Narang H. The complexity of mitogen-activated protein kinases (MAPKs) made simple. Cell Mol Life Sci 2008; 65: 3525-3544.
-
(2008)
Cell Mol Life Sci
, vol.65
, pp. 3525-3544
-
-
Krishna, M.1
Narang, H.2
-
72
-
-
48249115990
-
Beta-caryophyllene is a dietary cannabinoid
-
Gertsch J et al. Beta-caryophyllene is a dietary cannabinoid. Proc Natl Acad Sci USA 2008; 105: 9099-9104.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 9099-9104
-
-
Gertsch, J.1
-
73
-
-
0035951881
-
Human p8 is a HMG-I/Y-like protein with DNA binding activity enhanced by phosphorylation
-
Encinar JA et al. Human p8 is a HMG-I/Y-like protein with DNA binding activity enhanced by phosphorylation. J Biol Chem 2001; 276: 2742-2751.
-
(2001)
J Biol Chem
, vol.276
, pp. 2742-2751
-
-
Encinar, J.A.1
-
74
-
-
33746138649
-
Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
-
Carracedo A et al. Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res 2006; 66: 6748-6755.
-
(2006)
Cancer Res
, vol.66
, pp. 6748-6755
-
-
Carracedo, A.1
-
75
-
-
50649112355
-
JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells
-
Caffarel MM et al. JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene 2008; 27: 5033-5044.
-
(2008)
Oncogene
, vol.27
, pp. 5033-5044
-
-
Caffarel, M.M.1
-
76
-
-
57049106235
-
High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells
-
Widmer M et al. High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells. J Neurosci Res 2008; 86: 3212-3220.
-
(2008)
J Neurosci Res
, vol.86
, pp. 3212-3220
-
-
Widmer, M.1
-
77
-
-
33748417610
-
Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria
-
Jia W et al. Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria. Mol Cancer Res 2006; 4: 549-562.
-
(2006)
Mol Cancer Res
, vol.4
, pp. 549-562
-
-
Jia, W.1
-
78
-
-
51449092478
-
Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells
-
Galanti G et al. Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells. Acta Oncol 2008; 47: 1062-1070.
-
(2008)
Acta Oncol
, vol.47
, pp. 1062-1070
-
-
Galanti, G.1
-
79
-
-
0141594998
-
Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: Actions on signals involved in angiogenesis and metastasis
-
Portella G et al. Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis. FASEB J 2003; 17: 1771-1773.
-
(2003)
FASEB J
, vol.17
, pp. 1771-1773
-
-
Portella, G.1
-
80
-
-
33750507764
-
Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells
-
Laezza C et al. Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells. FEBS Lett 2006; 580: 6076-6082.
-
(2006)
FEBS Lett
, vol.580
, pp. 6076-6082
-
-
Laezza, C.1
-
81
-
-
33746125474
-
Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation
-
Caffarel MM et al. Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation. Cancer Res 2006; 66: 6615-6621.
-
(2006)
Cancer Res
, vol.66
, pp. 6615-6621
-
-
Caffarel, M.M.1
-
82
-
-
4644226099
-
Cannabinoids down-regulate PI3K/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein
-
Ellert-Miklaszewska A et al. Cannabinoids down-regulate PI3K/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein. Cell Signal 2005; 17: 25-37.
-
(2005)
Cell Signal
, vol.17
, pp. 25-37
-
-
Ellert-Miklaszewska, A.1
-
83
-
-
34249933789
-
Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review)
-
Bifulco M et al. Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review). Oncol Rep 2007; 17: 813-816.
-
(2007)
Oncol Rep
, vol.17
, pp. 813-816
-
-
Bifulco, M.1
-
84
-
-
0037365941
-
Inhibition of tumor angiogenesis by cannabinoids
-
Blazquez C et al. Inhibition of tumor angiogenesis by cannabinoids. FASEB J 2003; 17: 529-531.
-
(2003)
FASEB J
, vol.17
, pp. 529-531
-
-
Blazquez, C.1
-
85
-
-
0037253496
-
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
-
Casanova ML et al. Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest 2003; 111: 43-50.
-
(2003)
J Clin Invest
, vol.111
, pp. 43-50
-
-
Casanova, M.L.1
-
86
-
-
52049101546
-
Tumor microenvironment and angiogenesis
-
Nyberg P et al. Tumor microenvironment and angiogenesis. Front Biosci 2008; 13: 6537-6553.
-
(2008)
Front Biosci
, vol.13
, pp. 6537-6553
-
-
Nyberg, P.1
-
87
-
-
34147215056
-
Antiangiogenic activity of the endocannabinoid anandamide: Correlation to its tumor-suppressor efficacy
-
Pisanti S et al. Antiangiogenic activity of the endocannabinoid anandamide: correlation to its tumor-suppressor efficacy. J Cell Physiol 2007; 211: 495-503.
-
(2007)
J Cell Physiol
, vol.211
, pp. 495-503
-
-
Pisanti, S.1
-
88
-
-
49449115823
-
Cannabinoids reduce granulomaassociated angiogenesis in rats by controlling transcription and expression of mast cell protease-5
-
De Filippis D et al. Cannabinoids reduce granulomaassociated angiogenesis in rats by controlling transcription and expression of mast cell protease-5. Br J Pharmacol 2008; 154: 1672-1679.
-
(2008)
Br J Pharmacol
, vol.154
, pp. 1672-1679
-
-
De Filippis, D.1
-
89
-
-
41549162387
-
2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways
-
2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways. Am J Physiol Heart Circ Physiol 2008; 294: H1145-H1155.
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.294
-
-
Montecucco, F.1
-
90
-
-
38349086382
-
CB2 receptor-mediated migration of immune cells: It can go either way
-
Miller AM, Stella N. CB2 receptor-mediated migration of immune cells: it can go either way. Br J Pharmacol 2008; 153: 299-308.
-
(2008)
Br J Pharmacol
, vol.153
, pp. 299-308
-
-
Miller, A.M.1
Stella, N.2
-
91
-
-
33847043132
-
CB2 cannabinoid receptors promote mouse neural stem cell proliferation
-
Molina-Holgado F et al. CB2 cannabinoid receptors promote mouse neural stem cell proliferation. Eur J Neurosci 2007; 25: 629-634.
-
(2007)
Eur J Neurosci
, vol.25
, pp. 629-634
-
-
Molina-Holgado, F.1
-
92
-
-
0032897969
-
Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2
-
Valk PJ et al. Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2. J Virol 1999; 73: 3595-3602.
-
(1999)
J Virol
, vol.73
, pp. 3595-3602
-
-
Valk, P.J.1
-
93
-
-
0036141517
-
Leukemic predisposition of pSca-1/Cb2 transgenic mice
-
Joosten M et al. Leukemic predisposition of pSca-1/Cb2 transgenic mice. Exp Hematol 2002; 30: 142-149.
-
(2002)
Exp Hematol
, vol.30
, pp. 142-149
-
-
Joosten, M.1
-
94
-
-
0038806692
-
Identification, characterization, and function of a novel oncogene: The peripheral cannabinoid receptor Cb2
-
Jorda MA et al. Identification, characterization, and function of a novel oncogene: the peripheral cannabinoid receptor Cb2. Ann NY Acad Sci 2003; 996: 10-16.
-
(2003)
Ann NY Acad Sci
, vol.996
, pp. 10-16
-
-
Jorda, M.A.1
-
95
-
-
74749094518
-
Antiinflammatory cannabinoids in diet - towards a better understanding of CB2 receptor action?
-
Gertsch J. Antiinflammatory cannabinoids in diet - towards a better understanding of CB2 receptor action? Commun Integr Biol 2008; 1: 26-28.
-
(2008)
Commun Integr Biol
, vol.1
, pp. 26-28
-
-
Gertsch, J.1
-
96
-
-
0034069673
-
Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin-10 in endotoxemic mice
-
Smith SR et al. Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin-10 in endotoxemic mice. J Pharmacol Exp Ther 2000; 293: 136-150.
-
(2000)
J Pharmacol Exp Ther
, vol.293
, pp. 136-150
-
-
Smith, S.R.1
-
97
-
-
47349126394
-
Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists
-
Ashton JC et al. Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists. Curr Med Chem 2008; 15: 1428-1443.
-
(2008)
Curr Med Chem
, vol.15
, pp. 1428-1443
-
-
Ashton, J.C.1
-
98
-
-
33751198532
-
Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma
-
Gustafsson K et al. Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma. Mol Pharmacol 2006; 70: 1612-1620.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 1612-1620
-
-
Gustafsson, K.1
-
99
-
-
23944437209
-
Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells
-
McAllister SD et al. Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells. J Neurooncol 2005; 74: 31-40.
-
(2005)
J Neurooncol
, vol.74
, pp. 31-40
-
-
McAllister, S.D.1
-
100
-
-
33748492117
-
The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells
-
Massi P et al. The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells. Cell Mol Life Sci 2006; 63: 2057-2066.
-
(2006)
Cell Mol Life Sci
, vol.63
, pp. 2057-2066
-
-
Massi, P.1
-
101
-
-
1842529993
-
Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1
-
Contassot E et al. Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1. Gynecol Oncol 2004; 93: 182-188.
-
(2004)
Gynecol Oncol
, vol.93
, pp. 182-188
-
-
Contassot, E.1
-
102
-
-
23444431657
-
Delta9-tetrahydrocannabinol increases C6 glioma cell death produced by oxidative stress
-
Goncharov I et al. Delta9-tetrahydrocannabinol increases C6 glioma cell death produced by oxidative stress. Neuroscience 2005; 134: 567-574.
-
(2005)
Neuroscience
, vol.134
, pp. 567-574
-
-
Goncharov, I.1
-
103
-
-
1342280974
-
Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines
-
Massi P et al. Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. J Pharmacol Exp Ther 2004; 308: 838-845.
-
(2004)
J Pharmacol Exp Ther
, vol.308
, pp. 838-845
-
-
Massi, P.1
-
104
-
-
9444229367
-
Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells
-
Hinz B et al. Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells. Mol Pharmacol 2004; 66: 1643-1651.
-
(2004)
Mol Pharmacol
, vol.66
, pp. 1643-1651
-
-
Hinz, B.1
-
105
-
-
0042431524
-
Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: Variability in response and involvement of arachidonic acid
-
Fowler CJ et al. Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid. Biochem Pharmacol 2003; 66: 757-767.
-
(2003)
Biochem Pharmacol
, vol.66
, pp. 757-767
-
-
Fowler, C.J.1
-
106
-
-
0035200613
-
Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors
-
Jacobsson SO et al. Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors. J Pharmacol Exp Ther 2001; 299: 951-959.
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 951-959
-
-
Jacobsson, S.O.1
-
107
-
-
0035885205
-
Antitumor effects of ajulemic acid (CT3), a synthetic non-psychoactive cannabinoid
-
Recht LD et al. Antitumor effects of ajulemic acid (CT3), a synthetic non-psychoactive cannabinoid. Biochem Pharmacol 2001; 62: 755-763.
-
(2001)
Biochem Pharmacol
, vol.62
, pp. 755-763
-
-
Recht, L.D.1
-
108
-
-
0035422139
-
Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor
-
Sanchez C et al. Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. Cancer Res 2001; 61: 5784-5789.
-
(2001)
Cancer Res
, vol.61
, pp. 5784-5789
-
-
Sanchez, C.1
-
109
-
-
44849139287
-
Exploring the substituent effects on a novel series of C1′-dimethyl-aryl Delta8-tetrahydrocannabinol analogs
-
Krishnamurthy M et al. Exploring the substituent effects on a novel series of C1′-dimethyl-aryl Delta8-tetrahydrocannabinol analogs. Bioorg Med Chem 2008; 16: 6489-6500.
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 6489-6500
-
-
Krishnamurthy, M.1
-
110
-
-
0023278311
-
Interaction of delta-9-tetrahydrocannabinol with rat B103 neuroblastoma cells
-
Cabral GA et al. Interaction of delta-9-tetrahydrocannabinol with rat B103 neuroblastoma cells. Arch Toxicol 1987; 60: 438-449.
-
(1987)
Arch Toxicol
, vol.60
, pp. 438-449
-
-
Cabral, G.A.1
-
111
-
-
0017698323
-
A comparative study of the disposition of (-)-delta 9-tetrahydrocannabinol in neuroblastoma and glioma cells in tissue culture: Relation cellular impairment
-
End DW et al. A comparative study of the disposition of (-)-delta 9-tetrahydrocannabinol in neuroblastoma and glioma cells in tissue culture: relation cellular impairment. Mol Pharmacol 1977; 13: 864-871.
-
(1977)
Mol Pharmacol
, vol.13
, pp. 864-871
-
-
End, D.W.1
-
112
-
-
33747592582
-
Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression
-
McKallip RJ et al. Cannabidiol-induced apoptosis in human leukemia cells: a novel role of cannabidiol in the regulation of p22phox and Nox4 expression. Mol Pharmacol 2006; 70: 897-908.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 897-908
-
-
McKallip, R.J.1
-
113
-
-
24144455626
-
p38 MAPK is involved in CB2 receptor induced apoptosis of human leukaemia cells
-
Herrera B et al. p38 MAPK is involved in CB2 receptor induced apoptosis of human leukaemia cells. FEBS Lett 2005; 579: 5084-5088.
-
(2005)
FEBS Lett
, vol.579
, pp. 5084-5088
-
-
Herrera, B.1
-
114
-
-
20544444202
-
Targeting cannabinoid receptors to treat leukemia: Role of cross-talk between extrinsic and intrinsic pathways in Delta9-tetrahydrocannabinol (THC)-induced apoptosis of Jurkat cells
-
Lombard C et al. Targeting cannabinoid receptors to treat leukemia: role of cross-talk between extrinsic and intrinsic pathways in Delta9-tetrahydrocannabinol (THC)-induced apoptosis of Jurkat cells. Leuk Res 2005; 29: 915-922.
-
(2005)
Leuk Res
, vol.29
, pp. 915-922
-
-
Lombard, C.1
-
115
-
-
0037100312
-
Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
-
McKallip RJ et al. Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood 2002; 100: 627-634.
-
(2002)
Blood
, vol.100
, pp. 627-634
-
-
McKallip, R.J.1
-
116
-
-
0021679685
-
Effects of ethanol, CBD and delta THC on proliferation of K-562 cells
-
Dvilansky A et al. Effects of ethanol, CBD and delta THC on proliferation of K-562 cells. Int J Tissue React 1984; 6: 409-412.
-
(1984)
Int J Tissue React
, vol.6
, pp. 409-412
-
-
Dvilansky, A.1
-
117
-
-
0017643130
-
Effects of cannabinoids on L1210 murine leukemia. 1. Inhibition of DNA synthesis
-
Tucker AN, Friedman MA. Effects of cannabinoids on L1210 murine leukemia. 1. Inhibition of DNA synthesis. Res Commun Chem Pathol Pharmacol 1977; 17: 703-714.
-
(1977)
Res Commun Chem Pathol Pharmacol
, vol.17
, pp. 703-714
-
-
Tucker, A.N.1
Friedman, M.A.2
-
118
-
-
0017253510
-
The inhibition of DNA synthesis by cannabinoids
-
Carchman RA et al. The inhibition of DNA synthesis by cannabinoids. Cancer Res 1976; 36: 95-100.
-
(1976)
Cancer Res
, vol.36
, pp. 95-100
-
-
Carchman, R.A.1
-
119
-
-
28844473489
-
Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma
-
Flygare J et al. Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma. FEBS Lett 2005; 579: 6885-6889.
-
(2005)
FEBS Lett
, vol.579
, pp. 6885-6889
-
-
Flygare, J.1
-
120
-
-
58849113520
-
Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: Synergism with 5-fluorouracil
-
Gustafsson SB et al. Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: synergism with 5-fluorouracil. Cancer Chemother Pharmacol 2008; 63: 691-701.
-
(2008)
Cancer Chemother Pharmacol
, vol.63
, pp. 691-701
-
-
Gustafsson, S.B.1
-
121
-
-
0017607282
-
In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas
-
Friedmann MA. In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas. Cancer Biochem Biophys 1977; 2: 51-54.
-
(1977)
Cancer Biochem Biophys
, vol.2
, pp. 51-54
-
-
Friedmann, M.A.1
-
122
-
-
0017104302
-
Effects of delta9-tetrahydrocannabinol in Lewis lung adenocarcinoma cells in tissue culture
-
White AC et al. Effects of delta9-tetrahydrocannabinol in Lewis lung adenocarcinoma cells in tissue culture. J Natl Cancer Inst 1976; 56: 655-658.
-
(1976)
J Natl Cancer Inst
, vol.56
, pp. 655-658
-
-
White, A.C.1
-
123
-
-
28144431771
-
The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: A possible role for cyclooxygenase 2
-
Patsos HA et al. The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2. Gut 2005; 54: 1741-1750.
-
(2005)
Gut
, vol.54
, pp. 1741-1750
-
-
Patsos, H.A.1
-
124
-
-
0042972716
-
Possible endocannabinoid control of colorectal cancer growth
-
Ligresti A et al. Possible endocannabinoid control of colorectal cancer growth. Gastroenterology 2003; 125: 677-687.
-
(2003)
Gastroenterology
, vol.125
, pp. 677-687
-
-
Ligresti, A.1
-
125
-
-
33644901536
-
Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism
-
Fogli S et al. Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism. FEBS Lett 2006; 580: 1733-1739.
-
(2006)
FEBS Lett
, vol.580
, pp. 1733-1739
-
-
Fogli, S.1
-
126
-
-
33748933891
-
The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits human breast cancer cell proliferation through a lipid raft-mediated mechanism
-
Sarnataro D et al. The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits human breast cancer cell proliferation through a lipid raft-mediated mechanism. Mol Pharmacol 2006; 70: 1298-1306.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 1298-1306
-
-
Sarnataro, D.1
-
127
-
-
0036399326
-
Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems
-
De Petrocellis L et al. Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems. Fundam Clin Pharmacol 2002; 16: 297-302.
-
(2002)
Fundam Clin Pharmacol
, vol.16
, pp. 297-302
-
-
De Petrocellis, L.1
-
128
-
-
0035881542
-
Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells
-
Di Marzo V et al. Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells. Biochem J 2001; 358: 249-255.
-
(2001)
Biochem J
, vol.358
, pp. 249-255
-
-
Di Marzo, V.1
-
129
-
-
0034465259
-
Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation
-
Melck D et al. Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. Endocrinology 2000; 141: 118-126.
-
(2000)
Endocrinology
, vol.141
, pp. 118-126
-
-
Melck, D.1
-
130
-
-
0032526098
-
Biosynthesis and degradation of bioactive fatty acid amides in human breast cancer and rat pheochromocytoma cells-implications for cell proliferation and differentiation
-
Bisogno T et al. Biosynthesis and degradation of bioactive fatty acid amides in human breast cancer and rat pheochromocytoma cells-implications for cell proliferation and differentiation. Eur J Biochem 1998; 254: 634-642.
-
(1998)
Eur J Biochem
, vol.254
, pp. 634-642
-
-
Bisogno, T.1
-
131
-
-
0032493378
-
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
-
De Petrocellis L et al. The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. Proc Natl Acad Sci USA 1998; 95: 8375-8380.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8375-8380
-
-
De Petrocellis, L.1
-
132
-
-
16444375370
-
Cannabinoid receptor as a novel target for the treatment of prostate cancer
-
Sarfaraz S et al. Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Res 2005; 65: 1635-1641.
-
(2005)
Cancer Res
, vol.65
, pp. 1635-1641
-
-
Sarfaraz, S.1
-
133
-
-
0038751939
-
Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: Implication of epidermal growth factor receptor down-regulation and ceramide production
-
Mimeault M et al. Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production. Prostate 2003; 56: 1-2.
-
(2003)
Prostate
, vol.56
, pp. 1-2
-
-
Mimeault, M.1
-
134
-
-
0037380894
-
ASK1-p38 MAPK/JNK signaling cascade mediates anandamide-induced PC12 cell death
-
Sarker KP et al. ASK1-p38 MAPK/JNK signaling cascade mediates anandamide-induced PC12 cell death. J Neurochem 2003; 85: 50-51.
-
(2003)
J Neurochem
, vol.85
, pp. 50-51
-
-
Sarker, K.P.1
-
135
-
-
0032586054
-
Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism
-
Ruiz L et al. Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism. FEBS Lett 1999; 458: 400-404.
-
(1999)
FEBS Lett
, vol.458
, pp. 400-404
-
-
Ruiz, L.1
-
136
-
-
41149153235
-
A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells
-
Lee CY et al. A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells. Int Immunopharmacol 2008; 8: 732-740.
-
(2008)
Int Immunopharmacol
, vol.8
, pp. 732-740
-
-
Lee, C.Y.1
-
137
-
-
34250378332
-
Opposing actions of endocannabinoids on cholangiocarcinoma growth: Recruitment of Fas and Fas ligand to lipid rafts
-
De Morrow S et al. Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts. J Biol Chem 2007; 282: 13098-13113.
-
(2007)
J Biol Chem
, vol.282
, pp. 13098-13113
-
-
De Morrow, S.1
-
138
-
-
62649170623
-
Apoptosis induced in HepG2 cells by the synthetic cannabinoid WIN: Involvement of the transcription factor PPARgamma
-
Giuliano M et al. Apoptosis induced in HepG2 cells by the synthetic cannabinoid WIN: involvement of the transcription factor PPARgamma. Biochimie 2009; 91: 457-465.
-
(2009)
Biochimie
, vol.91
, pp. 457-465
-
-
Giuliano, M.1
-
139
-
-
38349022657
-
Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma
-
Shi Y et al. Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma. Cancer Gene Ther 2008; 15: 101-107.
-
(2008)
Cancer Gene Ther
, vol.15
, pp. 101-107
-
-
Shi, Y.1
-
140
-
-
77952236107
-
A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis
-
Feb 3 Epub ahead of print
-
Cozzolino R et al. A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis. Invest New Drugs 2009; Feb 3 (Epub ahead of print).
-
(2009)
Invest New Drugs
-
-
Cozzolino, R.1
-
141
-
-
66449121455
-
Lipid G-protein-coupled receptor ligand identification using beta-arrestin pathhunter assay
-
Yin H et al. Lipid G-protein-coupled receptor ligand identification using beta-arrestin pathhunter assay. J Biol Chem 2009; 284: 12328-12338.
-
(2009)
J Biol Chem
, vol.284
, pp. 12328-12338
-
-
Yin, H.1
-
142
-
-
58149386386
-
The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing
-
Nguyen et al. The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing. Proc Natl Acad Sci USA 2008; 105: 19750-19755.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19750-19755
-
-
Nguyen1
-
143
-
-
36448995830
-
GPR55: A new member of the cannabinoid receptor clan?
-
Pertwee RG. GPR55: a new member of the cannabinoid receptor clan? Br J Pharmacol 2007; 152: 984-986.
-
(2007)
Br J Pharmacol
, vol.152
, pp. 984-986
-
-
Pertwee, R.G.1
-
144
-
-
40649102938
-
GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current
-
Lauckner JE et al. GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current. Proc Natl Acad Sci USA 2008; 105: 2699-2704.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 2699-2704
-
-
Lauckner, J.E.1
-
145
-
-
58249109364
-
The GPR55 ligand L-alpha- lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation
-
Henstridge CM et al. The GPR55 ligand L-alpha- lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation. FASEB J 2009; 23: 183-193.
-
(2009)
FASEB J
, vol.23
, pp. 183-193
-
-
Henstridge, C.M.1
-
146
-
-
0037261140
-
NF-ATc induces apoptosis in Burkitt's lymphoma cells through signaling via the B cell antigen receptor
-
Kondo E et al. NF-ATc induces apoptosis in Burkitt's lymphoma cells through signaling via the B cell antigen receptor. Eur J Immunol 2003; 33: 1-11.
-
(2003)
Eur J Immunol
, vol.33
, pp. 1-11
-
-
Kondo, E.1
-
147
-
-
38449109178
-
5-Lipoxygenase and anadamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid
-
Massi P et al. 5-Lipoxygenase and anadamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. J Neurochem 2008; 104: 1091-1100.
-
(2008)
J Neurochem
, vol.104
, pp. 1091-1100
-
-
Massi, P.1
-
148
-
-
27744562012
-
Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells
-
Sarnataro D et al. Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. FEBS Lett 2005; 579: 6343-6349.
-
(2005)
FEBS Lett
, vol.579
, pp. 6343-6349
-
-
Sarnataro, D.1
-
149
-
-
33947697100
-
Biochemistry and pharmacology of endovanilloids
-
Starowicz K et al. Biochemistry and pharmacology of endovanilloids. Pharmacol Ther 2007; 114: 13-33.
-
(2007)
Pharmacol Ther
, vol.114
, pp. 13-33
-
-
Starowicz, K.1
-
150
-
-
23044475561
-
PPAR-gamma: A nuclear receptor with affinity for cannabinoids
-
Burstein S. PPAR-gamma: a nuclear receptor with affinity for cannabinoids. Life Sci 2005; 77: 1674-1684.
-
(2005)
Life Sci
, vol.77
, pp. 1674-1684
-
-
Burstein, S.1
-
151
-
-
38049185265
-
Inhibition of cancer cell invasion by cannabinoids via increased expressionof tissue inhibitor of matrix metalloproteinases-1
-
Ramer R, Hinz B. Inhibition of cancer cell invasion by cannabinoids via increased expressionof tissue inhibitor of matrix metalloproteinases-1. J Natl Cancer Inst 2008; 100: 59-69.
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 59-69
-
-
Ramer, R.1
Hinz, B.2
-
152
-
-
44249117614
-
Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8
-
De Petrocellis L et al. Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8. J Pharmacol Exp Ther 2008; 325: 1007-1015.
-
(2008)
J Pharmacol Exp Ther
, vol.325
, pp. 1007-1015
-
-
De Petrocellis, L.1
-
153
-
-
34547107881
-
Ajulemic acid, a synthetic nonpsychoactive cannabinoid acid, bound to the ligand binding domain of the human peroxisome proliferator-activated receptor gamma
-
Ambrosio Al et al. Ajulemic acid, a synthetic nonpsychoactive cannabinoid acid, bound to the ligand binding domain of the human peroxisome proliferator-activated receptor gamma. J Biol Chem 2007; 282: 18625-18633.
-
(2007)
J Biol Chem
, vol.282
, pp. 18625-18633
-
-
Ambrosio, A.1
-
154
-
-
16444375370
-
Cannabinoid receptor as a novel target for the treatment of prostate cancer
-
Sarfaraz S et al. Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Res 2005; 65: 1635-1641.
-
(2005)
Cancer Res
, vol.65
, pp. 1635-1641
-
-
Sarfaraz, S.1
-
155
-
-
48749102177
-
Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1)
-
Holland ML et al. Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1). Eur J Pharmacol 2008; 591: 128-131.
-
(2008)
Eur J Pharmacol
, vol.591
, pp. 128-131
-
-
Holland, M.L.1
-
156
-
-
35648948415
-
The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids
-
Holland ML et al. The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. Br J Pharmacol 2007; 152: 815-824.
-
(2007)
Br J Pharmacol
, vol.152
, pp. 815-824
-
-
Holland, M.L.1
-
157
-
-
33644828740
-
The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells
-
Holland ML et al. The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. Biochem Pharmacol 2006; 71: 1146-1154.
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 1146-1154
-
-
Holland, M.L.1
-
158
-
-
33745620507
-
Modulation of P-glycoprotein activity by cannabinoid molecules in HK-2 renal cells
-
Nieri P et al. Modulation of P-glycoprotein activity by cannabinoid molecules in HK-2 renal cells. Br J Pharmacol 2006; 148: 682-687.
-
(2006)
Br J Pharmacol
, vol.148
, pp. 682-687
-
-
Nieri, P.1
-
159
-
-
33645841349
-
Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana
-
Zhu HJ et al. Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana. J Pharmacol Exp Ther 2006; 317: 850-757.
-
(2006)
J Pharmacol Exp Ther
, vol.317
, pp. 850-757
-
-
Zhu, H.J.1
-
160
-
-
33747624175
-
Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
-
Ligresti A et al. Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. J Pharmacol Exp Ther 2006; 318: 1375-1387.
-
(2006)
J Pharmacol Exp Ther
, vol.318
, pp. 1375-1387
-
-
Ligresti, A.1
-
161
-
-
45549095987
-
The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development
-
Zheng D et al. The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development. Cancer Res 2008; 68: 3992-3998.
-
(2008)
Cancer Res
, vol.68
, pp. 3992-3998
-
-
Zheng, D.1
-
162
-
-
34250323489
-
Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis
-
Aguado T et al. Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis. J Biol Chem 2007; 282: 6854-6862.
-
(2007)
J Biol Chem
, vol.282
, pp. 6854-6862
-
-
Aguado, T.1
-
163
-
-
57649242673
-
A high cannabinoid CB(1) receptor immunoreactivity is associated with disease severity and outcome in prostate cancer
-
Chung SC et al. A high cannabinoid CB(1) receptor immunoreactivity is associated with disease severity and outcome in prostate cancer. Eur J Cancer 2009; 45: 174-182.
-
(2009)
Eur J Cancer
, vol.45
, pp. 174-182
-
-
Chung, S.C.1
-
164
-
-
41549121013
-
Cannabinoids in the management of difficult to treat pain
-
Russo EB. Cannabinoids in the management of difficult to treat pain. Ther Clin Risk Manag 2008; 4: 245-259.
-
(2008)
Ther Clin Risk Manag
, vol.4
, pp. 245-259
-
-
Russo, E.B.1
-
165
-
-
34548255920
-
Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting: Beyond prevention of acute emesis
-
Slatkin NE. Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting: beyond prevention of acute emesis. J Support Oncol 2007; 5: 1-9.
-
(2007)
J Support Oncol
, vol.5
, pp. 1-9
-
-
Slatkin, N.E.1
-
166
-
-
14844362003
-
Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response
-
McKallip RJ et al. Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response. J Immunol 2005; 174: 3281-3289.
-
(2005)
J Immunol
, vol.174
, pp. 3281-3289
-
-
McKallip, R.J.1
-
167
-
-
38449100291
-
TNF and cancer: The two sides of the coin
-
Mocellin S, Nitti D. TNF and cancer: the two sides of the coin. Front Biosci 2008; 13: 2774-2783.
-
(2008)
Front Biosci
, vol.13
, pp. 2774-2783
-
-
Mocellin, S.1
Nitti, D.2
-
168
-
-
42649124339
-
TNF: A master switch for inflammation to cancer
-
Sethi G et al. TNF: a master switch for inflammation to cancer. Front Biosci 2008; 13: 5094-5107.
-
(2008)
Front Biosci
, vol.13
, pp. 5094-5107
-
-
Sethi, G.1
-
169
-
-
51049102995
-
Loss of cannabinoid receptor 1 accelerates intestinal tumor growth
-
Wang D et al. Loss of cannabinoid receptor 1 accelerates intestinal tumor growth. Cancer Res 2008; 68: 6468-6476.
-
(2008)
Cancer Res
, vol.68
, pp. 6468-6476
-
-
Wang, D.1
-
170
-
-
38149055682
-
Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon
-
Izzo AA et al. Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon. J Mol Med 2008; 86: 89-98.
-
(2008)
J Mol Med
, vol.86
, pp. 89-98
-
-
Izzo, A.A.1
-
171
-
-
65449146377
-
Emerging strategies for exploiting cannabinoid receptor agonists as medicines
-
Pertwee RG. Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br J Pharmacol 2009; 156: 397-411.
-
(2009)
Br J Pharmacol
, vol.156
, pp. 397-411
-
-
Pertwee, R.G.1
-
172
-
-
52349114996
-
Enhancing the in vitro cytotoxic activity of Delta-9-tetrahydrocannabinol in leukemic cells through combinatorial approach
-
Liu WM et al. Enhancing the in vitro cytotoxic activity of Delta-9-tetrahydrocannabinol in leukemic cells through combinatorial approach. Leuk Lymphoma 2008; 49: 1800-1809.
-
(2008)
Leuk Lymphoma
, vol.49
, pp. 1800-1809
-
-
Liu, W.M.1
-
173
-
-
52449107732
-
Medicinal plants and cancer chemoprevention
-
Desai AG et al. Medicinal plants and cancer chemoprevention. Curr Drug Metab 2008; 9: 581-591.
-
(2008)
Curr Drug Metab
, vol.9
, pp. 581-591
-
-
Desai, A.G.1
-
174
-
-
38149049269
-
Cannabinoids as potential new therapy for the treatment of gliomas
-
Parolaro D, Massi P. Cannabinoids as potential new therapy for the treatment of gliomas. Expert Rev Neurother 2008; 8: 37-49.
-
(2008)
Expert Rev Neurother
, vol.8
, pp. 37-49
-
-
Parolaro, D.1
Massi, P.2
-
175
-
-
0030774482
-
Marijuana use and cancer incidence (California, United States)
-
Sidney S et al. Marijuana use and cancer incidence (California, United States). Cancer Causes Control 1997; 8: 722-728.
-
(1997)
Cancer Causes Control
, vol.8
, pp. 722-728
-
-
Sidney, S.1
-
176
-
-
39649085680
-
Cannabis use and risk of lung cancer: A case-control study
-
Aldington S et al. Cannabis use and risk of lung cancer: a case-control study. Eur Respir J 2008; 31: 280-286.
-
(2008)
Eur Respir J
, vol.31
, pp. 280-286
-
-
Aldington, S.1
-
177
-
-
58149374478
-
Doubts about the role of cannabis in causing lung cancer
-
Sewell RA et al. Doubts about the role of cannabis in causing lung cancer. Eur Respir J 2008; 32: 815-816.
-
(2008)
Eur Respir J
, vol.32
, pp. 815-816
-
-
Sewell, R.A.1
-
178
-
-
63449100550
-
Association of marijuana use and the incidence of testicular germ cell tumors
-
Daling et al. Association of marijuana use and the incidence of testicular germ cell tumors. Cancer 2009; 115: 1215-1223.
-
(2009)
Cancer
, vol.115
, pp. 1215-1223
-
-
Daling1
|