메뉴 건너뛰기




Volumn 61, Issue 7, 2009, Pages 839-853

Cannabinoid receptor ligands as potential anticancer agents - High hopes for new therapies?

Author keywords

Anticancer agent; Cancer; Cannabinoids; Chemoprevention; Endocannabinoid system

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N MORPHOLINO 1H PYRAZOLE 3 CARBOXAMIDE; 1 AG; 1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 2 AG; 2 METHYL 3 (1 NAPHTHOYL) 1 PROPYLINDOLE; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 3,3' DIINDOLMETHANE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; AJULEMIC ACID; ANANDAMIDE; ANTINEOPLASTIC AGENT; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR AGONIST; CANNABINOID 1 RECEPTOR ANTAGONIST; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CAPASZEPINE; CERAMIDE; DEXANABINOL; DRONABINOL; ENDOCANNABINOID; G PROTEIN COUPLED RECEPTOR 55; METHANANDAMIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN P8; RIMONABANT; UNCLASSIFIED DRUG; CANNABINOID RECEPTOR; LIGAND; TETRAHYDROCANNABINOL;

EID: 69149097969     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp/61.07.0002     Document Type: Review
Times cited : (41)

References (178)
  • 1
    • 33144480327 scopus 로고    scopus 로고
    • Cannabinoid receptors as therapeutic targets
    • Mackie K. Cannabinoid receptors as therapeutic targets. Annu Rev Pharmacol Toxicol 2006; 46: 101-122.
    • (2006) Annu Rev Pharmacol Toxicol , vol.46 , pp. 101-122
    • Mackie, K.1
  • 2
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda LA et al. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 1990; 346: 561-564.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1
  • 3
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • Munro S et al. Molecular characterization of a peripheral receptor for cannabinoids. Nature 1993; 365: 61-65.
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1
  • 4
    • 35748973885 scopus 로고    scopus 로고
    • Novel cannabinoid receptors
    • Brown AJ. Novel cannabinoid receptors. Br J Pharmacol 152: 567-575.
    • Br J Pharmacol , vol.152 , pp. 567-575
    • Brown, A.J.1
  • 5
    • 35649015179 scopus 로고    scopus 로고
    • The orphan receptor GPR55 is a novel cannabinoid receptor
    • Ryberg E et al. The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol 2007; 152: 1092-1101.
    • (2007) Br J Pharmacol , vol.152 , pp. 1092-1101
    • Ryberg, E.1
  • 6
    • 40349114501 scopus 로고    scopus 로고
    • GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity
    • Overton et al. GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity. Br J Pharmacol 2008; 153: 76-81.
    • (2008) Br J Pharmacol , vol.153 , pp. 76-81
    • Overton1
  • 7
    • 33646814424 scopus 로고    scopus 로고
    • Cannabinoid receptors and endocannabinoids: Evidence for new players
    • Mackie K, Stella N. Cannabinoid receptors and endocannabinoids: evidence for new players. AAPS J 2006; 8: E298-E306.
    • (2006) AAPS J , vol.8
    • Mackie, K.1    Stella, N.2
  • 8
    • 64249138218 scopus 로고    scopus 로고
    • The therapeutic potential of novel cannabinoid receptors
    • Kreitzer FR, Stella N. The therapeutic potential of novel cannabinoid receptors. Pharmacol Ther 2009; 122: 83-96.
    • (2009) Pharmacol Ther , vol.122 , pp. 83-96
    • Kreitzer, F.R.1    Stella, N.2
  • 9
    • 48249097797 scopus 로고    scopus 로고
    • Endocannabinoids: Synthesis and degradation
    • Di Marzo V. Endocannabinoids: synthesis and degradation. Rev Physiol Biochem Pharmacol 2008; 160: 1-24.
    • (2008) Rev Physiol Biochem Pharmacol , vol.160 , pp. 1-24
    • Di Marzo, V.1
  • 10
    • 34548500793 scopus 로고    scopus 로고
    • Discovery and isolation of anandamide and other endocannabinoids
    • Hanus LO. Discovery and isolation of anandamide and other endocannabinoids. Chem Biodivers 2007; 4: 1828-1841.
    • (2007) Chem Biodivers , vol.4 , pp. 1828-1841
    • Hanus, L.O.1
  • 11
    • 0344873175 scopus 로고    scopus 로고
    • Anandamide and vanilloid TRPV1 receptors
    • Ross RA. Anandamide and vanilloid TRPV1 receptors. Br J Pharmacol 2003; 140: 790-801.
    • (2003) Br J Pharmacol , vol.140 , pp. 790-801
    • Ross, R.A.1
  • 12
    • 34547881031 scopus 로고    scopus 로고
    • Interaction of ligands for the peroxisome proliferator-activated receptor gamma with the endocannabinoid system
    • Lenman A, Fowler CJ. Interaction of ligands for the peroxisome proliferator-activated receptor gamma with the endocannabinoid system. Br J Pharmacol 2007; 151: 1343-1351.
    • (2007) Br J Pharmacol , vol.151 , pp. 1343-1351
    • Lenman, A.1    Fowler, C.J.2
  • 13
    • 53049084435 scopus 로고    scopus 로고
    • Anandamide effects on 5-HT(3) receptors in vivo
    • Racz I et al. Anandamide effects on 5-HT(3) receptors in vivo. Eur J Pharmacol 2008; 596: 98-101.
    • (2008) Eur J Pharmacol , vol.596 , pp. 98-101
    • Racz, I.1
  • 14
    • 61349143694 scopus 로고    scopus 로고
    • The enigmatic pharmacology of GPR55
    • Ross RA. The enigmatic pharmacology of GPR55. Trends Pharmacol Sci 2009; 30: 156-163.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 156-163
    • Ross, R.A.1
  • 15
    • 42349086864 scopus 로고    scopus 로고
    • Endocannabinoids and the regulation of bone metabolism
    • Bab I et al. Endocannabinoids and the regulation of bone metabolism. J Neuroendocrinol 2008; 20(Suppl 1): 69-74.
    • (2008) J Neuroendocrinol , vol.20 , Issue.SUPPL. 1 , pp. 69-74
    • Bab, I.1
  • 16
    • 0041411118 scopus 로고    scopus 로고
    • The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis
    • Maccarrone M, Finazzi-Agro A. The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis. Cell Death Differ 2003; 10: 946-955.
    • (2003) Cell Death Differ , vol.10 , pp. 946-955
    • Maccarrone, M.1    Finazzi-Agro, A.2
  • 17
    • 52049093883 scopus 로고    scopus 로고
    • Endocannabinoids as positive or negative factors in hematopoietic cell migration and differentiation
    • Patinkin D et al. Endocannabinoids as positive or negative factors in hematopoietic cell migration and differentiation. Eur J Pharmacol 2008; 595: 1-6.
    • (2008) Eur J Pharmacol , vol.595 , pp. 1-6
    • Patinkin, D.1
  • 18
    • 0013779962 scopus 로고
    • The isolation and structure of cannabinolic cannabidiolic and cannabigerolic acids
    • Mechoulam R, Gaoni Y, Hashish IV. The isolation and structure of cannabinolic cannabidiolic and cannabigerolic acids. Tetrahedron 1965; 21: 1223-1229.
    • (1965) Tetrahedron , vol.21 , pp. 1223-1229
    • Mechoulam, R.1    Gaoni, Y.2    Hashish, I.V.3
  • 19
    • 0024263922 scopus 로고
    • Determination and characterization of a cannabinoid receptor in rat brain
    • Devane WA et al. Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol 1988; 34: 605-613.
    • (1988) Mol Pharmacol , vol.34 , pp. 605-613
    • Devane, W.A.1
  • 20
    • 43249100162 scopus 로고    scopus 로고
    • Targeting the endocannabinoid system: To enhance or reduce?
    • Di Marzo V. Targeting the endocannabinoid system: to enhance or reduce? Nat Rev Drug Discov 2008; 7: 438-455.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 438-455
    • Di Marzo, V.1
  • 21
    • 48249106686 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor antagonists in therapeutic and structural perspectives
    • Lange JH, Kruse CG. Cannabinoid CB1 receptor antagonists in therapeutic and structural perspectives. Chem Rec 2008; 8: 156-168.
    • (2008) Chem Rec , vol.8 , pp. 156-168
    • Lange, J.H.1    Kruse, C.G.2
  • 22
    • 50349086035 scopus 로고    scopus 로고
    • Therapeutic use of Cannabis sativa on chemotherapy-induced nausea and vomiting among cancer patients: Systematic review and meta-analysis
    • Machado Rocha FC et al. Therapeutic use of Cannabis sativa on chemotherapy-induced nausea and vomiting among cancer patients: systematic review and meta-analysis. Eur J Cancer Care (Engl) 2008; 17: 431-443.
    • (2008) Eur J Cancer Care (Engl) , vol.17 , pp. 431-443
    • Machado Rocha, F.C.1
  • 23
    • 18844400058 scopus 로고    scopus 로고
    • Cannabinoid-based drugs as anti-inflammatory therapeutics
    • Klein TW. Cannabinoid-based drugs as anti-inflammatory therapeutics. Nat Rev Immunol 2005; 5: 400-411.
    • (2005) Nat Rev Immunol , vol.5 , pp. 400-411
    • Klein, T.W.1
  • 24
    • 34248219556 scopus 로고    scopus 로고
    • Cannabinoids for the treatment of inflammation
    • Ashton JC. Cannabinoids for the treatment of inflammation. Curr Opin Investig Drugs 2007; 8: 373-384.
    • (2007) Curr Opin Investig Drugs , vol.8 , pp. 373-384
    • Ashton, J.C.1
  • 25
    • 63449105700 scopus 로고    scopus 로고
    • Role of cannabinoids in chronic liver disease
    • Parfienuk A et al. Role of cannabinoids in chronic liver disease. World J Gastroenterol 2008; 14: 6109-6114.
    • (2008) World J Gastroenterol , vol.14 , pp. 6109-6114
    • Parfienuk, A.1
  • 26
    • 52949090419 scopus 로고    scopus 로고
    • CNS immune surveillance and neuroinflammation: Endocannabinoids keep control
    • Wolf SA et al. CNS immune surveillance and neuroinflammation: endocannabinoids keep control. Curr Pharm Des 2008; 14: 2266-2278.
    • (2008) Curr Pharm Des , vol.14 , pp. 2266-2278
    • Wolf, S.A.1
  • 27
    • 33749165439 scopus 로고    scopus 로고
    • Endocannabinoid overactivity and intestinal inflammation
    • Di Marzo V, Izzo AA. Endocannabinoid overactivity and intestinal inflammation. Gut 2006; 55: 1371-1376.
    • (2006) Gut , vol.55 , pp. 1371-1376
    • Di Marzo, V.1    Izzo, A.A.2
  • 28
    • 34250209535 scopus 로고    scopus 로고
    • Attenuation of allergic contact dermatitis through the endocannabinoid system
    • Karsak M et al. Attenuation of allergic contact dermatitis through the endocannabinoid system. Science 2007; 316: 1494-1497.
    • (2007) Science , vol.316 , pp. 1494-1497
    • Karsak, M.1
  • 29
    • 38349119137 scopus 로고    scopus 로고
    • Biology and therapeutic potential of cannabinoid CB2 receptor inverse agonists
    • Lunn CA et al. Biology and therapeutic potential of cannabinoid CB2 receptor inverse agonists. Br J Pharmacol 2008; 153: 226-239.
    • (2008) Br J Pharmacol , vol.153 , pp. 226-239
    • Lunn, C.A.1
  • 30
    • 38349099590 scopus 로고    scopus 로고
    • The peripheral cannabinoid receptor knockout mice: An update
    • Buckley NE. The peripheral cannabinoid receptor knockout mice: an update. Br J Pharmacol 2008; 153: 309-318.
    • (2008) Br J Pharmacol , vol.153 , pp. 309-318
    • Buckley, N.E.1
  • 31
    • 22544439953 scopus 로고    scopus 로고
    • Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors
    • Idris AI et al. Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors. Nat Med 2005; 11: 774-779.
    • (2005) Nat Med , vol.11 , pp. 774-779
    • Idris, A.I.1
  • 32
    • 27944510259 scopus 로고    scopus 로고
    • Cannabinoid receptor type 2 gene is associated with human osteoporosis
    • Karsak M et al. Cannabinoid receptor type 2 gene is associated with human osteoporosis. Hum Mol Genet 2005; 14: 3389-3396.
    • (2005) Hum Mol Genet , vol.14 , pp. 3389-3396
    • Karsak, M.1
  • 33
    • 31444437185 scopus 로고    scopus 로고
    • Peripheral cannabinoid receptor, CB2, regulates bone mass
    • Ofek O et al. Peripheral cannabinoid receptor, CB2, regulates bone mass. Proc Natl Acad Sci USA 2006; 103: 696-701.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 696-701
    • Ofek, O.1
  • 34
    • 38349132542 scopus 로고    scopus 로고
    • Cannabinoid receptors and the regulation of bone mass
    • Bab I, Zimmer A. Cannabinoid receptors and the regulation of bone mass. Br J Pharmacol 2008; 153: 182-188.
    • (2008) Br J Pharmacol , vol.153 , pp. 182-188
    • Bab, I.1    Zimmer, A.2
  • 35
    • 34548181608 scopus 로고    scopus 로고
    • The cannabinoid CB(2) receptor: A good friend in the gut
    • Izzo AA. The cannabinoid CB(2) receptor: a good friend in the gut. Neurogastroenterol Motil 2007; 19: 704-708.
    • (2007) Neurogastroenterol Motil , vol.19 , pp. 704-708
    • Izzo, A.A.1
  • 36
    • 34347397535 scopus 로고    scopus 로고
    • The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration
    • Ashton JC, Glass M. The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration. Curr Neuropharmacol 2007; 5: 73-80.
    • (2007) Curr Neuropharmacol , vol.5 , pp. 73-80
    • Ashton, J.C.1    Glass, M.2
  • 37
    • 17144400758 scopus 로고    scopus 로고
    • Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice
    • Steffens S et al. Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature 2005; 434: 782-786.
    • (2005) Nature , vol.434 , pp. 782-786
    • Steffens, S.1
  • 38
    • 42349116948 scopus 로고    scopus 로고
    • The role of the endocannabinoid system in atherosclerosis
    • Mach F, Steffens S. The role of the endocannabinoid system in atherosclerosis. J Neuroendocrinol 2008; 20(Suppl 1): 53-57.
    • (2008) J Neuroendocrinol , vol.20 , Issue.SUPPL. 1 , pp. 53-57
    • Mach, F.1    Steffens, S.2
  • 39
    • 35648999552 scopus 로고    scopus 로고
    • Endocannabinoid metabolism and uptake: Novel targets for neuropathic and inflammatory pain
    • Jhaveri MD et al. Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain. Br J Pharmacol 2007; 152: 624-632.
    • (2007) Br J Pharmacol , vol.152 , pp. 624-632
    • Jhaveri, M.D.1
  • 40
    • 0037709942 scopus 로고    scopus 로고
    • The endocannabinoid system as a target for the development of new drugs for cancer therapy]
    • Bifulco M, Di Marzo V. [The endocannabinoid system as a target for the development of new drugs for cancer therapy]. Recenti Prog Med 2003; 94: 194-198.
    • (2003) Recenti Prog Med , vol.94 , pp. 194-198
    • Bifulco, M.1    Di Marzo, V.2
  • 41
    • 33745013193 scopus 로고    scopus 로고
    • Cannabinoids and cancer: Pros and cons of an antitumour strategy
    • Bifulco M et al. Cannabinoids and cancer: pros and cons of an antitumour strategy. Br J Pharmacol 2006; 148: 123-135.
    • (2006) Br J Pharmacol , vol.148 , pp. 123-135
    • Bifulco, M.1
  • 42
    • 43049127845 scopus 로고    scopus 로고
    • The endocannabinoid system in cancer-potential therapeutic target?
    • Flygare J, Sander B. The endocannabinoid system in cancer-potential therapeutic target? Semin Cancer Biol 2008; 18: 176-189.
    • (2008) Semin Cancer Biol , vol.18 , pp. 176-189
    • Flygare, J.1    Sander, B.2
  • 43
    • 39049104489 scopus 로고    scopus 로고
    • Cannabinoids for cancer treatment: Progress and promise
    • Sarfaraz S et al. Cannabinoids for cancer treatment: progress and promise. Cancer Res 2008; 68: 339-342.
    • (2008) Cancer Res , vol.68 , pp. 339-342
    • Sarfaraz, S.1
  • 44
    • 0016804266 scopus 로고
    • Antineoplastic activity of cannabinoids
    • Munson AE et al. Antineoplastic activity of cannabinoids. J Natl Cancer Inst 1975; 55: 597-602.
    • (1975) J Natl Cancer Inst , vol.55 , pp. 597-602
    • Munson, A.E.1
  • 45
    • 54249155522 scopus 로고    scopus 로고
    • Network pharmacology: The next paradigm in drug discovery
    • Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 2008; 4: 682-690.
    • (2008) Nat Chem Biol , vol.4 , pp. 682-690
    • Hopkins, A.L.1
  • 46
    • 33846474121 scopus 로고    scopus 로고
    • G-protein-coupled receptors and cancer
    • Dorsam RT, Gutkind JS. G-protein-coupled receptors and cancer. Nat Rev Cancer 2007; 7: 79-94.
    • (2007) Nat Rev Cancer , vol.7 , pp. 79-94
    • Dorsam, R.T.1    Gutkind, J.S.2
  • 47
    • 23044517184 scopus 로고    scopus 로고
    • Cannabinoids and ceramide: Two lipids acting hand-by-hand
    • Velasco G et al. Cannabinoids and ceramide: two lipids acting hand-by-hand. Life Sci 2005; 77: 1723-1731.
    • (2005) Life Sci , vol.77 , pp. 1723-1731
    • Velasco, G.1
  • 48
    • 0032566430 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells
    • Sanchez C et al. Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells. FEBS Lett 1998; 436: 6-10.
    • (1998) FEBS Lett , vol.436 , pp. 6-10
    • Sanchez, C.1
  • 49
    • 0031724645 scopus 로고    scopus 로고
    • Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol- induced stimulation of glucose metabolism in primary astrocytes
    • Sanchez C et al. Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol- induced stimulation of glucose metabolism in primary astrocytes. Mol Pharmacol 1998; 54: 834-843.
    • (1998) Mol Pharmacol , vol.54 , pp. 834-843
    • Sanchez, C.1
  • 50
    • 33645763253 scopus 로고    scopus 로고
    • The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
    • Carracedo A et al. The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. Cancer Cell 2000; 9: 301-312.
    • (2000) Cancer Cell , vol.9 , pp. 301-312
    • Carracedo, A.1
  • 51
    • 0036534724 scopus 로고    scopus 로고
    • De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis
    • Gomez del Pulgar T et al. De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis. Biochem J 2002; 363: 183-188.
    • (2002) Biochem J , vol.363 , pp. 183-188
    • Gomez del Pulgar, T.1
  • 52
    • 40949083594 scopus 로고    scopus 로고
    • Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression
    • Blazquez C et al. Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Res 2008; 68: 1945-1952.
    • (2008) Cancer Res , vol.68 , pp. 1945-1952
    • Blazquez, C.1
  • 53
    • 37349095918 scopus 로고    scopus 로고
    • Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: A new marker of cannabinoid antitumoral activity?
    • Blazquez C et al. Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity? Neuropharmacology 2008; 54: 235-243.
    • (2008) Neuropharmacology , vol.54 , pp. 235-243
    • Blazquez, C.1
  • 54
    • 59449111015 scopus 로고    scopus 로고
    • Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells
    • Cianchi F et al. Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells. Clin Cancer Res 2008; 14: 7691-7700.
    • (2008) Clin Cancer Res , vol.14 , pp. 7691-7700
    • Cianchi, F.1
  • 55
    • 2942729530 scopus 로고    scopus 로고
    • Ceramide sensitizes astrocytes to oxidative stress: Protective role of cannabinoids
    • Carracedo A et al. Ceramide sensitizes astrocytes to oxidative stress: protective role of cannabinoids. Biochem J 2004; 380: 435-440.
    • (2004) Biochem J , vol.380 , pp. 435-440
    • Carracedo, A.1
  • 56
  • 57
    • 36249002916 scopus 로고    scopus 로고
    • PKB and the mitochondria: AKTing on apoptosis
    • Parcellier A et al. PKB and the mitochondria: AKTing on apoptosis. Cell Signal 2008; 20: 21-30.
    • (2008) Cell Signal , vol.20 , pp. 21-30
    • Parcellier, A.1
  • 58
    • 35148860072 scopus 로고    scopus 로고
    • PI3K class IB pathway
    • Andrews S et al. PI3K class IB pathway. Sci STKE 2007: cm2.
    • (2007) Sci STKE
    • Andrews, S.1
  • 59
    • 0028334738 scopus 로고
    • A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits
    • Stephens L et al. A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits. Cell 1994; 77: 83-93.
    • (1994) Cell , vol.77 , pp. 83-93
    • Stephens, L.1
  • 60
    • 0037184060 scopus 로고    scopus 로고
    • Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway
    • Gomez Del Pulgar T et al. Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 2002; 277: 36527-36533.
    • (2002) J Biol Chem , vol.277 , pp. 36527-36533
    • Gomez Del Pulgar, T.1
  • 61
    • 0034654660 scopus 로고    scopus 로고
    • The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt
    • Gomez del Pulgar T et al. The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt. Biochem J 2000; 347: 369-373.
    • (2000) Biochem J , vol.347 , pp. 369-373
    • Gomez del Pulgar, T.1
  • 62
    • 34547484379 scopus 로고    scopus 로고
    • Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain
    • Ozaita A et al. Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain. J Neurochem 2007; 102: 1105-1114.
    • (2007) J Neurochem , vol.102 , pp. 1105-1114
    • Ozaita, A.1
  • 63
    • 34948815127 scopus 로고    scopus 로고
    • PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis
    • Fang J et al. PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis. Cell Signal 2007; 19: 2487-2497.
    • (2007) Cell Signal , vol.19 , pp. 2487-2497
    • Fang, J.1
  • 64
    • 1542510624 scopus 로고    scopus 로고
    • Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor
    • Hart S et al. Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor. Cancer Res 2004; 64: 1943-1950.
    • (2004) Cancer Res , vol.64 , pp. 1943-1950
    • Hart, S.1
  • 65
    • 35348910284 scopus 로고    scopus 로고
    • The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells
    • Greenhough A et al. The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells. Int J Cancer 2007; 121: 2172-2180.
    • (2007) Int J Cancer , vol.121 , pp. 2172-2180
    • Greenhough, A.1
  • 66
    • 33845973763 scopus 로고    scopus 로고
    • Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest
    • Sarfaraz S et al. Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest. J Biol Chem 2006; 281: 39480-39491.
    • (2006) J Biol Chem , vol.281 , pp. 39480-39491
    • Sarfaraz, S.1
  • 67
    • 33845627660 scopus 로고    scopus 로고
    • Cannabinoid receptors as novel targets for the treatment of melanoma
    • Blazquez C et al. Cannabinoid receptors as novel targets for the treatment of melanoma. FASEB J 2006; 20: 2633-2635.
    • (2006) FASEB J , vol.20 , pp. 2633-2635
    • Blazquez, C.1
  • 68
    • 17344380844 scopus 로고    scopus 로고
    • Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extra-cellular signal-regulated kinase activation
    • Galve-Roperh I et al. Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extra-cellular signal-regulated kinase activation. Nat Med 2000; 6: 313-319.
    • (2000) Nat Med , vol.6 , pp. 313-319
    • Galve-Roperh, I.1
  • 69
    • 0033405883 scopus 로고    scopus 로고
    • Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells
    • Melck D et al. Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells. FEBS Lett 1999; 463: 235-240.
    • (1999) FEBS Lett , vol.463 , pp. 235-240
    • Melck, D.1
  • 70
    • 38049143945 scopus 로고    scopus 로고
    • Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
    • Preet A et al. Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Oncogene 2008; 27: 339-346.
    • (2008) Oncogene , vol.27 , pp. 339-346
    • Preet, A.1
  • 71
    • 56549091431 scopus 로고    scopus 로고
    • The complexity of mitogen-activated protein kinases (MAPKs) made simple
    • Krishna M, Narang H. The complexity of mitogen-activated protein kinases (MAPKs) made simple. Cell Mol Life Sci 2008; 65: 3525-3544.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3525-3544
    • Krishna, M.1    Narang, H.2
  • 72
    • 48249115990 scopus 로고    scopus 로고
    • Beta-caryophyllene is a dietary cannabinoid
    • Gertsch J et al. Beta-caryophyllene is a dietary cannabinoid. Proc Natl Acad Sci USA 2008; 105: 9099-9104.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 9099-9104
    • Gertsch, J.1
  • 73
    • 0035951881 scopus 로고    scopus 로고
    • Human p8 is a HMG-I/Y-like protein with DNA binding activity enhanced by phosphorylation
    • Encinar JA et al. Human p8 is a HMG-I/Y-like protein with DNA binding activity enhanced by phosphorylation. J Biol Chem 2001; 276: 2742-2751.
    • (2001) J Biol Chem , vol.276 , pp. 2742-2751
    • Encinar, J.A.1
  • 74
    • 33746138649 scopus 로고    scopus 로고
    • Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
    • Carracedo A et al. Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res 2006; 66: 6748-6755.
    • (2006) Cancer Res , vol.66 , pp. 6748-6755
    • Carracedo, A.1
  • 75
    • 50649112355 scopus 로고    scopus 로고
    • JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells
    • Caffarel MM et al. JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene 2008; 27: 5033-5044.
    • (2008) Oncogene , vol.27 , pp. 5033-5044
    • Caffarel, M.M.1
  • 76
    • 57049106235 scopus 로고    scopus 로고
    • High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells
    • Widmer M et al. High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells. J Neurosci Res 2008; 86: 3212-3220.
    • (2008) J Neurosci Res , vol.86 , pp. 3212-3220
    • Widmer, M.1
  • 77
    • 33748417610 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria
    • Jia W et al. Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria. Mol Cancer Res 2006; 4: 549-562.
    • (2006) Mol Cancer Res , vol.4 , pp. 549-562
    • Jia, W.1
  • 78
    • 51449092478 scopus 로고    scopus 로고
    • Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells
    • Galanti G et al. Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells. Acta Oncol 2008; 47: 1062-1070.
    • (2008) Acta Oncol , vol.47 , pp. 1062-1070
    • Galanti, G.1
  • 79
    • 0141594998 scopus 로고    scopus 로고
    • Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: Actions on signals involved in angiogenesis and metastasis
    • Portella G et al. Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis. FASEB J 2003; 17: 1771-1773.
    • (2003) FASEB J , vol.17 , pp. 1771-1773
    • Portella, G.1
  • 80
    • 33750507764 scopus 로고    scopus 로고
    • Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells
    • Laezza C et al. Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells. FEBS Lett 2006; 580: 6076-6082.
    • (2006) FEBS Lett , vol.580 , pp. 6076-6082
    • Laezza, C.1
  • 81
    • 33746125474 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation
    • Caffarel MM et al. Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation. Cancer Res 2006; 66: 6615-6621.
    • (2006) Cancer Res , vol.66 , pp. 6615-6621
    • Caffarel, M.M.1
  • 82
    • 4644226099 scopus 로고    scopus 로고
    • Cannabinoids down-regulate PI3K/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein
    • Ellert-Miklaszewska A et al. Cannabinoids down-regulate PI3K/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein. Cell Signal 2005; 17: 25-37.
    • (2005) Cell Signal , vol.17 , pp. 25-37
    • Ellert-Miklaszewska, A.1
  • 83
    • 34249933789 scopus 로고    scopus 로고
    • Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review)
    • Bifulco M et al. Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review). Oncol Rep 2007; 17: 813-816.
    • (2007) Oncol Rep , vol.17 , pp. 813-816
    • Bifulco, M.1
  • 84
    • 0037365941 scopus 로고    scopus 로고
    • Inhibition of tumor angiogenesis by cannabinoids
    • Blazquez C et al. Inhibition of tumor angiogenesis by cannabinoids. FASEB J 2003; 17: 529-531.
    • (2003) FASEB J , vol.17 , pp. 529-531
    • Blazquez, C.1
  • 85
    • 0037253496 scopus 로고    scopus 로고
    • Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
    • Casanova ML et al. Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest 2003; 111: 43-50.
    • (2003) J Clin Invest , vol.111 , pp. 43-50
    • Casanova, M.L.1
  • 86
    • 52049101546 scopus 로고    scopus 로고
    • Tumor microenvironment and angiogenesis
    • Nyberg P et al. Tumor microenvironment and angiogenesis. Front Biosci 2008; 13: 6537-6553.
    • (2008) Front Biosci , vol.13 , pp. 6537-6553
    • Nyberg, P.1
  • 87
    • 34147215056 scopus 로고    scopus 로고
    • Antiangiogenic activity of the endocannabinoid anandamide: Correlation to its tumor-suppressor efficacy
    • Pisanti S et al. Antiangiogenic activity of the endocannabinoid anandamide: correlation to its tumor-suppressor efficacy. J Cell Physiol 2007; 211: 495-503.
    • (2007) J Cell Physiol , vol.211 , pp. 495-503
    • Pisanti, S.1
  • 88
    • 49449115823 scopus 로고    scopus 로고
    • Cannabinoids reduce granulomaassociated angiogenesis in rats by controlling transcription and expression of mast cell protease-5
    • De Filippis D et al. Cannabinoids reduce granulomaassociated angiogenesis in rats by controlling transcription and expression of mast cell protease-5. Br J Pharmacol 2008; 154: 1672-1679.
    • (2008) Br J Pharmacol , vol.154 , pp. 1672-1679
    • De Filippis, D.1
  • 89
    • 41549162387 scopus 로고    scopus 로고
    • 2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways
    • 2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways. Am J Physiol Heart Circ Physiol 2008; 294: H1145-H1155.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Montecucco, F.1
  • 90
    • 38349086382 scopus 로고    scopus 로고
    • CB2 receptor-mediated migration of immune cells: It can go either way
    • Miller AM, Stella N. CB2 receptor-mediated migration of immune cells: it can go either way. Br J Pharmacol 2008; 153: 299-308.
    • (2008) Br J Pharmacol , vol.153 , pp. 299-308
    • Miller, A.M.1    Stella, N.2
  • 91
    • 33847043132 scopus 로고    scopus 로고
    • CB2 cannabinoid receptors promote mouse neural stem cell proliferation
    • Molina-Holgado F et al. CB2 cannabinoid receptors promote mouse neural stem cell proliferation. Eur J Neurosci 2007; 25: 629-634.
    • (2007) Eur J Neurosci , vol.25 , pp. 629-634
    • Molina-Holgado, F.1
  • 92
    • 0032897969 scopus 로고    scopus 로고
    • Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2
    • Valk PJ et al. Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2. J Virol 1999; 73: 3595-3602.
    • (1999) J Virol , vol.73 , pp. 3595-3602
    • Valk, P.J.1
  • 93
    • 0036141517 scopus 로고    scopus 로고
    • Leukemic predisposition of pSca-1/Cb2 transgenic mice
    • Joosten M et al. Leukemic predisposition of pSca-1/Cb2 transgenic mice. Exp Hematol 2002; 30: 142-149.
    • (2002) Exp Hematol , vol.30 , pp. 142-149
    • Joosten, M.1
  • 94
    • 0038806692 scopus 로고    scopus 로고
    • Identification, characterization, and function of a novel oncogene: The peripheral cannabinoid receptor Cb2
    • Jorda MA et al. Identification, characterization, and function of a novel oncogene: the peripheral cannabinoid receptor Cb2. Ann NY Acad Sci 2003; 996: 10-16.
    • (2003) Ann NY Acad Sci , vol.996 , pp. 10-16
    • Jorda, M.A.1
  • 95
    • 74749094518 scopus 로고    scopus 로고
    • Antiinflammatory cannabinoids in diet - towards a better understanding of CB2 receptor action?
    • Gertsch J. Antiinflammatory cannabinoids in diet - towards a better understanding of CB2 receptor action? Commun Integr Biol 2008; 1: 26-28.
    • (2008) Commun Integr Biol , vol.1 , pp. 26-28
    • Gertsch, J.1
  • 96
    • 0034069673 scopus 로고    scopus 로고
    • Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin-10 in endotoxemic mice
    • Smith SR et al. Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin-10 in endotoxemic mice. J Pharmacol Exp Ther 2000; 293: 136-150.
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 136-150
    • Smith, S.R.1
  • 97
    • 47349126394 scopus 로고    scopus 로고
    • Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists
    • Ashton JC et al. Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists. Curr Med Chem 2008; 15: 1428-1443.
    • (2008) Curr Med Chem , vol.15 , pp. 1428-1443
    • Ashton, J.C.1
  • 98
    • 33751198532 scopus 로고    scopus 로고
    • Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma
    • Gustafsson K et al. Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma. Mol Pharmacol 2006; 70: 1612-1620.
    • (2006) Mol Pharmacol , vol.70 , pp. 1612-1620
    • Gustafsson, K.1
  • 99
    • 23944437209 scopus 로고    scopus 로고
    • Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells
    • McAllister SD et al. Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells. J Neurooncol 2005; 74: 31-40.
    • (2005) J Neurooncol , vol.74 , pp. 31-40
    • McAllister, S.D.1
  • 100
    • 33748492117 scopus 로고    scopus 로고
    • The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells
    • Massi P et al. The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells. Cell Mol Life Sci 2006; 63: 2057-2066.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2057-2066
    • Massi, P.1
  • 101
    • 1842529993 scopus 로고    scopus 로고
    • Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1
    • Contassot E et al. Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1. Gynecol Oncol 2004; 93: 182-188.
    • (2004) Gynecol Oncol , vol.93 , pp. 182-188
    • Contassot, E.1
  • 102
    • 23444431657 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol increases C6 glioma cell death produced by oxidative stress
    • Goncharov I et al. Delta9-tetrahydrocannabinol increases C6 glioma cell death produced by oxidative stress. Neuroscience 2005; 134: 567-574.
    • (2005) Neuroscience , vol.134 , pp. 567-574
    • Goncharov, I.1
  • 103
    • 1342280974 scopus 로고    scopus 로고
    • Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines
    • Massi P et al. Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. J Pharmacol Exp Ther 2004; 308: 838-845.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 838-845
    • Massi, P.1
  • 104
    • 9444229367 scopus 로고    scopus 로고
    • Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells
    • Hinz B et al. Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells. Mol Pharmacol 2004; 66: 1643-1651.
    • (2004) Mol Pharmacol , vol.66 , pp. 1643-1651
    • Hinz, B.1
  • 105
    • 0042431524 scopus 로고    scopus 로고
    • Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: Variability in response and involvement of arachidonic acid
    • Fowler CJ et al. Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid. Biochem Pharmacol 2003; 66: 757-767.
    • (2003) Biochem Pharmacol , vol.66 , pp. 757-767
    • Fowler, C.J.1
  • 106
    • 0035200613 scopus 로고    scopus 로고
    • Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors
    • Jacobsson SO et al. Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors. J Pharmacol Exp Ther 2001; 299: 951-959.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 951-959
    • Jacobsson, S.O.1
  • 107
    • 0035885205 scopus 로고    scopus 로고
    • Antitumor effects of ajulemic acid (CT3), a synthetic non-psychoactive cannabinoid
    • Recht LD et al. Antitumor effects of ajulemic acid (CT3), a synthetic non-psychoactive cannabinoid. Biochem Pharmacol 2001; 62: 755-763.
    • (2001) Biochem Pharmacol , vol.62 , pp. 755-763
    • Recht, L.D.1
  • 108
    • 0035422139 scopus 로고    scopus 로고
    • Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor
    • Sanchez C et al. Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. Cancer Res 2001; 61: 5784-5789.
    • (2001) Cancer Res , vol.61 , pp. 5784-5789
    • Sanchez, C.1
  • 109
    • 44849139287 scopus 로고    scopus 로고
    • Exploring the substituent effects on a novel series of C1′-dimethyl-aryl Delta8-tetrahydrocannabinol analogs
    • Krishnamurthy M et al. Exploring the substituent effects on a novel series of C1′-dimethyl-aryl Delta8-tetrahydrocannabinol analogs. Bioorg Med Chem 2008; 16: 6489-6500.
    • (2008) Bioorg Med Chem , vol.16 , pp. 6489-6500
    • Krishnamurthy, M.1
  • 110
    • 0023278311 scopus 로고
    • Interaction of delta-9-tetrahydrocannabinol with rat B103 neuroblastoma cells
    • Cabral GA et al. Interaction of delta-9-tetrahydrocannabinol with rat B103 neuroblastoma cells. Arch Toxicol 1987; 60: 438-449.
    • (1987) Arch Toxicol , vol.60 , pp. 438-449
    • Cabral, G.A.1
  • 111
    • 0017698323 scopus 로고
    • A comparative study of the disposition of (-)-delta 9-tetrahydrocannabinol in neuroblastoma and glioma cells in tissue culture: Relation cellular impairment
    • End DW et al. A comparative study of the disposition of (-)-delta 9-tetrahydrocannabinol in neuroblastoma and glioma cells in tissue culture: relation cellular impairment. Mol Pharmacol 1977; 13: 864-871.
    • (1977) Mol Pharmacol , vol.13 , pp. 864-871
    • End, D.W.1
  • 112
    • 33747592582 scopus 로고    scopus 로고
    • Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression
    • McKallip RJ et al. Cannabidiol-induced apoptosis in human leukemia cells: a novel role of cannabidiol in the regulation of p22phox and Nox4 expression. Mol Pharmacol 2006; 70: 897-908.
    • (2006) Mol Pharmacol , vol.70 , pp. 897-908
    • McKallip, R.J.1
  • 113
    • 24144455626 scopus 로고    scopus 로고
    • p38 MAPK is involved in CB2 receptor induced apoptosis of human leukaemia cells
    • Herrera B et al. p38 MAPK is involved in CB2 receptor induced apoptosis of human leukaemia cells. FEBS Lett 2005; 579: 5084-5088.
    • (2005) FEBS Lett , vol.579 , pp. 5084-5088
    • Herrera, B.1
  • 114
    • 20544444202 scopus 로고    scopus 로고
    • Targeting cannabinoid receptors to treat leukemia: Role of cross-talk between extrinsic and intrinsic pathways in Delta9-tetrahydrocannabinol (THC)-induced apoptosis of Jurkat cells
    • Lombard C et al. Targeting cannabinoid receptors to treat leukemia: role of cross-talk between extrinsic and intrinsic pathways in Delta9-tetrahydrocannabinol (THC)-induced apoptosis of Jurkat cells. Leuk Res 2005; 29: 915-922.
    • (2005) Leuk Res , vol.29 , pp. 915-922
    • Lombard, C.1
  • 115
    • 0037100312 scopus 로고    scopus 로고
    • Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
    • McKallip RJ et al. Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood 2002; 100: 627-634.
    • (2002) Blood , vol.100 , pp. 627-634
    • McKallip, R.J.1
  • 116
    • 0021679685 scopus 로고
    • Effects of ethanol, CBD and delta THC on proliferation of K-562 cells
    • Dvilansky A et al. Effects of ethanol, CBD and delta THC on proliferation of K-562 cells. Int J Tissue React 1984; 6: 409-412.
    • (1984) Int J Tissue React , vol.6 , pp. 409-412
    • Dvilansky, A.1
  • 117
    • 0017643130 scopus 로고
    • Effects of cannabinoids on L1210 murine leukemia. 1. Inhibition of DNA synthesis
    • Tucker AN, Friedman MA. Effects of cannabinoids on L1210 murine leukemia. 1. Inhibition of DNA synthesis. Res Commun Chem Pathol Pharmacol 1977; 17: 703-714.
    • (1977) Res Commun Chem Pathol Pharmacol , vol.17 , pp. 703-714
    • Tucker, A.N.1    Friedman, M.A.2
  • 118
    • 0017253510 scopus 로고
    • The inhibition of DNA synthesis by cannabinoids
    • Carchman RA et al. The inhibition of DNA synthesis by cannabinoids. Cancer Res 1976; 36: 95-100.
    • (1976) Cancer Res , vol.36 , pp. 95-100
    • Carchman, R.A.1
  • 119
    • 28844473489 scopus 로고    scopus 로고
    • Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma
    • Flygare J et al. Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma. FEBS Lett 2005; 579: 6885-6889.
    • (2005) FEBS Lett , vol.579 , pp. 6885-6889
    • Flygare, J.1
  • 120
    • 58849113520 scopus 로고    scopus 로고
    • Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: Synergism with 5-fluorouracil
    • Gustafsson SB et al. Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: synergism with 5-fluorouracil. Cancer Chemother Pharmacol 2008; 63: 691-701.
    • (2008) Cancer Chemother Pharmacol , vol.63 , pp. 691-701
    • Gustafsson, S.B.1
  • 121
    • 0017607282 scopus 로고
    • In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas
    • Friedmann MA. In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas. Cancer Biochem Biophys 1977; 2: 51-54.
    • (1977) Cancer Biochem Biophys , vol.2 , pp. 51-54
    • Friedmann, M.A.1
  • 122
    • 0017104302 scopus 로고
    • Effects of delta9-tetrahydrocannabinol in Lewis lung adenocarcinoma cells in tissue culture
    • White AC et al. Effects of delta9-tetrahydrocannabinol in Lewis lung adenocarcinoma cells in tissue culture. J Natl Cancer Inst 1976; 56: 655-658.
    • (1976) J Natl Cancer Inst , vol.56 , pp. 655-658
    • White, A.C.1
  • 123
    • 28144431771 scopus 로고    scopus 로고
    • The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: A possible role for cyclooxygenase 2
    • Patsos HA et al. The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2. Gut 2005; 54: 1741-1750.
    • (2005) Gut , vol.54 , pp. 1741-1750
    • Patsos, H.A.1
  • 124
    • 0042972716 scopus 로고    scopus 로고
    • Possible endocannabinoid control of colorectal cancer growth
    • Ligresti A et al. Possible endocannabinoid control of colorectal cancer growth. Gastroenterology 2003; 125: 677-687.
    • (2003) Gastroenterology , vol.125 , pp. 677-687
    • Ligresti, A.1
  • 125
    • 33644901536 scopus 로고    scopus 로고
    • Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism
    • Fogli S et al. Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism. FEBS Lett 2006; 580: 1733-1739.
    • (2006) FEBS Lett , vol.580 , pp. 1733-1739
    • Fogli, S.1
  • 126
    • 33748933891 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits human breast cancer cell proliferation through a lipid raft-mediated mechanism
    • Sarnataro D et al. The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits human breast cancer cell proliferation through a lipid raft-mediated mechanism. Mol Pharmacol 2006; 70: 1298-1306.
    • (2006) Mol Pharmacol , vol.70 , pp. 1298-1306
    • Sarnataro, D.1
  • 127
    • 0036399326 scopus 로고    scopus 로고
    • Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems
    • De Petrocellis L et al. Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems. Fundam Clin Pharmacol 2002; 16: 297-302.
    • (2002) Fundam Clin Pharmacol , vol.16 , pp. 297-302
    • De Petrocellis, L.1
  • 128
    • 0035881542 scopus 로고    scopus 로고
    • Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells
    • Di Marzo V et al. Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells. Biochem J 2001; 358: 249-255.
    • (2001) Biochem J , vol.358 , pp. 249-255
    • Di Marzo, V.1
  • 129
    • 0034465259 scopus 로고    scopus 로고
    • Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation
    • Melck D et al. Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. Endocrinology 2000; 141: 118-126.
    • (2000) Endocrinology , vol.141 , pp. 118-126
    • Melck, D.1
  • 130
    • 0032526098 scopus 로고    scopus 로고
    • Biosynthesis and degradation of bioactive fatty acid amides in human breast cancer and rat pheochromocytoma cells-implications for cell proliferation and differentiation
    • Bisogno T et al. Biosynthesis and degradation of bioactive fatty acid amides in human breast cancer and rat pheochromocytoma cells-implications for cell proliferation and differentiation. Eur J Biochem 1998; 254: 634-642.
    • (1998) Eur J Biochem , vol.254 , pp. 634-642
    • Bisogno, T.1
  • 131
    • 0032493378 scopus 로고    scopus 로고
    • The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
    • De Petrocellis L et al. The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. Proc Natl Acad Sci USA 1998; 95: 8375-8380.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8375-8380
    • De Petrocellis, L.1
  • 132
    • 16444375370 scopus 로고    scopus 로고
    • Cannabinoid receptor as a novel target for the treatment of prostate cancer
    • Sarfaraz S et al. Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Res 2005; 65: 1635-1641.
    • (2005) Cancer Res , vol.65 , pp. 1635-1641
    • Sarfaraz, S.1
  • 133
    • 0038751939 scopus 로고    scopus 로고
    • Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: Implication of epidermal growth factor receptor down-regulation and ceramide production
    • Mimeault M et al. Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production. Prostate 2003; 56: 1-2.
    • (2003) Prostate , vol.56 , pp. 1-2
    • Mimeault, M.1
  • 134
    • 0037380894 scopus 로고    scopus 로고
    • ASK1-p38 MAPK/JNK signaling cascade mediates anandamide-induced PC12 cell death
    • Sarker KP et al. ASK1-p38 MAPK/JNK signaling cascade mediates anandamide-induced PC12 cell death. J Neurochem 2003; 85: 50-51.
    • (2003) J Neurochem , vol.85 , pp. 50-51
    • Sarker, K.P.1
  • 135
    • 0032586054 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism
    • Ruiz L et al. Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism. FEBS Lett 1999; 458: 400-404.
    • (1999) FEBS Lett , vol.458 , pp. 400-404
    • Ruiz, L.1
  • 136
    • 41149153235 scopus 로고    scopus 로고
    • A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells
    • Lee CY et al. A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells. Int Immunopharmacol 2008; 8: 732-740.
    • (2008) Int Immunopharmacol , vol.8 , pp. 732-740
    • Lee, C.Y.1
  • 137
    • 34250378332 scopus 로고    scopus 로고
    • Opposing actions of endocannabinoids on cholangiocarcinoma growth: Recruitment of Fas and Fas ligand to lipid rafts
    • De Morrow S et al. Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts. J Biol Chem 2007; 282: 13098-13113.
    • (2007) J Biol Chem , vol.282 , pp. 13098-13113
    • De Morrow, S.1
  • 138
    • 62649170623 scopus 로고    scopus 로고
    • Apoptosis induced in HepG2 cells by the synthetic cannabinoid WIN: Involvement of the transcription factor PPARgamma
    • Giuliano M et al. Apoptosis induced in HepG2 cells by the synthetic cannabinoid WIN: involvement of the transcription factor PPARgamma. Biochimie 2009; 91: 457-465.
    • (2009) Biochimie , vol.91 , pp. 457-465
    • Giuliano, M.1
  • 139
    • 38349022657 scopus 로고    scopus 로고
    • Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma
    • Shi Y et al. Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma. Cancer Gene Ther 2008; 15: 101-107.
    • (2008) Cancer Gene Ther , vol.15 , pp. 101-107
    • Shi, Y.1
  • 140
    • 77952236107 scopus 로고    scopus 로고
    • A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis
    • Feb 3 Epub ahead of print
    • Cozzolino R et al. A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis. Invest New Drugs 2009; Feb 3 (Epub ahead of print).
    • (2009) Invest New Drugs
    • Cozzolino, R.1
  • 141
    • 66449121455 scopus 로고    scopus 로고
    • Lipid G-protein-coupled receptor ligand identification using beta-arrestin pathhunter assay
    • Yin H et al. Lipid G-protein-coupled receptor ligand identification using beta-arrestin pathhunter assay. J Biol Chem 2009; 284: 12328-12338.
    • (2009) J Biol Chem , vol.284 , pp. 12328-12338
    • Yin, H.1
  • 142
    • 58149386386 scopus 로고    scopus 로고
    • The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing
    • Nguyen et al. The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing. Proc Natl Acad Sci USA 2008; 105: 19750-19755.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19750-19755
    • Nguyen1
  • 143
    • 36448995830 scopus 로고    scopus 로고
    • GPR55: A new member of the cannabinoid receptor clan?
    • Pertwee RG. GPR55: a new member of the cannabinoid receptor clan? Br J Pharmacol 2007; 152: 984-986.
    • (2007) Br J Pharmacol , vol.152 , pp. 984-986
    • Pertwee, R.G.1
  • 144
    • 40649102938 scopus 로고    scopus 로고
    • GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current
    • Lauckner JE et al. GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current. Proc Natl Acad Sci USA 2008; 105: 2699-2704.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 2699-2704
    • Lauckner, J.E.1
  • 145
    • 58249109364 scopus 로고    scopus 로고
    • The GPR55 ligand L-alpha- lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation
    • Henstridge CM et al. The GPR55 ligand L-alpha- lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation. FASEB J 2009; 23: 183-193.
    • (2009) FASEB J , vol.23 , pp. 183-193
    • Henstridge, C.M.1
  • 146
    • 0037261140 scopus 로고    scopus 로고
    • NF-ATc induces apoptosis in Burkitt's lymphoma cells through signaling via the B cell antigen receptor
    • Kondo E et al. NF-ATc induces apoptosis in Burkitt's lymphoma cells through signaling via the B cell antigen receptor. Eur J Immunol 2003; 33: 1-11.
    • (2003) Eur J Immunol , vol.33 , pp. 1-11
    • Kondo, E.1
  • 147
    • 38449109178 scopus 로고    scopus 로고
    • 5-Lipoxygenase and anadamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid
    • Massi P et al. 5-Lipoxygenase and anadamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. J Neurochem 2008; 104: 1091-1100.
    • (2008) J Neurochem , vol.104 , pp. 1091-1100
    • Massi, P.1
  • 148
    • 27744562012 scopus 로고    scopus 로고
    • Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells
    • Sarnataro D et al. Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. FEBS Lett 2005; 579: 6343-6349.
    • (2005) FEBS Lett , vol.579 , pp. 6343-6349
    • Sarnataro, D.1
  • 149
    • 33947697100 scopus 로고    scopus 로고
    • Biochemistry and pharmacology of endovanilloids
    • Starowicz K et al. Biochemistry and pharmacology of endovanilloids. Pharmacol Ther 2007; 114: 13-33.
    • (2007) Pharmacol Ther , vol.114 , pp. 13-33
    • Starowicz, K.1
  • 150
    • 23044475561 scopus 로고    scopus 로고
    • PPAR-gamma: A nuclear receptor with affinity for cannabinoids
    • Burstein S. PPAR-gamma: a nuclear receptor with affinity for cannabinoids. Life Sci 2005; 77: 1674-1684.
    • (2005) Life Sci , vol.77 , pp. 1674-1684
    • Burstein, S.1
  • 151
    • 38049185265 scopus 로고    scopus 로고
    • Inhibition of cancer cell invasion by cannabinoids via increased expressionof tissue inhibitor of matrix metalloproteinases-1
    • Ramer R, Hinz B. Inhibition of cancer cell invasion by cannabinoids via increased expressionof tissue inhibitor of matrix metalloproteinases-1. J Natl Cancer Inst 2008; 100: 59-69.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 59-69
    • Ramer, R.1    Hinz, B.2
  • 152
    • 44249117614 scopus 로고    scopus 로고
    • Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8
    • De Petrocellis L et al. Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8. J Pharmacol Exp Ther 2008; 325: 1007-1015.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 1007-1015
    • De Petrocellis, L.1
  • 153
    • 34547107881 scopus 로고    scopus 로고
    • Ajulemic acid, a synthetic nonpsychoactive cannabinoid acid, bound to the ligand binding domain of the human peroxisome proliferator-activated receptor gamma
    • Ambrosio Al et al. Ajulemic acid, a synthetic nonpsychoactive cannabinoid acid, bound to the ligand binding domain of the human peroxisome proliferator-activated receptor gamma. J Biol Chem 2007; 282: 18625-18633.
    • (2007) J Biol Chem , vol.282 , pp. 18625-18633
    • Ambrosio, A.1
  • 154
    • 16444375370 scopus 로고    scopus 로고
    • Cannabinoid receptor as a novel target for the treatment of prostate cancer
    • Sarfaraz S et al. Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Res 2005; 65: 1635-1641.
    • (2005) Cancer Res , vol.65 , pp. 1635-1641
    • Sarfaraz, S.1
  • 155
    • 48749102177 scopus 로고    scopus 로고
    • Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1)
    • Holland ML et al. Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1). Eur J Pharmacol 2008; 591: 128-131.
    • (2008) Eur J Pharmacol , vol.591 , pp. 128-131
    • Holland, M.L.1
  • 156
    • 35648948415 scopus 로고    scopus 로고
    • The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids
    • Holland ML et al. The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. Br J Pharmacol 2007; 152: 815-824.
    • (2007) Br J Pharmacol , vol.152 , pp. 815-824
    • Holland, M.L.1
  • 157
    • 33644828740 scopus 로고    scopus 로고
    • The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells
    • Holland ML et al. The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. Biochem Pharmacol 2006; 71: 1146-1154.
    • (2006) Biochem Pharmacol , vol.71 , pp. 1146-1154
    • Holland, M.L.1
  • 158
    • 33745620507 scopus 로고    scopus 로고
    • Modulation of P-glycoprotein activity by cannabinoid molecules in HK-2 renal cells
    • Nieri P et al. Modulation of P-glycoprotein activity by cannabinoid molecules in HK-2 renal cells. Br J Pharmacol 2006; 148: 682-687.
    • (2006) Br J Pharmacol , vol.148 , pp. 682-687
    • Nieri, P.1
  • 159
    • 33645841349 scopus 로고    scopus 로고
    • Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana
    • Zhu HJ et al. Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana. J Pharmacol Exp Ther 2006; 317: 850-757.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 850-757
    • Zhu, H.J.1
  • 160
    • 33747624175 scopus 로고    scopus 로고
    • Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
    • Ligresti A et al. Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. J Pharmacol Exp Ther 2006; 318: 1375-1387.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 1375-1387
    • Ligresti, A.1
  • 161
    • 45549095987 scopus 로고    scopus 로고
    • The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development
    • Zheng D et al. The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development. Cancer Res 2008; 68: 3992-3998.
    • (2008) Cancer Res , vol.68 , pp. 3992-3998
    • Zheng, D.1
  • 162
    • 34250323489 scopus 로고    scopus 로고
    • Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis
    • Aguado T et al. Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis. J Biol Chem 2007; 282: 6854-6862.
    • (2007) J Biol Chem , vol.282 , pp. 6854-6862
    • Aguado, T.1
  • 163
    • 57649242673 scopus 로고    scopus 로고
    • A high cannabinoid CB(1) receptor immunoreactivity is associated with disease severity and outcome in prostate cancer
    • Chung SC et al. A high cannabinoid CB(1) receptor immunoreactivity is associated with disease severity and outcome in prostate cancer. Eur J Cancer 2009; 45: 174-182.
    • (2009) Eur J Cancer , vol.45 , pp. 174-182
    • Chung, S.C.1
  • 164
    • 41549121013 scopus 로고    scopus 로고
    • Cannabinoids in the management of difficult to treat pain
    • Russo EB. Cannabinoids in the management of difficult to treat pain. Ther Clin Risk Manag 2008; 4: 245-259.
    • (2008) Ther Clin Risk Manag , vol.4 , pp. 245-259
    • Russo, E.B.1
  • 165
    • 34548255920 scopus 로고    scopus 로고
    • Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting: Beyond prevention of acute emesis
    • Slatkin NE. Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting: beyond prevention of acute emesis. J Support Oncol 2007; 5: 1-9.
    • (2007) J Support Oncol , vol.5 , pp. 1-9
    • Slatkin, N.E.1
  • 166
    • 14844362003 scopus 로고    scopus 로고
    • Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response
    • McKallip RJ et al. Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response. J Immunol 2005; 174: 3281-3289.
    • (2005) J Immunol , vol.174 , pp. 3281-3289
    • McKallip, R.J.1
  • 167
    • 38449100291 scopus 로고    scopus 로고
    • TNF and cancer: The two sides of the coin
    • Mocellin S, Nitti D. TNF and cancer: the two sides of the coin. Front Biosci 2008; 13: 2774-2783.
    • (2008) Front Biosci , vol.13 , pp. 2774-2783
    • Mocellin, S.1    Nitti, D.2
  • 168
    • 42649124339 scopus 로고    scopus 로고
    • TNF: A master switch for inflammation to cancer
    • Sethi G et al. TNF: a master switch for inflammation to cancer. Front Biosci 2008; 13: 5094-5107.
    • (2008) Front Biosci , vol.13 , pp. 5094-5107
    • Sethi, G.1
  • 169
    • 51049102995 scopus 로고    scopus 로고
    • Loss of cannabinoid receptor 1 accelerates intestinal tumor growth
    • Wang D et al. Loss of cannabinoid receptor 1 accelerates intestinal tumor growth. Cancer Res 2008; 68: 6468-6476.
    • (2008) Cancer Res , vol.68 , pp. 6468-6476
    • Wang, D.1
  • 170
    • 38149055682 scopus 로고    scopus 로고
    • Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon
    • Izzo AA et al. Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon. J Mol Med 2008; 86: 89-98.
    • (2008) J Mol Med , vol.86 , pp. 89-98
    • Izzo, A.A.1
  • 171
    • 65449146377 scopus 로고    scopus 로고
    • Emerging strategies for exploiting cannabinoid receptor agonists as medicines
    • Pertwee RG. Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br J Pharmacol 2009; 156: 397-411.
    • (2009) Br J Pharmacol , vol.156 , pp. 397-411
    • Pertwee, R.G.1
  • 172
    • 52349114996 scopus 로고    scopus 로고
    • Enhancing the in vitro cytotoxic activity of Delta-9-tetrahydrocannabinol in leukemic cells through combinatorial approach
    • Liu WM et al. Enhancing the in vitro cytotoxic activity of Delta-9-tetrahydrocannabinol in leukemic cells through combinatorial approach. Leuk Lymphoma 2008; 49: 1800-1809.
    • (2008) Leuk Lymphoma , vol.49 , pp. 1800-1809
    • Liu, W.M.1
  • 173
    • 52449107732 scopus 로고    scopus 로고
    • Medicinal plants and cancer chemoprevention
    • Desai AG et al. Medicinal plants and cancer chemoprevention. Curr Drug Metab 2008; 9: 581-591.
    • (2008) Curr Drug Metab , vol.9 , pp. 581-591
    • Desai, A.G.1
  • 174
    • 38149049269 scopus 로고    scopus 로고
    • Cannabinoids as potential new therapy for the treatment of gliomas
    • Parolaro D, Massi P. Cannabinoids as potential new therapy for the treatment of gliomas. Expert Rev Neurother 2008; 8: 37-49.
    • (2008) Expert Rev Neurother , vol.8 , pp. 37-49
    • Parolaro, D.1    Massi, P.2
  • 175
    • 0030774482 scopus 로고    scopus 로고
    • Marijuana use and cancer incidence (California, United States)
    • Sidney S et al. Marijuana use and cancer incidence (California, United States). Cancer Causes Control 1997; 8: 722-728.
    • (1997) Cancer Causes Control , vol.8 , pp. 722-728
    • Sidney, S.1
  • 176
    • 39649085680 scopus 로고    scopus 로고
    • Cannabis use and risk of lung cancer: A case-control study
    • Aldington S et al. Cannabis use and risk of lung cancer: a case-control study. Eur Respir J 2008; 31: 280-286.
    • (2008) Eur Respir J , vol.31 , pp. 280-286
    • Aldington, S.1
  • 177
    • 58149374478 scopus 로고    scopus 로고
    • Doubts about the role of cannabis in causing lung cancer
    • Sewell RA et al. Doubts about the role of cannabis in causing lung cancer. Eur Respir J 2008; 32: 815-816.
    • (2008) Eur Respir J , vol.32 , pp. 815-816
    • Sewell, R.A.1
  • 178
    • 63449100550 scopus 로고    scopus 로고
    • Association of marijuana use and the incidence of testicular germ cell tumors
    • Daling et al. Association of marijuana use and the incidence of testicular germ cell tumors. Cancer 2009; 115: 1215-1223.
    • (2009) Cancer , vol.115 , pp. 1215-1223
    • Daling1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.