Effects of lead on gene expression

NeuroToxicology

Volumn 21, Issue 6, 2000, Pages 1045-1055

  Bouton, C M L S ^a   Pevsner, J ^a  

^a KENNEDY KRIEGER INSTITUTE   (United States)

Author keywords

Calcium; Metal; Microarray; Transcription; Zinc

Indexed keywords

CALCIUM; DNA; LEAD; METAL; TRANSCRIPTION FACTOR; ZINC;

BINDING AFFINITY; BINDING SITE; CONFERENCE PAPER; DNA MICROARRAY; GENE EXPRESSION SYSTEM; GENE MUTATION; GENE TARGETING; GENOME; HEALTH HAZARD; HUMAN; LEAD POISONING; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CALCIUM SIGNALING; GENE EXPRESSION; HUMANS; LEAD; ZINC;

EID: 0034470353     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (90)

1. Lead intoxication: Antioxidant defenses and oxidative damage in rat brain
2. Application of complementary DNA microarray technology to carcinogen identification, toxicology, and drug safety evaluation
3. Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead
4. Gene regulation by nuclear and cytoplasmic calcium signals
5. Functional analysis of the proximal 5′-flanking region of the N-Methyl-D-asparate receptor subunit gene, NMDAR1
6. Phosphorylation of membrane proteins in erythrocytes treated with lead
7. Zinc fingers and other metal-binding domains
8. Lessons from zinc-binding peptides
9. Lead binding to gamma-aminolevulinic acid dehydratase (ALAD) in human erythrocytes
10. The role of the blood-brain barrier in neurotoxicology
11. Mechanisms of lead neurotoxicity
12. Molecular mechanisms of lead neurotoxicity
13. Regulation of translational initiation during cellular responses to stress
14. Expression of the NMDAR1 subunit and its relationship to Sp1 DNA-binding in the rat hippocampus following developmental lead exposure
15. Calcium channels as target sites of heavy metals
16. 2+ reduces voltage-and N-methyl-D-asparate (NMDA)-activated calcium channel currents
17. Increased AP-1 DNA binding activity in PC12 cells treated with lead
18. Zinc and brain injury
19. Effects of lead on rat kidney and liver: GST expression and oxidative stress
20. Stimulation of sialytransferaseby subchronic low-level lead exposure in the developing nervous system
21. Lead reduces depolarization-induced calcium entry in cultured DRG neurons without crossing the cell membrane: Fura-2 measurements
22. Regulation of inducible nitric oxide synthase expression in b cells by environmental factors: Heavy metals
23. Low-level lead-induced neurotoxicology in children: An update on central nervous system effects
24. Transcription factor AP-1, and the role of Fra-2
25. Roles of lead-binding proteins in mediating lead bioavailability
26. Lead-binding proteins of intestinal calcium-binding proteins
27. Calcium regulation of gene expression: Isn't that spatial?
28. Lead-protein interactions as a basis for lead toxicity
29. Neurologic concepts of lead poisoning in children
30. Evidence that lead acts as a calcium substitute in second messenger metabolism
31. Lead activates calmodulin sensitive processes
32. Hippocampal NMDA receptor mRNA undergoes subunit specific changes during developmental lead exposure
33. 2+ neurotoxicity
34. 2+ in calmodulin
35. Lead inhibition of DNA-binding mechanism of Cys(2)His(2) zinc finger proteins
36. Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression
37. Lead-induced alterations of glial fibrillary acidic protein (GFAP) in the developing rat brain
38. Correlation between lead-induced changes in cerebral ornithine decarboxylase and protein kinase C activities during development and in cultured PC12 cells
39. Signal integration at the c-fos promoter
40. The genetic effects of environmental lead
41. Induction of metallothionein synthesis by bismuth in cultured vascular endothelial cells
42. Metalloenzymes, structural motifs, and inorganic models
43. Induction of c-fos mRNA by lead in PC12 cells
44. Immediate early gene expression in PC12 cells exposed to lead: Requirement for protein kinase C
45. Effects of toxic levels of lead on gene regulation in the male axis: Increase in messenger ribonucleic acids and intracellular stores of gonadotrophs within the central nervous system
46. Induction of metallothionein mRNA and protein in murine astrocyte cultures
47. Lead poisoning
48. Presynaptic glutamatergic function in dentate gyrus in vivo is diminished by chronic exposure to inorganic lead
49. Inhibition of astroglia-induced endothelial differentiation by inorganic lead: A role for protein kinase C
50. Picomolar concentrations of lead stimulate brain protein kinase C
51. Drug target validation and identification of secondary drug target effects using DNA microarrays
52. The chipping forecast
53. The long-term effects of exposure to low doses of lead in childhood
54. Childhood lead poisoning
55. Childhood lead poisoning: The promise and abandonment of primary prevention
56. 2+ during development
57. Microarrays and toxicology: The advent of toxicogenomics
58. Transition metals in control of gene expression
59. Relationship of lead-induced proteins to stress response proteins in astroglial cells
60. Metal ion binding to calmodulin: NMR and fluorescence studies
61. 2+ binding to structural zinc-binding domains determined directly by monitoring lead-thiolate charge-transfer bands
62. Lead-induced developmental changes in AP-1 DNA Binding in Rat Brain
63. Effects of chronic low level lead exposure on the expression of GFAP and Vimentin mRNA in the rat brain hippocampus analysed by In situ hybridization
64. Inorganic lead activates NF-kB in primary human CD4+ T lymphocytes
65. Lead activates Nuclear Transcription Factor-kB, Activator Protein-1, and amino-terminal c-Jun kinase in Pheochromacytoma cells
66. 2+-binding domain
67. Effect of treatment with mercury chloride and lead acetate during the second stage of rapid postnatal brain growth on gamma-aminolevulinic acid dehydratase (ALAD) activity in brain, liver, kidney and blood of suckling rats
68. Application of DNA array to toxicology
69. Increase in hypothalamic pro-opiomelanocortin gene expression in response to prolonged low level lead exposure
70. Calmodulin and cAMP dependent synaptic vesicle protein phosphorylation in rat cortex following lead exposure
71. Effect of lead on the biological activity of calmodulin in rat brain
72. Lead perturbs calmodulin dependent cyclic AMP metabolism in rat central nervous system
73. Interactions of excitatory neurotransmitters and xenobiotics in excitotoxicity and oxidative stress: Glutamate and lead
74. Lead induced rise in intracellular free calcium is mediated through activation of protein kinase C in osteoblastic bone cells
75. GAP-43 mRNA expression in the developing rat brain: Alterations following lead-acetate exposure
76. Lead/cytokine-mediated oxidative DNA damage in cultured mouse hepatocytes
77. Lead-calcium interactions in cellular lead toxicity
78. The Ca-calmodulin-dependent protein kinase cascade
79. Glial fibrillary, acidic protein and RNA expression in adult rat hippocampus following low-level lead exposure during development
80. Activation of Glutathione Transferase P gene by lead requires Glutathione Transferase P Enhancer I
81. Cell culture models for lead toxicity in neuronal and glial cells
82. Lead poisoning, haem synthesis and 5-aminolaevulinic acid dehydratase
83. Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization
84. A study on oxidative stress in lead-exposed workers
85. Trimethyltin-induced c-fos expression: Adolescent vs neonatal rat hippocampus
86. Developmental exposure to lead interferes with glial and nueronal differential gene expression in the rat cerebellum
87. Developmental profiles of ornithine decarboxylase activity in the hippocampus, neocortex and cerebellum: Modulation following lead exposure
88. Sp1 as a target site for metal-induced perturbations of transcriptional regulation of developmental brain gene expression
89. Toxic metal-responsive gene transcription