Interaction between arsenic trioxide and human primary cells: Emphasis on human cells of myeloid origin

Inflammation and Allergy - Drug Targets

Volumn 8, Issue 1, 2009, Pages 21-27

  Binet, François ^a   Antoine, Francis ^a   Girard, Denis ^a  

^a UNIVERSITÉ LAVAL   (Canada)

Author keywords

Apoptosis; Arsenic trioxide; Cell functions; Cell signaling; Macrophages; Monocytes; Neutrophils

Indexed keywords

ARSENIC TRIOXIDE; CASPASE 3; CASPASE 8; CYTOSKELETON PROTEIN; HEAT SHOCK PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

BONE MARROW CELL; CANCER CELL; CANCER CHEMOTHERAPY; CELL ADHESION; CELL DIFFERENTIATION; CELL FUNCTION; CELL POPULATION; CELL PROLIFERATION; CHROMOSOME TRANSLOCATION; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; IMMUNOCOMPETENT CELL; MACROPHAGE; MONOCYTE; NEUTROPHIL; NONHUMAN; PROMYELOCYTIC LEUKEMIA; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARSENICALS; CELL DEGRANULATION; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; LEUKEMIA, PROMYELOCYTIC, ACUTE; MAP KINASE SIGNALING SYSTEM; MYELOID CELLS; NADPH OXIDASE; OXIDATIVE STRESS; OXIDES; REACTIVE OXYGEN SPECIES;

EID: 70349510144     PISSN: 18715281     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152809787582516     Document Type: Review

References (61)

1. Yoshida, T.; Yamauchi, H.; Fan Sun, G. Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review. Toxicol. Appl. Pharmacol., 2004, 198, 243-252.
2. Mervis, J. Ancient remedy performs new tricks. Science, 1996, 273, 578.
3. Sears, D.A. History of the treatment of chronic myelocytic leukemia. Am. J. Med. Sci., 1988, 296, 85-86.
4. Shen, Z.Y.; Shen, W.Y.; Chen, M.H.; Shen, J.; Zeng, Y. Reactive oxygen species and antioxidants in apoptosis of esophageal cancer cells induced by As2O3. Int. J. Mol. Med., 2003, 11, 479-484.
5. Shen, Z.X.; Chen, G.Q.; Ni, J.H.; Li, X.S.; Xiong, S.M.; Qiu, Q.Y.; Zhu, J.; Tang, W.; Sun, G.L.; Yang, K.Q.; Chen, Y.; Zhou, L.; Fang, Z.W.; Wang, Y.T.; Ma, J.; Zhang, P.; Zhang, T.D.; Chen, S.J.; Chen, Z.; Wang, Z.Y. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood, 1997, 89, 3354-3360.
6. Yoshida, T.; Yamauchi, H.; Fan Sun, G. Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review. Toxicol. Appl. Pharmacol., 2004, 198, 243-252.
7. Cai, X.; Shen, Y.L.; Zhu, Q.; Jia, P.M.; Yu, Y.; Zhou, L.; Huang, Y.; Zhang, J.W.; Xiong, S.M.; Chen, S.J.; Wang, Z.Y.; Chen, Z.; Chen, G.Q. Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia. Leukemia, 2000, 14, 262-270.
8. Leoni, F.; Gianfaldoni, G.; Annunziata, M.; Fanci, R.; Ciolli, S.; Nozzoli, C.; Ferrara, F. Arsenic trioxide therapy for relapsed acute promyelocytic leukemia: a bridge to transplantation. Haematologica, 2002, 87, 485-489.
9. Rojewski, M.T.; Baldus, C.; Knauf, W.; Thiel, E.; Schrezenmeier, H. Dual effects of arsenic trioxide (As2O3) on non-acute promyelocytic leukaemia myeloid cell lines: induction of apoptosis and inhibition of proliferation. Br. J. Haematol., 2002, 116, 555-563.
10. Rousselot, P.; Labaume, S.; Marolleau, J.P.; Larghero, J.; Noguera, M.H.; Brouet, J.C.; Fermand, J.P. Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients. Cancer Res., 1999, 59, 1041-1048.
11. Gupta, S., Yel, L.; Kim, D.; Kim, C.; Chiplunkar, S.; Gollapudi, S. Arsenic trioxide induces apoptosis in peripheral blood T lymphocyte subsets by inducing oxidative stress: a role of Bcl-2. Mol. Cancer Ther., 2003, 2, 711-719.
12. Hussein, M.A.; Saleh, M.; Ravandi, F.; Mason, J.; Rifkin, R.M.; Ellison, R. Phase 2 study of arsenic trioxide in patients with relapsed or refractory multiple myeloma. Br. J. Haematol., 2004, 125, 470-476.
13. Munshi, N.C.; Tricot, G.; Desikan, R.; Badros, A.; Zangari, M.; Toor, A.; Morris, C.; Anaissie, E.; Barlogie, B. Clinical activity of arsenic trioxide for the treatment of multiple myeloma. Leukemia, 2002, 16, 1835-1837.
14. Korper, S.; Nolte, F.; Thiel, E.; Schrezenmeier, H.; Rojewski, M.T. The role of mitochondrial targeting in arsenic trioxide-induced apoptosis in myeloid cell lines. Br. J. Haematol., 2004, 124, 186-189.
15. Zuo, L.; Li, J.; Yang, Y.; Wang, X.; Shen, T.; Xu, C.M.; Zhang, Z.N. Sodium selenite induces apoptosis in acute promyelocytic leukemia-derived NB4 cells by a caspase-3-dependent mechanism and a redox pathway different from that of arsenic trioxide. Ann. Hematol., 2004, 83, 751-758.
16. Wang, H.Y.; Liu, S.X.; Zhang, M. Gene expression profile changes in NB4 cells induced by arsenic trioxide. Acta Pharmacol. Sin., 2003, 24, 646-650.
17. Sturlan, S.; Baumgartner, M.; Roth, E.; Bachleitner-Hofmann, T. Docosahexaenoic acid enhances arsenic trioxide-mediated apoptosis in arsenic trioxide-resistant HL-60 cells. Blood, 2003, 101, 4990-4997.
18. Binet, F.; Cavalli, H.; Moisan, E.; Girard, D. Arsenic trioxide (AT) is a novel human neutrophil proapoptotic agent: effects of catalase on AT-induced apoptosis, degradation of cytoskeletal proteins and de novo protein synthesis. Br. J. Haematol., 2006, 132, 349-358.
19. Lisiewicz, J. Immunotoxic and hematotoxic effects of occupational exposures. Folia. Med. Cracov., 1993, 34, 29-47.
20. Park, I.C.; Park, M.J.; Woo, S.H.; Lee, H.C.; An, S.; Gwak, H.S.; Lee, S.H.; Hong, S.I.; Bae, I.J.; Seo, K.M.; Rhee, C.H. Tetraarsenic oxide induces apoptosis in U937 leukemic cells through a reactive oxygen species-dependent pathway. Int. J. Oncol., 2003, 23, 943- 948.
21. Woo, S.H.; Park, I.C.; Park, M.J.; Lee, H.C.; Lee, S.J.; Chun, Y.J.; Lee, S.H.; Hong, S.I.; Rhee, C.H. Arsenic trioxide induces apoptosis through a reactive oxygen species-dependent pathway and loss of mitochondrial membrane potential in HeLa cells. Int. J. Oncol., 2002, 21, 57-63.
22. Chen, Z.X.; Deng, S.P.; Li, X.K. Micellization and synergistic interaction of binary surfactant mixtures based on sodium nonylphenol polyoxyethylene ether sulfate. J. Colloid Interface Sci., 2008, 318, 389-396.
23. Li, Y.M.; Broome, J.D. Arsenic targets tubulins to induce apoptosis in myeloid leukemia cells. Cancer Res., 1999, 59, 776-780.
24. Miller, W.H.Jr.; Schipper, H.M.; Lee, J.S.; Singer, J.; Waxman, S. Mechanisms of action of arsenic trioxide. Cancer Res., 2002, 62, 3893-3903.
25. Carre, M.; Carles, G.; Andre, N.; Douillard, S.; Ciccolini, J.; Briand, C.; Braguer, D. Involvement of microtubules and mitochondria in the antagonism of arsenic trioxide on paclitaxel-induced apoptosis. Biochem. Pharmacol., 2002, 63, 1831-1842.
26. +-dependent production of superoxide. Int. J. Cancer, 2001, 92, 518-526.
27. Verma, A.; Mohindru, M.; Deb, D.K.; Sassano, A.; Kambhampati, S.; Ravandi, F.; Minucci, S.; Kalvakolanu, D.V.; Platanias, L.C. Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to arsenic trioxide. J. Biol. Chem., 2002, 277, 44988-44995.
28. Shim, M.J.; Kim, H.J.; Yang, S.J.; Lee, I.S.; Choi, H.I.; Kim, T. Arsenic trioxide induces apoptosis in chronic myelogenous leukemia K562 cells: possible involvement of p38 MAP kinase. J. Biochem. Mol. Biol., 2002, 35, 377-383.
29. Davison, K.; Mann, K.K.; Waxman, S.; Miller, W.H.Jr. JNK activation is a mediator of arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells. Blood, 2004, 103, 3496-3502.
30. Mann, K.K.; Padovani, A.M.; Guo, Q.; Colosimo, A.L.; Lee, H.Y.; Kurie, J.M.; Miller, W.H.Jr. Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXRalpha phosphorylation. J. Clin. Invest., 2005, 115, 2924-2933.
31. Cheng, Y.; Chang, L.W.; Tsou, T.C. Mitogen-activated protein kinases mediate arsenic-induced down-regulation of survivin in human lung adenocarcinoma cells. Arch. Toxicol., 2006, 80, 310-318.
32. Barchowsky, A.; Dudek, E.J.; Treadwell, M.D.; Wetterhahn, K.E. Arsenic induces oxidant stress and NF-kappa B activation in cultured aortic endothelial cells. Free Radic. Biol. Med., 1996, 21, 783-790.
33. Barchowsky, A.; Roussel, R.R.; Klei, L.R.; James, P.E.; Ganju, N.; Smith, K.R.; Dudek, E.J. Low levels of arsenic trioxide stimulate proliferative signals in primary vascular cells without activating stress effector pathways. Toxicol. Appl. Pharmacol., 1999, 159, 65-75.
34. Sasaki, A.; Oshima, Y.; Fujimura, A. An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. Exp. Hematol., 2007, 35, 252-262.
35. Sandoval, M.; Morales, M.; Tapia, R.; del Carmen Alarcon, L.; Sordo, M.; Ostrosky-Wegman, P.; Ortega, A.; Lopez-Bayghen, E. p53 response to arsenic exposure in epithelial cells: protein kinase B/Akt involvement. Toxicol. Sci., 2007, 99, 126-140.
36. Tsou, T.C.; Tsai, F.Y.; Yeh, S.C.; Chang, L.W. ATM/ATR-related checkpoint signals mediate arsenite-induced G2/M arrest in primary aortic endothelial cells. Arch. Toxicol., 2006, 80, 804-810.
37. Meng, Z. Effects of arsenic on DNA synthesis in human lymphocytes. Arch. Environ. Contam. Toxicol., 1993, 25, 525-528.
38. Kim, J.Y.; Bae, J.H.; Lee, S.H.; Lee, E.Y.; Chung, B.S.; Kim, S.H.; Kang, C.D. Induction of NKG2D ligands and subsequent enhancement of NK Cell-mediated lysis of cancer cells by arsenic trioxide. J. Immunother., 2008, 31, 475-486.
39. Lemarie, A.; Morzadec, C.; Bourdonnay, E.; Fardel, O.; Vernhet, L. Human macrophages constitute targets for immunotoxic inorganic arsenic. J. Immunol., 2006, 177, 3019-3027.
40. Lemarie, A.; Morzadec, C.; Merino, D.; Micheau, O.; Fardel, O.; Vernhet, L. Arsenic trioxide induces apoptosis of human monocytes during macrophagic differentiation through nuclear factor-kappaB-related survival pathway down-regulation. J. Pharmacol. Exp. Ther., 2006, 316, 304-314.
41. Bishayi, B.; Sengupta, M. Intracellular survival of Staphylococcus aureus due to alteration of cellular activity in arsenic and lead intoxicated mature Swiss albino mice. Toxicology, 2003, 184, 31-39.
42. Lemarie, A.; Bourdonnay, E.; Morzadec, C.; Fardel, O.; Vernhet, L. Inorganic arsenic activates reduced NADPH oxidase in human primary macrophages through a Rho kinase/p38 kinase pathway. J. Immunol., 2008, 180, 6010-6017.
43. Lavastre, V.; Pelletier, M.; Saller, R.; Hostanska, K.; Girard, D. Mechanisms involved in spontaneous and Viscum album agglutinin-I-induced human neutrophil apoptosis: Viscum album agglutinin-I accelerates the loss of antiapoptotic Mcl-1 expression and the degradation of cytoskeletal paxillin and vimentin proteins via caspases. J. Immunol., 2002, 168, 1419-1427.
44. Lavastre, V.; Chiasson, S.; Cavalli, H.; Girard, D. Viscum album agglutinin-I (VAA-I) induces apoptosis and degradation of cytoskeletal proteins in human leukemia PLB-985 and X-CGD cells via caspases: lamin B1 is a novel target of VAA-I. Leuk. Res., 2005, 29, 1443-1453.
45. Lavastre, V.; Binet, F.; Moisan, E.; Chiasson, S.; Girard, D. Viscum album agglutinin-I induces degradation of cytoskeletal proteins in leukaemia PLB-985 cells differentiated toward neutrophils: cleavage of non-muscle myosin heavy chain-IIA by caspases. Br. J. Haematol., 2007, 138, 545-554.
46. Lavastre, V.; Chiasson, S.; Cavalli, H.; Girard, D. Viscum album agglutinin-I induces apoptosis and degradation of cytoskeletal proteins via caspases in human leukaemia eosinophil AML14.3D10 cells: differences with purified human eosinophils. Br. J. Haematol., 2005, 130, 527-535.
47. Hiraoka, W.; Vazquez, N.; Nieves-Neira, W.; Chanock, S.J.; Pommier, Y. Role of oxygen radicals generated by NADPH oxidase in apoptosis induced in human leukemia cells. J. Clin. Invest., 1998, 102, 1961-1968.
48. Girard, D.; Paquin, R.; Beaulieu, A.D. Responsiveness of human neutrophils to interleukin-4: induction of cytoskeletal rearrangements, de novo protein synthesis and delay of apoptosis. Biochem. J., 1997, 325, 147-153.
49. Girard, D.; Paquet, M.E.; Paquin, R.; Beaulieu, A.D. Differential effects of interleukin-15 (IL-15) and IL-2 on human neutrophils: modulation of phagocytosis, cytoskeleton rearrangement, gene expression, and apoptosis by IL-15. Blood, 1996, 88, 3176-3184.
50. Bouchard, A.; Ratthe, C.; Girard, D. Interleukin-15 delays human neutrophil apoptosis by intracellular events and not via extracellular factors: role of Mcl-1 and decreased activity of caspase-3 and caspase-8. J. Leukoc. Biol., 2004, 75, 893-900.
51. Stringer, R.E.; Hart, C.A.; Edwards, S.W. Sodium butyrate delays neutrophil apoptosis: role of protein biosynthesis in neutrophil survival. Br. J. Haematol., 1996, 92, 169-175.
52. Cox, G.; Austin, R.C. Dexamethasone-induced suppression of apoptosis in human neutrophils requires continuous stimulation of new protein synthesis. J. Leukoc. Biol., 1997, 61, 224-230.
53. Sakamoto, C.; Suzuki, K.; Hato, F.; Akahori, M.; Hasegawa, T.; Hino, M.; Kitagawa, S. Antiapoptotic effect of granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and cyclic AMP on human neutrophils: protein synthesis-dependent and protein synthesis-independent mechanisms and the role of the Janus kinase-STAT pathway. Int. J. Hematol., 2003, 77, 60-70.
54. Binet, F.; Chiasson, S.; Girard, D. Arsenic trioxide induces de novo protein synthesis of annexin-1 in neutrophils: association with a heat shock-like response and not apoptosis. Br. J. Haematol., 2008, 140, 454-463.
55. Gerke, V.; Moss, S.E. Annexins: from structure to function. Physiol. Rev., 2002, 82, 331-371.
56. Raynal, P.; Pollard, H.B. Annexins: the problem of assessing the biological role for a gene family of multifunctional calcium- and phospholipid-binding proteins. Biochim. Biophys. Acta, 1994, 1197, 63-93.
57. Parente, L.; Solito, E. Annexin 1: more than an anti-phospholipase protein. Inflamm. Res., 2004, 53, 125-132.
58. Solito, E.; Kamal, A.; Russo-Marie, F.; Buckingham, J.C.; Marullo, S.; Perretti, M. A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils. FASEB. J., 2003, 17, 1544-1546.
59. Kim, G.Y.; Lee, H.B.; Lee, S.O.; Rhee, H.J.; Na, D.S. Chaperone-like function of lipocortin 1. Biochem. Mol. Biol. Int., 1997, 43, 521-528.
60. Rhee, H.J.; Kim, G.Y.; Huh, J.W.; Kim, S.W.; Na, D.S. Annexin I is a stress protein induced by heat, oxidative stress and a sulfhydryl-reactive agent. Eur. J. Biochem., 2000, 267, 3220-3225.
61. Binet, F.; Girard, D. Novel human neutrophil agonistic properties of arsenic trioxide: involvement of p38 mitogen-activated protein kinase and/or c-jun NH2-terminal MAPK but not extracellular signal-regulated kinases-1/2. J. Leukoc. Biol., 2008, 84, 1613-1622.