The role of proteomics in toxicology: Identification of biomarkers of toxicity by protein expression analysis

Biomarkers

Volumn 7, Issue 4, 2002, Pages 269-290

  Kennedy, Sandy ^a  

^a Oxford GlycoSciences   (United Kingdom)

Author keywords

Biomarkers; Carcinogenesis; Cardiotoxicity; Hepatotoxicity; Nephrotoxicity; Proteomics; Screening

Indexed keywords

ACETYLGLUCOSAMINIDASE; ALDEHYDE REDUCTASE; ALPHA FETOPROTEIN; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; CADMIUM; CARCINOGEN; CYCLOSPORIN A; CYTOTOXIC AGENT; DOXORUBICIN; GAMMA GLUTAMYLTRANSFERASE; GENTAMICIN; GLUTATHIONE TRANSFERASE; HEAT SHOCK PROTEIN; IMMUNOSUPPRESSIVE AGENT; LEAD; LEAD ACETATE; METAL; MEVINOLIN; PARACETAMOL; PEROXISOME PROLIFERATOR; PIROXICAM; PUROMYCIN; TENIDAP; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AUTOMATION; CARDIOTOXICITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; ISOTOPE LABELING; LIVER CELL CARCINOMA; LIVER TOXICITY; MEDICAL LITERATURE; METHODOLOGY; MOUSE; NEPHROTOXICITY; NEUROTOXICITY; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; RAT; REVIEW; RHEUMATOID ARTHRITIS; SCREENING TEST; SENSITIVITY ANALYSIS; TOXICITY TESTING; TOXICOLOGY;

ANIMALS; AUTOMATION; BIOLOGICAL MARKERS; CARCINOGENS; COMPUTATIONAL BIOLOGY; DRUG DESIGN; GENE EXPRESSION PROFILING; GENOMICS; HEART; HUMANS; KIDNEY; LIVER; PROTEOME; TOXICOLOGY;

ANIMALIA;

EID: 0036649486     PISSN: 1354750X     EISSN: None     Source Type: Journal    
DOI: 10.1080/13547500210127318     Document Type: Review

References (57)

1. New insights into cyclosporine A nephrotoxicity by proteome analysis
2. Proteome and proteomics: New technologies, new concepts, and new words
3. A comparison of selected mRNA and protein abundances in human liver
4. Covalent protein modifications and gene expression changes in rodent liver following administration of methapyrilene: A study using two-dimensional electrophoresis
5. Simultaneous measurement of hundreds of liver proteins: Application in assessment of liver function
6. The effects of peroxisome proliferators on protein abundances in mouse liver
7. Changes in the liver protein pattern of female Wistar rats treated with the hypoglycemic agent SDZ PGU 693
8. Confirmed identities of proteins from a two dimensional map of Syrian embryo cells
9. The potential use of laser capture microdissection to selectively obtain distinct populations of cells for proteomic analysis - Preliminary findings
10. Proteomics: Quantitative and physical mapping of cellular proteins
11. Inhibition of protein phosphatase activity and changes in protein phosphorylation following acetominophen exposure in cultured mouse hepatocytes
12. Identification and characterization of a novel human aldose reductase-like gene
13. 2D protein electrophoresis: Can it be perfected?
14. Proteomic analysis of differential protein expression in primary hepatocytes induced by EGF, tumour necrosis factor or the peroxisome proliferator nafenopin
15. The hepatocarcinogen methapyrilene but not the analog pyrilamine induces sustained hepatocellular replication and protein alterations in F344 rats in a 13-week feed study
16. An integrated approach to studying glomerular nephrotoxicity
17. Analysis of changes in acute-phase plasma proteins in an acute inflammatory response and in rheumatoid arthritis using two-dimensional gel electrophoresis
18. A proteome analysis of livers from obese (ob/ob) mice treated with the peroxisome proliferator WY 14,643
19. Two-dimensional database of mouse live proteins: Changes in hepatic protein levels following treatment with acetaminophen or its nontoxic regioisomer 3-acetamidophenol
20. A comparative study of the effects of clofibrate, ciprofibrate, WY-14,643, and di-(2-ethylhexyl)-phthalate on liver protein expression in mice
21. Functional proteomics of signal transduction by membrane receptors
22. Quantitative analysis of complex protein mixtures using isotope-coded affinity tags
23. Reduction of chronic doxorubicin cardiotoxicity by pretreatment with 1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187)
24. Proteomics and safety biomarker discovery
25. Two-dimensional gel electrophoresis analysis of Syrian hamster embryo cells: Morphological transformation is not cell type specific
26. Application of proteome analysis to the detection of 'hepatoma specific' serum proteins
27. Proteomics in human disease: Cancer, heart and infectious diseases
28. Proteomic profiling from human samples: The body fluid alternative
29. Automating proteome analysis: From soup to nuts
30. PPARalpha- dependent alteration of GRP94 expression in mouse hepatocytes
31. Two-dimensional gel electrophoresis: A powerful method to elucidate cellular responses to toxic compounds
32. Pharmacogenetics, genomics, proteomics: The new frontiers in drug development
33. Defining a molecularly normal colon
34. A protein expression database for the molecular pharmacology of cancer
35. Two-dimensional electrophoresis of liver proteins: Characterization of a drug-induced hepatomegaly in rats
36. Initiating ocular proteomics for cataloguing bovine retinal proteins: Microanalytical techniques permit the identification of proteins derived from a novel photoreceptor preparation
37. Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties
38. The principles and practice of toxicogenomics: Applications and opportunities
39. Comparisons of protein changes in human and rodent hepatocytes induced by the rat-specific carcinogen, methapyrilene
40. Dose-responses in rat hepatic protein modification and expression following exposure to the rat hepatocarcinogen methapyrilene
41. Apoptotic cell death analyzed at the molecular level by two-dimensional gel electrophoresis
42. Peptidometics: The comprehensive analysis of peptides in complex biological mixtures
43. Cyclosporine A decreases the protein level of the calcium binding protein calbindin-D 28kDa in rat kidney
44. Proteomics to display lovastatin- induced protein and pathway regulation in rat liver
45. Cholangiocyte -specific rat liver proteins identified by establishment of a two-dimensional gel protein database
46. Proteomic detection of changes in protein synthesis induced by fibroblast growth factor-2 in MCF-7 human breast cancer cells
47. A proteome analysis of the cadmium response in Saccharomyces cerevisiae
48. Correlation of clinical data with proteomics profiles in 24 patients with B-cell chronic lymphocytic leukemia
49. An information-intensive approach to the molecular pharmacology of cancer
50. Comparative 2D-electrophoretic mapping of human and rodent hepatic stress proteins as potential biomarkers
51. Two-dimensional electrophoretic mapping of hepatic and renal stress proteins
52. Toxicant-induced alterations in two-dimensional electrophoretic patterns of hepatic and renal stress proteins
53. Differential expression of cytosolic proteins in the rat kidney cortex and medulla: Preliminary proteomics
54. Proteomic analysis of simulated occupational jet fuel exposure in the lung
55. Regional protein alterations in rat kidneys induced by lead exposure
56. Proteomic analysis of the renal effects of simulated occupational jet fuel exposure
57. Toxicity of chemical mixtures: Proteomic analysis of persisting liver and kidney protein alterations induced by repeated exposure of rats to JP-8 jet fuel vapour