The protective role of Nrf2 in cadmium-induced DNA damage

Molecular and Cellular Toxicology

Volumn 7, Issue 1, 2011, Pages 61-66

  Park, Jee Yeon ^a   Seo, Young Rok ^a  

^a Dongguk University   (South Korea)

Author keywords

Cadmium; Carcinogenicity; DNA damage; Nuclear factor erythroid 2 related factor 2; Oxidative stress

Indexed keywords

EID: 79960099275     PISSN: 1738642X     EISSN: 20928467     Source Type: Journal    
DOI: 10.1007/s13273-011-0009-x     Document Type: Article

References (21)

1. Niture, S. K. et al. Nrf2 signaling and cell survival. Toxicol Appl Pharmacol 244:37-42 (2010).
2. Ramos-Gomez, M. et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci 98:3410-3415 (2001). (Pubitemid 32220859)
3. Li, N. et al. Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: Protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals. J Immunol 173:3467-3481 (2004). (Pubitemid 39142058)
4. Hu, X. et al. Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice. Mol Cell Biol 26:940-954 (2006). (Pubitemid 43146488)
5. Osburn, W. O. et al. Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults. Mutat Res 659:31-39 (2008).
6. Jin, T. et al. Toxicokinetics and biochemistry of cadmium with special emphasis on the role of metallothioneins. Neurotoxicology 19:529-535 (1998).
7. IARC. Monographs on the Evaluation of Carcinogenic Risks to formation in DNA preferentially over strand breakage. Nucleic Acids Res. Humans, Vol. 58: Beryllium, Cadmium, Mercury, and Exposures in the Glass 18, 631-635. Manufacturing Industry. IARC, Lyon, France (1993).
8. Shih, C. M. et al. Mediating of caspase-independent apoptosis by cadmium through the mitochondria-ROS pathway in MRC-5 fibroblasts. J Cell Biochem 91: 384-397 (2004).
9. Lee, D. H. et al. Graded associations of blood lead and urinary cadmium concentrations with oxidativestress- related markers in the U.S. population: results from the third National Health and Nutrition Examination Survey. Environ Health Perspect 114:350-354 (2006).
10. Joseph, P. et al. Cadmium-induced cell transformation and tumorigenesis are associated with transcriptionalactiavation of c-fos, c-jun and c-myc proto-oncogenes: Role of cellular calcium and reactive oxygen species. Toxicol Sci 61:295-303 (2001). (Pubitemid 32499397)
11. Itoh, K. et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 236:313-322 (1997). (Pubitemid 27373291)
12. Kensler, T. W. et al. Cell survival response to environmental stresses via the keap 1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47:89-116 (2007).
13. Liu, J. et al. Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicology and Applied Pharmacology 238:209-214 (2009).
14. Ramirez, D. C. et al. Induction of redox changes, inducible nitric oxide synthase and cyclooxygenase-2 by chronic cadmium exposure in mouse peritoneal macrophages. Toxicol Lett 145:121-132 (2003). (Pubitemid 37329513)
15. Filipic, M. et al. Mutagenicity of cadmium in mammalian cells: implication of oxidative DNA damage. Mutat Res 546:81-91 (2004). (Pubitemid 38130222)
16. Waisberg, M. et al. Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 192:95-117 (2003). (Pubitemid 37311405)
17. He, X. et al. Activation of Nrf2 in defense against cadmium-induced oxidative stress. Chem Res Toxicol 21:1375-1383 (2008).
18. Fenech, M. The in vitro micronucleus technique. Mutat Res 455:81-95 (2000).
19. Lau, A. et al. Dual roles of Nrf2 in cancer. Pharmacol Res 58:262-270 (2008).
20. Wang, X. J. et al. Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2. Carcinogenesis 29:1235-1243 (2008).
21. Singh, N. P. et al. A simple technique for quantification of low levels of DNA damage in individual cells. Exp Cell Res 171:184-191 (1988).