Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: Aberrant genomic DNA methylation and K-ras oncogene activation

Toxicology and Applied Pharmacology

Volumn 206, Issue 3, 2005, Pages 288-298

  Benbrahim Tallaa, Lamia ^a   Waterland, Robert A ^b   Styblo, Miroslav ^c   Achanzar, William E ^a,e   Webber, Mukta M ^d   Waalkes, Michael P ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d MICHIGAN STATE UNIVERSITY   (United States)

^e BRISTOL MYERS SQUIBB   (United States)

Author keywords

Arsenic; Chronic exposure; DNA methylation; K ras

Indexed keywords

ARSENIC; DNA METHYLTRANSFERASE; GENOMIC DNA; K RAS PROTEIN; MESSENGER RNA;

ARTICLE; CANCER GROWTH; CANCER SCREENING; CHROMOSOME ABERRATION; CODON; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA MICROARRAY; ENZYME ACTIVITY; EPITHELIUM CELL; GENE ACTIVATION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC SCREENING; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MOLECULAR MECHANICS; NORTHERN BLOTTING; ONCOGENE K RAS; PROMOTER REGION; PROSTATE EPITHELIUM; TIME; WESTERN BLOTTING;

ARSENITES; CELL TRANSFORMATION, NEOPLASTIC; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA MUTATIONAL ANALYSIS; EPITHELIAL CELLS; GENE EXPRESSION; GENES, RAS; HUMANS; MALE; MATRIX METALLOPROTEINASE 9; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROSTATE; SODIUM COMPOUNDS;

EID: 22544437866     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2004.11.017     Document Type: Article

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