Identification of genes associated with local aggressiveness and metastatic behavior in soft tissue tumors

Translational Oncology

Volumn 3, Issue 1, 2010, Pages 23-32

  Cunha, Isabela Werneck ^a   Carvalho, Katia Candido ^a   Martins, Waleska Keller ^a   Marques, Sarah Martins ^a   Muto, Nair Hideko ^a   Falzoni, Roberto ^a   Rocha, Rafael Malagoli ^a   Aguiar Jr , Samuel ^a   Simoes, Ana C Q ^b   Fahham, Lucas ^b   Neves, Eduardo Jordão ^b   Soares, Fernando Augusto ^a   Reis, Luiz Fernando Lima ^c  

^a A C CAMARGO CANCER CENTER   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c HOSPITAL SÍRIO LIBANÊS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

MINICHROMOSOME MAINTENANCE PROTEIN 2;

ABCF1 GENE; AFAP1L2 GENE; ARL6IP5 GENE; ARTICLE; CELL INTERACTION; CELL PROLIFERATION; CONTROLLED STUDY; DNA MICROARRAY; ENDOD1 GENE; GENE; GENE AMPLIFICATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; HUMAN; HUMAN CELL; HYBRIDIZATION; IMMUNOHISTOCHEMISTRY; MEGF9 GENE; METASTASIS; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; RNA EXTRACTION; SERPIN5 GENE; SNRPD3 GENE; SOFT TISSUE TUMOR; SPTAN 1 GENE; TISSUE MICROARRAY; TOP2A GENE; UBE2C GENE; ZWINTAS GENE;

EID: 77953432087     PISSN: None     EISSN: 19365233     Source Type: Journal    
DOI: 10.1593/tlo.09166     Document Type: Article

References (58)

1. Fletcher CDM, Fletcher K, Unni KK, and Mertens F (2000). Tumors of Soft Tissue and Bone. Lyon, France: IARC, pp. 12-16.
2. Costa J, Wesley RA, Glatstein E, and Rosemberg SA (1984). The grading of soft tissue sarcomas. Results of clinicohistopathologic correlation in a series of 163 cases. Cancer 53, 530-541.
3. Guillou L, Coindre JM, Bonichon F, Nguyen BB, Terrier P, Collin F, Vilain MO, Mandard AM, Le D, Leroux A, et al. (1997). Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma. J Clin Oncol 15, 350-362.
4. Borden EC, Baker LH, Bell RS, Bramwell V, Demetri GD, Eisenberg BL, Fletcher CD, Fletcher JA, Ladanyi M,Meltzer P, et al. (2003). Soft tissue sarcomas of adults: state of the translational science. Clin Cancer Res 9, 1941-1956.
5. Fletcher CDM, Fletcher K, Unni KK, and Mertens F (2000). Tumors of Soft Tissue and Bone. Lyon, France: IARC, pp. 83-84.
6. Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, Kawano K, Hanada M, Kurata A, Takeda M, et al. (1998). Gain of function mutations of c-kit in human gastrointestinal stromal tumors. Science 279, 577-580.
7. Terry J, Saito T, Subramanian S, Ruttan C, Antonescu CR, Goldblum JR, Downs-Kelly E, Corless CL, Rubin BP, van de Rijn M, et al. (2007). TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies. Am J Surg Pathol 31, 240-246.
8. Lee YF, John M, Falconer A, Edwards S, Clark J, Flohr P, Roe T, Wang R, Shipley J, Grimer RJ, et al. (2004). A gene expression signature associated with metastatic outcome in human leiomyosarcomas. Cancer Res 64, 7201-7204.
9. Ohali A, Avigad S, Zaizov R, Ophir R, Horn-Saban S, Cohen IJ, Meller I, Kollender Y, Issakov J, and Yaniv I (2004). Prediction of high risk Ewing's sarcoma by gene expression profiling. Oncogene 23, 8997-9006.
10. Khan J, Wei JS, Ringner M, Saal LH, Ladanyi M, Westermann F, Berthold F, Schwab M, Antonescu CR, Peterson C, et al. (2001). Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks. Nat Med 7, 673-679.
11. West RB, Harvell J, Linn SC, Liu CL, Prapong W, Hernandez-Boussard T, Montgomery K, Nielsen TO, Rubin BP, Patel R, et al. (2004). Apo D in soft tissue tumors: a novel marker for dermatofibrosarcoma protuberans. Am J Surg Pathol 28, 1063-1069.
12. Allander SV, Illei PB, Chen Y, Antonescu CR, Bittner M, Ladanyi M, and Meltzer PS (2002). Expression profiling of synovial sarcoma by cDNA microarrays. Am J Pathol 161, 1587-1595.
13. Nagayama S, Katagiri T, Tsunoda T, Hosaka T, Nakashima Y, Araki N, Kusuzaki K, Nagayama T, Tsuboyama T, Nakamura T, et al. (2002). Genome-wide analysis of gene expression in synovial sarcomas using a cDNA microarray. Cancer Res 62, 5859-5866.
14. Nielsen TO, West RB, Linn SC, Alter O, Knowling MA, O'Conell JX, Zhu S, Fero M, Sherlock G, Pollack JR, et al. (2002). Molecular characterization of soft tissue tumors: a gene expression study. Lancet 359, 1301-1307.
15. Segal NH, Pavlidis P, Antonescu CR, Maki RG, Noble WS, DeSantis D, Woodruff JM, Lewis JJ, Brennan MF, Houghton AN, et al. (2003). Classification and subtype prediction of adult soft tissue sarcoma by functional genomics. Am J Pathol 163, 691-700.
16. Baird K, Davis S, Antonescu CR, Harper UL, Walker RL, Chen Y, Glatfelter AA, Duray PH, and Meltzer PS (2005). Gene expression profiling of human sarcomas: insights into sarcoma biology. Cancer Res 65, 9226-9235.
17. Gomes LI, Silva RL, Stolf BS, Cristo EB, Hirata R, Soares FA, Reis LF, Neves EJ, and Carvalho AF (2003). Comparative analysis of amplified and nonamplified RNA for hybridization in cDNA microarray. Anal Biochem 321, 244-251.
18. Pollack JR (2002). RNA common reference sets. In D Bowtell and J Shambrook (Eds.), DNA Microarrays: A Molecular Cloning Manual. Cold Spring Harbor, NY: Cold Spring Harbor Press, pp. 168-172.
19. Pfaffl MW (2002). A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29, e45.
20. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, and Speleman F (2002). Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3, RESEARCH0034.
21. Cunha IW, Lopes A, Falzoni R, and Soares FA (2006). Sarcomas often express constitutive nitric oxide synthases (NOS) but infrequently inducible NOS. Appl Immunohistochem Mol Morphol 14, 404-410.
22. Hochberg Y (1988). A sharper Bonferroni procedure for multiple tests of significance. Biometrika 75, 800-802.
23. Benjamini Y and Hochberg Y (1995). Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statist Soc B 57, 289-300.
24. Chiang AC and Massagué J (2008). Molecular basis of metastasis. N Engl J Med 359, 2814-2823.
25. van 't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT, et al. (2002). Gene expression profiling predicts clinical outcome of breast cancer. Nature 415, 484-485.
26. Ramaswamy S, Ross KN, Lander ES, and Golub TR (2003). A molecular signature of metastasis in primary solid tumors. Nat Genet 33, 49-54.
27. Lee YF, John M, Falconer A, Edwards S, Clark J, Flohr P, Roe T, Wang R, Shipley J, Grimer RJ, et al. (2004). A gene expression signature associated with metastatic outcome in human leiomyosarcomas. Cancer Res 64, 7201-7204.
28. Ren B, Yu YP, Jing L, Liu L, Michalopoulos GK, Luo JH, and Rao UN (2003). Gene expression analysis of human soft tissue leiomyosarcomas. Hum Pathol 34, 549-558.
29. Francis P, Namløs HM, Müller C, Edén P, Fernebro J, Berner JM, Bjerkehagen B, Akerman M, Bendahl PO, Isinger A, et al. (2007). Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential. BMC Genomics 8, 73.
30. Nakano T, Tani M, Ishibashi Y, Kimura K, Park YB, Imaizumi N, Tsuda H, Aoyagi K, Sasaki H, Ohwada S, et al. (2003). Biological properties and gene expression associated with metastatic potential of human osteosarcoma. Clin Exp Metastasis 20, 665-674.
31. Suzuki K and Hayashi T (2007). Protein C and its inhibitor in malignancy. Semin Thromb Hemost 33, 667-672.
32. Asanuma K, Yoshikawa T, Hayashi T, Akita N, Nakagawa N, Hamada Y, Nishioka J, Kamada H, Gabazza EC, Ido M, et al. (2007). Protein C inhibitor inhibits breast cancer cell growth, metastasis and angiogenesis independently of its protease inhibitory activity. Int J Cancer 121, 955-965.
33. Wakita T, Hayashi T, Nishioka J, Tamaru H, Akita N, Asanuma K, Kamada H, Gabazza EC, Ido M, Kawamura J, et al. (2004). Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinoma. Int J Cancer 108, 516-523.
34. Li W, Adams TE, Kjellberg M, Stenflo J, and Huntington JA (2007). Structure of native protein C inhibitor provides insight into its multiple functions. J Biol Chem 282, 13759-13768.
35. Brandt-Bohne U, Keene DR, White FA, and Koch M (2007). MEGF9: a novel transmembrane protein with a strong and developmentally regulated expression in the nervous system. Biochem J 401, 447-457.
36. Dowgiert J, Sosne G, and Kurpakus-Wheater M (2004). Laminin-2 stimulates the proliferation of epithelial cells in a conjunctival epithelial cell line. Cell Prolif 37, 161-175.
37. Haritunians T, Boulter J, Hicks C, Buhrman J, DiSibio G, Shawber C, Weinmaster G, Nofziger D, and Schanen C (2002). CADASIL Notch3 mutant proteins localize to the cell surface and bind ligand. Circ Res 90, 506-508.
38. Camasses A, Bragado-Nilsson E, Martin R, Séraphin B, and Bordonné R (1998). Interactions within the yeast Sm core complex: from proteins to amino acids. Mol Cell Biol 18, 1956-1966.
39. Xu J, Bai XH, Lodyga M, Han B, Xiao H, Keshavjee S, Hu J, Zhang H, Yang BB, and Liu M (2007). XB130, a novel adaptor protein for signal transduction. J Biol Chem 22, 16401-16412.
40. L'Espérance S, Popa I, Bachvarova M, Plante M, Patten N, Wu L, Têtu B, and Bachvarov D (2006). Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemo-resistant tumors. Int J Oncol 29, 5-24.
41. Zhang WM, Liu WT, Xu Y, Xuan Q, Zheng J, and Li YY (2004). Study of genes related to gastric cancer and its premalignant lesions with fluorescent differential display. Ai Zheng 23, 264-268.
42. Kosari F, Munz JM, Savci-Heijink CD, Spiro C, Klee EW, Kube DM, Tillmans L, Slezak J, Karnes RJ, Cheville JC, et al. (2008). Identification of prognostic biomarkers for prostate cancer. Clin Cancer Res 14, 1734-1743.
43. Okamoto Y, Ozaki T, Miyazaki K, Aoyama M, Miyazaki M, and Nakagawara A (2003). UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme. Cancer Res 63, 4167-4173.
44. Takahashi Y, Ishii Y, Nishida Y, Ikarashi M, Nagata T, Nakamura T, Yamamori S, and Asai S (2006). Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH. Cancer Genet Cytogenet 168, 30-35.
45. Arvand A, Bastians H, Welford SM, Thompson AD, Ruderman JV, and Denny CT (1998). EWS/FLI1 up regulates mE2-C, a cyclin-selective ubiquitin conjugating enzyme involved in cyclin B destruction. Oncogene 17, 2039-2045.
46. Pruitt SC, Bailey KJ, and Freeland A (2007). Reduced Mcm2 expression results in severe stem/progenitor cell deficiency and cancer. Stem Cells 25, 3121-3132.
47. Grützmann R, Pilarsky C, Ammerpohl O, Lüttges J, Böhme A, Sipos B, Foerder M, Alldinger I, Jahnke B, Schackert HK, et al. (2004). Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays. Neoplasia 6, 611-622.
48. Quaglia A, McStay M, Stoeber K, Loddo M, Caplin M, Fanshawe T, Williams G, and Dhillon A (2006). Novel markers of cell kinetics to evaluate progression from cirrhosis to hepatocellular carcinoma. Liver Int 26, 424-432.
49. Sington JD, Freeman A, Morris LS, Vowler SL, ArchBN, Fisher C, and ColemanN (2004). Minichromosome maintenance protein in myxofibrosarcoma. Mod Pathol 17, 235-240.
50. Huang HY, Kang HY, Li CF, Eng HL, Chou SC, Lin CN, and Hsiung CY (2006). Skp2 overexpression is highly representative of intrinsic biological aggressiveness and independently associated with poor prognosis in primary localized myxofibrosarcomas. Clin Cancer Res 12, 487-498.
51. Chen R, Qiu W, Liu Z, Cao X, Zhu T, Li A, Wei Q, and Zhou J (2007). Identification of JWA as a novel functional gene responsive to environmental oxidative stress induced by benzo[a]pyrene and hydrogen peroxide. Free Radic Biol Med 42, 1704-1714.
52. Chen H, Bai J, Ye J, Liu Z, Chen R, Mao W, Li A, and Zhou J (2007). JWA as a functional molecule to regulate cancer cell migration via MAPK cascades and F-actin cytoskeleton. Cell Signal 19, 1315-1327.
53. Zhu YJ, Li CP, Tang WY, Li AP, Liu QZ, and Zhou JW (2007). Single nucleotide polymorphism of the JWA gene is associated with risk of leukemia: a case-control study in a Chinese population. J Toxicol Environ Health A 70, 895-900.
54. Tang WY, Wang L, Li C, Hu ZB, Chen R, Zhu YJ, Shen HB, Wei QY, and Zhou JW (2007). Identification and functional characterization of JWA polymorphisms and their association with risk of gastric cancer and esophageal squamous cell carcinoma in a Chinese population. J Toxicol Environ Health A 70, 885-894.
55. Li CP, Zhu YJ, Chen R, Wu W, Li AP, Liu J, Liu QZ, Wei QY, Zhang ZD, and Zhou JW (2007). Functional polymorphisms of JWA gene are associated with risk of bladder cancer. J Toxicol Environ Health A 70, 876-884.
56. Kantardzhieva A, Gosens I, Alexeeva S, Punte IM, Versteeg I, Krieger E, Neefjes-Mol CA, den Hollander AI, Letteboer SJ, Klooster J, et al. (2005). MPP5 recruits MPP4 to the CRB1 complex in photoreceptors. Invest Ophthalmol Vis Sci 46, 2192-2201.
57. Michel D, Arsanto JP,Massey-Harroche D, Béclin C, Wijnholds J, and Le Bivic A (2005). PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells. J Cell Sci 118, 4049-4057.
58. Serra M, Scotlandi K, Manara MC, Maurici D, Benini S, Sarti M, Nini G, Barbanti-Brodano G, and Baldini N (1996). Evaluation of P-glycoprotein expression in soft tissue sarcomas of the extremities. Cytotechnology 19, 253-256.