Metabolomic analyses of body fluids after subchronic manganese inhalation in Rhesus monkeys

Toxicological Sciences

Volumn 106, Issue 1, 2008, Pages 46-54

  Dorman, David C ^a   Struve, Melanie F ^a   Norris, Amy ^b   Higgins, Alan J ^b  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b Division of Clinical Data ^*  (United States)

Author keywords

Metabolomics; Metal; Neurotoxicity

Indexed keywords

ADENOSINE; ALLANTOIN; AMINOBUTYRATE; BIOLOGICAL MARKER; DISACCHARIDE; GLUTAMINE; GLUTATHIONE DISULFIDE; GUANOSINE; MANGANESE SULFATE; PHENYLALANINE; PHENYLPYRUVIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; BODY FLUID; BRAIN LEVEL; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; GLOBUS PALLIDUS; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; METABOLOMICS; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; OXIDATIVE STRESS; PREDICTION; RHESUS MONKEY; TANDEM MASS SPECTROMETRY; URINALYSIS;

AIR POLLUTANTS; ANIMALS; BIOLOGICAL MARKERS; CHROMATOGRAPHY, LIQUID; CLUSTER ANALYSIS; ENVIRONMENTAL MONITORING; GLOBUS PALLIDUS; INHALATION EXPOSURE; MACACA MULATTA; MALE; MANGANESE COMPOUNDS; METABOLOMICS; PRINCIPAL COMPONENT ANALYSIS; SULFATES; TANDEM MASS SPECTROMETRY;

MACACA MULATTA;

EID: 54349089416     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn159     Document Type: Article

References (38)

1. Andersen, M. E., Gearhart, J. M., and Clewell, H. J., III. (1999). Phmmacokinetic data needs to support risk assessments for inhaled and ingested manganese. Neurotoxicology. 20, 161-171.
2. Anderson, J. G., Cooney, P. T., and Erikson, K. M. (2007). Brain manganese accumulation is inversely related to gamma-amino butyric acid uptake in male and female rats. Toxicol. Sci. 95, 188-195.
3. Aschner, M. A., Erikson, K. M., and Dorman, D. C. (2005). A review of manganese toxicokinetics. Crit. Rev. Toxicol. 35, 1-32.
4. ATSDR. (1992). Toxicological Profile for Manganese. U.S. Department of Health and Human Services, Atlanta, GA.
5. Beleboni, R. O., Carolino, R. O. G., Pizzo, A. B., Castellan-Baldam, L., Coutinho-Netto, J., dos Santos, W. F., and Coimbra, N. C. (2004). Pharmacological and biochemical aspects of GABAergic neurotransmission: Pathological and neuropsychobiological relationships. Cell Mol. Neurobiol. 24, 707-728.
6. Bowser, R., Cudkowicz, M., and Kaddurah-Daouk, R. (2006). Biomarkers for amyotrophic lateral sclerosis. Expert Rev. Mol. Diagn. 6, 387-298.
7. Calne, D. B., Chu, N.-S., Huang, C.-C., Lu, C.-S., and Olanow, W. (1994). Manganism and idiopathic parkinsonism: Similarities and differences. Neurology 44, 1583-1586.
8. Dorman, D. C., McManus, B. E., Marshall, M. W., James, R. A., and Struve, M. F. (2004). Old age and gender influence the pharmacokinetics of inhaled manganese sulfate and manganese phosphate in rats. Toxicol. Appl. Pharmacol. 197, 113-124.
9. Dorman, D. C., Struve, M. F., Marshall, M. W., Parkinson, C. U., James, R. A., and Wong, B. A. (2006a). Tissue manganese concentrations in young male rhesus monkeys following subchronic manganese sulfate inhalation. Toxicol. Sci. 92, 201-210.
10. Dorman, D. C., Struve, M. F., Wong, B. A., Dye, J. A., and Robertson, I. D. (2006b). Correlation of brain magnetic resonance imaging changes with pallidal manganese concentrations in rhesus monkeys following subchronic manganese inhalation. Toxicol. Sci. 92, 219-227.
11. Ellingsen, D. G., Dubeikovskaya, L., Dahl, K., Chashchin, M., Chashchin, V., Zibarev, E., and Thomassen, Y. (2006). Air exposure assessment and biological monitoring of manganese and other major welding fume components in welders. J. Environ. Monit. 8, 1078-1086.
12. Ellingsen, D. G., Hetland, S. M., and Thomassen, Y. (2003). Manganese air exposure assessment and biological monitoring in the manganese alloy production industry. J. Environ. Monit. 5, 84-90.
13. Erikson, K. M., Dorman, D. C., Lash, L. H., and Aschner, M. (2007). Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of oxidative stress including glutamate transporters. Toxicol. Sci. 97, 459-466.
14. Fitsanakis, V. A., An, C., Erikson, K. M., and Aschner, M. (2006a). The effects of manganese on glutamate, dopamine and gamma-aminobutyric acid regulation. Neurochem. Int. 48, 426-433.
15. Fitsanakis, V. A., Zhang, N., Avison, M. J., Gore, J. C., Aschner, J. L., and Aschner, M. (2006b). The use of magnetic resonance imaging (MRI) in the study of manganese neurotoxicity. Neurotoxicology 27, 798-806.
16. Fowler, B. A., Conner, E. A., and Yamauchi, H. (2005). Metabolomic and proteomic biomarkers for III-V semiconductors: Chemical-specific porphyrinurias and proteinurias. Toxicol. Appl. Pharmacol. 206 121-130.
17. Kim, Y. (2004). High signal intensities on T1-weighted MRI as a biomarker of exposure to manganese. Ind. Health 42, 111-115.
18. Kim, Y., Kim, K. S., Yang, J. S., Park, I. J., Kim, E., Jin, Y., Kwon, K. R., Chang, K. H., Kim, J. W., Park, S. H., et al. (1999). Increase in signal intensities on T1-weighted magnetic resonance images in asymptomatic manganese-exposed workers. Neurotoxicology 20 901-907.
19. Levy, B. S., and Nassetta, W. J. (2003). Neurologic effects of manganese in humans: A review. Int. J. Occup. Environ. Health 9, 153-163.
20. Ljung, K., and Vahter, M. (2007). Time to re-evaluate the guideline value for manganese in drinking water? Environ. Health Perspect. 115, 1533-1538.
21. Lu, L., Zhang, L. L., Lim, G. J., Guo, W., Liang, W., and Zheng, W. (2005). Alteration of serum concentrations of manganese, iron, ferritin, and transferrin receptor following exposure to welding fumes among career welders. Neurotoxicology 26, 257-265.
22. Lucchini, R., Apostoli, P., Perrone, C., Placidi, D., Albini, E., Migliorati, P., Mergler, D., Sassine, M. P., Palmi, S., and Alessio, L. (1999). Long-term exposure to "low levels" of manganese oxides and neurofunctional changes in ferroalloy workers. Neurotoxicology 20, 287-297.
23. Malecki, E. A., Devenyi, A. G., Beard, J. L., and Connor, J. R. (1999). Existing and emerging mechanisms for transport of iron and manganese to the brain. J. Neurosci. Res. 56, 113-122.
24. McMillan, G. (2005). Is electric are welding linked to manganism or Parkinson's disease? Toxicol. Rev. 24, 237-257.
25. Mergler, D., Huel, G., Bowler, R., Iregren, A., Belanger, S., Baldwin, M., Trardif, R., Smargiassi, A., and Martin, L. (1994). Nervous system dysfunction among workers with long-term exposure to manganese. Environ. Res. 64, 151-180.
26. National Research Council. (1996). Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, D.C.
27. Nelson, K., Golnick, J., Kom, T., and Angle, C. (1993). Manganese encephalopathy: Utility of early magnetic resonance imaging. Br. J. Ind. Med. 50, 510-513.
28. Oresic, M., Vidal-Puig, A., and Hanninen, V. (2006). Metabolomic approaches to phenotype characterization and applications to complex diseases. Expert Rev. Mol. Diagn. 6, 575-585.
29. Pal, P. K., Samii, A., and Calne, D. B. (1999). Manganese neurotoxicity: A review of clinical feaftm, imaging and pathology. Neurotoxicology 20, 227-238.
30. Perroud, B., Lee, J., Valkova, N., Dhirapong, A., Lin, P. Y., Fielm, O., Kultz, D., and Weiss, R. H. (2006). Pathway analysis of kidney cancer using proteomics and metabolic profiling. Mol. Cancer 5, 64.
31. Portilla, D., Li, S., Nagothu, K. K., Megyesi, J., Kaissling, B., Schnackenberg, L., Safirstein, R. L., and Beger, R. D. (2006). Metabotomic study of cisplatin-induced nephrotoxicity. Kidney Int. 69, 2194-2204.
32. Raamsdonk, L. M., Teusink, B., Broadhurst, D., Zhang, N., Hayes, A., Walsh, M. C., Berden, J. A., Brindle, K. M., Kell, D. B., Rowland, J. J., et al. (2001). A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nat. Biotechnol. 19, 45-50.
33. Sabatine, M. S., Liu, E., Morrow, D. A., Heller, E., McCarroll, R., Wiegand, R., Berriz, G. F., Roth, F. P., and Gerszten, R. E. (2005). Metabolomic identification of novel biomarkers of myocardial ischemia. Circulation 112, 3868-3875.
34. Smith, C. A., O'Maille, G., Want, E. J., Qin, C., Trauger, S. A., Brandon, T. R., Custodio, D. E., Abagyan, R., and Siuzdak, G. (2005). METLIN: A metabolite mass spectral database. Ther. Drug Monit. 27, 747-751.
35. Struve, M. F., McManus, B. E., Wong, B. A., and Dorman, D. C. (2007). Basal ganglia neurotransmitter concentrations in rhesus monkeys following subchronic manganese sulfate inhalation. Am. J. Ind. Med. 50, 772-778.
36. Taylor, M. D., Erikson, K. M., Dobson, A. W., Fitsanakis, V. A., Dorman, D. C., and Aschner, M. (2006). Effects of inhaled manganese on biomarkers of oxidative stress in the rat brain. Neurotoxicology 27, 788-797.
37. Villablanca, M., and Cilento, G. (1987). Oxidation of phenylpyruvic acid. Biochim. Biophys. Acta 7, 224-230.
38. Weckwerth, W., and Morgenthal, K. (2005). Metabolomics: From pattern recognition to biological interpretation. Drug Discov. Today 10 1551-1558.