Biologically motivated quantitative models and the mixture toxicity problem

Toxicological Sciences

Volumn 63, Issue 1, 2001, Pages 1-2

  Conolly, R B ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIOTECHNOLOGY; COMPUTER; CONTROLLED STUDY; DOSE RESPONSE; DOSIMETRY; HEALTH HAZARD; HUMAN; HYPOTHESIS; METABOLISM; MODEL; PHARMACODYNAMICS; PHARMACOKINETICS; PREDICTION; RISK ASSESSMENT; TOXICOLOGY;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; HAZARDOUS SUBSTANCES; HUMANS; MODELS, BIOLOGICAL; RISK ASSESSMENT; SPECIES SPECIFICITY; TOXICITY TESTS;

EID: 0034873805     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/63.1.1     Document Type: Article

References (10)

1. Mode-of-action-based dosimeters for interspecies extrapolation of vinyl acetate inhalation risk
2. The utility of PBPK in the safety assessment of chloroform and carbon tetrachloride
3. A hybrid computational fluid dynamics and physiologically based pharmacokinetic model for comparison of predicted tissue concentrations of acrylic acid and other vapors in the rat and human nasal cavities following inhalation exposure
4. Resolution of dose-response toxicity data for chemicals requiring metabolic activation: Example-vinyl chloride
5. Physiological modeling of the pharmacokinetics interactions in a quaternary mixture of aromatic hydrocarbons
6. Validation of a physiological modeling framework for simulating the toxicokinetics of chemicals in mixtures
7. The toxicology of an aniline-furfuryl alcohol-hydrazine vapor mixture
8. Mixture of tranquilizers, lighter fluid, paint thinner, and iodine poisonings
9. Physiologically based pharmacokinetic modeling of inhalation exposure of humans to dichloromethane during moderate to heavy exercise