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Volumn 34, Issue 29, 2013, Pages 7158-7167

A review of therapeutic prospects of non-viral gene therapy in the retinal pigment epithelium

Author keywords

DNA nanoparticle; Non viral gene therapy; Retinal pigment epithelium; RPE65

Indexed keywords

ADENO-ASSOCIATED VIRUS; CLINICAL APPLICATION; DNA NANOPARTICLES; NONVIRAL GENE THERAPY; POLYETHYLENE IMINES; RETINAL PIGMENT EPITHELIUM; RPE65; TRANSFECTION EFFICIENCY;

EID: 84879606470     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.06.002     Document Type: Review
Times cited : (62)

References (152)
  • 1
    • 21244451958 scopus 로고    scopus 로고
    • The retinal pigment epithelium in visual function
    • Strauss O. The retinal pigment epithelium in visual function. Physiol Rev 2005, 85:845-881.
    • (2005) Physiol Rev , vol.85 , pp. 845-881
    • Strauss, O.1
  • 2
    • 0038125664 scopus 로고    scopus 로고
    • Participation of pigment epithelium in ocular immune privilege. 3. Epithelia cultured from iris, ciliary body, and retina suppress T-cell activation by partially non-overlapping mechanisms
    • Ishida K., Panjwani N., Cao Z., Streilein J.W. Participation of pigment epithelium in ocular immune privilege. 3. Epithelia cultured from iris, ciliary body, and retina suppress T-cell activation by partially non-overlapping mechanisms. Ocul Immunol Inflamm 2003, 11:91-105.
    • (2003) Ocul Immunol Inflamm , vol.11 , pp. 91-105
    • Ishida, K.1    Panjwani, N.2    Cao, Z.3    Streilein, J.W.4
  • 3
    • 0037166342 scopus 로고    scopus 로고
    • Recovery of visual functions in a mouse model of Leber congenital amaurosis
    • Van Hooser J.P., Liang Y., Maeda T., Kuksa V., Jang G.F., He Y.G., et al. Recovery of visual functions in a mouse model of Leber congenital amaurosis. JBiol Chem 2002, 277:19173-19182.
    • (2002) JBiol Chem , vol.277 , pp. 19173-19182
    • Van Hooser, J.P.1    Liang, Y.2    Maeda, T.3    Kuksa, V.4    Jang, G.F.5    He, Y.G.6
  • 4
    • 28444452653 scopus 로고    scopus 로고
    • Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis
    • Batten M.L., Imanishi Y., Tu D.C., Doan T., Zhu L., Pang J., et al. Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis. PLoS Med 2005, 2:e333.
    • (2005) PLoS Med , vol.2
    • Batten, M.L.1    Imanishi, Y.2    Tu, D.C.3    Doan, T.4    Zhu, L.5    Pang, J.6
  • 5
    • 84861973365 scopus 로고    scopus 로고
    • Chemical Chaperone TUDCA preserves cone photoreceptors in a mouse model of Leber congenital amaurosis
    • Zhang T., Baehr W., Fu Y. Chemical Chaperone TUDCA preserves cone photoreceptors in a mouse model of Leber congenital amaurosis. Invest Ophthalmol Vis Sci 2012, 53:3349-3356.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 3349-3356
    • Zhang, T.1    Baehr, W.2    Fu, Y.3
  • 6
    • 79953749322 scopus 로고    scopus 로고
    • Self-organizing optic-cup morphogenesis in three-dimensional culture
    • Eiraku M., Takata N., Ishibashi H., Kawada M., Sakakura E., Okuda S., et al. Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature 2011, 472:51-56.
    • (2011) Nature , vol.472 , pp. 51-56
    • Eiraku, M.1    Takata, N.2    Ishibashi, H.3    Kawada, M.4    Sakakura, E.5    Okuda, S.6
  • 7
    • 84862526635 scopus 로고    scopus 로고
    • Self-formation of optic cups and storable stratified neural retina from human ESCs
    • Nakano T., Ando S., Takata N., Kawada M., Muguruma K., Sekiguchi K., et al. Self-formation of optic cups and storable stratified neural retina from human ESCs. Cell Stem Cell 2012, 10:771-785.
    • (2012) Cell Stem Cell , vol.10 , pp. 771-785
    • Nakano, T.1    Ando, S.2    Takata, N.3    Kawada, M.4    Muguruma, K.5    Sekiguchi, K.6
  • 10
    • 26444505481 scopus 로고    scopus 로고
    • Retinal progenitor cell xenografts to the pig retina: morphologic integration and cytochemical differentiation
    • Warfvinge K., Kiilgaard J.F., Lavik E.B., Scherfig E., Langer R., Klassen H.J., et al. Retinal progenitor cell xenografts to the pig retina: morphologic integration and cytochemical differentiation. Arch Ophthalmol 2005, 123:1385-1393.
    • (2005) Arch Ophthalmol , vol.123 , pp. 1385-1393
    • Warfvinge, K.1    Kiilgaard, J.F.2    Lavik, E.B.3    Scherfig, E.4    Langer, R.5    Klassen, H.J.6
  • 11
    • 79952025858 scopus 로고    scopus 로고
    • Human retinal pigment epithelium (RPE) transplantation: outcome after autologous RPE-choroid sheet and RPE cell-suspension in a randomised clinical study
    • Falkner-Radler C.I., Krebs I., Glittenberg C., Povazay B., Drexler W., Graf A., et al. Human retinal pigment epithelium (RPE) transplantation: outcome after autologous RPE-choroid sheet and RPE cell-suspension in a randomised clinical study. Br J Ophthalmol 2011, 95:370-375.
    • (2011) Br J Ophthalmol , vol.95 , pp. 370-375
    • Falkner-Radler, C.I.1    Krebs, I.2    Glittenberg, C.3    Povazay, B.4    Drexler, W.5    Graf, A.6
  • 12
    • 39849110435 scopus 로고    scopus 로고
    • Reversal of blindness in animal models of leber congenital amaurosis using optimized AAV2-mediated gene transfer
    • Bennicelli J., Wright J.F., Komaromy A., Jacobs J.B., Hauck B., Zelenaia O., et al. Reversal of blindness in animal models of leber congenital amaurosis using optimized AAV2-mediated gene transfer. Mol Ther 2008, 16:458-465.
    • (2008) Mol Ther , vol.16 , pp. 458-465
    • Bennicelli, J.1    Wright, J.F.2    Komaromy, A.3    Jacobs, J.B.4    Hauck, B.5    Zelenaia, O.6
  • 13
    • 33846933945 scopus 로고    scopus 로고
    • Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium
    • Le Meur G., Stieger K., Smith A.J., Weber M., Deschamps J.Y., Nivard D., et al. Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium. Gene Ther 2007, 14:292-303.
    • (2007) Gene Ther , vol.14 , pp. 292-303
    • Le Meur, G.1    Stieger, K.2    Smith, A.J.3    Weber, M.4    Deschamps, J.Y.5    Nivard, D.6
  • 14
    • 54549125880 scopus 로고    scopus 로고
    • Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential
    • Li Q., Miller R., Han P.Y., Pang J., Dinculescu A., Chiodo V., et al. Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential. Mol Vis 2008, 14:1760-1769.
    • (2008) Mol Vis , vol.14 , pp. 1760-1769
    • Li, Q.1    Miller, R.2    Han, P.Y.3    Pang, J.4    Dinculescu, A.5    Chiodo, V.6
  • 15
    • 84855611189 scopus 로고    scopus 로고
    • Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years
    • Jacobson S.G., Cideciyan A.V., Ratnakaram R., Heon E., Schwartz S.B., Roman A.J., et al. Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years. Arch Ophthalmol 2012, 130:9-24.
    • (2012) Arch Ophthalmol , vol.130 , pp. 9-24
    • Jacobson, S.G.1    Cideciyan, A.V.2    Ratnakaram, R.3    Heon, E.4    Schwartz, S.B.5    Roman, A.J.6
  • 17
    • 74049085498 scopus 로고    scopus 로고
    • Effect of genome size on AAV vector packaging
    • Wu Z., Yang H., Colosi P. Effect of genome size on AAV vector packaging. Mol Ther 2010, 18:80-86.
    • (2010) Mol Ther , vol.18 , pp. 80-86
    • Wu, Z.1    Yang, H.2    Colosi, P.3
  • 19
    • 0031230466 scopus 로고    scopus 로고
    • Aphotoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy
    • Allikmets R. Aphotoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet 1997, 17:122.
    • (1997) Nat Genet , vol.17 , pp. 122
    • Allikmets, R.1
  • 20
    • 34248353947 scopus 로고    scopus 로고
    • Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells
    • Liu X., Bulgakov O.V., Darrow K.N., Pawlyk B., Adamian M., Liberman M.C., et al. Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells. Proc Natl Acad Sci U S A 2007, 104:4413-4418.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 4413-4418
    • Liu, X.1    Bulgakov, O.V.2    Darrow, K.N.3    Pawlyk, B.4    Adamian, M.5    Liberman, M.C.6
  • 21
    • 0032737034 scopus 로고    scopus 로고
    • Dynamin is required for recombinant adeno-associated virus type 2 infection
    • Duan D., Li Q., Kao A.W., Yue Y., Pessin J.E., Engelhardt J.F. Dynamin is required for recombinant adeno-associated virus type 2 infection. JVirol 1999, 73:10371-10376.
    • (1999) JVirol , vol.73 , pp. 10371-10376
    • Duan, D.1    Li, Q.2    Kao, A.W.3    Yue, Y.4    Pessin, J.E.5    Engelhardt, J.F.6
  • 23
    • 0035902477 scopus 로고    scopus 로고
    • TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors
    • Torchilin V.P., Rammohan R., Weissig V., Levchenko T.S. TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors. Proc Natl Acad Sci U S A 2001, 98:8786-8791.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 8786-8791
    • Torchilin, V.P.1    Rammohan, R.2    Weissig, V.3    Levchenko, T.S.4
  • 24
    • 0027460861 scopus 로고
    • Antibody-targeted delivery of doxorubicin entrapped in sterically stabilized liposomes can eradicate lung cancer in mice
    • Ahmad I., Longenecker M., Samuel J., Allen T.M. Antibody-targeted delivery of doxorubicin entrapped in sterically stabilized liposomes can eradicate lung cancer in mice. Cancer Res 1993, 53:1484-1488.
    • (1993) Cancer Res , vol.53 , pp. 1484-1488
    • Ahmad, I.1    Longenecker, M.2    Samuel, J.3    Allen, T.M.4
  • 25
    • 77950497463 scopus 로고    scopus 로고
    • Liposome formulations of hydrophobic drugs
    • Schwendener R.A., Schott H. Liposome formulations of hydrophobic drugs. Methods Mol Biol 2010, 605:129-138.
    • (2010) Methods Mol Biol , vol.605 , pp. 129-138
    • Schwendener, R.A.1    Schott, H.2
  • 26
    • 0029949266 scopus 로고    scopus 로고
    • Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection
    • Xu Y., Szoka F.C. Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection. Biochemistry (Mosc) 1996, 35:5616-5623.
    • (1996) Biochemistry (Mosc) , vol.35 , pp. 5616-5623
    • Xu, Y.1    Szoka, F.C.2
  • 27
    • 0032962975 scopus 로고    scopus 로고
    • Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer
    • Lechardeur D., Sohn K.J., Haardt M., Joshi P.B., Monck M., Graham R.W., et al. Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer. Gene Ther 1999, 6:482-497.
    • (1999) Gene Ther , vol.6 , pp. 482-497
    • Lechardeur, D.1    Sohn, K.J.2    Haardt, M.3    Joshi, P.B.4    Monck, M.5    Graham, R.W.6
  • 28
    • 0031768405 scopus 로고    scopus 로고
    • Safety study and characterization of E1A-liposome complex gene-delivery protocol in an ovarian cancer model
    • Xing X., Zhang S., Chang J.Y., Tucker S.D., Chen H., Huang L., et al. Safety study and characterization of E1A-liposome complex gene-delivery protocol in an ovarian cancer model. Gene Ther 1998, 5:1538-1544.
    • (1998) Gene Ther , vol.5 , pp. 1538-1544
    • Xing, X.1    Zhang, S.2    Chang, J.Y.3    Tucker, S.D.4    Chen, H.5    Huang, L.6
  • 29
    • 0031032759 scopus 로고    scopus 로고
    • Phase I study of direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7, in patients with metastatic melanoma
    • Stopeck A.T., Hersh E.M., Akporiaye E.T., Harris D.T., Grogan T., Unger E., et al. Phase I study of direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7, in patients with metastatic melanoma. JClin Oncol 1997, 15:341-349.
    • (1997) JClin Oncol , vol.15 , pp. 341-349
    • Stopeck, A.T.1    Hersh, E.M.2    Akporiaye, E.T.3    Harris, D.T.4    Grogan, T.5    Unger, E.6
  • 30
    • 77957999206 scopus 로고    scopus 로고
    • Human trial of liposomal lactoferrin supplementation for periodontal disease
    • Ishikado A., Uesaki S., Suido H., Nomura Y., Sumikawa K., Maeda M., et al. Human trial of liposomal lactoferrin supplementation for periodontal disease. Biol Pharm Bull 2010, 33:1758-1762.
    • (2010) Biol Pharm Bull , vol.33 , pp. 1758-1762
    • Ishikado, A.1    Uesaki, S.2    Suido, H.3    Nomura, Y.4    Sumikawa, K.5    Maeda, M.6
  • 32
    • 80052386408 scopus 로고    scopus 로고
    • Alipid nanoparticle system improves siRNA efficacy in RPE cells and a laser-induced murine CNV model
    • Liu H.A., Liu Y.L., Ma Z.Z., Wang J.C., Zhang Q. Alipid nanoparticle system improves siRNA efficacy in RPE cells and a laser-induced murine CNV model. Invest Ophthalmol Vis Sci 2011, 52:4789-4794.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 4789-4794
    • Liu, H.A.1    Liu, Y.L.2    Ma, Z.Z.3    Wang, J.C.4    Zhang, Q.5
  • 34
    • 73849132937 scopus 로고    scopus 로고
    • Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous
    • Dalkara D., Kolstad K.D., Caporale N., Visel M., Klimczak R.R., Schaffer D.V., et al. Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous. Mol Ther 2009, 17:2096-2102.
    • (2009) Mol Ther , vol.17 , pp. 2096-2102
    • Dalkara, D.1    Kolstad, K.D.2    Caporale, N.3    Visel, M.4    Klimczak, R.R.5    Schaffer, D.V.6
  • 35
    • 0030444807 scopus 로고    scopus 로고
    • Invivo gene transfer into the retina mediated by a novel liposome system
    • Hangai M., Kaneda Y., Tanihara H., Honda Y. Invivo gene transfer into the retina mediated by a novel liposome system. Invest Ophthalmol Vis Sci 1996, 37:2678-2685.
    • (1996) Invest Ophthalmol Vis Sci , vol.37 , pp. 2678-2685
    • Hangai, M.1    Kaneda, Y.2    Tanihara, H.3    Honda, Y.4
  • 36
    • 33750190748 scopus 로고    scopus 로고
    • Gene transfer with liposomes to the intraocular tissues by different routes of administration
    • Masuda I., Matsuo T., Yasuda T., Matsuo N. Gene transfer with liposomes to the intraocular tissues by different routes of administration. Invest Ophthalmol Vis Sci 1996, 37:1914-1920.
    • (1996) Invest Ophthalmol Vis Sci , vol.37 , pp. 1914-1920
    • Masuda, I.1    Matsuo, T.2    Yasuda, T.3    Matsuo, N.4
  • 37
    • 0029160083 scopus 로고
    • Aversatile vector for gene and oligonucleotide transfer into cells in culture and invivo: polyethylenimine
    • Boussif O., Lezoualc'h F., Zanta M.A., Mergny M.D., Scherman D., Demeneix B., et al. Aversatile vector for gene and oligonucleotide transfer into cells in culture and invivo: polyethylenimine. Proc Natl Acad Sci U S A 1995, 92:7297-7301.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 7297-7301
    • Boussif, O.1    Lezoualc'h, F.2    Zanta, M.A.3    Mergny, M.D.4    Scherman, D.5    Demeneix, B.6
  • 38
    • 0030927586 scopus 로고    scopus 로고
    • Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery
    • Kircheis R., Kichler A., Wallner G., Kursa M., Ogris M., Felzmann T., et al. Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery. Gene Ther 1997, 4:409-418.
    • (1997) Gene Ther , vol.4 , pp. 409-418
    • Kircheis, R.1    Kichler, A.2    Wallner, G.3    Kursa, M.4    Ogris, M.5    Felzmann, T.6
  • 40
    • 33750525488 scopus 로고    scopus 로고
    • Cytotoxicity of polyethyleneimine (PEI), precursor base layer of polyelectrolyte multilayer films
    • Brunot C., Ponsonnet L., Lagneau C., Farge P., Picart C., Grosgogeat B. Cytotoxicity of polyethyleneimine (PEI), precursor base layer of polyelectrolyte multilayer films. Biomaterials 2007, 28:632-640.
    • (2007) Biomaterials , vol.28 , pp. 632-640
    • Brunot, C.1    Ponsonnet, L.2    Lagneau, C.3    Farge, P.4    Picart, C.5    Grosgogeat, B.6
  • 41
    • 78650311464 scopus 로고    scopus 로고
    • Modified polyethyleneimine with histidine-lysine short peptides as gene carrier
    • Hashemi M., Parhiz B.H., Hatefi A., Ramezani M. Modified polyethyleneimine with histidine-lysine short peptides as gene carrier. Cancer Gene Ther 2011, 18:12-19.
    • (2011) Cancer Gene Ther , vol.18 , pp. 12-19
    • Hashemi, M.1    Parhiz, B.H.2    Hatefi, A.3    Ramezani, M.4
  • 42
    • 33646427165 scopus 로고    scopus 로고
    • Oligonucleotide-polyethylenimine complexes targeting retinal cells: structural analysis and application to anti-TGFbeta-2 therapy
    • Gomes dos Santos A.L., Bochot A., Tsapis N., Artzner F., Bejjani R.A., Thillaye-Goldenberg B., et al. Oligonucleotide-polyethylenimine complexes targeting retinal cells: structural analysis and application to anti-TGFbeta-2 therapy. Pharm Res 2006, 23:770-781.
    • (2006) Pharm Res , vol.23 , pp. 770-781
    • Gomes dos Santos, A.L.1    Bochot, A.2    Tsapis, N.3    Artzner, F.4    Bejjani, R.A.5    Thillaye-Goldenberg, B.6
  • 43
    • 2442707464 scopus 로고    scopus 로고
    • Gel and solid matrix systems for the controlled delivery of drug carrier-associated nucleic acids
    • Fattal E., De Rosa G., Bochot A. Gel and solid matrix systems for the controlled delivery of drug carrier-associated nucleic acids. Int J Pharm 2004, 277:25-30.
    • (2004) Int J Pharm , vol.277 , pp. 25-30
    • Fattal, E.1    De Rosa, G.2    Bochot, A.3
  • 44
    • 0037392838 scopus 로고    scopus 로고
    • Vitreous is a barrier in nonviral gene transfer by cationic lipids and polymers
    • Pitkanen L., Ruponen M., Nieminen J., Urtti A. Vitreous is a barrier in nonviral gene transfer by cationic lipids and polymers. Pharm Res 2003, 20:576-583.
    • (2003) Pharm Res , vol.20 , pp. 576-583
    • Pitkanen, L.1    Ruponen, M.2    Nieminen, J.3    Urtti, A.4
  • 46
    • 31544456364 scopus 로고    scopus 로고
    • Dehydrated form of plasmid expressing basic fibroblast growth factor-polyethylenimine complex is a novel and accurate method for gene transfer to the cornea
    • Kuo C.N., Yang L.C., Wu P.C., Kuo H.K., Kuo C.J., Tai M.H. Dehydrated form of plasmid expressing basic fibroblast growth factor-polyethylenimine complex is a novel and accurate method for gene transfer to the cornea. Curr Eye Res 2005, 30:1015-1024.
    • (2005) Curr Eye Res , vol.30 , pp. 1015-1024
    • Kuo, C.N.1    Yang, L.C.2    Wu, P.C.3    Kuo, H.K.4    Kuo, C.J.5    Tai, M.H.6
  • 47
    • 84861316754 scopus 로고    scopus 로고
    • Poly(beta-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells invitro and invivo
    • Sunshine J.C., Sunshine S.B., Bhutto I., Handa J.T., Green J.J. Poly(beta-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells invitro and invivo. PLoS One 2012, 7:e37543.
    • (2012) PLoS One , vol.7
    • Sunshine, J.C.1    Sunshine, S.B.2    Bhutto, I.3    Handa, J.T.4    Green, J.J.5
  • 48
    • 80053107237 scopus 로고    scopus 로고
    • Delivery of Oct4 and SirT1 with cationic polyurethanes-short branch PEI to aged retinal pigment epithelium
    • Peng C.H., Cherng J.Y., Chiou G.Y., Chen Y.C., Chien C.H., Kao C.L., et al. Delivery of Oct4 and SirT1 with cationic polyurethanes-short branch PEI to aged retinal pigment epithelium. Biomaterials 2011, 32:9077-9088.
    • (2011) Biomaterials , vol.32 , pp. 9077-9088
    • Peng, C.H.1    Cherng, J.Y.2    Chiou, G.Y.3    Chen, Y.C.4    Chien, C.H.5    Kao, C.L.6
  • 49
    • 0000041724 scopus 로고
    • Chitin and chitosan as chromatographic supports and adsorbents for collection of metal ions from organic and aqueous solutions and sea-water
    • Muzzarelli R.A., Tubertini O. Chitin and chitosan as chromatographic supports and adsorbents for collection of metal ions from organic and aqueous solutions and sea-water. Talanta 1969, 16:1571-1577.
    • (1969) Talanta , vol.16 , pp. 1571-1577
    • Muzzarelli, R.A.1    Tubertini, O.2
  • 50
    • 0035213983 scopus 로고    scopus 로고
    • Structural characteristics of size-controlled self-aggregates of deoxycholic acid-modified chitosan and their application as a DNA delivery carrier
    • Kim Y.H., Gihm S.H., Park C.R., Lee K.Y., Kim T.W., Kwon I.C., et al. Structural characteristics of size-controlled self-aggregates of deoxycholic acid-modified chitosan and their application as a DNA delivery carrier. Bioconjug Chem 2001, 12:932-938.
    • (2001) Bioconjug Chem , vol.12 , pp. 932-938
    • Kim, Y.H.1    Gihm, S.H.2    Park, C.R.3    Lee, K.Y.4    Kim, T.W.5    Kwon, I.C.6
  • 51
    • 0031722107 scopus 로고    scopus 로고
    • Chitosan-based vector/DNA complexes for gene delivery: biophysical characteristics and transfection ability
    • Erbacher P., Zou S., Bettinger T., Steffan A.M., Remy J.S. Chitosan-based vector/DNA complexes for gene delivery: biophysical characteristics and transfection ability. Pharm Res 1998, 15:1332-1339.
    • (1998) Pharm Res , vol.15 , pp. 1332-1339
    • Erbacher, P.1    Zou, S.2    Bettinger, T.3    Steffan, A.M.4    Remy, J.S.5
  • 52
    • 84856587267 scopus 로고    scopus 로고
    • Mechanistic study of transfection of chitosan/DNA complexes coated by anionic poly(gamma-glutamic acid)
    • Liao Z.X., Peng S.F., Ho Y.C., Mi F.L., Maiti B., Sung H.W. Mechanistic study of transfection of chitosan/DNA complexes coated by anionic poly(gamma-glutamic acid). Biomaterials 2012, 33:3306-3315.
    • (2012) Biomaterials , vol.33 , pp. 3306-3315
    • Liao, Z.X.1    Peng, S.F.2    Ho, Y.C.3    Mi, F.L.4    Maiti, B.5    Sung, H.W.6
  • 53
    • 84859602944 scopus 로고    scopus 로고
    • Formulation and invitro characterization of PEGylated chitosan and polyethylene imine polymers with thrombospondin-I gene bearing pDNA
    • Mehmet Saka O., Bozkir A. Formulation and invitro characterization of PEGylated chitosan and polyethylene imine polymers with thrombospondin-I gene bearing pDNA. JBiomed Mater Res B Appl Biomater 2012, 100:984-992.
    • (2012) JBiomed Mater Res B Appl Biomater , vol.100 , pp. 984-992
    • Mehmet Saka, O.1    Bozkir, A.2
  • 54
    • 84862907712 scopus 로고    scopus 로고
    • Exploring N-imidazolyl-O-carboxymethyl chitosan for high performance gene delivery
    • Shi B., Shen Z., Zhang H., Bi J., Dai S. Exploring N-imidazolyl-O-carboxymethyl chitosan for high performance gene delivery. Biomacromolecules 2012, 13:146-153.
    • (2012) Biomacromolecules , vol.13 , pp. 146-153
    • Shi, B.1    Shen, Z.2    Zhang, H.3    Bi, J.4    Dai, S.5
  • 55
    • 84870363103 scopus 로고    scopus 로고
    • Downregulation of VEGF mRNA expression by triamcinolone acetonide acetate-loaded chitosan derivative nanoparticles in human retinal pigment epithelial cells
    • Zhou H., Yang L., Li H., Gong H., Cheng L., Zheng H., et al. Downregulation of VEGF mRNA expression by triamcinolone acetonide acetate-loaded chitosan derivative nanoparticles in human retinal pigment epithelial cells. Int J Nanomedicine 2012, 7:4649-4660.
    • (2012) Int J Nanomedicine , vol.7 , pp. 4649-4660
    • Zhou, H.1    Yang, L.2    Li, H.3    Gong, H.4    Cheng, L.5    Zheng, H.6
  • 56
    • 55949127631 scopus 로고    scopus 로고
    • Ocular nanoparticle toxicity and transfection of the retina and retinal pigment epithelium
    • Prow T.W., Bhutto I., Kim S.Y., Grebe R., Merges C., McLeod D.S., et al. Ocular nanoparticle toxicity and transfection of the retina and retinal pigment epithelium. Nanomedicine 2008, 4:340-349.
    • (2008) Nanomedicine , vol.4 , pp. 340-349
    • Prow, T.W.1    Bhutto, I.2    Kim, S.Y.3    Grebe, R.4    Merges, C.5    McLeod, D.S.6
  • 57
    • 84863177498 scopus 로고    scopus 로고
    • Corneal gene delivery: chitosan oligomer as a carrier of CpG rich, CpG free, or S/MAR plasmid DNA
    • Klausner E.A., Zhang Z., Wong S.P., Chapman R.L., Volin M.V., Harbottle R.P. Corneal gene delivery: chitosan oligomer as a carrier of CpG rich, CpG free, or S/MAR plasmid DNA. JGene Med 2011, 14:100-108.
    • (2011) JGene Med , vol.14 , pp. 100-108
    • Klausner, E.A.1    Zhang, Z.2    Wong, S.P.3    Chapman, R.L.4    Volin, M.V.5    Harbottle, R.P.6
  • 58
    • 80051513044 scopus 로고    scopus 로고
    • Anti-inflammatory and antiangiogenic effects of nanoparticle-mediated delivery of a natural angiogenic inhibitor
    • Jin J., Zhou K.K., Park K., Hu Y., Xu X., Zheng Z., et al. Anti-inflammatory and antiangiogenic effects of nanoparticle-mediated delivery of a natural angiogenic inhibitor. Invest Ophthalmol Vis Sci 2011, 52:6230-6237.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 6230-6237
    • Jin, J.1    Zhou, K.K.2    Park, K.3    Hu, Y.4    Xu, X.5    Zheng, Z.6
  • 59
    • 81155154255 scopus 로고    scopus 로고
    • Invivo transfection study of chitosan-DNA-FAP-B nanoparticles as a new non viral vector for gene delivery to the lung
    • Mohammadi Z., Dorkoosh F.A., Hosseinkhani S., Gilani K., Amini T., Najafabadi A.R., et al. Invivo transfection study of chitosan-DNA-FAP-B nanoparticles as a new non viral vector for gene delivery to the lung. Int J Pharm 2011, 421:183-188.
    • (2011) Int J Pharm , vol.421 , pp. 183-188
    • Mohammadi, Z.1    Dorkoosh, F.A.2    Hosseinkhani, S.3    Gilani, K.4    Amini, T.5    Najafabadi, A.R.6
  • 60
    • 84865814615 scopus 로고    scopus 로고
    • Nano chitosan peptide as a potential therapeutic carrier for retinal delivery to treat age-related macular degeneration
    • Jayaraman M.S., Bharali D.J., Sudha T., Mousa S.A. Nano chitosan peptide as a potential therapeutic carrier for retinal delivery to treat age-related macular degeneration. Mol Vis 2012, 18:2300-2308.
    • (2012) Mol Vis , vol.18 , pp. 2300-2308
    • Jayaraman, M.S.1    Bharali, D.J.2    Sudha, T.3    Mousa, S.A.4
  • 61
    • 78650974784 scopus 로고    scopus 로고
    • Invitro response of retinal pigment epithelial cells exposed to chitosan materials prepared with different cross-linkers
    • Lai J.Y., Li Y.T., Wang T.P. Invitro response of retinal pigment epithelial cells exposed to chitosan materials prepared with different cross-linkers. Int J Mol Sci 2010, 11:5256-5272.
    • (2010) Int J Mol Sci , vol.11 , pp. 5256-5272
    • Lai, J.Y.1    Li, Y.T.2    Wang, T.P.3
  • 63
    • 0347354994 scopus 로고    scopus 로고
    • Transfection of airway epithelium by stable PEGylated poly-l-lysine DNA nanoparticles invivo
    • Ziady A.G., Gedeon C.R., Miller T., Quan W., Payne J.M., Hyatt S.L., et al. Transfection of airway epithelium by stable PEGylated poly-l-lysine DNA nanoparticles invivo. Mol Ther 2003, 8:936-947.
    • (2003) Mol Ther , vol.8 , pp. 936-947
    • Ziady, A.G.1    Gedeon, C.R.2    Miller, T.3    Quan, W.4    Payne, J.M.5    Hyatt, S.L.6
  • 64
    • 34247876190 scopus 로고    scopus 로고
    • Vectors for airway gene delivery
    • Davis P.B., Cooper M.J. Vectors for airway gene delivery. AAPS J 2007, 9:E11-E17.
    • (2007) AAPS J , vol.9
    • Davis, P.B.1    Cooper, M.J.2
  • 65
    • 80053588027 scopus 로고    scopus 로고
    • Nanoparticle-mediated gene transfer specific to retinal pigment epithelial cells
    • Koirala A., Makkia R.S., Cooper M.J., Naash M.I. Nanoparticle-mediated gene transfer specific to retinal pigment epithelial cells. Biomaterials 2011, 32:9483-9493.
    • (2011) Biomaterials , vol.32 , pp. 9483-9493
    • Koirala, A.1    Makkia, R.S.2    Cooper, M.J.3    Naash, M.I.4
  • 66
    • 33745224788 scopus 로고    scopus 로고
    • Plasmid size up to 20 kbp does not limit effective invivo lung gene transfer using compacted DNA nanoparticles
    • Fink T.L., Klepcyk P.J., Oette S.M., Gedeon C.R., Hyatt S.L., Kowalczyk T.H., et al. Plasmid size up to 20 kbp does not limit effective invivo lung gene transfer using compacted DNA nanoparticles. Gene Ther 2006, 13:1048-1051.
    • (2006) Gene Ther , vol.13 , pp. 1048-1051
    • Fink, T.L.1    Klepcyk, P.J.2    Oette, S.M.3    Gedeon, C.R.4    Hyatt, S.L.5    Kowalczyk, T.H.6
  • 67
    • 84865977758 scopus 로고    scopus 로고
    • DNA nanoparticle-mediated ABCA4 delivery rescues Stargardt dystrophy in mice
    • Han Z., Conley S.M., Makkia R.S., Cooper M.J., Naash M.I. DNA nanoparticle-mediated ABCA4 delivery rescues Stargardt dystrophy in mice. JClin Invest 2012, 122:3221-3226.
    • (2012) JClin Invest , vol.122 , pp. 3221-3226
    • Han, Z.1    Conley, S.M.2    Makkia, R.S.3    Cooper, M.J.4    Naash, M.I.5
  • 68
    • 38649138015 scopus 로고    scopus 로고
    • Cell surface nucleolin serves as receptor for DNA nanoparticles composed of pegylated polylysine and DNA
    • Chen X., Kube D.M., Cooper M.J., Davis P.B. Cell surface nucleolin serves as receptor for DNA nanoparticles composed of pegylated polylysine and DNA. Mol Ther 2008, 16:333-342.
    • (2008) Mol Ther , vol.16 , pp. 333-342
    • Chen, X.1    Kube, D.M.2    Cooper, M.J.3    Davis, P.B.4
  • 69
    • 78650868217 scopus 로고    scopus 로고
    • Nucleolin-mediated cellular trafficking of DNA nanoparticle is lipid raft and microtubule dependent and can be modulated by glucocorticoid
    • Chen X., Shank S., Davis P.B., Ziady A.G. Nucleolin-mediated cellular trafficking of DNA nanoparticle is lipid raft and microtubule dependent and can be modulated by glucocorticoid. Mol Ther 2011, 19:93-102.
    • (2011) Mol Ther , vol.19 , pp. 93-102
    • Chen, X.1    Shank, S.2    Davis, P.B.3    Ziady, A.G.4
  • 70
    • 84855721343 scopus 로고    scopus 로고
    • Enhancement of airway gene transfer by DNA nanoparticles using a pH-responsive block copolymer of polyethylene glycol and poly-l-lysine
    • Boylan N.J., Kim A.J., Suk J.S., Adstamongkonkul P., Simons B.W., Lai S.K., et al. Enhancement of airway gene transfer by DNA nanoparticles using a pH-responsive block copolymer of polyethylene glycol and poly-l-lysine. Biomaterials 2012, 33:2361-2371.
    • (2012) Biomaterials , vol.33 , pp. 2361-2371
    • Boylan, N.J.1    Kim, A.J.2    Suk, J.S.3    Adstamongkonkul, P.4    Simons, B.W.5    Lai, S.K.6
  • 72
    • 75149113700 scopus 로고    scopus 로고
    • Compacted DNA nanoparticle gene transfer of GDNF to the rat striatum enhances the survival of grafted fetal dopamine neurons
    • Yurek D.M., Flectcher A.M., Kowalczyk T.H., Padegimas L., Cooper M.J. Compacted DNA nanoparticle gene transfer of GDNF to the rat striatum enhances the survival of grafted fetal dopamine neurons. Cell Transplant 2009, 18:1183-1196.
    • (2009) Cell Transplant , vol.18 , pp. 1183-1196
    • Yurek, D.M.1    Flectcher, A.M.2    Kowalczyk, T.H.3    Padegimas, L.4    Cooper, M.J.5
  • 73
    • 19944398726 scopus 로고    scopus 로고
    • Compacted DNA nanoparticles administered to the nasal mucosa of cystic fibrosis subjects are safe and demonstrate partial to complete cystic fibrosis transmembrane regulator reconstitution
    • Konstan M.W., Davis P.B., Wagener J.S., Hilliard K.A., Stern R.C., Milgram L.J., et al. Compacted DNA nanoparticles administered to the nasal mucosa of cystic fibrosis subjects are safe and demonstrate partial to complete cystic fibrosis transmembrane regulator reconstitution. Hum Gene Ther 2004, 15:1255-1269.
    • (2004) Hum Gene Ther , vol.15 , pp. 1255-1269
    • Konstan, M.W.1    Davis, P.B.2    Wagener, J.S.3    Hilliard, K.A.4    Stern, R.C.5    Milgram, L.J.6
  • 74
    • 80053109227 scopus 로고    scopus 로고
    • Transgene expression in the striatum following intracerebral injections of DNA nanoparticles encoding for human glial cell line-derived neurotrophic factor
    • Fletcher A.M., Kowalczyk T.H., Padegimas L., Cooper M.J., Yurek D.M. Transgene expression in the striatum following intracerebral injections of DNA nanoparticles encoding for human glial cell line-derived neurotrophic factor. Neuroscience 2011, 194:220-226.
    • (2011) Neuroscience , vol.194 , pp. 220-226
    • Fletcher, A.M.1    Kowalczyk, T.H.2    Padegimas, L.3    Cooper, M.J.4    Yurek, D.M.5
  • 75
    • 65449178420 scopus 로고    scopus 로고
    • Apartial structural and functional rescue of a retinitis pigmentosa model with compacted DNA nanoparticles
    • Cai X., Nash Z., Conley S.M., Fliesler S.J., Cooper M.J., Naash M.I. Apartial structural and functional rescue of a retinitis pigmentosa model with compacted DNA nanoparticles. PLoS One 2009, 4:e5290.
    • (2009) PLoS One , vol.4
    • Cai, X.1    Nash, Z.2    Conley, S.M.3    Fliesler, S.J.4    Cooper, M.J.5    Naash, M.I.6
  • 76
    • 34248570405 scopus 로고    scopus 로고
    • Efficient non-viral ocular gene transfer with compacted DNA nanoparticles
    • Farjo R., Skaggs J., Quiambao A.B., Cooper M.J., Naash M.I. Efficient non-viral ocular gene transfer with compacted DNA nanoparticles. PLoS One 2006, 1:e38.
    • (2006) PLoS One , vol.1
    • Farjo, R.1    Skaggs, J.2    Quiambao, A.B.3    Cooper, M.J.4    Naash, M.I.5
  • 77
    • 77951632478 scopus 로고    scopus 로고
    • Gene delivery to mitotic and postmitotic photoreceptors via compacted DNA nanoparticles results in improved phenotype in a mouse model of retinitis pigmentosa
    • Cai X., Conley S.M., Nash Z., Fliesler S.J., Cooper M.J., Naash M.I. Gene delivery to mitotic and postmitotic photoreceptors via compacted DNA nanoparticles results in improved phenotype in a mouse model of retinitis pigmentosa. FASEB J 2010, 24:1178-1191.
    • (2010) FASEB J , vol.24 , pp. 1178-1191
    • Cai, X.1    Conley, S.M.2    Nash, Z.3    Fliesler, S.J.4    Cooper, M.J.5    Naash, M.I.6
  • 78
    • 84871276292 scopus 로고    scopus 로고
    • Comparative analysis of DNA nanoparticles and AAVs for ocular gene delivery
    • Han Z., Conley S.M., Makkia R., Guo J., Cooper M.J., Naash M.I. Comparative analysis of DNA nanoparticles and AAVs for ocular gene delivery. PLoS One 2012, 7:e52189.
    • (2012) PLoS One , vol.7
    • Han, Z.1    Conley, S.M.2    Makkia, R.3    Guo, J.4    Cooper, M.J.5    Naash, M.I.6
  • 79
    • 84875765994 scopus 로고    scopus 로고
    • S/MAR-containing DNA nanoparticles promote persistent RPE gene expression and improvement in RPE65-associated LCA
    • Koirala A., Makkia R.S., Conley S.M., Cooper M.J., Naash M.I. S/MAR-containing DNA nanoparticles promote persistent RPE gene expression and improvement in RPE65-associated LCA. Hum Mol Genet 2013, 22:1632-1642.
    • (2013) Hum Mol Genet , vol.22 , pp. 1632-1642
    • Koirala, A.1    Makkia, R.S.2    Conley, S.M.3    Cooper, M.J.4    Naash, M.I.5
  • 80
    • 84859454384 scopus 로고    scopus 로고
    • Direct gene transfer with compacted DNA nanoparticles in retinal pigment epithelial cells: expression, repeat delivery and lack of toxicity
    • Han Z., Koirala A., Makkia R., Cooper M.J., Naash M.I. Direct gene transfer with compacted DNA nanoparticles in retinal pigment epithelial cells: expression, repeat delivery and lack of toxicity. Nanomedicine (Lond) 2012, 7:521-539.
    • (2012) Nanomedicine (Lond) , vol.7 , pp. 521-539
    • Han, Z.1    Koirala, A.2    Makkia, R.3    Cooper, M.J.4    Naash, M.I.5
  • 82
    • 0000080813 scopus 로고
    • Cell genetics and hereditary symbiosis
    • Lederberg J. Cell genetics and hereditary symbiosis. Physiol Rev 1952, 32:403-430.
    • (1952) Physiol Rev , vol.32 , pp. 403-430
    • Lederberg, J.1
  • 83
    • 79952114792 scopus 로고    scopus 로고
    • Regulatory regions in DNA: promoters, enhancers, silencers, and insulators
    • Riethoven J.J. Regulatory regions in DNA: promoters, enhancers, silencers, and insulators. Methods Mol Biol 2010, 674:33-42.
    • (2010) Methods Mol Biol , vol.674 , pp. 33-42
    • Riethoven, J.J.1
  • 84
    • 79960850563 scopus 로고    scopus 로고
    • Sustained, high transgene expression in liver with plasmid vectors using optimized promoter-enhancer combinations
    • Magnusson T., Haase R., Schleef M., Wagner E., Ogris M. Sustained, high transgene expression in liver with plasmid vectors using optimized promoter-enhancer combinations. JGene Med 2011, 13:382-391.
    • (2011) JGene Med , vol.13 , pp. 382-391
    • Magnusson, T.1    Haase, R.2    Schleef, M.3    Wagner, E.4    Ogris, M.5
  • 85
    • 0027033259 scopus 로고
    • Hepatic gene therapy: persistent expression of human alpha 1-antitrypsin in mice after direct gene delivery invivo
    • Kay M.A., Li Q., Liu T.J., Leland F., Toman C., Finegold M., et al. Hepatic gene therapy: persistent expression of human alpha 1-antitrypsin in mice after direct gene delivery invivo. Hum Gene Ther 1992, 3:641-647.
    • (1992) Hum Gene Ther , vol.3 , pp. 641-647
    • Kay, M.A.1    Li, Q.2    Liu, T.J.3    Leland, F.4    Toman, C.5    Finegold, M.6
  • 86
    • 0026336989 scopus 로고
    • Apotential approach for gene therapy targeting hepatoma using a liver-specific promoter on a retroviral vector
    • Kuriyama S., Yoshikawa M., Ishizaka S., Tsujii T., Ikenaka K., Kagawa T., et al. Apotential approach for gene therapy targeting hepatoma using a liver-specific promoter on a retroviral vector. Cell Struct Funct 1991, 16:503-510.
    • (1991) Cell Struct Funct , vol.16 , pp. 503-510
    • Kuriyama, S.1    Yoshikawa, M.2    Ishizaka, S.3    Tsujii, T.4    Ikenaka, K.5    Kagawa, T.6
  • 87
    • 20444494936 scopus 로고    scopus 로고
    • Interchromosomal associations between alternatively expressed loci
    • Spilianakis C.G., Lalioti M.D., Town T., Lee G.R., Flavell R.A. Interchromosomal associations between alternatively expressed loci. Nature 2005, 435:637-645.
    • (2005) Nature , vol.435 , pp. 637-645
    • Spilianakis, C.G.1    Lalioti, M.D.2    Town, T.3    Lee, G.R.4    Flavell, R.A.5
  • 88
    • 79953777976 scopus 로고    scopus 로고
    • Improved antibiotic-free plasmid vector design by incorporation of transient expression enhancers
    • Luke J.M., Vincent J.M., Du S.X., Gerdemann U., Leen A.M., Whalen R.G., et al. Improved antibiotic-free plasmid vector design by incorporation of transient expression enhancers. Gene Ther 2011, 18:334-343.
    • (2011) Gene Ther , vol.18 , pp. 334-343
    • Luke, J.M.1    Vincent, J.M.2    Du, S.X.3    Gerdemann, U.4    Leen, A.M.5    Whalen, R.G.6
  • 89
    • 0041876302 scopus 로고    scopus 로고
    • Anovel combination of promoter and enhancers increases transgene expression in vascular smooth muscle cells invitro and coronary arteries invivo after adenovirus-mediated gene transfer
    • Appleby C.E., Kingston P.A., David A., Gerdes C.A., Umana P., Castro M.G., et al. Anovel combination of promoter and enhancers increases transgene expression in vascular smooth muscle cells invitro and coronary arteries invivo after adenovirus-mediated gene transfer. Gene Ther 2003, 10:1616-1622.
    • (2003) Gene Ther , vol.10 , pp. 1616-1622
    • Appleby, C.E.1    Kingston, P.A.2    David, A.3    Gerdes, C.A.4    Umana, P.5    Castro, M.G.6
  • 90
    • 37349009018 scopus 로고    scopus 로고
    • Development of photoreceptor-specific promoters and their utility to investigate EIAV lentiviral vector mediated gene transfer to photoreceptors
    • Nicoud M., Kong J., Iqball S., Kan O., Naylor S., Gouras P., et al. Development of photoreceptor-specific promoters and their utility to investigate EIAV lentiviral vector mediated gene transfer to photoreceptors. JGene Med 2007, 9:1015-1023.
    • (2007) JGene Med , vol.9 , pp. 1015-1023
    • Nicoud, M.1    Kong, J.2    Iqball, S.3    Kan, O.4    Naylor, S.5    Gouras, P.6
  • 91
    • 42949153889 scopus 로고    scopus 로고
    • Functional characterization of the GDEP promoter and three enhancer elements in retinoblastoma and prostate cell lines
    • Cross D.S., Burmester J.K. Functional characterization of the GDEP promoter and three enhancer elements in retinoblastoma and prostate cell lines. Med Oncol 2008, 25:40-49.
    • (2008) Med Oncol , vol.25 , pp. 40-49
    • Cross, D.S.1    Burmester, J.K.2
  • 92
    • 43649085073 scopus 로고    scopus 로고
    • The role of cis-regulatory elements in the design of gene therapy vectors for inherited blindness
    • Corbo J.C. The role of cis-regulatory elements in the design of gene therapy vectors for inherited blindness. Expert Opin Biol Ther 2008, 8:599-608.
    • (2008) Expert Opin Biol Ther , vol.8 , pp. 599-608
    • Corbo, J.C.1
  • 93
    • 0036467996 scopus 로고    scopus 로고
    • Insulators: many functions, many mechanisms
    • West A.G., Gaszner M., Felsenfeld G. Insulators: many functions, many mechanisms. Genes Dev 2002, 16:271-288.
    • (2002) Genes Dev , vol.16 , pp. 271-288
    • West, A.G.1    Gaszner, M.2    Felsenfeld, G.3
  • 95
    • 63949083133 scopus 로고    scopus 로고
    • Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator
    • Li C.L., Xiong D., Stamatoyannopoulos G., Emery D.W. Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator. Mol Ther 2009, 17:716-724.
    • (2009) Mol Ther , vol.17 , pp. 716-724
    • Li, C.L.1    Xiong, D.2    Stamatoyannopoulos, G.3    Emery, D.W.4
  • 96
    • 61949341072 scopus 로고    scopus 로고
    • Incorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrants
    • Nielsen T.T., Jakobsson J., Rosenqvist N., Lundberg C. Incorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrants. BMC Biotechnol 2009, 9:13.
    • (2009) BMC Biotechnol , vol.9 , pp. 13
    • Nielsen, T.T.1    Jakobsson, J.2    Rosenqvist, N.3    Lundberg, C.4
  • 97
    • 84868128257 scopus 로고    scopus 로고
    • The impact of cHS4 insulators on DNA transposon vector mobilization and silencing in retinal pigment epithelium cells
    • Sharma N., Hollensen A.K., Bak R.O., Staunstrup N.H., Schroder L.D., Mikkelsen J.G. The impact of cHS4 insulators on DNA transposon vector mobilization and silencing in retinal pigment epithelium cells. PLoS One 2012, 7:e48421.
    • (2012) PLoS One , vol.7
    • Sharma, N.1    Hollensen, A.K.2    Bak, R.O.3    Staunstrup, N.H.4    Schroder, L.D.5    Mikkelsen, J.G.6
  • 98
    • 82555187500 scopus 로고    scopus 로고
    • The GATA1-HS2 enhancer allows persistent and position-independent expression of a beta-globin transgene
    • Miccio A., Poletti V., Tiboni F., Rossi C., Antonelli A., Mavilio F., et al. The GATA1-HS2 enhancer allows persistent and position-independent expression of a beta-globin transgene. PLoS One 2011, 6:e27955.
    • (2011) PLoS One , vol.6
    • Miccio, A.1    Poletti, V.2    Tiboni, F.3    Rossi, C.4    Antonelli, A.5    Mavilio, F.6
  • 100
    • 0034255145 scopus 로고    scopus 로고
    • Achromatin insulator protects retrovirus vectors from chromosomal position effects
    • Emery D.W., Yannaki E., Tubb J., Stamatoyannopoulos G. Achromatin insulator protects retrovirus vectors from chromosomal position effects. Proc Natl Acad Sci U S A 2000, 97:9150-9155.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 9150-9155
    • Emery, D.W.1    Yannaki, E.2    Tubb, J.3    Stamatoyannopoulos, G.4
  • 101
    • 78649819161 scopus 로고    scopus 로고
    • Mutation of a barrier insulator in the human ankyrin-1 gene is associated with hereditary spherocytosis
    • Gallagher P.G., Steiner L.A., Liem R.I., Owen A.N., Cline A.P., Seidel N.E., et al. Mutation of a barrier insulator in the human ankyrin-1 gene is associated with hereditary spherocytosis. JClin Invest 2010, 120:4453-4465.
    • (2010) JClin Invest , vol.120 , pp. 4453-4465
    • Gallagher, P.G.1    Steiner, L.A.2    Liem, R.I.3    Owen, A.N.4    Cline, A.P.5    Seidel, N.E.6
  • 102
    • 0023941165 scopus 로고
    • Methylation of single CpG dinucleotides within a promoter element of the Herpes simplex virus tk gene reduces its transcription invivo
    • Ben-Hattar J., Jiricny J. Methylation of single CpG dinucleotides within a promoter element of the Herpes simplex virus tk gene reduces its transcription invivo. Gene 1988, 65:219-227.
    • (1988) Gene , vol.65 , pp. 219-227
    • Ben-Hattar, J.1    Jiricny, J.2
  • 103
    • 39849089752 scopus 로고    scopus 로고
    • Silencing of episomal transgene expression in liver by plasmid bacterial backbone DNA is independent of CpG methylation
    • Chen Z.Y., Riu E., He C.Y., Xu H., Kay M.A. Silencing of episomal transgene expression in liver by plasmid bacterial backbone DNA is independent of CpG methylation. Mol Ther 2008, 16:548-556.
    • (2008) Mol Ther , vol.16 , pp. 548-556
    • Chen, Z.Y.1    Riu, E.2    He, C.Y.3    Xu, H.4    Kay, M.A.5
  • 104
    • 2942594082 scopus 로고    scopus 로고
    • Cytosine methylation and CpG, TpG (CpA) and TpA frequencies
    • Jabbari K., Bernardi G. Cytosine methylation and CpG, TpG (CpA) and TpA frequencies. Gene 2004, 333:143-149.
    • (2004) Gene , vol.333 , pp. 143-149
    • Jabbari, K.1    Bernardi, G.2
  • 105
    • 42949093707 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA
    • Ramirez-Ortiz Z.G., Specht C.A., Wang J.P., Lee C.K., Bartholomeu D.C., Gazzinelli R.T., et al. Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA. Infect Immun 2008, 76:2123-2129.
    • (2008) Infect Immun , vol.76 , pp. 2123-2129
    • Ramirez-Ortiz, Z.G.1    Specht, C.A.2    Wang, J.P.3    Lee, C.K.4    Bartholomeu, D.C.5    Gazzinelli, R.T.6
  • 107
    • 79959201563 scopus 로고    scopus 로고
    • The genome of self-complementary adeno-associated viral vectors increases toll-like receptor 9-dependent innate immune responses in the liver
    • Martino A.T., Suzuki M., Markusic D.M., Zolotukhin I., Ryals R.C., Moghimi B., et al. The genome of self-complementary adeno-associated viral vectors increases toll-like receptor 9-dependent innate immune responses in the liver. Blood 2011, 117:6459-6468.
    • (2011) Blood , vol.117 , pp. 6459-6468
    • Martino, A.T.1    Suzuki, M.2    Markusic, D.M.3    Zolotukhin, I.4    Ryals, R.C.5    Moghimi, B.6
  • 108
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
    • Klinman D.M., Yi A.K., Beaucage S.L., Conover J., Krieg A.M. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc Natl Acad Sci U S A 1996, 93:2879-2883.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 2879-2883
    • Klinman, D.M.1    Yi, A.K.2    Beaucage, S.L.3    Conover, J.4    Krieg, A.M.5
  • 109
    • 0030239828 scopus 로고    scopus 로고
    • Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
    • Ballas Z.K., Rasmussen W.L., Krieg A.M. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. JImmunol 1996, 157:1840-1845.
    • (1996) JImmunol , vol.157 , pp. 1840-1845
    • Ballas, Z.K.1    Rasmussen, W.L.2    Krieg, A.M.3
  • 110
    • 0035989006 scopus 로고    scopus 로고
    • CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression invivo
    • Yew N.S., Zhao H., Przybylska M., Wu I.H., Tousignant J.D., Scheule R.K., et al. CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression invivo. Mol Ther 2002, 5:731-738.
    • (2002) Mol Ther , vol.5 , pp. 731-738
    • Yew, N.S.1    Zhao, H.2    Przybylska, M.3    Wu, I.H.4    Tousignant, J.D.5    Scheule, R.K.6
  • 111
    • 0031436820 scopus 로고    scopus 로고
    • Anew DNA vehicle for nonviral gene delivery: supercoiled minicircle
    • Darquet A.M., Cameron B., Wils P., Scherman D., Crouzet J. Anew DNA vehicle for nonviral gene delivery: supercoiled minicircle. Gene Ther 1997, 4:1341-1349.
    • (1997) Gene Ther , vol.4 , pp. 1341-1349
    • Darquet, A.M.1    Cameron, B.2    Wils, P.3    Scherman, D.4    Crouzet, J.5
  • 112
    • 34250739823 scopus 로고    scopus 로고
    • Histone modifications are associated with the persistence or silencing of vector-mediated transgene expression invivo
    • Riu E., Chen Z.Y., Xu H., He C.Y., Kay M.A. Histone modifications are associated with the persistence or silencing of vector-mediated transgene expression invivo. Mol Ther 2007, 15:1348-1355.
    • (2007) Mol Ther , vol.15 , pp. 1348-1355
    • Riu, E.1    Chen, Z.Y.2    Xu, H.3    He, C.Y.4    Kay, M.A.5
  • 113
    • 0033023054 scopus 로고    scopus 로고
    • Minicircle: an improved DNA molecule for invitro and invivo gene transfer
    • Darquet A.M., Rangara R., Kreiss P., Schwartz B., Naimi S., Delaere P., et al. Minicircle: an improved DNA molecule for invitro and invivo gene transfer. Gene Ther 1999, 6:209-218.
    • (1999) Gene Ther , vol.6 , pp. 209-218
    • Darquet, A.M.1    Rangara, R.2    Kreiss, P.3    Schwartz, B.4    Naimi, S.5    Delaere, P.6
  • 114
    • 79952187756 scopus 로고    scopus 로고
    • Minicircle DNA-based gene therapy coupled with immune modulation permits long-term expression of alpha-L-iduronidase in mice with mucopolysaccharidosis type I
    • Osborn M.J., McElmurry R.T., Lees C.J., DeFeo A.P., Chen Z.Y., Kay M.A., et al. Minicircle DNA-based gene therapy coupled with immune modulation permits long-term expression of alpha-L-iduronidase in mice with mucopolysaccharidosis type I. Mol Ther 2011, 19:450-460.
    • (2011) Mol Ther , vol.19 , pp. 450-460
    • Osborn, M.J.1    McElmurry, R.T.2    Lees, C.J.3    DeFeo, A.P.4    Chen, Z.Y.5    Kay, M.A.6
  • 115
    • 79955705789 scopus 로고    scopus 로고
    • Development of S/MAR minicircles for enhanced and persistent transgene expression in the mouse liver
    • Argyros O., Wong S.P., Fedonidis C., Tolmachov O., Waddington S.N., Howe S.J., et al. Development of S/MAR minicircles for enhanced and persistent transgene expression in the mouse liver. JMol Med (Berl) 2011, 89:515-529.
    • (2011) JMol Med (Berl) , vol.89 , pp. 515-529
    • Argyros, O.1    Wong, S.P.2    Fedonidis, C.3    Tolmachov, O.4    Waddington, S.N.5    Howe, S.J.6
  • 116
    • 34748906174 scopus 로고    scopus 로고
    • Design of PCR-amplified DNA fragments for invivo gene delivery: size-dependency on stability and transgene expression
    • Hirata K., Nishikawa M., Kobayashi N., Takahashi Y., Takakura Y. Design of PCR-amplified DNA fragments for invivo gene delivery: size-dependency on stability and transgene expression. JPharm Sci 2007, 96:2251-2261.
    • (2007) JPharm Sci , vol.96 , pp. 2251-2261
    • Hirata, K.1    Nishikawa, M.2    Kobayashi, N.3    Takahashi, Y.4    Takakura, Y.5
  • 117
    • 0037221408 scopus 로고    scopus 로고
    • Helper-independent and AAV-ITR-independent chromosomal integration of double-stranded linear DNA vectors in mice
    • Nakai H., Montini E., Fuess S., Storm T.A., Meuse L., Finegold M., et al. Helper-independent and AAV-ITR-independent chromosomal integration of double-stranded linear DNA vectors in mice. Mol Ther 2003, 7:101-111.
    • (2003) Mol Ther , vol.7 , pp. 101-111
    • Nakai, H.1    Montini, E.2    Fuess, S.3    Storm, T.A.4    Meuse, L.5    Finegold, M.6
  • 118
    • 0034993252 scopus 로고    scopus 로고
    • Linear DNAs concatemerize invivo and result in sustained transgene expression in mouse liver
    • Chen Z.Y., Yant S.R., He C.Y., Meuse L., Shen S., Kay M.A. Linear DNAs concatemerize invivo and result in sustained transgene expression in mouse liver. Mol Ther 2001, 3:403-410.
    • (2001) Mol Ther , vol.3 , pp. 403-410
    • Chen, Z.Y.1    Yant, S.R.2    He, C.Y.3    Meuse, L.4    Shen, S.5    Kay, M.A.6
  • 120
    • 17844404286 scopus 로고    scopus 로고
    • Anovel minimal-size vector (MIDGE) improves transgene expression in colon carcinoma cells and avoids transfection of undesired DNA
    • Schakowski F., Gorschluter M., Junghans C., Schroff M., Buttgereit P., Ziske C., et al. Anovel minimal-size vector (MIDGE) improves transgene expression in colon carcinoma cells and avoids transfection of undesired DNA. Mol Ther 2001, 3:793-800.
    • (2001) Mol Ther , vol.3 , pp. 793-800
    • Schakowski, F.1    Gorschluter, M.2    Junghans, C.3    Schroff, M.4    Buttgereit, P.5    Ziske, C.6
  • 121
    • 84864883775 scopus 로고    scopus 로고
    • Adesigned curved DNA sequence remarkably enhances transgene expression from plasmid DNA in mouse liver
    • Fukunaga S., Kanda G., Tanase J., Harashima H., Ohyama T., Kamiya H. Adesigned curved DNA sequence remarkably enhances transgene expression from plasmid DNA in mouse liver. Gene Ther 2012, 19:828-835.
    • (2012) Gene Ther , vol.19 , pp. 828-835
    • Fukunaga, S.1    Kanda, G.2    Tanase, J.3    Harashima, H.4    Ohyama, T.5    Kamiya, H.6
  • 122
    • 33845479489 scopus 로고    scopus 로고
    • Adesigned curved DNA segment that is a remarkable activator of eukaryotic transcription
    • Sumida N., Nishikawa J., Kishi H., Amano M., Furuya T., Sonobe H., et al. Adesigned curved DNA segment that is a remarkable activator of eukaryotic transcription. FEBS J 2006, 273:5691-5702.
    • (2006) FEBS J , vol.273 , pp. 5691-5702
    • Sumida, N.1    Nishikawa, J.2    Kishi, H.3    Amano, M.4    Furuya, T.5    Sonobe, H.6
  • 124
    • 0041878327 scopus 로고    scopus 로고
    • From DNA structure to gene expression: mediators of nuclear compartmentalization and dynamics
    • Bode J., Goetze S., Heng H., Krawetz S.A., Benham C. From DNA structure to gene expression: mediators of nuclear compartmentalization and dynamics. Chromosome Res 2003, 11:435-445.
    • (2003) Chromosome Res , vol.11 , pp. 435-445
    • Bode, J.1    Goetze, S.2    Heng, H.3    Krawetz, S.A.4    Benham, C.5
  • 125
    • 0030690098 scopus 로고    scopus 로고
    • Stress-induced duplex DNA destabilization in scaffold/matrix attachment regions
    • Benham C., Kohwi-Shigematsu T., Bode J. Stress-induced duplex DNA destabilization in scaffold/matrix attachment regions. JMol Biol 1997, 274:181-196.
    • (1997) JMol Biol , vol.274 , pp. 181-196
    • Benham, C.1    Kohwi-Shigematsu, T.2    Bode, J.3
  • 126
    • 0036208002 scopus 로고    scopus 로고
    • Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes
    • Martens J.H., Verlaan M., Kalkhoven E., Dorsman J.C., Zantema A. Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes. Mol Cell Biol 2002, 22:2598-2606.
    • (2002) Mol Cell Biol , vol.22 , pp. 2598-2606
    • Martens, J.H.1    Verlaan, M.2    Kalkhoven, E.3    Dorsman, J.C.4    Zantema, A.5
  • 128
    • 0030977226 scopus 로고    scopus 로고
    • An atypical homeodomain in SATB1 promotes specific recognition of the key structural element in a matrix attachment region
    • Dickinson L.A., Dickinson C.D., Kohwi-Shigematsu T. An atypical homeodomain in SATB1 promotes specific recognition of the key structural element in a matrix attachment region. JBiol Chem 1997, 272:11463-11470.
    • (1997) JBiol Chem , vol.272 , pp. 11463-11470
    • Dickinson, L.A.1    Dickinson, C.D.2    Kohwi-Shigematsu, T.3
  • 129
    • 33749260340 scopus 로고    scopus 로고
    • Designing nonviral vectors for efficient gene transfer and long-term gene expression
    • Jackson D.A., Juranek S., Lipps H.J. Designing nonviral vectors for efficient gene transfer and long-term gene expression. Mol Ther 2006, 14:613-626.
    • (2006) Mol Ther , vol.14 , pp. 613-626
    • Jackson, D.A.1    Juranek, S.2    Lipps, H.J.3
  • 130
    • 0037435614 scopus 로고    scopus 로고
    • Computational and invitro analysis of destabilized DNA regions in the interferon gene cluster: potential of predicting functional gene domains
    • Goetze S., Gluch A., Benham C., Bode J. Computational and invitro analysis of destabilized DNA regions in the interferon gene cluster: potential of predicting functional gene domains. Biochemistry (Mosc) 2003, 42:154-166.
    • (2003) Biochemistry (Mosc) , vol.42 , pp. 154-166
    • Goetze, S.1    Gluch, A.2    Benham, C.3    Bode, J.4
  • 131
    • 0034103927 scopus 로고    scopus 로고
    • Transcriptional augmentation: modulation of gene expression by scaffold/matrix-attached regions (S/MAR elements)
    • Bode J., Benham C., Knopp A., Mielke C. Transcriptional augmentation: modulation of gene expression by scaffold/matrix-attached regions (S/MAR elements). Crit Rev Eukaryot Gene Expr 2000, 10:73-90.
    • (2000) Crit Rev Eukaryot Gene Expr , vol.10 , pp. 73-90
    • Bode, J.1    Benham, C.2    Knopp, A.3    Mielke, C.4
  • 132
    • 0042379603 scopus 로고    scopus 로고
    • Exploiting a minimal system to study the epigenetic control of DNA replication: the interplay between transcription and replication
    • Stehle I.M., Scinteie M.F., Baiker A., Jenke A.C., Lipps H.J. Exploiting a minimal system to study the epigenetic control of DNA replication: the interplay between transcription and replication. Chromosome Res 2003, 11:413-421.
    • (2003) Chromosome Res , vol.11 , pp. 413-421
    • Stehle, I.M.1    Scinteie, M.F.2    Baiker, A.3    Jenke, A.C.4    Lipps, H.J.5
  • 134
    • 0023050122 scopus 로고
    • Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster
    • Gasser S.M., Laemmli U.K. Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster. Cell 1986, 46:521-530.
    • (1986) Cell , vol.46 , pp. 521-530
    • Gasser, S.M.1    Laemmli, U.K.2
  • 135
    • 0026711089 scopus 로고
    • Agroup of scs elements function as domain boundaries in an enhancer-blocking assay
    • Kellum R., Schedl P. Agroup of scs elements function as domain boundaries in an enhancer-blocking assay. Mol Cell Biol 1992, 12:2424-2431.
    • (1992) Mol Cell Biol , vol.12 , pp. 2424-2431
    • Kellum, R.1    Schedl, P.2
  • 137
    • 78650991635 scopus 로고    scopus 로고
    • Non-viral S/MAR vectors replicate episomally invivo when provided with a selective advantage
    • Wong S.P., Argyros O., Coutelle C., Harbottle R.P. Non-viral S/MAR vectors replicate episomally invivo when provided with a selective advantage. Gene Ther 2011, 18:82-87.
    • (2011) Gene Ther , vol.18 , pp. 82-87
    • Wong, S.P.1    Argyros, O.2    Coutelle, C.3    Harbottle, R.P.4
  • 138
    • 57049172006 scopus 로고    scopus 로고
    • Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector
    • Argyros O., Wong S.P., Niceta M., Waddington S.N., Howe S.J., Coutelle C., et al. Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector. Gene Ther 2008, 15:1593-1605.
    • (2008) Gene Ther , vol.15 , pp. 1593-1605
    • Argyros, O.1    Wong, S.P.2    Niceta, M.3    Waddington, S.N.4    Howe, S.J.5    Coutelle, C.6
  • 139
    • 29244487057 scopus 로고    scopus 로고
    • Gene transfer into human hematopoietic progenitor cells with an episomal vector carrying an S/MAR element
    • Papapetrou E.P., Ziros P.G., Micheva I.D., Zoumbos N.C., Athanassiadou A. Gene transfer into human hematopoietic progenitor cells with an episomal vector carrying an S/MAR element. Gene Ther 2006, 13:40-51.
    • (2006) Gene Ther , vol.13 , pp. 40-51
    • Papapetrou, E.P.1    Ziros, P.G.2    Micheva, I.D.3    Zoumbos, N.C.4    Athanassiadou, A.5
  • 141
    • 54449085219 scopus 로고    scopus 로고
    • Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics
    • Cideciyan A.V., Aleman T.S., Boye S.L., Schwartz S.B., Kaushal S., Roman A.J., et al. Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics. Proc Natl Acad Sci U S A 2008, 105:15112-15117.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 15112-15117
    • Cideciyan, A.V.1    Aleman, T.S.2    Boye, S.L.3    Schwartz, S.B.4    Kaushal, S.5    Roman, A.J.6
  • 143
    • 33646663892 scopus 로고    scopus 로고
    • Neural retina limits the nonviral gene transfer to retinal pigment epithelium in an invitro bovine eye model
    • Pitkanen L., Pelkonen J., Ruponen M., Ronkko S., Urtti A. Neural retina limits the nonviral gene transfer to retinal pigment epithelium in an invitro bovine eye model. AAPS J 2004, 6:e25.
    • (2004) AAPS J , vol.6
    • Pitkanen, L.1    Pelkonen, J.2    Ruponen, M.3    Ronkko, S.4    Urtti, A.5
  • 144
    • 84859634004 scopus 로고    scopus 로고
    • Electroporation-mediated invivo gene delivery of the Na+/K+-ATPase pump reduced lung injury in a mouse model of lung contusion
    • Machado-Aranda D.A., Suresh M., Yu B., Raghavendran K. Electroporation-mediated invivo gene delivery of the Na+/K+-ATPase pump reduced lung injury in a mouse model of lung contusion. JTrauma 2012, 72:32-40.
    • (2012) JTrauma , vol.72 , pp. 32-40
    • Machado-Aranda, D.A.1    Suresh, M.2    Yu, B.3    Raghavendran, K.4
  • 147
    • 84860220147 scopus 로고    scopus 로고
    • Delivery of a DNA vaccine for Alzheimer's disease by electroporation versus gene gun generates potent and similar immune responses
    • Davtyan H., Ghochikyan A., Movsesyan N., Ellefsen B., Petrushina I., Cribbs D.H., et al. Delivery of a DNA vaccine for Alzheimer's disease by electroporation versus gene gun generates potent and similar immune responses. Neurodegener Dis 2012, 10:261-264.
    • (2012) Neurodegener Dis , vol.10 , pp. 261-264
    • Davtyan, H.1    Ghochikyan, A.2    Movsesyan, N.3    Ellefsen, B.4    Petrushina, I.5    Cribbs, D.H.6
  • 148
    • 82755164546 scopus 로고    scopus 로고
    • Shooting DNA, dyes, or indicators into tissue slices using the gene gun
    • Morgan J.L., Kerschensteiner D. Shooting DNA, dyes, or indicators into tissue slices using the gene gun. Cold Spring Harb Protoc 2011, 2011:1512-1514.
    • (2011) Cold Spring Harb Protoc , vol.2011 , pp. 1512-1514
    • Morgan, J.L.1    Kerschensteiner, D.2
  • 149
    • 0025033069 scopus 로고
    • Gene transfer by electroporation: a model for gene therapy
    • Keating A., Toneguzzo F. Gene transfer by electroporation: a model for gene therapy. Prog Clin Biol Res 1990, 333:491-498.
    • (1990) Prog Clin Biol Res , vol.333 , pp. 491-498
    • Keating, A.1    Toneguzzo, F.2
  • 150
    • 84864529935 scopus 로고    scopus 로고
    • Suprachoroidal electrotransfer: a nonviral gene delivery method to transfect the choroid and the retina without detaching the retina
    • Touchard E., Berdugo M., Bigey P., El Sanharawi M., Savoldelli M., Naud M.C., et al. Suprachoroidal electrotransfer: a nonviral gene delivery method to transfect the choroid and the retina without detaching the retina. Mol Ther 2012, 20:1559-1570.
    • (2012) Mol Ther , vol.20 , pp. 1559-1570
    • Touchard, E.1    Berdugo, M.2    Bigey, P.3    El Sanharawi, M.4    Savoldelli, M.5    Naud, M.C.6
  • 151
    • 0034946364 scopus 로고    scopus 로고
    • Invivo gene delivery into ocular tissues by eye drops of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) polymeric micelles
    • Liaw J., Chang S.F., Hsiao F.C. Invivo gene delivery into ocular tissues by eye drops of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) polymeric micelles. Gene Ther 2001, 8:999-1004.
    • (2001) Gene Ther , vol.8 , pp. 999-1004
    • Liaw, J.1    Chang, S.F.2    Hsiao, F.C.3


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