Delivery of Oct4 and SirT1 with cationic polyurethanes-short branch PEI to aged retinal pigment epithelium

Biomaterials

Volumn 32, Issue 34, 2011, Pages 9077-9088

  Peng, Chi Hsien ^a,c   Cherng, Jong Yuh ^b   Chiou, Guang Yuh ^a   Chen, Yu Chih ^a,d   Chien, Chen Hsiu ^a,d   Kao, Chung Lan ^a,d   Chang, Yuh Lih ^a   Chien, Yueh ^a,d   Chen, Liang Kung ^a,d   Liu, Jorn hon ^a,e   Chen, Shih Jen ^a,d   Chiou, Shih Hwa ^a,d  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG CHENG UNIVERSITY   (Taiwan)

^c SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^e CHENG HSIN GENERAL HOSPITAL   (Taiwan)

Author keywords

Age related macular degeneration; Oct4; Polyurethane short branch polyethylenimine; Reprogramming; Retinal pigment epithelium cells; SirT1

Indexed keywords

AGE-RELATED MACULAR DEGENERATION; OCT4; POLYETHYLENIMINES; REPROGRAMMING; RETINAL PIGMENT EPITHELIUM; SIRT1;

GENE TRANSFER; GENES; HYDROGEN; HYDROGEN PEROXIDE; OPHTHALMOLOGY; POLYURETHANES; RATS; STEM CELLS; TRANSCRIPTION; TRANSCRIPTION FACTORS;

ALDEHYDES;

HYDROGEN PEROXIDE; OCTAMER TRANSCRIPTION FACTOR 4; POLYETHYLENEIMINE; POLYURETHAN; REACTIVE OXYGEN METABOLITE; SIRTUIN 1;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL LOSS; CELL PROTECTION; CELL RENEWAL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ELECTRORETINOGRAPHY; FEMALE; GENE OVEREXPRESSION; GENE TRANSFER; HUMAN; MALE; NONHUMAN; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETINA; RETINA CELL; RETINA MACULA AGE RELATED DEGENERATION;

ADULT; AGED; ANIMALS; CELL LINE; FEMALE; GENE EXPRESSION; HUMANS; MACULAR DEGENERATION; MALE; MIDDLE AGED; OCTAMER TRANSCRIPTION FACTOR-3; POLYETHYLENEIMINE; POLYURETHANES; RATS; RATS, SPRAGUE-DAWLEY; RETINA; RETINAL PIGMENT EPITHELIUM; SIRTUIN 1;

RATTUS;

EID: 80053107237     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.08.008     Document Type: Article

References (56)

1. Bonnel S., Mohand-Said S., Sahel J.A. The aging of the retina. Exp Gerontol 2003, 38(8):825-831.
2. Coleman H.R., Chan C.C., Ferris F.L., Chew E.Y. Age-related macular degeneration. Lancet 2008, 372(9652):1835-1845.
3. Ding X., Patel M., Chan C.C. Molecular pathology of age-related macular degeneration. Prog Retin Eye Res. 2009, 28(1):1-18.
4. Simonelli F., Maguire A.M., Testa F., Pierce E.A., Mingozzi F., Bennicelli J.L., et al. Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration. Mol Ther 2010, 18(3):643-650.
5. Maguire A.M., Simonelli F., Pierce E.A., Pugh E.N., Mingozzi F., Bennicelli J., et al. Safety and efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med 2008, 358(21):2240-2248.
6. Thomas C.E., Ehrhardt A., Kay M.A. Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet. 2003, 4(5):346-358.
7. Boussif O., Lezoualc'h F., Zanta M.A., Mergny M.D., Scherman D., Demeneix B., et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci U S A 1995, 92(16):7297-7301.
8. Luten J., van Nostrum C.F., De Smedt S.C., Hennink W.E. Biodegradable polymers as non-viral carriers for plasmid DNA delivery. J Control Release 2008, 126(2):97-110.
9. Guan J., Fujimoto K.L., Sacks M.S., Wagner W.R. Preparation and characterization of highly porous, biodegradable polyurethane scaffolds for soft tissue applications. Biomaterials 2005, 26(18):3961-3971.
10. Shau M.D., Tseng S.J., Yang T.F., Cherng J.Y., Chin W.K. Effect of molecular weight on the transfection efficiency of novel polyurethane as a biodegradable gene vector. J Biomed Mater Res A 2006, 77(4):736-746.
11. Tseng S.J., Tang S.C., Shau M.D., Zeng Y.F., Cherng J.Y., Shih M.F. Structural characterization and buffering capacity in relation to the transfection efficiency of biodegradable polyurethane. Bioconjug Chem. 2005, 16(6):1375-1381.
12. Hung W.C., Shau M.D., Kao H.C., Shih M.F., Cherng J.Y. The synthesis of cationic polyurethanes to study the effect of amines and structures on their DNA transfection potential. J Control Release 2009, 133(1):68-76.
13. Liu X.Y., Ho W.Y., Hung W.J., Shau M.D. The characteristics and transfection efficiency of cationic poly (ester-co-urethane) - short chain PEI conjugates self-assembled with DNA. Biomaterials 2009, 30(34):6665-6673.
14. Prigione A., Fauler B., Lurz R., Lehrach H., Adjaye J. The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells. Stem Cells 2010, 28(4):721-733.
15. Li H.Y., Chien Y., Chen Y.J., Chen S.F., Chang Y.L., Chiang C.H., et al. Reprogramming induced pluripotent stem cells in the absence of c-Myc for differentiation into hepatocyte-like cells. Biomaterials 2011.
16. Okamoto K., Okazawa H., Okuda A., Sakai M., Muramatsu M., Hamada H. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell. 1990, 60(3):461-472.
17. Rosner M.H., Vigano M.A., Ozato K., Timmons P.M., Poirier F., Rigby P.W., et al. A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 1990, 345(6277):686-692.
18. Burdon T., Smith A., Savatier P. Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol 2002, 12(9):432-438.
19. Pesce M., Wang X., Wolgemuth D.J., Scholer H. Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation. Mech Dev 1998, 71(1-2):89-98.
20. Alcain F.J., Villalba J.M. Sirtuin inhibitors. Expert Opin Ther Pat 2009, 19(3):283-294.
21. Gasser S.M., Cockell M.M. The molecular biology of the SIR proteins. Gene 2001, 279(1):1-16.
22. Yang Y., Hou H., Haller E.M., Nicosia S.V., Bai W. Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. EMBO J 2005, 24(5):1021-1032.
23. Chen Y.C., Hsu H.S., Chen Y.W., Tsai T.H., How C.K., Wang C.Y., et al. Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells. PLoS One 2008, 3(7):e2637.
24. Wu W.C., Lai C.C., Chen S.L., Xiao X., Chen T.L., Tsai R.J., et al. Gene therapy for detached retina by adeno-associated virus vector expressing glial cell line-derived neurotrophic factor. Invest Ophthalmol Vis Sci 2002, 43(11):3480-3488.
25. Wenzel A., Grimm C., Samardzija M., Reme C.E. Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. Prog Retin Eye Res 2005, 24(2):275-306.
26. Peng Y.J., Wen C.W., Chiou S.H., Liu S.J. Sustained release of ganciclovir and foscarnet from biodegradable scleral plugs for the treatment of cytomegalovirus retinitis. Biomaterials 2010, 31(7):1773-1779.
27. Smith J.A., Ndoye A.M., Geary K., Lisanti M.P., Igoucheva O., Daniel R. A role for the Werner syndrome protein in epigenetic inactivation of the pluripotency factor Oct4. Aging Cell 2010, 9(4):580-591.
28. Bianco B., Oliveira K.C., Guedes A.D., Barbosa C.P., Lipay M.V., Verreschi I.T. OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome. Fertil Steril 2010, 94(6):2347-2349.
29. Cheng L., Sung M.T., Cossu-Rocca P., Jones T.D., MacLennan G.T., De Jong J., et al. OCT4: biological functions and clinical applications as a marker of germ cell neoplasia. J Pathol 2007, 211(1):1-9.
30. Dhodapkar K.M., Feldman D., Matthews P., Radfar S., Pickering R., Turkula S., et al. Natural immunity to pluripotency antigen OCT4 in humans. Proc Natl Acad Sci U S A 2010, 107(19):8718-8723.
31. Blander G., Guarente L. The Sir2 family of protein deacetylases. Annu Rev Biochem 2004, 73:417-435.
32. Oberdoerffer P., Michan S., McVay M., Mostoslavsky R., Vann J., Park S.K., et al. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 2008, 135(5):907-918.
33. Milne J.C., Lambert P.D., Schenk S., Carney D.P., Smith J.J., Gagne D.J., et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007, 450(7170):712-716.
34. Qin W., Yang T., Ho L., Zhao Z., Wang J., Chen L., et al. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem 2006, 281(31):21745-21754.
35. Borradaile N.M., Pickering J.G. NAD(+), sirtuins, and cardiovascular disease. Curr Pharm Des 2009, 15(1):110-117.
36. Peng C.H., Chiou S.H., Chen S.J., Chou Y.C., Ku H.H., Cheng C.K., et al. Neuroprotection by Imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway. Eur Neuropsychopharmacol 2008, 18(2):128-140.
37. Okita K., Ichisaka T., Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature 2007, 448(7151):313-317.
38. Mikkelsen T.S., Hanna J., Zhang X., Ku M., Wernig M., Schorderet P., et al. Dissecting direct reprogramming through integrative genomic analysis. Nature 2008, 454(7200):49-55.
39. Pfeifer A., Verma I.M. Gene therapy: promises and problems. Annu Rev Genomics Hum Genet 2001, 2:177-211.
40. Ballios B.G., Cooke M.J., van der Kooy D., Shoichet M.S. A hydrogel-based stem cell delivery system to treat retinal degenerative diseases. Biomaterials 2010, 31(9):2555-2564.
41. Boiani M., Scholer H.R. Regulatory networks in embryo-derived pluripotent stem cells. Nat Rev Mol Cell Biol 2005, 6(11):872-884.
42. Saunders L.R., Sharma A.D., Tawney J., Nakagawa M., Okita K., Yamanaka S., et al. miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY) 2010, 2(7):415-431.
43. Orren D.K. Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging. Front Biosci 2006, 11:2657-2671.
44. Sedding D.G. FoxO transcription factors in oxidative stress response and ageing-a new fork on the way to longevity?. Biol Chem 2008, 389(3):279-283.
45. Gan B.Q., Tang B.L. Sirt1's beneficial roles in neurodegenerative diseases - a chaperonin containing TCP-1 (CCT) connection?. Aging Cell 2010, 9(5):924-929.
46. Boiani M., Eckardt S., Scholer H.R., McLaughlin K.J. Oct4 distribution and level in mouse clones: consequences for pluripotency. Genes Dev 2002, 16(10):1209-1219.
47. Lowry W.E., Richter L., Yachechko R., Pyle A.D., Tchieu J., Sridharan R., et al. Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc Natl Acad Sci U S A 2008, 105(8):2883-2888.
48. Guo Y., Mantel C., Hromas R.A., Broxmeyer H.E. Oct-4 is critical for survival/antiapoptosis of murine embryonic stem cells subjected to stress: effects associated with Stat3/survivin. Stem Cells 2008, 26(1):30-34.
49. Longo V.D., Kennedy B.K. Sirtuins in aging and age-related disease. Cell 2006, 126(2):257-268.
50. Donmez G., Guarente L. Aging and disease: connections to sirtuins. Aging Cell 2010, 9(2):285-290.
51. Kuzmichev A., Margueron R., Vaquero A., Preissner T.S., Scher M., Kirmizis A., et al. Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc Natl Acad Sci U S A 2005, 102(6):1859-1864.
52. Han M.K., Song E.K., Guo Y., Ou X., Mantel C., Broxmeyer H.E. SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. Cell Stem Cell 2008, 2(3):241-251.
53. Armstrong L., Tilgner K., Saretzki G., Atkinson S.P., Stojkovic M., Moreno R., et al. Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells. Stem Cells 2010, 28(4):661-673.
54. Saretzki G., Walter T., Atkinson S., Passos J.F., Bareth B., Keith W.N., et al. Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells. Stem Cells 2008, 26(2):455-464.
55. Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126(4):663-676.
56. Esteban M.A., Wang T., Qin B., Yang J., Qin D., Cai J., et al. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 2010, 6(1):71-79.