Gene delivery to mitotic and postmitotic photoreceptors via compacted DNA nanoparticles results in improved phenotype in a mouse model of retinitis pigmentosa

FASEB Journal

Volumn 24, Issue 4, 2010, Pages 1178-1191

  Cai, Xue ^a   Conley, Shannon M ^a   Nash, Zack ^a   Fliesler, Steven J ^b,c   Cooper, Mark J ^d   Naash, Muna I ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b VA WESTERN NEW YORK HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

^d Copernicus Therapeutics Inc ^*  (United States)

Author keywords

Gene replacement therapy; Mouse opsin promoter; Retinal degeneration slow protein

Indexed keywords

INTERLEUKIN 6; NANOPARTICLE; OPSIN; TUMOR NECROSIS FACTOR ALPHA; DNA; INTERMEDIATE FILAMENT PROTEIN; MEMBRANE PROTEIN; NERVE PROTEIN; PERIPHERIN;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRORETINOGRAPHY; GENE; GENE REPLACEMENT THERAPY; GENE TARGETING; MACROPHAGE ACTIVATION; MOUSE; NEWBORN; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; RDS GENE; RETINA CONE; RETINA DEGENERATION; RETINA ROD; RETINITIS PIGMENTOSA; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; DRUG EFFECT; GENE THERAPY; GENETIC TRANSDUCTION; GENETICS; HUMAN; MACROPHAGE; METABOLISM; MITOSIS; MUTATION; PATHOLOGY; PROMOTER REGION; TIME; ULTRASTRUCTURE;

ANIMALS; DISEASE MODELS, ANIMAL; DNA; GENE THERAPY; HUMANS; INTERLEUKIN-6; INTERMEDIATE FILAMENT PROTEINS; MACROPHAGE ACTIVATION; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MITOSIS; MUTATION; NANOPARTICLES; NERVE TISSUE PROTEINS; OPSINS; PROMOTER REGIONS, GENETIC; RETINAL CONE PHOTORECEPTOR CELLS; RETINAL ROD PHOTORECEPTOR CELLS; RETINITIS PIGMENTOSA; TIME FACTORS; TRANSDUCTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 77951632478     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.09-139147     Document Type: Article

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