Transgene expression in the striatum following intracerebral injections of DNA nanoparticles encoding for human glial cell line-derived neurotrophic factor

Neuroscience

Volumn 194, Issue , 2011, Pages 220-226

  Fletcher, A M ^a   Kowalczyk, T H ^b   Padegimas, L ^b   Cooper, M J ^b   Yurek, D M ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Copernicus Therapeutics Inc ^*  (United States)

Author keywords

Gene therapy; Parkinson's disease; Plasmid optimization; Splice variant

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NANOPARTICLE; PLASMID DNA; POLYUBIQUITIN; POLYUBIQUITIN C; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; FETUS; GENE ACTIVITY; GENE EXPRESSION; MALE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROMOTER REGION; RAT; RNA SEQUENCE; TRANSGENE;

ANIMALS; BRAIN CHEMISTRY; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DNA; DRUG DELIVERY SYSTEMS; GENE EXPRESSION REGULATION; GENETIC THERAPY; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; MALE; MICROINJECTIONS; NANOPARTICLES; PARKINSONIAN DISORDERS; PRIMARY CELL CULTURE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 80053109227     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2011.07.072     Document Type: Article

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