Non-viral S/MAR vectors replicate episomally in vivo when provided with a selective advantage

Gene Therapy

Volumn 18, Issue 1, 2011, Pages 82-87

  Wong, S P ^a   Argyros, O ^a   Coutelle, C ^a   Harbottle, R P ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Bcl 2 gene; episomal vector; mitotic stability; scaffold matrix attachment region (S MAR)

Indexed keywords

FAS ANTIBODY; FAS ANTIGEN; LUCIFERASE; MATRIX ATTACHMENT REGION BINDING PROTEIN; PLASMID VECTOR; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HYDRODYNAMICS; IN VIVO STUDY; MATRIX ATTACHMENT REGION; MOUSE; NONHUMAN; NONVIRAL GENE THERAPY; PRIORITY JOURNAL; REPORTER GENE; SUPERNUMERARY CHROMOSOME; TRANSGENE;

ANIMALS; DNA REPLICATION; GENE THERAPY; GENES, BCL-2; GENES, REPORTER; GENETIC VECTORS; LUCIFERASES; MATRIX ATTACHMENT REGIONS; MICE; MICE, SCID; NOD SIGNALING ADAPTOR PROTEINS; PLASMIDS; TRANSGENES;

ANIMALIA; MUS;

EID: 78650991635     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2010.116     Document Type: Article

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