Electroporation-mediated in vivo gene delivery of the Na +/K +- ATPase pump reduced lung injury in a mouse model of lung contusion

Journal of Trauma and Acute Care Surgery

Volumn 72, Issue 1, 2012, Pages 32-40

  MacHado Aranda, David A ^a   Suresh, M V ^a   Yu, Bi ^a   Raghavendran, Krishnan ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Electroporation; Gene delivery; Lung contusion; Na + K + ATPase pump

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALBUMIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; PLASMID DNA; SODIUM CHLORIDE; CHEMOKINE; CYTOKINE;

ACUTE LUNG INJURY; ALPHA CHAIN; ANESTHESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; BETA CHAIN; CONFERENCE PAPER; CONTROLLED STUDY; ELECTROPORATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE TRANSFER; HISTOPATHOLOGY; IN VIVO STUDY; INFERIOR CAVA VEIN; INFLAMMATORY CELL; LUNG ALVEOLUS; LUNG COMPLIANCE; LUNG CONTUSION; LUNG LAVAGE; LUNG MECHANICS; LUNG PRESSURE; LUNG VOLUME; MALE; MOUSE; NEUTROPHIL; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; ARTICLE; C57BL MOUSE; CHEMISTRY; CONTUSION; DISEASE MODEL; ELECTROCHEMOTHERAPY; GENE THERAPY; GENETICS; LUNG; LUNG INJURY; METHODOLOGY; PATHOPHYSIOLOGY;

ANIMALS; CHEMOKINES; CONTUSIONS; CYTOKINES; DISEASE MODELS, ANIMAL; ELECTROCHEMOTHERAPY; GENE THERAPY; LUNG; LUNG INJURY; MALE; MICE; MICE, INBRED C57BL; SODIUM-POTASSIUM-EXCHANGING ATPASE;

EID: 84859634004     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e31823f0606     Document Type: Conference Paper

References (32)

1. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 2000;342:1334-1349.
2. Hoth JJ, Wells JD, Brownlee NA, et al. Toll-like receptor 4-dependent responses to lung injury in a murine model of pulmonary contusion. Shock. 2009;31:376-381.
3. Rubenfeld GD, Caldwell E, Peabody E, et al. Incidence and outcomes of acute lung injury. N Engl J Med. 2005;353:1685-1693.
4. Looney MR, Sartori C, Chakraborty S, James PF, Lingrel JB, Matthay MA. Decreased expression of both the alpha1-and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2005;289:L104-L110.
5. Berthiaume Y, Matthay MA. Alveolar edema fluid clearance and acute lung injury. Respir Physiol Neurobiol. 2007;159:350-359.
6. Raghavendran K, Davidson BA, Woytash JA, et al. The evolution of isolated bilateral lung contusion from blunt chest trauma in rats: cellular and cytokine responses. Shock. 2005;24:132-138.
7. Raghavendran K, Notter RH, Davidson BA, Helinski JD, Kunkel SL, Knight PR. Lung contusion: inflammatory mechanisms and interaction with other injuries. Shock. 2009;32:122-130.
8. Lin X, Dean DA. Gene therapy for ALI/ARDS. Crit Care Clin. 2011; 27:705-718.
9. Factor P, Saldias F, Ridge K, et al. Augmentation of lung liquid clearance via adenovirus-mediated transfer of a Na, K-ATPase beta1 subunit gene. J Clin Invest. 1998;102:1421-1430.
10. Filippatos GS, Hughes WF, Qiao R, Sznajder JI, Uhal BD. Mechanisms of liquid flux across pulmonary alveolar epithelial cell monolayers. In Vitro Cell Dev Biol Anim. 1997;33:195-200.
11. Gonzalez-Flecha B, Evelson P, Ridge K, Sznajder JI. Hydrogen peroxide increases Na+/K(+)-ATPase function in alveolar type II cells. Biochim Biophys Acta. 1996;1290:46-52.
12. Violette MI, Madan P, Watson AJ. Na+/K+-ATPase regulates tight junction formation and function during mouse preimplantation development. Dev Biol. 2006;289:406-419.
13. Yang Y, Dai M, Wilson TM, et al. Na+/K+-ATPase alpha1 identified as an abundant protein in the blood-labyrinth barrier that plays an essential role in the barrier integrity. PLoS One. 2011;6:e16547.
14. Qiao R, Zhou B, Harboe-Schmidt E, et al. Subunit-specific coordinate upregulation of sodium pump activity in alveolar epithelial cells by lentivirus-mediated gene transfer. Hum Gene Ther. 2004;15:457-468.
15. Stern M, Ulrich K, Robinson C, et al. Pretreatment with cationic lipid-mediated transfer of the Na+K+-ATPase pump in a mouse model in vivo augments resolution of high permeability pulmonary oedema. Gene Ther. 2000;7:960-966.
16. Machado-Aranda D, Adir Y, Young JL, et al. Gene transfer of the Na+, K+-ATPase beta1 subunit using electroporation increases lung liquid clearance. Am J Respir Crit Care Med. 2005;171:204-211.
17. Dean DA, Machado-Aranda D, Blair-Parks K, Yeldandi AV, Young JL. Electroporation as a method for high-level nonviral gene transfer to the lung. Gene Ther. 2003;10:1608-1615.
18. Hoth JJ, Hudson WP, Brownlee NA, et al. Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion. Shock 2007;28:447-452.
19. Weiss YG, Maloyan A, Tazelaar J, Raj N, Deutschman CS. Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome. J Clin Invest. 2002;110:801-806.
20. Vanoirbeek JA, Rinaldi M, De Vooght V, et al. Noninvasive and invasive pulmonary function in mouse models of obstructive and restrictive respiratory diseases. Am J Respir Cell Mol Biol. 2010;42:96-104.
21. Raghavendran K, Davidson BA, Helinski JD, et al. A rat model for isolated bilateral lung contusion from blunt chest trauma. Anesth Analg. 2005;101:1482-1489.
22. Jaitovich A, Sznajder JI. Improving survival by increasing lung edema clearance: is airspace delivery of dopamine a solution? Crit Care. 2008;12:135.
23. Mutlu GM, Adir Y, Jameel M, et al. Interdependency of beta-adrenergic receptors and CFTR in regulation of alveolar active Na+ transport. Circ Res. 2005;96:999-1005.
24. Eid L, Bromberg Z, El-Latif MA, Zeira E, Oppenheim A, Weiss YG. Simian virus 40 vectors for pulmonary gene therapy. Respir Res. 2007;8:74.
25. Factor P, Mendez M, Mutlu GM, Dumasius V. Acute hyperoxic lung injury does not impede adenoviral-mediated alveolar gene transfer. Am J Respir Crit Care Med. 2002;165:521-526.
26. Dumasius V, Sznajder JI, Azzam ZS, et al. beta(2)-adrenergic receptor overexpression increases alveolar fluid clearance and responsiveness to endogenous catecholamines in rats. Circ Res. 2001;89:907-914.
27. Ulrich K, Stern M, Goddard ME, et al. Keratinocyte growth factor therapy in murine oleic acid-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2005;288:L1179-L1192.
28. Mutlu GM, Machado-Aranda D, Norton JE, et al. Electroporationmediated gene transfer of the Na+, K+-ATPase rescues endotoxininduced lung injury. Am J Respir Crit Care Med. 2007;176:582-590.
29. Gazdhar A, Bilici M, Pierog J, et al. In vivo electroporation and ubiquitin promoter-a protocol for sustained gene expression in the lung. J Gene Med. 2006;8:910-918.
30. Larre I, Lazaro A, Contreras RG, et al. Ouabain modulates epithelial cell tight junction. Proc Natl Acad Sci U S A. 2010;107:11387-11392.
31. Raghavendran K, Davidson BA, Knight PR, et al. Surfactant dysfunction in lung contusion with and without superimposed gastric aspiration in a rat model. Shock. 2008;30:508-517.
32. Perl M, Gebhard F, Bruckner UB, et al. Pulmonary contusion causes impairment of macrophage and lymphocyte immune functions and increases mortality associated with a subsequent septic challenge. Crit Care Med. 2005;33:1351-1358.