Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium

Gene Therapy

Volumn 14, Issue 4, 2007, Pages 292-303

  Le Meur, G ^a   Stieger, K ^a   Smith, A J ^b   Weber, M ^a   Deschamps, J Y ^c   Nivard, D ^a   Mendes Madeira, A ^a   Provost, N ^a   Pereon Y ^a   Cherel, Y ^d   Ali, R R ^b   Hamel, C ^e   Moullier, P ^a   Rolling, F ^a  

^a HÔTEL DIEU   (France)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c LUNAM UNIVERSITÉ   (France)

^d INRA UMR 703   (France)

^e HÔPITAL SAINT ELOI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS ACTING ON THE EYE; COMPLEMENTARY DNA; PARVOVIRUS VECTOR; RETINAL PIGMENT EPITHELIUM PROTEIN 65; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG ADMINISTRATION ROUTE; FLUORESCENCE ANGIOGRAPHY; GENE CASSETTE; GENE REPLACEMENT THERAPY; GENE TARGETING; GENE TRANSFER; LEBER CONGENITAL AMAUROSIS; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROMOTER REGION; RETINA CONE; RETINA ROD; SAFETY; SUBRETINAL DRUG ADMINISTRATION; TREATMENT OUTCOME; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; BLINDNESS; BREEDING; CARRIER PROTEINS; DARK ADAPTATION; DEPENDOVIRUS; DOGS; ELECTRORETINOGRAPHY; EYE PROTEINS; FLUORESCEIN ANGIOGRAPHY; GENE THERAPY; GENETIC ENGINEERING; GENETIC VECTORS; IMMUNOHISTOCHEMISTRY; MODELS, ANIMAL; PIGMENT EPITHELIUM OF EYE; SEROTYPING; TRANSDUCTION, GENETIC; TRANSGENES; VISION;

ADENO-ASSOCIATED VIRUS; ANIMALIA; CANIS FAMILIARIS;

EID: 33846933945     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/sj.gt.3302861     Document Type: Article

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