Linear DNAs concatemerize in vivo and result in sustained transgene expression in mouse liver

Molecular Therapy

Volumn 3, Issue 3, 2001, Pages 403-410

  Chen, Zhi Ying ^a   Yant, Stephen R ^a,b   He, Cheng Yi ^a   Meuse, Leonard ^a   Shen, Shiliang ^a   Kay, Mark A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

AAV; Factor IX; Gene therapy; Hemophilia; Liver; Nonviral; 1 antitrypsin

Indexed keywords

ALPHA 1 ANTITRYPSIN; BLOOD CLOTTING FACTOR 9; CIRCULAR DNA; DNA; UNCLASSIFIED DRUG;

ADENO ASSOCIATED VIRUS; ANIMAL TISSUE; ARTICLE; BLEEDING TENDENCY; CELLULAR DISTRIBUTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA BINDING; DNA FLANKING REGION; DNA STRUCTURE; DNA VECTOR; FEMALE; GENE CASSETTE; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSFECTION; HEMOPHILIA B; IN VIVO STUDY; INTERSPERSED REPEAT; LINEAR DNA; LIVER; MOUSE; NONHUMAN; PLASMID; SOUTHERN BLOTTING; TRANSGENE;

ADENO-ASSOCIATED VIRUS; ANIMALIA;

EID: 0034993252     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2001.0278     Document Type: Article

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