Human retinal pigment epithelium (RPE) transplantation: Outcome after autologous RPE-choroid sheet and RPE cell-suspension in a randomised clinical study

British Journal of Ophthalmology

Volumn 95, Issue 3, 2011, Pages 370-375

  Falkner Radler, Christiane I ^a   Krebs, Ilse ^a   Glittenberg, Carl ^a   Považay, Boris ^b   Drexler, Wolfgang ^b   Graf, Alexandra ^c   Binder, Susanne ^a  

^a KRANKENANSTALT RUDOLFSTIFTUNG   (Austria)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

SILICONE OIL;

AGED; ARTICLE; AUTOFLUORESCENCE IMAGING; CATARACT EXTRACTION; CELL SUSPENSION; CELL TRANSPLANTATION; CHOROID; CHOROID VASCULARIZATION; CLINICAL ARTICLE; COHORT ANALYSIS; EPIRETINAL MEMBRANE; EYE SURGERY; FEMALE; FOLLOW UP; FUNCTIONAL STATUS; GRAFT PERFUSION; HUMAN; INDOCYANINE GREEN ANGIOGRAPHY; INTERMETHOD COMPARISON; LOW LEVEL LASER THERAPY; MALE; MEMBRANE PEELING; OPTICAL COHERENCE TOMOGRAPHY; OUTCOME ASSESSMENT; PIGMENT EPITHELIUM; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENCE RISK; REOPERATION; RETINA DETACHMENT; RETINA FLUORESCEIN ANGIOGRAPHY; RETINA MACULA AGE RELATED DEGENERATION; RETINAL PIGMENT EPITHELIUM CELL SUSPENSION TRANSPLANTATION; RETINAL PIGMENT EPITHELIUM CHOROID SHEET TRANSPLANTATION; REVASCULARIZATION; SILICONE OIL TAMPONADE; SUBRETINAL NEOVASCULARIZATION; VISION TEST; VISUAL ACUITY; VISUAL IMPAIRMENT; VITRECTOMY; VITREORETINOPATHY;

AGED; AGED, 80 AND OVER; CHOROID; CHOROIDAL NEOVASCULARIZATION; FEMALE; HUMANS; MACULAR DEGENERATION; MALE; RETINAL PIGMENT EPITHELIUM; TOMOGRAPHY, OPTICAL COHERENCE; TREATMENT OUTCOME; VISUAL ACUITY;

EID: 79952025858     PISSN: 00071161     EISSN: 14682079     Source Type: Journal    
DOI: 10.1136/bjo.2009.176305     Document Type: Article

References (24)

1. Del Priore LV, Tezel TH, Kaplan HJ. Maculoplastyfor age-related macular degeneration: reengineering Burch's membrane and the human macula. Prog Retin Eye Res 2006;25:539-62. (Pubitemid 44666508)
2. Flood MT, Gouras P, Kjeldbye H. Growth characteristics and ultrastructure of human retinal pigment epithelium in vitro. Invest Ophthalmol Vis Sci 1980;19:1309-20. (Pubitemid 11078429)
3. Lopez R, Gouras P, Brittis M, et al. Transplantation of cultured rabbit retinal epithelium to rabbit retina using a closed-eye method. Invest Ophthalmol Vis Sci 1987;19:1131-7. (Pubitemid 17089951)
4. Gouras P, Algvere P. Retinal cell transplantation in the macula: new techniques. Vision Res 1996;36:4121-5.
5. Aisenbrey S, Lafaut BA, Szurman P, et al. Iris pigment epithelial translocation in the treatment of exudative macular degeneration: a 3-year follow-up. Arch Ophthalmol 2006;124:183-8. (Pubitemid 43247067)
6. Chai H, Shin MC, Tezel TH, et al. Use of iris pigment epithelium to replace retinal pigment epithelium in age-related macular degeneration: a gene expression analysis. Arch Ophthalmol 2006;124:1276-85. (Pubitemid 44379862)
7. van Meurs JC, ter Averst E, Hofland LJ, et al. Autologous peripheral retinal pigment epithelium translocation in patients with subfoveal neovascular membranes. Br J Ophthalmol 2004;88:110-13.
8. Binder S, Krebs I, Hilgers RD, et al. Outcome of transplantation of autologous retinal pigment epithelium in age-related macular degeneration: a prospective trial. Invest Ophthalmol Vis Sci 2004;45:4151-60. (Pubitemid 39411174)
9. Stanga PE, Kychenthal A, Fitzke FW, et al. Retinal pigment epithelium translocation after choroidal neovascular membrane removal in age-related macular-degeneration. Ophthalmology 2002;109:1492-8.
10. Tezel TH, Del Priore LV, Berger AS, et al. Adult retinal pigment epithelial transplantation in exsudative age-related macular degeneration. Am J Ophthalmol 2007;143:584-95.
11. Binder S, Stanzel BV, Krebs I, et al. Transplantation of RPE in AMD. Prog Retin Eye Res 2007;26:516-54.
12. da Cruz L, Chen FK, Ahmado A, et al. RPE transplantation and its role in retinal disease. Prog Retin Eye Res 2007;26:598-635. (Pubitemid 47615562)
13. van Meurs JC, Van den Biesen PR. Autologous retinal pigment epithelium and choroids translocation in patients with exudative age-related macular degeneration: short term follow-up. Am J Ophthalmol 2003;1136:688-95.
14. Binder S, Stolba U, Krebs I, et al. Transplantation of autologous retinal pigment epithelium in eyes with foveal neovascularization resulting from age-related macular degeneration: a pilot study. Am J Ophthalmol 2002;133:215-25. (Pubitemid 34072050)
15. Maaijwee K, Heimann H, Missotten T, et al. Retinal pigment epithelium and choroids translocation in patients with exudative age-related macular-degeneration: long term results. Graefes Arch Clin Exp Ophthalmol 2007;245:1681-9. (Pubitemid 47491558)
16. Chen FK, Patel PJ, Uppal GS, et al. A comparison of macular translocation with patch graft in neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 2009;50:1848-55.
17. Joussen AM, Joeres S, Fawzy N, et al. Autologous translocation of the choroids and retinal pigment epithelium in patients with geographic atrophy. Ophthalmology 2007:114:551-60. (Pubitemid 46282952)
18. MacLaren RE, Uppal GS, Balaggan KS, et al. Autologous transplantation of the retinal pigment epithelium and choroids in the treatment of neovascular age-related macular degeneration. Ophthalmology 2007:114:561-570.
19. Treumer F, Bunse A, Klatt C, et al. Autologous retinal pigment epithelium-choroid sheet transplantation in age related macular degeneration: morphological and functional results. Br J Ophthalmol 2007:91:349-53. (Pubitemid 46586533)
20. Tsukahara I, Ninomiya S, Castellarin A, et al. Early attachment of uncultured retinal pigment epithelium from aged donors onto Bruch's membrane explants. Exp Eye Res 2002;74:255-66. (Pubitemid 34948401)
21. Zarbin MA. Analysis of retinal pigment epithelium integrin expression and adhesion to aged submacular human Bruch's membrane. Trans Am Ophthalmol Soc 2003;101:499-520. (Pubitemid 38209342)
22. MacLaren RE, Bird AC, Sathia PJ, et al. Long-term results of submacular surgery combined with macular translocation of the retinal pigment epithelium in neovascular age-related macular degeneration. Ophthalmology 2005;112:2081-7. (Pubitemid 41720984)
23. Ciulla TA, Rosenfeld PJ. Antivascular endothelial growth factor therapy for neovascular age-related macular degeneration. Curr Opin Ophthalmol 2009;20:158-65.
24. Jeganathan VS, Verma N. Safety and efficacy of intravitreal anti-VEGF injections for age-related macular degeneration. Curr Opin Ophthalmol 2009;20:223-5.