메뉴 건너뛰기




Volumn 254, Issue 1, 2013, Pages 170-189

Dendritic cell dysregulation during HIV-1 infection

Author keywords

3 dioxygenase (IDO); HIV 1; Immune activation; Indolemine 2; Myeloid dendritic cell; Plasmacytoid dendritic cell; T regulatory cell

Indexed keywords

ADENOVIRUS VECTOR; BACTERIAL VECTOR; CD11 ANTIGEN; CD123 ANTIGEN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CYCLOPHILIN A; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; INTERFERON; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 22; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MODIFIED VACCINIA VIRUS ANKARA 5T4 VACCINE; PATTERN RECOGNITION RECEPTOR; RANTES; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

EID: 84879285507     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12082     Document Type: Article
Times cited : (78)

References (199)
  • 1
    • 80051783110 scopus 로고    scopus 로고
    • Innate immunity in acute HIV-1 infection
    • Borrow P. Innate immunity in acute HIV-1 infection. Curr Opin HIV AIDS 2011;6:353-363.
    • (2011) Curr Opin HIV AIDS , vol.6 , pp. 353-363
    • Borrow, P.1
  • 2
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392:245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 3
    • 79952132247 scopus 로고    scopus 로고
    • DCs and NK cells: critical effectors in the immune response to HIV-1
    • Altfeld M, Fadda L, Frleta D, Bhardwaj N. DCs and NK cells: critical effectors in the immune response to HIV-1. Nat Rev Immunol 2011;11:176-186.
    • (2011) Nat Rev Immunol , vol.11 , pp. 176-186
    • Altfeld, M.1    Fadda, L.2    Frleta, D.3    Bhardwaj, N.4
  • 4
    • 12444346742 scopus 로고    scopus 로고
    • Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells
    • Nakao Y, et al. Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells. J Immunol 2005;174:1566-1573.
    • (2005) J Immunol , vol.174 , pp. 1566-1573
    • Nakao, Y.1
  • 5
    • 0033490502 scopus 로고    scopus 로고
    • Interleukin-12: a cytokine at the interface of inflammation and immunity
    • Trinchieri G. Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv Immunol 1998;70:83-243.
    • (1998) Adv Immunol , vol.70 , pp. 83-243
    • Trinchieri, G.1
  • 6
    • 0027240219 scopus 로고
    • Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
    • D'Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G. Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993;178:1041-1048.
    • (1993) J Exp Med , vol.178 , pp. 1041-1048
    • D'Andrea, A.1    Aste-Amezaga, M.2    Valiante, N.M.3    Ma, X.4    Kubin, M.5    Trinchieri, G.6
  • 7
    • 0025875022 scopus 로고
    • Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
    • Wolf SF, et al. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol 1991;146:3074-3081.
    • (1991) J Immunol , vol.146 , pp. 3074-3081
    • Wolf, S.F.1
  • 8
    • 0035862333 scopus 로고    scopus 로고
    • Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
    • Dhodapkar MV, Steinman RM, Krasovsky J, Munz C, Bhardwaj N. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med 2001;193:233-238.
    • (2001) J Exp Med , vol.193 , pp. 233-238
    • Dhodapkar, M.V.1    Steinman, R.M.2    Krasovsky, J.3    Munz, C.4    Bhardwaj, N.5
  • 9
    • 12644269220 scopus 로고    scopus 로고
    • Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors
    • Granelli-Piperno A, et al. Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors. J Exp Med 1996;184:2433-2438.
    • (1996) J Exp Med , vol.184 , pp. 2433-2438
    • Granelli-Piperno, A.1
  • 10
    • 78149442321 scopus 로고    scopus 로고
    • Evidence of dysregulation of dendritic cells in primary HIV infection
    • Sabado RL, et al. Evidence of dysregulation of dendritic cells in primary HIV infection. Blood 2010;116:3839-3852.
    • (2010) Blood , vol.116 , pp. 3839-3852
    • Sabado, R.L.1
  • 11
    • 0033011902 scopus 로고    scopus 로고
    • Dendritic cells generated from blood monocytes of HIV-1 patients are not infected and act as competent antigen presenting cells eliciting potent T-cell responses
    • Sapp M, Engelmayer J, Larsson M, Granelli-Piperno A, Steinman R, Bhardwaj N. Dendritic cells generated from blood monocytes of HIV-1 patients are not infected and act as competent antigen presenting cells eliciting potent T-cell responses. Immunol Lett 1999;66:121-128.
    • (1999) Immunol Lett , vol.66 , pp. 121-128
    • Sapp, M.1    Engelmayer, J.2    Larsson, M.3    Granelli-Piperno, A.4    Steinman, R.5    Bhardwaj, N.6
  • 12
    • 21644483118 scopus 로고    scopus 로고
    • Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells
    • Smed-Sorensen A, et al. Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells. J Virol 2005;79:8861-8869.
    • (2005) J Virol , vol.79 , pp. 8861-8869
    • Smed-Sorensen, A.1
  • 13
    • 67650446501 scopus 로고    scopus 로고
    • Monocyte-derived dendritic cells from HIV type 1-infected individuals show reduced ability to stimulate T cells and have altered production of interleukin (IL)-12 and IL-10
    • Buisson S, Benlahrech A, Gazzard B, Gotch F, Kelleher P, Patterson S. Monocyte-derived dendritic cells from HIV type 1-infected individuals show reduced ability to stimulate T cells and have altered production of interleukin (IL)-12 and IL-10. J Infect Dis 2009;199:1862-1871.
    • (2009) J Infect Dis , vol.199 , pp. 1862-1871
    • Buisson, S.1    Benlahrech, A.2    Gazzard, B.3    Gotch, F.4    Kelleher, P.5    Patterson, S.6
  • 14
    • 84855172914 scopus 로고    scopus 로고
    • Differential regulation of toll-like receptor pathways in acute and chronic HIV-1 infection
    • Chang JJ, et al. Differential regulation of toll-like receptor pathways in acute and chronic HIV-1 infection. AIDS 2012;26:533-541.
    • (2012) AIDS , vol.26 , pp. 533-541
    • Chang, J.J.1
  • 15
    • 34948822417 scopus 로고    scopus 로고
    • Dendritic cell function during chronic hepatitis C virus and human immunodeficiency virus type 1 infection
    • Fan Z, Huang XL, Kalinski P, Young S, Rinaldo CR Jr. Dendritic cell function during chronic hepatitis C virus and human immunodeficiency virus type 1 infection. Clin Vaccine Immunol 2007;14:1127-1137.
    • (2007) Clin Vaccine Immunol , vol.14 , pp. 1127-1137
    • Fan, Z.1    Huang, X.L.2    Kalinski, P.3    Young, S.4    Rinaldo Jr., C.R.5
  • 16
    • 84870484583 scopus 로고    scopus 로고
    • HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44
    • Frleta D, et al. HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44. J Clin Invest 2012;122:4685-4697.
    • (2012) J Clin Invest , vol.122 , pp. 4685-4697
    • Frleta, D.1
  • 17
    • 2442684197 scopus 로고    scopus 로고
    • HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
    • Granelli-Piperno A, Golebiowska A, Trumpfheller C, Siegal FP, Steinman RM. HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation. Proc Natl Acad Sci USA 2004;101:7669-7674.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 7669-7674
    • Granelli-Piperno, A.1    Golebiowska, A.2    Trumpfheller, C.3    Siegal, F.P.4    Steinman, R.M.5
  • 18
    • 20744435124 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Vpr impairs dendritic cell maturation and T-cell activation: implications for viral immune escape
    • Majumder B, et al. Human immunodeficiency virus type 1 Vpr impairs dendritic cell maturation and T-cell activation: implications for viral immune escape. J Virol 2005;79:7990-8003.
    • (2005) J Virol , vol.79 , pp. 7990-8003
    • Majumder, B.1
  • 19
    • 84873120085 scopus 로고    scopus 로고
    • Plasma factors during chronic HIV-1 infection impair IL-12 secretion by myeloid dendritic cells via a virus-independent pathway
    • Miller EA, et al. Plasma factors during chronic HIV-1 infection impair IL-12 secretion by myeloid dendritic cells via a virus-independent pathway. J Acquir Immune Defic Syndr 2012;61:535-544.
    • (2012) J Acquir Immune Defic Syndr , vol.61 , pp. 535-544
    • Miller, E.A.1
  • 20
    • 7244240713 scopus 로고    scopus 로고
    • HIV-1-infected dendritic cells up-regulate cell surface markers but fail to produce IL-12 p70 in response to CD40 ligand stimulation
    • Smed-Sorensen A, Lore K, Walther-Jallow L, Andersson J, Spetz AL. HIV-1-infected dendritic cells up-regulate cell surface markers but fail to produce IL-12 p70 in response to CD40 ligand stimulation. Blood 2004;104:2810-2817.
    • (2004) Blood , vol.104 , pp. 2810-2817
    • Smed-Sorensen, A.1    Lore, K.2    Walther-Jallow, L.3    Andersson, J.4    Spetz, A.L.5
  • 21
    • 15444368103 scopus 로고    scopus 로고
    • Different subsets of peripheral blood dendritic cells show distinct phenotypic and functional abnormalities in HIV-1 infection
    • Almeida M, Cordero M, Almeida J, Orfao A. Different subsets of peripheral blood dendritic cells show distinct phenotypic and functional abnormalities in HIV-1 infection. AIDS 2005;19:261-271.
    • (2005) AIDS , vol.19 , pp. 261-271
    • Almeida, M.1    Cordero, M.2    Almeida, J.3    Orfao, A.4
  • 22
    • 33646799484 scopus 로고    scopus 로고
    • Persistent abnormalities in peripheral blood dendritic cells and monocytes from HIV-1-positive patients after 1 year of antiretroviral therapy
    • Almeida M, Cordero M, Almeida J, Orfao A. Persistent abnormalities in peripheral blood dendritic cells and monocytes from HIV-1-positive patients after 1 year of antiretroviral therapy. J Acquir Immune Defic Syndr 2006;41:405-415.
    • (2006) J Acquir Immune Defic Syndr , vol.41 , pp. 405-415
    • Almeida, M.1    Cordero, M.2    Almeida, J.3    Orfao, A.4
  • 23
    • 78650062880 scopus 로고    scopus 로고
    • Blood myeloid dendritic cells from HIV-1-infected individuals display a proapoptotic profile characterized by decreased Bcl-2 levels and by caspase-3+ frequencies that are associated with levels of plasma viremia and T cell activation in an exploratory study
    • Dillon SM, et al. Blood myeloid dendritic cells from HIV-1-infected individuals display a proapoptotic profile characterized by decreased Bcl-2 levels and by caspase-3+ frequencies that are associated with levels of plasma viremia and T cell activation in an exploratory study. J Virol 2011;85:397-409.
    • (2011) J Virol , vol.85 , pp. 397-409
    • Dillon, S.M.1
  • 24
    • 80052379842 scopus 로고    scopus 로고
    • Systemic immune activation in HIV infection is associated with decreased MDC responsiveness to TLR ligand and inability to activate naive CD4 T-cells
    • Yonkers NL, Rodriguez B, Asaad R, Lederman MM, Anthony DD. Systemic immune activation in HIV infection is associated with decreased MDC responsiveness to TLR ligand and inability to activate naive CD4 T-cells. PLoS ONE 2011;6:e23884.
    • (2011) PLoS ONE , vol.6
    • Yonkers, N.L.1    Rodriguez, B.2    Asaad, R.3    Lederman, M.M.4    Anthony, D.D.5
  • 25
    • 2342648904 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells
    • Fonteneau JF, et al. Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells. J Virol 2004;78:5223-5232.
    • (2004) J Virol , vol.78 , pp. 5223-5232
    • Fonteneau, J.F.1
  • 26
    • 32044462951 scopus 로고    scopus 로고
    • Abnormal presence of semimature dendritic cells that induce regulatory T cells in HIV-infected subjects
    • Krathwohl MD, Schacker TW, Anderson JL. Abnormal presence of semimature dendritic cells that induce regulatory T cells in HIV-infected subjects. J Infect Dis 2006;193:494-504.
    • (2006) J Infect Dis , vol.193 , pp. 494-504
    • Krathwohl, M.D.1    Schacker, T.W.2    Anderson, J.L.3
  • 27
    • 34249088361 scopus 로고    scopus 로고
    • Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication
    • Hodges A, et al. Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication. Nat Immunol 2007;8:569-577.
    • (2007) Nat Immunol , vol.8 , pp. 569-577
    • Hodges, A.1
  • 28
    • 41349107635 scopus 로고    scopus 로고
    • Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection
    • Lester RT, et al. Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection. AIDS 2008;22:685-694.
    • (2008) AIDS , vol.22 , pp. 685-694
    • Lester, R.T.1
  • 29
    • 37349066496 scopus 로고    scopus 로고
    • HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells
    • Shan M, et al. HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells. PLoS Pathog 2007;3:e169.
    • (2007) PLoS Pathog , vol.3
    • Shan, M.1
  • 30
    • 77953216462 scopus 로고    scopus 로고
    • IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection
    • Alter G, et al. IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection. J Clin Invest 2010;120:1905-1913.
    • (2010) J Clin Invest , vol.120 , pp. 1905-1913
    • Alter, G.1
  • 31
    • 9144271619 scopus 로고    scopus 로고
    • Escape of monocyte-derived dendritic cells of HIV-1 infected individuals from natural killer cell-mediated lysis
    • Tasca S, et al. Escape of monocyte-derived dendritic cells of HIV-1 infected individuals from natural killer cell-mediated lysis. AIDS 2003;17:2291-2298.
    • (2003) AIDS , vol.17 , pp. 2291-2298
    • Tasca, S.1
  • 32
    • 0037017387 scopus 로고    scopus 로고
    • Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells
    • Ferlazzo G, Tsang ML, Moretta L, Melioli G, Steinman RM, Munz C. Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. J Exp Med 2002;195:343-351.
    • (2002) J Exp Med , vol.195 , pp. 343-351
    • Ferlazzo, G.1    Tsang, M.L.2    Moretta, L.3    Melioli, G.4    Steinman, R.M.5    Munz, C.6
  • 33
    • 84866488122 scopus 로고    scopus 로고
    • Innate immune recognition of HIV-1
    • Iwasaki A. Innate immune recognition of HIV-1. Immunity 2012;37:389-398.
    • (2012) Immunity , vol.37 , pp. 389-398
    • Iwasaki, A.1
  • 34
    • 84867654572 scopus 로고    scopus 로고
    • Innate immune sensing of HIV-1 by dendritic cells
    • Luban J. Innate immune sensing of HIV-1 by dendritic cells. Cell Host Microbe 2012;12:408-418.
    • (2012) Cell Host Microbe , vol.12 , pp. 408-418
    • Luban, J.1
  • 35
    • 83555164881 scopus 로고    scopus 로고
    • HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
    • Goldstone DC, et al. HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature 2011;480:379-382.
    • (2011) Nature , vol.480 , pp. 379-382
    • Goldstone, D.C.1
  • 36
    • 79959843617 scopus 로고    scopus 로고
    • SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
    • Laguette N, et al. SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature 2011;474:654-657.
    • (2011) Nature , vol.474 , pp. 654-657
    • Laguette, N.1
  • 37
    • 84862777555 scopus 로고    scopus 로고
    • SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates
    • Lahouassa H, et al. SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. Nat Immunol 2012;13:223-228.
    • (2012) Nat Immunol , vol.13 , pp. 223-228
    • Lahouassa, H.1
  • 38
    • 83755162644 scopus 로고    scopus 로고
    • Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase
    • Powell RD, Holland PJ, Hollis T, Perrino FW. Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase. J Biol Chem 2011;286:43596-43600.
    • (2011) J Biol Chem , vol.286 , pp. 43596-43600
    • Powell, R.D.1    Holland, P.J.2    Hollis, T.3    Perrino, F.W.4
  • 39
    • 77956497003 scopus 로고    scopus 로고
    • A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
    • Manel N, Hogstad B, Wang Y, Levy DE, Unutmaz D, Littman DR. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature 2010;467:214-217.
    • (2010) Nature , vol.467 , pp. 214-217
    • Manel, N.1    Hogstad, B.2    Wang, Y.3    Levy, D.E.4    Unutmaz, D.5    Littman, D.R.6
  • 40
    • 80051792497 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 modified to package Simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cells
    • Sunseri N, O'Brien M, Bhardwaj N, Landau NR. Human immunodeficiency virus type 1 modified to package Simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cells. J Virol 2011;85:6263-6274.
    • (2011) J Virol , vol.85 , pp. 6263-6274
    • Sunseri, N.1    O'Brien, M.2    Bhardwaj, N.3    Landau, N.R.4
  • 41
    • 84877298095 scopus 로고    scopus 로고
    • Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease
    • Cavaleiro R, et al. Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease. J Infect Dis 2013;207:1730-1742.
    • (2013) J Infect Dis , vol.207 , pp. 1730-1742
    • Cavaleiro, R.1
  • 42
    • 42249096487 scopus 로고    scopus 로고
    • Polyfunctional T cell responses are a hallmark of HIV-2 infection
    • Duvall MG, et al. Polyfunctional T cell responses are a hallmark of HIV-2 infection. Eur J Immunol 2008;38:350-363.
    • (2008) Eur J Immunol , vol.38 , pp. 350-363
    • Duvall, M.G.1
  • 43
    • 49549100511 scopus 로고    scopus 로고
    • Trex1 prevents cell-intrinsic initiation of autoimmunity
    • Stetson DB, Ko JS, Heidmann T, Medzhitov R. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 2008;134:587-598.
    • (2008) Cell , vol.134 , pp. 587-598
    • Stetson, D.B.1    Ko, J.S.2    Heidmann, T.3    Medzhitov, R.4
  • 44
    • 77958114725 scopus 로고    scopus 로고
    • The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
    • Yan N, Regalado-Magdos AD, Stiggelbout B, Lee-Kirsch MA, Lieberman J. The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol 2010;11:1005-1013.
    • (2010) Nat Immunol , vol.11 , pp. 1005-1013
    • Yan, N.1    Regalado-Magdos, A.D.2    Stiggelbout, B.3    Lee-Kirsch, M.A.4    Lieberman, J.5
  • 45
    • 77957969218 scopus 로고    scopus 로고
    • Strain-specific differences in the impact of human TRIM5alpha, different TRIM5alpha alleles, and the inhibition of capsid-cyclophilin A interactions on the infectivity of HIV-1
    • Battivelli E, Lecossier D, Matsuoka S, Migraine J, Clavel F, Hance AJ. Strain-specific differences in the impact of human TRIM5alpha, different TRIM5alpha alleles, and the inhibition of capsid-cyclophilin A interactions on the infectivity of HIV-1. J Virol 2010;84:11010-11019.
    • (2010) J Virol , vol.84 , pp. 11010-11019
    • Battivelli, E.1    Lecossier, D.2    Matsuoka, S.3    Migraine, J.4    Clavel, F.5    Hance, A.J.6
  • 46
    • 79955377543 scopus 로고    scopus 로고
    • TRIM5 is an innate immune sensor for the retrovirus capsid lattice
    • Pertel T, et al. TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature 2011;472:361-365.
    • (2011) Nature , vol.472 , pp. 361-365
    • Pertel, T.1
  • 47
    • 1542288934 scopus 로고    scopus 로고
    • The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys
    • Stremlau M, Owens CM, Perron MJ, Kiessling M, Autissier P, Sodroski J. The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys. Nature 2004;427:848-853.
    • (2004) Nature , vol.427 , pp. 848-853
    • Stremlau, M.1    Owens, C.M.2    Perron, M.J.3    Kiessling, M.4    Autissier, P.5    Sodroski, J.6
  • 48
    • 58149502601 scopus 로고    scopus 로고
    • Double-stranded RNA analog poly(I:C) inhibits human immunodeficiency virus amplification in dendritic cells via type I interferon-mediated activation of APOBEC3G
    • Trapp S, et al. Double-stranded RNA analog poly(I:C) inhibits human immunodeficiency virus amplification in dendritic cells via type I interferon-mediated activation of APOBEC3G. J Virol 2009;83:884-895.
    • (2009) J Virol , vol.83 , pp. 884-895
    • Trapp, S.1
  • 49
    • 0041828179 scopus 로고    scopus 로고
    • Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection
    • Fiebig EW, et al. Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection. AIDS 2003;17:1871-1879.
    • (2003) AIDS , vol.17 , pp. 1871-1879
    • Fiebig, E.W.1
  • 50
    • 64049116643 scopus 로고    scopus 로고
    • Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections
    • Stacey AR, et al. Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections. J Virol 2009;83:3719-3733.
    • (2009) J Virol , vol.83 , pp. 3719-3733
    • Stacey, A.R.1
  • 51
    • 77954060985 scopus 로고    scopus 로고
    • Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection
    • Kramer HB, et al. Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection. PLoS Pathog 2010;6:e1000893.
    • (2010) PLoS Pathog , vol.6
    • Kramer, H.B.1
  • 52
    • 67449119122 scopus 로고    scopus 로고
    • Kinetics of expansion of epitope-specific T cell responses during primary HIV-1 infection
    • Turnbull EL, et al. Kinetics of expansion of epitope-specific T cell responses during primary HIV-1 infection. J Immunol 2009;182:7131-7145.
    • (2009) J Immunol , vol.182 , pp. 7131-7145
    • Turnbull, E.L.1
  • 54
    • 64149110846 scopus 로고    scopus 로고
    • Accessory cell dependent NK cell mediated PBMC IFN-gamma production is defective in HIV infection
    • Yonkers NL, et al. Accessory cell dependent NK cell mediated PBMC IFN-gamma production is defective in HIV infection. Clin Immunol 2009;131:288-297.
    • (2009) Clin Immunol , vol.131 , pp. 288-297
    • Yonkers, N.L.1
  • 55
    • 0027743305 scopus 로고
    • Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro
    • Clerici M, et al. Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science 1993;262:1721-1724.
    • (1993) Science , vol.262 , pp. 1721-1724
    • Clerici, M.1
  • 56
    • 0034254205 scopus 로고    scopus 로고
    • CD40 ligand trimer and IL-12 enhance peripheral blood mononuclear cells and CD4+ T cell proliferation and production of IFN-gamma in response to p24 antigen in HIV-infected individuals: potential contribution of anergy to HIV-specific unresponsiveness
    • Dybul M, et al. CD40 ligand trimer and IL-12 enhance peripheral blood mononuclear cells and CD4+ T cell proliferation and production of IFN-gamma in response to p24 antigen in HIV-infected individuals: potential contribution of anergy to HIV-specific unresponsiveness. J Immunol 2000;165:1685-1691.
    • (2000) J Immunol , vol.165 , pp. 1685-1691
    • Dybul, M.1
  • 57
    • 0029899102 scopus 로고    scopus 로고
    • In vitro restoration of T cell immune function in human immunodeficiency virus-positive persons: effects of interleukin (IL)-12 and anti-IL-10
    • Landay AL, Clerici M, Hashemi F, Kessler H, Berzofsky JA, Shearer GM. In vitro restoration of T cell immune function in human immunodeficiency virus-positive persons: effects of interleukin (IL)-12 and anti-IL-10. J Infect Dis 1996;173:1085-1091.
    • (1996) J Infect Dis , vol.173 , pp. 1085-1091
    • Landay, A.L.1    Clerici, M.2    Hashemi, F.3    Kessler, H.4    Berzofsky, J.A.5    Shearer, G.M.6
  • 58
    • 0028839280 scopus 로고
    • T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons
    • Estaquier J, et al. T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons. J Exp Med 1995;182:1759-1767.
    • (1995) J Exp Med , vol.182 , pp. 1759-1767
    • Estaquier, J.1
  • 59
    • 0034690620 scopus 로고    scopus 로고
    • In vitro and in vivo responses to interleukin 12 are maintained until the late SIV infection stage but lost during AIDS
    • Villinger F, et al. In vitro and in vivo responses to interleukin 12 are maintained until the late SIV infection stage but lost during AIDS. AIDS Res Hum Retroviruses 2000;16:751-763.
    • (2000) AIDS Res Hum Retroviruses , vol.16 , pp. 751-763
    • Villinger, F.1
  • 60
    • 0032549621 scopus 로고    scopus 로고
    • Administration of recombinant human interleukin 12 to chronically SIVmac-infected rhesus monkeys
    • Watanabe N, et al. Administration of recombinant human interleukin 12 to chronically SIVmac-infected rhesus monkeys. AIDS Res Hum Retroviruses 1998;14:393-399.
    • (1998) AIDS Res Hum Retroviruses , vol.14 , pp. 393-399
    • Watanabe, N.1
  • 61
    • 0036148075 scopus 로고    scopus 로고
    • Administration of recombinant rhesus interleukin-12 during acute simian immunodeficiency virus (SIV) infection leads to decreased viral loads associated with prolonged survival in SIVmac251-infected rhesus macaques
    • Ansari AA, et al. Administration of recombinant rhesus interleukin-12 during acute simian immunodeficiency virus (SIV) infection leads to decreased viral loads associated with prolonged survival in SIVmac251-infected rhesus macaques. J Virol 2002;76:1731-1743.
    • (2002) J Virol , vol.76 , pp. 1731-1743
    • Ansari, A.A.1
  • 62
    • 34248544993 scopus 로고    scopus 로고
    • C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB
    • Gringhuis SI, den Dunnen J, Litjens M, van Het Hof B, van Kooyk Y, Geijtenbeek TB. C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB. Immunity 2007;26:605-616.
    • (2007) Immunity , vol.26 , pp. 605-616
    • Gringhuis, S.I.1    den Dunnen, J.2    Litjens, M.3    van Het Hof, B.4    van Kooyk, Y.5    Geijtenbeek, T.B.6
  • 63
    • 0032526338 scopus 로고    scopus 로고
    • Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10
    • Aste-Amezaga M, Ma X, Sartori A, Trinchieri G. Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10. J Immunol 1998;160:5936-5944.
    • (1998) J Immunol , vol.160 , pp. 5936-5944
    • Aste-Amezaga, M.1    Ma, X.2    Sartori, A.3    Trinchieri, G.4
  • 64
    • 0024408824 scopus 로고
    • Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    • Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989;170:2081-2095.
    • (1989) J Exp Med , vol.170 , pp. 2081-2095
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 65
    • 33748162638 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells: cytokine modulation comes of age
    • Rutella S, Danese S, Leone G. Tolerogenic dendritic cells: cytokine modulation comes of age. Blood 2006;108:1435-1440.
    • (2006) Blood , vol.108 , pp. 1435-1440
    • Rutella, S.1    Danese, S.2    Leone, G.3
  • 66
    • 33748947326 scopus 로고    scopus 로고
    • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    • Day CL, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006;443:350-354.
    • (2006) Nature , vol.443 , pp. 350-354
    • Day, C.L.1
  • 67
    • 77953272740 scopus 로고    scopus 로고
    • Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses
    • Blanchet FP, et al. Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses. Immunity 2010;32:654-669.
    • (2010) Immunity , vol.32 , pp. 654-669
    • Blanchet, F.P.1
  • 68
    • 84876867850 scopus 로고    scopus 로고
    • Phenotypic properties of transmitted founder HIV-1
    • Parrish NF, et al. Phenotypic properties of transmitted founder HIV-1. Proc Natl Acad Sci USA 2013;110:6626-6633.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 6626-6633
    • Parrish, N.F.1
  • 69
    • 47749103401 scopus 로고    scopus 로고
    • Induction of plasma (TRAIL), TNFR-2, Fas ligand, and plasma microparticles after human immunodeficiency virus type 1 (HIV-1) transmission: implications for HIV-1 vaccine design
    • Gasper-Smith N, et al. Induction of plasma (TRAIL), TNFR-2, Fas ligand, and plasma microparticles after human immunodeficiency virus type 1 (HIV-1) transmission: implications for HIV-1 vaccine design. J Virol 2008;82:7700-7710.
    • (2008) J Virol , vol.82 , pp. 7700-7710
    • Gasper-Smith, N.1
  • 70
    • 0025944878 scopus 로고
    • The transmembrane hyaluronate receptor (CD44): multiple functions, multiple forms
    • Haynes BF, Liao HX, Patton KL. The transmembrane hyaluronate receptor (CD44): multiple functions, multiple forms. Cancer Cell 1991;3:347-350.
    • (1991) Cancer Cell , vol.3 , pp. 347-350
    • Haynes, B.F.1    Liao, H.X.2    Patton, K.L.3
  • 71
    • 33646559230 scopus 로고    scopus 로고
    • CD44 is a phagocytic receptor
    • Vachon E, et al. CD44 is a phagocytic receptor. Blood 2006;107:4149-4158.
    • (2006) Blood , vol.107 , pp. 4149-4158
    • Vachon, E.1
  • 72
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley JM, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006;12:1365-1371.
    • (2006) Nat Med , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1
  • 73
    • 39349088126 scopus 로고    scopus 로고
    • Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy
    • Hunt PW, et al. Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J Infect Dis 2008;197:126-133.
    • (2008) J Infect Dis , vol.197 , pp. 126-133
    • Hunt, P.W.1
  • 74
    • 65649102237 scopus 로고    scopus 로고
    • Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection
    • Jiang W, et al. Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection. J Infect Dis 2009;199:1177-1185.
    • (2009) J Infect Dis , vol.199 , pp. 1177-1185
    • Jiang, W.1
  • 75
    • 58149177783 scopus 로고    scopus 로고
    • Cutting edge: experimentally induced immune activation in natural hosts of simian immunodeficiency virus induces significant increases in viral replication and CD4+ T cell depletion
    • Pandrea I, et al. Cutting edge: experimentally induced immune activation in natural hosts of simian immunodeficiency virus induces significant increases in viral replication and CD4+ T cell depletion. J Immunol 2008;181:6687-6691.
    • (2008) J Immunol , vol.181 , pp. 6687-6691
    • Pandrea, I.1
  • 76
    • 80051706186 scopus 로고    scopus 로고
    • TLR4 engagement during TLR3-induced proinflammatory signaling in dendritic cells promotes IL-10-mediated suppression of antitumor immunity
    • Bogunovic D, et al. TLR4 engagement during TLR3-induced proinflammatory signaling in dendritic cells promotes IL-10-mediated suppression of antitumor immunity. Cancer Res 2011;71:5467-5476.
    • (2011) Cancer Res , vol.71 , pp. 5467-5476
    • Bogunovic, D.1
  • 77
    • 0021165018 scopus 로고
    • Circulating immune complexes in AIDS
    • Gupta S, Licorish K. Circulating immune complexes in AIDS. N Engl J Med 1984;310:1530-1531.
    • (1984) N Engl J Med , vol.310 , pp. 1530-1531
    • Gupta, S.1    Licorish, K.2
  • 78
    • 84863337769 scopus 로고    scopus 로고
    • Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation
    • Shan L, et al. Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation. Immunity 2012;36:491-501.
    • (2012) Immunity , vol.36 , pp. 491-501
    • Shan, L.1
  • 79
    • 0031045622 scopus 로고    scopus 로고
    • Origin, maturation and antigen presenting function of dendritic cells
    • Cella M, Sallusto F, Lanzavecchia A. Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol 1997;9:10-16.
    • (1997) Curr Opin Immunol , vol.9 , pp. 10-16
    • Cella, M.1    Sallusto, F.2    Lanzavecchia, A.3
  • 80
    • 70349299844 scopus 로고    scopus 로고
    • A randomized therapeutic vaccine trial of canarypox-HIV-pulsed dendritic cells vs. canarypox-HIV alone in HIV-1-infected patients on antiretroviral therapy
    • Gandhi RT, et al. A randomized therapeutic vaccine trial of canarypox-HIV-pulsed dendritic cells vs. canarypox-HIV alone in HIV-1-infected patients on antiretroviral therapy. Vaccine 2009;27:6088-6094.
    • (2009) Vaccine , vol.27 , pp. 6088-6094
    • Gandhi, R.T.1
  • 81
    • 20844456226 scopus 로고    scopus 로고
    • Therapeutic immunization with dendritic cells loaded with heat-inactivated autologous HIV-1 in patients with chronic HIV-1 infection
    • Garcia F, et al. Therapeutic immunization with dendritic cells loaded with heat-inactivated autologous HIV-1 in patients with chronic HIV-1 infection. J Infect Dis 2005;191:1680-1685.
    • (2005) J Infect Dis , vol.191 , pp. 1680-1685
    • Garcia, F.1
  • 82
    • 33646480371 scopus 로고    scopus 로고
    • Peptide-loaded dendritic-cell vaccination followed by treatment interruption for chronic HIV-1 infection: a phase 1 trial
    • Ide F, et al. Peptide-loaded dendritic-cell vaccination followed by treatment interruption for chronic HIV-1 infection: a phase 1 trial. J Med Virol 2006;78:711-718.
    • (2006) J Med Virol , vol.78 , pp. 711-718
    • Ide, F.1
  • 83
    • 11144283687 scopus 로고    scopus 로고
    • Therapeutic dendritic-cell vaccine for chronic HIV-1 infection
    • Lu W, Arraes LC, Ferreira WT, Andrieu JM. Therapeutic dendritic-cell vaccine for chronic HIV-1 infection. Nat Med 2004;10:1359-1365.
    • (2004) Nat Med , vol.10 , pp. 1359-1365
    • Lu, W.1    Arraes, L.C.2    Ferreira, W.T.3    Andrieu, J.M.4
  • 84
    • 80051668754 scopus 로고    scopus 로고
    • Challenges in dendritic cells-based therapeutic vaccination in HIV-1 infection Workshop in dendritic cell-based vaccine clinical trials in HIV-1
    • Garcia F, Routy JP. Challenges in dendritic cells-based therapeutic vaccination in HIV-1 infection Workshop in dendritic cell-based vaccine clinical trials in HIV-1. Vaccine 2011;29:6454-6463.
    • (2011) Vaccine , vol.29 , pp. 6454-6463
    • Garcia, F.1    Routy, J.P.2
  • 85
    • 79751500441 scopus 로고    scopus 로고
    • A therapeutic dendritic cell-based vaccine for HIV-1 infection
    • Garcia F, et al. A therapeutic dendritic cell-based vaccine for HIV-1 infection. J Infect Dis 2011;203:473-478.
    • (2011) J Infect Dis , vol.203 , pp. 473-478
    • Garcia, F.1
  • 86
    • 84872037286 scopus 로고    scopus 로고
    • A dendritic cell-based vaccine elicits T cell responses associated with control of HIV-1 replication
    • Garcia F, et al. A dendritic cell-based vaccine elicits T cell responses associated with control of HIV-1 replication. Sci Trans Med 2013;5:166ra2.
    • (2013) Sci Trans Med , vol.5
    • Garcia, F.1
  • 87
    • 84857374529 scopus 로고    scopus 로고
    • A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption
    • Allard SD, et al. A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption. Clin Immunol 2012;142:252-268.
    • (2012) Clin Immunol , vol.142 , pp. 252-268
    • Allard, S.D.1
  • 88
    • 84857045791 scopus 로고    scopus 로고
    • mRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1-infected patients
    • Van Gulck E, et al. mRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1-infected patients. AIDS 2012;26:F1-F12.
    • (2012) AIDS , vol.26
    • Van Gulck, E.1
  • 89
    • 73549125003 scopus 로고    scopus 로고
    • Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy
    • Routy JP, et al. Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy. Clin Immunol 2010;134:140-147.
    • (2010) Clin Immunol , vol.134 , pp. 140-147
    • Routy, J.P.1
  • 90
    • 40449119721 scopus 로고    scopus 로고
    • Therapeutic immunization with human immunodeficiency virus type 1 (HIV-1) peptide-loaded dendritic cells is safe and induces immunogenicity in HIV-1-infected individuals
    • Connolly NC, Whiteside TL, Wilson C, Kondragunta V, Rinaldo CR, Riddler SA. Therapeutic immunization with human immunodeficiency virus type 1 (HIV-1) peptide-loaded dendritic cells is safe and induces immunogenicity in HIV-1-infected individuals. Clin Vaccine Immunol 2008;15:284-292.
    • (2008) Clin Vaccine Immunol , vol.15 , pp. 284-292
    • Connolly, N.C.1    Whiteside, T.L.2    Wilson, C.3    Kondragunta, V.4    Rinaldo, C.R.5    Riddler, S.A.6
  • 91
    • 77954973455 scopus 로고    scopus 로고
    • Arcelis AGS-004 dendritic cell-based immunotherapy for HIV infection
    • Routy JP, Nicolette C. Arcelis AGS-004 dendritic cell-based immunotherapy for HIV infection. Immunotherapy 2010;2:467-476.
    • (2010) Immunotherapy , vol.2 , pp. 467-476
    • Routy, J.P.1    Nicolette, C.2
  • 92
    • 0037234103 scopus 로고    scopus 로고
    • Therapeutic dendritic-cell vaccine for simian AIDS
    • Lu W, Wu X, Lu Y, Guo W, Andrieu JM. Therapeutic dendritic-cell vaccine for simian AIDS. Nat Med 2003;9:27-32.
    • (2003) Nat Med , vol.9 , pp. 27-32
    • Lu, W.1    Wu, X.2    Lu, Y.3    Guo, W.4    Andrieu, J.M.5
  • 93
    • 0031694872 scopus 로고    scopus 로고
    • Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins
    • Rossio JL, et al. Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins. J Virol 1998;72:7992-8001.
    • (1998) J Virol , vol.72 , pp. 7992-8001
    • Rossio, J.L.1
  • 94
    • 34447534178 scopus 로고    scopus 로고
    • Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1
    • Sabado RL, et al. Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1. Eur J Immunol 2007;37:1752-1763.
    • (2007) Eur J Immunol , vol.37 , pp. 1752-1763
    • Sabado, R.L.1
  • 95
    • 0037024751 scopus 로고    scopus 로고
    • Activation of HIV-1 specific CD4 and CD8 T cells by human dendritic cells: roles for cross-presentation and non-infectious HIV-1 virus
    • Larsson M, Fonteneau JF, Lirvall M, Haslett P, Lifson JD, Bhardwaj N. Activation of HIV-1 specific CD4 and CD8 T cells by human dendritic cells: roles for cross-presentation and non-infectious HIV-1 virus. AIDS 2002;16:1319-1329.
    • (2002) AIDS , vol.16 , pp. 1319-1329
    • Larsson, M.1    Fonteneau, J.F.2    Lirvall, M.3    Haslett, P.4    Lifson, J.D.5    Bhardwaj, N.6
  • 96
    • 0034858032 scopus 로고    scopus 로고
    • In vitro human immunodeficiency virus eradication by autologous CD8(+) T cells expanded with inactivated-virus-pulsed dendritic cells
    • Lu W, Andrieu JM. In vitro human immunodeficiency virus eradication by autologous CD8(+) T cells expanded with inactivated-virus-pulsed dendritic cells. J Virol 2001;75:8949-8956.
    • (2001) J Virol , vol.75 , pp. 8949-8956
    • Lu, W.1    Andrieu, J.M.2
  • 97
    • 64249124659 scopus 로고    scopus 로고
    • In vitro priming recapitulates in vivo HIV-1 specific T cell responses, revealing rapid loss of virus reactive CD4 T cells in acute HIV-1 infection
    • Lubong SR, et al. In vitro priming recapitulates in vivo HIV-1 specific T cell responses, revealing rapid loss of virus reactive CD4 T cells in acute HIV-1 infection. PLoS ONE 2009;4:e4256.
    • (2009) PLoS ONE , vol.4
    • Lubong, S.R.1
  • 98
    • 0035128160 scopus 로고    scopus 로고
    • Mature dendritic cells infected with canarypox virus elicit strong anti-human immunodeficiency virus CD8+ and CD4+ T-cell responses from chronically infected individuals
    • Engelmayer J, et al. Mature dendritic cells infected with canarypox virus elicit strong anti-human immunodeficiency virus CD8+ and CD4+ T-cell responses from chronically infected individuals. J Virol 2001;75:2142-2153.
    • (2001) J Virol , vol.75 , pp. 2142-2153
    • Engelmayer, J.1
  • 99
    • 77955261234 scopus 로고    scopus 로고
    • CD8+ T cell priming by dendritic cell vaccines requires antigen transfer to endogenous antigen presenting cells
    • Yewdall AW, Drutman SB, Jinwala F, Bahjat KS, Bhardwaj N. CD8+ T cell priming by dendritic cell vaccines requires antigen transfer to endogenous antigen presenting cells. PLoS ONE 2010;5:e11144.
    • (2010) PLoS ONE , vol.5
    • Yewdall, A.W.1    Drutman, S.B.2    Jinwala, F.3    Bahjat, K.S.4    Bhardwaj, N.5
  • 100
    • 79952294318 scopus 로고    scopus 로고
    • Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A
    • Idoyaga J, et al. Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A. Proc Natl Acad Sci USA 2011;108:2384-2389.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 2384-2389
    • Idoyaga, J.1
  • 101
    • 77956608213 scopus 로고    scopus 로고
    • Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR
    • Klechevsky E, et al. Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR. Blood 2010;116:1685-1697.
    • (2010) Blood , vol.116 , pp. 1685-1697
    • Klechevsky, E.1
  • 102
    • 77749254882 scopus 로고    scopus 로고
    • Dendritic cell targeted HIV gag protein vaccine provides help to a DNA vaccine including mobilization of protective CD8+ T cells
    • Nchinda G, Amadu D, Trumpfheller C, Mizenina O, Uberla K, Steinman RM. Dendritic cell targeted HIV gag protein vaccine provides help to a DNA vaccine including mobilization of protective CD8+ T cells. Proc Natl Acad Sci USA 2010;107:4281-4286.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4281-4286
    • Nchinda, G.1    Amadu, D.2    Trumpfheller, C.3    Mizenina, O.4    Uberla, K.5    Steinman, R.M.6
  • 103
    • 78149432061 scopus 로고    scopus 로고
    • Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody
    • Cheong C, et al. Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody. Blood 2010;116:3828-3838.
    • (2010) Blood , vol.116 , pp. 3828-3838
    • Cheong, C.1
  • 104
    • 84855931820 scopus 로고    scopus 로고
    • Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity
    • Trumpfheller C, et al. Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity. J Int Med 2012;271:183-192.
    • (2012) J Int Med , vol.271 , pp. 183-192
    • Trumpfheller, C.1
  • 105
    • 79955551576 scopus 로고    scopus 로고
    • Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates
    • Flynn BJ, et al. Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates. Proc Natl Acad Sci USA 2011;108:7131-7136.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 7131-7136
    • Flynn, B.J.1
  • 106
    • 77953502765 scopus 로고    scopus 로고
    • Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
    • Jongbloed SL, et al. Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens. J Exp Med 2010;207:1247-1260.
    • (2010) J Exp Med , vol.207 , pp. 1247-1260
    • Jongbloed, S.L.1
  • 107
    • 77953484184 scopus 로고    scopus 로고
    • Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells
    • Poulin LF, et al. Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells. J Exp Med 2010;207:1261-1271.
    • (2010) J Exp Med , vol.207 , pp. 1261-1271
    • Poulin, L.F.1
  • 108
    • 79953766748 scopus 로고    scopus 로고
    • A randomized controlled trial of HIV therapeutic vaccination using ALVAC with or without Remune
    • Angel JB, et al. A randomized controlled trial of HIV therapeutic vaccination using ALVAC with or without Remune. AIDS 2011;25:731-739.
    • (2011) AIDS , vol.25 , pp. 731-739
    • Angel, J.B.1
  • 109
    • 49849090609 scopus 로고    scopus 로고
    • Greater viral rebound and reduced time to resume antiretroviral therapy after therapeutic immunization with the ALVAC-HIV vaccine (vCP1452)
    • Autran B, et al. Greater viral rebound and reduced time to resume antiretroviral therapy after therapeutic immunization with the ALVAC-HIV vaccine (vCP1452). AIDS 2008;22:1313-1322.
    • (2008) AIDS , vol.22 , pp. 1313-1322
    • Autran, B.1
  • 110
    • 33845401825 scopus 로고    scopus 로고
    • A randomized, partially blinded phase 2 trial of antiretroviral therapy, HIV-specific immunizations, and interleukin-2 cycles to promote efficient control of viral replication (ACTG A5024)
    • Kilby JM, et al. A randomized, partially blinded phase 2 trial of antiretroviral therapy, HIV-specific immunizations, and interleukin-2 cycles to promote efficient control of viral replication (ACTG A5024). J Infect Dis 2006;194:1672-1676.
    • (2006) J Infect Dis , vol.194 , pp. 1672-1676
    • Kilby, J.M.1
  • 111
    • 23244463710 scopus 로고    scopus 로고
    • Impact of therapeutic immunization on HIV-1 viremia after discontinuation of antiretroviral therapy initiated during acute infection
    • Kinloch-de LS, et al. Impact of therapeutic immunization on HIV-1 viremia after discontinuation of antiretroviral therapy initiated during acute infection. J Infect Dis 2005;192:607-617.
    • (2005) J Infect Dis , vol.192 , pp. 607-617
    • Kinloch-de, L.S.1
  • 112
    • 20144381894 scopus 로고    scopus 로고
    • Immunological and virological efficacy of a therapeutic immunization combined with interleukin-2 in chronically HIV-1 infected patients
    • Levy Y, et al. Immunological and virological efficacy of a therapeutic immunization combined with interleukin-2 in chronically HIV-1 infected patients. AIDS 2005;19:279-286.
    • (2005) AIDS , vol.19 , pp. 279-286
    • Levy, Y.1
  • 113
    • 34047189908 scopus 로고    scopus 로고
    • Safety and tolerability of recombinant modified vaccinia virus Ankara expressing an HIV-1 gag/multiepitope immunogen (MVA.HIVA) in HIV-1-infected persons receiving combination antiretroviral therapy
    • Dorrell L, et al. Safety and tolerability of recombinant modified vaccinia virus Ankara expressing an HIV-1 gag/multiepitope immunogen (MVA.HIVA) in HIV-1-infected persons receiving combination antiretroviral therapy. Vaccine 2007;25:3277-3283.
    • (2007) Vaccine , vol.25 , pp. 3277-3283
    • Dorrell, L.1
  • 114
    • 33646449925 scopus 로고    scopus 로고
    • Expansion and diversification of virus-specific T cells following immunization of human immunodeficiency virus type 1 (HIV-1)-infected individuals with a recombinant modified vaccinia virus Ankara/HIV-1 Gag vaccine
    • Dorrell L, et al. Expansion and diversification of virus-specific T cells following immunization of human immunodeficiency virus type 1 (HIV-1)-infected individuals with a recombinant modified vaccinia virus Ankara/HIV-1 Gag vaccine. J Virol 2006;80:4705-4716.
    • (2006) J Virol , vol.80 , pp. 4705-4716
    • Dorrell, L.1
  • 115
    • 22844441961 scopus 로고    scopus 로고
    • Therapeutic vaccination of HIV-1-infected patients on HAART with a recombinant HIV-1 nef-expressing MVA: safety, immunogenicity and influence on viral load during treatment interruption
    • Harrer E, et al. Therapeutic vaccination of HIV-1-infected patients on HAART with a recombinant HIV-1 nef-expressing MVA: safety, immunogenicity and influence on viral load during treatment interruption. Antiviral Ther 2005;10:285-300.
    • (2005) Antiviral Ther , vol.10 , pp. 285-300
    • Harrer, E.1
  • 116
    • 77955671541 scopus 로고    scopus 로고
    • AIDS clinical trials group 5197: a placebo-controlled trial of immunization of HIV-1-infected persons with a replication-deficient adenovirus type 5 vaccine expressing the HIV-1 core protein
    • Schooley RT, et al. AIDS clinical trials group 5197: a placebo-controlled trial of immunization of HIV-1-infected persons with a replication-deficient adenovirus type 5 vaccine expressing the HIV-1 core protein. J Infect Dis 2010;202:705-716.
    • (2010) J Infect Dis , vol.202 , pp. 705-716
    • Schooley, R.T.1
  • 117
    • 73349094086 scopus 로고    scopus 로고
    • Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand
    • Rerks-Ngarm S, et al. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med 2009;361:2209-2220.
    • (2009) N Engl J Med , vol.361 , pp. 2209-2220
    • Rerks-Ngarm, S.1
  • 118
    • 84879322129 scopus 로고    scopus 로고
    • Dendritic cells transduced with Vpx-packaged LV vector encoding CD40L enhance cytotoxic T cell responses and disrupt HIV-1 latency. Conference on Retroviruses and Opportunistic Infections (CROI) 2013, March 3-7, 2013. Atlanta, GA, USA; Paper #125.
    • Norton EM, Bhardwaj N, Landau N. Dendritic cells transduced with Vpx-packaged LV vector encoding CD40L enhance cytotoxic T cell responses and disrupt HIV-1 latency. Conference on Retroviruses and Opportunistic Infections (CROI) 2013, March 3-7, 2013. Atlanta, GA, USA; Paper #125.
    • Norton, E.M.1    Bhardwaj, N.2    Landau, N.3
  • 119
    • 84879283591 scopus 로고    scopus 로고
    • Rescue of myeloid dendritic cell dysfunction in the setting of chronic HIV-1 infection with recombinant, Attenuated listeria monocytogenes vectors. Conference on Retroviruses and Opportunistic Infections (CROI) 2013, March 3-7, 2013. Atlanta, GA, USA; Paper # 389.
    • Miller MS, Demmler M, Lauer P, Brockstedt D, Bhardwaj N. Rescue of myeloid dendritic cell dysfunction in the setting of chronic HIV-1 infection with recombinant, Attenuated listeria monocytogenes vectors. Conference on Retroviruses and Opportunistic Infections (CROI) 2013, March 3-7, 2013. Atlanta, GA, USA; Paper # 389.
    • Miller, M.S.1    Demmler, M.2    Lauer, P.3    Brockstedt, D.4    Bhardwaj, N.5
  • 120
    • 73849167296 scopus 로고
    • Cellular resistance to infection
    • Mackaness GB. Cellular resistance to infection. J Exp Med 1962;116:381-406.
    • (1962) J Exp Med , vol.116 , pp. 381-406
    • Mackaness, G.B.1
  • 121
    • 84868569570 scopus 로고    scopus 로고
    • RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids
    • Abdullah Z, et al. RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids. EMBO J 2012;31:4153-4164.
    • (2012) EMBO J , vol.31 , pp. 4153-4164
    • Abdullah, Z.1
  • 122
    • 64049083526 scopus 로고    scopus 로고
    • Listeria monocytogenes infection in the face of innate immunity
    • Corr SC, O'Neill LA. Listeria monocytogenes infection in the face of innate immunity. Cell Microbiol 2009;11:703-709.
    • (2009) Cell Microbiol , vol.11 , pp. 703-709
    • Corr, S.C.1    O'Neill, L.A.2
  • 124
    • 0035953543 scopus 로고    scopus 로고
    • The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
    • Hayashi F, et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 2001;410:1099-1103.
    • (2001) Nature , vol.410 , pp. 1099-1103
    • Hayashi, F.1
  • 125
    • 77953305895 scopus 로고    scopus 로고
    • Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome
    • Kim S, et al. Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome. Eur J Immunol 2010;40:1545-1551.
    • (2010) Eur J Immunol , vol.40 , pp. 1545-1551
    • Kim, S.1
  • 126
    • 77957578665 scopus 로고    scopus 로고
    • Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes
    • Wu J, Fernandes-Alnemri T, Alnemri ES. Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes. J Clin Immunol 2010;30:693-702.
    • (2010) J Clin Immunol , vol.30 , pp. 693-702
    • Wu, J.1    Fernandes-Alnemri, T.2    Alnemri, E.S.3
  • 127
    • 53549117440 scopus 로고    scopus 로고
    • Induction of autophagy via innate bacterial recognition
    • Yano T, Kurata S. Induction of autophagy via innate bacterial recognition. Autophagy 2008;4:958-960.
    • (2008) Autophagy , vol.4 , pp. 958-960
    • Yano, T.1    Kurata, S.2
  • 128
    • 80053985011 scopus 로고    scopus 로고
    • DermaVir: a plasmid DNA-based nanomedicine therapeutic vaccine for the treatment of HIV/AIDS
    • Lori F. DermaVir: a plasmid DNA-based nanomedicine therapeutic vaccine for the treatment of HIV/AIDS. Exp Rev Vaccines 2011;10:1371-1384.
    • (2011) Exp Rev Vaccines , vol.10 , pp. 1371-1384
    • Lori, F.1
  • 129
    • 79960354477 scopus 로고    scopus 로고
    • Amplified antigen-specific immune responses in HIV-1 infected individuals in a double blind DNA immunization and therapy interruption trial
    • Gudmundsdotter L, et al. Amplified antigen-specific immune responses in HIV-1 infected individuals in a double blind DNA immunization and therapy interruption trial. Vaccine 2011;29:5558-5566.
    • (2011) Vaccine , vol.29 , pp. 5558-5566
    • Gudmundsdotter, L.1
  • 130
    • 77954637904 scopus 로고    scopus 로고
    • Safety and immunogenicity of therapeutic DNA vaccination in individuals treated with antiretroviral therapy during acute/early HIV-1 infection
    • Rosenberg ES, et al. Safety and immunogenicity of therapeutic DNA vaccination in individuals treated with antiretroviral therapy during acute/early HIV-1 infection. PLoS ONE 2010;5:e10555.
    • (2010) PLoS ONE , vol.5
    • Rosenberg, E.S.1
  • 131
    • 47049122594 scopus 로고    scopus 로고
    • Clinical phase 1 testing of the safety and immunogenicity of an epitope-based DNA vaccine in human immunodeficiency virus type 1-infected subjects receiving highly active antiretroviral therapy
    • Wilson CC, et al. Clinical phase 1 testing of the safety and immunogenicity of an epitope-based DNA vaccine in human immunodeficiency virus type 1-infected subjects receiving highly active antiretroviral therapy. Clin Vaccine Immunol 2008;15:986-994.
    • (2008) Clin Vaccine Immunol , vol.15 , pp. 986-994
    • Wilson, C.C.1
  • 132
    • 84860745751 scopus 로고    scopus 로고
    • Single DermaVir immunization: dose-dependent expansion of precursor/memory T cells against all HIV antigens in HIV-1 infected individuals
    • Lisziewicz J, et al. Single DermaVir immunization: dose-dependent expansion of precursor/memory T cells against all HIV antigens in HIV-1 infected individuals. PLoS ONE 2012;7:e35416.
    • (2012) PLoS ONE , vol.7
    • Lisziewicz, J.1
  • 133
    • 80051618656 scopus 로고    scopus 로고
    • Cutting edge: dendritic cell-restricted antigen presentation initiates the follicular helper T cell program but cannot complete ultimate effector differentiation
    • Goenka R, et al. Cutting edge: dendritic cell-restricted antigen presentation initiates the follicular helper T cell program but cannot complete ultimate effector differentiation. J Immunol 2011;187:1091-1095.
    • (2011) J Immunol , vol.187 , pp. 1091-1095
    • Goenka, R.1
  • 134
    • 79251547700 scopus 로고    scopus 로고
    • IL-21 receptor is critical for the development of memory B cell responses
    • Rankin AL, et al. IL-21 receptor is critical for the development of memory B cell responses. J Immunol 2011;186:667-674.
    • (2011) J Immunol , vol.186 , pp. 667-674
    • Rankin, A.L.1
  • 135
    • 68249158536 scopus 로고    scopus 로고
    • Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12
    • Schmitt N, et al. Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12. Immunity 2009;31:158-169.
    • (2009) Immunity , vol.31 , pp. 158-169
    • Schmitt, N.1
  • 136
    • 78650969171 scopus 로고    scopus 로고
    • High expression levels of B lymphocyte stimulator (BLyS) by dendritic cells correlate with HIV-related B-cell disease progression in humans
    • Fontaine J, Chagnon-Choquet J, Valcke HS, Poudrier J, Roger M. High expression levels of B lymphocyte stimulator (BLyS) by dendritic cells correlate with HIV-related B-cell disease progression in humans. Blood 2011;117:145-155.
    • (2011) Blood , vol.117 , pp. 145-155
    • Fontaine, J.1    Chagnon-Choquet, J.2    Valcke, H.S.3    Poudrier, J.4    Roger, M.5
  • 137
    • 0033546053 scopus 로고    scopus 로고
    • The nature of the principal type 1 interferon-producing cells in human blood
    • Siegal FP, et al. The nature of the principal type 1 interferon-producing cells in human blood. Science 1999;284:1835-1837.
    • (1999) Science , vol.284 , pp. 1835-1837
    • Siegal, F.P.1
  • 138
    • 0028048051 scopus 로고
    • Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature
    • O'Doherty U, et al. Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. Immunology 1994;82:487-493.
    • (1994) Immunology , vol.82 , pp. 487-493
    • O'Doherty, U.1
  • 139
    • 0027323998 scopus 로고
    • Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium
    • O'Doherty U, et al. Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium. J Exp Med 1993;178:1067-1076.
    • (1993) J Exp Med , vol.178 , pp. 1067-1076
    • O'Doherty, U.1
  • 140
    • 67650507029 scopus 로고    scopus 로고
    • Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction
    • Cao W, et al. Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J Exp Med 2009;206:1603-1614.
    • (2009) J Exp Med , vol.206 , pp. 1603-1614
    • Cao, W.1
  • 141
    • 77349088003 scopus 로고    scopus 로고
    • Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance
    • Swiecki M, Colonna M. Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol Rev 2010;234:142-162.
    • (2010) Immunol Rev , vol.234 , pp. 142-162
    • Swiecki, M.1    Colonna, M.2
  • 142
    • 0037217830 scopus 로고    scopus 로고
    • Influence of plasma viremia on defects in number and immunophenotype of blood dendritic cell subsets in human immunodeficiency virus 1-infected individuals
    • Barron MA, Blyveis N, Palmer BE, MaWhinney S, Wilson CC. Influence of plasma viremia on defects in number and immunophenotype of blood dendritic cell subsets in human immunodeficiency virus 1-infected individuals. J Infect Dis 2003;187:26-37.
    • (2003) J Infect Dis , vol.187 , pp. 26-37
    • Barron, M.A.1    Blyveis, N.2    Palmer, B.E.3    MaWhinney, S.4    Wilson, C.C.5
  • 143
    • 0038142359 scopus 로고    scopus 로고
    • Dysfunction and infection of freshly isolated blood myeloid and plasmacytoid dendritic cells in patients infected with HIV-1
    • Donaghy H, Gazzard B, Gotch F, Patterson S. Dysfunction and infection of freshly isolated blood myeloid and plasmacytoid dendritic cells in patients infected with HIV-1. Blood 2003;101:4505-4511.
    • (2003) Blood , vol.101 , pp. 4505-4511
    • Donaghy, H.1    Gazzard, B.2    Gotch, F.3    Patterson, S.4
  • 144
    • 0035889156 scopus 로고    scopus 로고
    • Loss of blood CD11c(+) myeloid and CD11c(-) plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load
    • Donaghy H, et al. Loss of blood CD11c(+) myeloid and CD11c(-) plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load. Blood 2001;98:2574-2576.
    • (2001) Blood , vol.98 , pp. 2574-2576
    • Donaghy, H.1
  • 145
    • 84879300791 scopus 로고    scopus 로고
    • SIV infection induces increased trafficking of pDC to gut mucosa. Conference on Retroviruses and Opportunistic Infections (CROI) 2011, February 27 March 2, 2011. Boston, MA, USA.
    • Reeves K, Evans T, Gillis J, Rajakumar P, Kuzmichev Y, Johnson P. SIV infection induces increased trafficking of pDC to gut mucosa. Conference on Retroviruses and Opportunistic Infections (CROI) 2011, February 27 March 2, 2011. Boston, MA, USA.
    • Reeves, K.1    Evans, T.2    Gillis, J.3    Rajakumar, P.4    Kuzmichev, Y.5    Johnson, P.6
  • 146
    • 42649126710 scopus 로고    scopus 로고
    • Plasmacytoid and myeloid dendritic cells with a partial activation phenotype accumulate in lymphoid tissue during asymptomatic chronic HIV-1 infection
    • Dillon SM, et al. Plasmacytoid and myeloid dendritic cells with a partial activation phenotype accumulate in lymphoid tissue during asymptomatic chronic HIV-1 infection. J Acquir Immune Defic Syndr 2008;48:1-12.
    • (2008) J Acquir Immune Defic Syndr , vol.48 , pp. 1-12
    • Dillon, S.M.1
  • 147
    • 77955249196 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells accumulate and secrete interferon alpha in lymph nodes of HIV-1 patients
    • Lehmann C, et al. Plasmacytoid dendritic cells accumulate and secrete interferon alpha in lymph nodes of HIV-1 patients. PLoS ONE 2010;5:e11110.
    • (2010) PLoS ONE , vol.5
    • Lehmann, C.1
  • 148
    • 80755140097 scopus 로고    scopus 로고
    • Rapid disease progression in HIV-1-infected men who have sex with men is negatively correlated with peripheral plasmacytoid dendritic cell counts at the early stage of primary infection
    • Geng W, et al. Rapid disease progression in HIV-1-infected men who have sex with men is negatively correlated with peripheral plasmacytoid dendritic cell counts at the early stage of primary infection. J Clin Immunol 2011;31:882-890.
    • (2011) J Clin Immunol , vol.31 , pp. 882-890
    • Geng, W.1
  • 149
    • 50949107953 scopus 로고    scopus 로고
    • Increased interferon alpha expression in circulating plasmacytoid dendritic cells of HIV-1-infected patients
    • Lehmann C, et al. Increased interferon alpha expression in circulating plasmacytoid dendritic cells of HIV-1-infected patients. J Acquir Immune Defic Syndr 2008;48:522-530.
    • (2008) J Acquir Immune Defic Syndr , vol.48 , pp. 522-530
    • Lehmann, C.1
  • 150
    • 27644513772 scopus 로고    scopus 로고
    • Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions
    • Beignon AS, et al. Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions. J Clin Invest 2005;115:3265-3275.
    • (2005) J Clin Invest , vol.115 , pp. 3265-3275
    • Beignon, A.S.1
  • 151
    • 50149120913 scopus 로고    scopus 로고
    • CD4 binding affinity determines human immunodeficiency virus type 1-induced alpha interferon production in plasmacytoid dendritic cells
    • Haupt S, et al. CD4 binding affinity determines human immunodeficiency virus type 1-induced alpha interferon production in plasmacytoid dendritic cells. J Virol 2008;82:8900-8905.
    • (2008) J Virol , vol.82 , pp. 8900-8905
    • Haupt, S.1
  • 152
    • 79952217825 scopus 로고    scopus 로고
    • Innate sensing of HIV-infected cells
    • Lepelley A, et al. Innate sensing of HIV-infected cells. PLoS Pathog 2011;7:e1001284.
    • (2011) PLoS Pathog , vol.7
    • Lepelley, A.1
  • 153
    • 79952234401 scopus 로고    scopus 로고
    • Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-alpha-producing and partially matured phenotype
    • O'Brien M, et al. Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-alpha-producing and partially matured phenotype. J Clin Invest 2011;121:1088-1101.
    • (2011) J Clin Invest , vol.121 , pp. 1088-1101
    • O'Brien, M.1
  • 154
    • 17844380477 scopus 로고    scopus 로고
    • Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
    • Honda K, et al. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 2005;434:1035-1040.
    • (2005) Nature , vol.434 , pp. 1035-1040
    • Honda, K.1
  • 156
    • 0041327667 scopus 로고    scopus 로고
    • Persistent immune activation in HIV-1 infection is associated with progression to AIDS
    • Hazenberg MD, et al. Persistent immune activation in HIV-1 infection is associated with progression to AIDS. AIDS 2003;17:1881-1888.
    • (2003) AIDS , vol.17 , pp. 1881-1888
    • Hazenberg, M.D.1
  • 157
    • 34548680261 scopus 로고    scopus 로고
    • Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction
    • Kaufmann DE, et al. Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction. Nat Immunol 2007;8:1246-1254.
    • (2007) Nat Immunol , vol.8 , pp. 1246-1254
    • Kaufmann, D.E.1
  • 158
    • 33749009709 scopus 로고    scopus 로고
    • Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
    • Trautmann L, et al. Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med 2006;12:1198-1202.
    • (2006) Nat Med , vol.12 , pp. 1198-1202
    • Trautmann, L.1
  • 159
    • 0030055293 scopus 로고    scopus 로고
    • Engagement of adhesion molecules (CD18, CD11a, CD45, CD44, and CD58) enhances human immunodeficiency virus type 1 replication in monocytic cells through a tumor necrosis factor-modulated pathway
    • Shattock RJ, Rizzardi GP, Hayes P, Griffin GE. Engagement of adhesion molecules (CD18, CD11a, CD45, CD44, and CD58) enhances human immunodeficiency virus type 1 replication in monocytic cells through a tumor necrosis factor-modulated pathway. J Infect Dis 1996;174:54-62.
    • (1996) J Infect Dis , vol.174 , pp. 54-62
    • Shattock, R.J.1    Rizzardi, G.P.2    Hayes, P.3    Griffin, G.E.4
  • 160
    • 0030987288 scopus 로고    scopus 로고
    • CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro
    • Wu L, et al. CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. J Exp Med 1997;185:1681-1691.
    • (1997) J Exp Med , vol.185 , pp. 1681-1691
    • Wu, L.1
  • 161
    • 0037007670 scopus 로고    scopus 로고
    • HIV preferentially infects HIV-specific CD4+ T cells
    • Douek DC, et al. HIV preferentially infects HIV-specific CD4+ T cells. Nature 2002;417:95-98.
    • (2002) Nature , vol.417 , pp. 95-98
    • Douek, D.C.1
  • 162
    • 0032504919 scopus 로고    scopus 로고
    • Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements
    • Fahey JL, et al. Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements. AIDS 1998;12:1581-1590.
    • (1998) AIDS , vol.12 , pp. 1581-1590
    • Fahey, J.L.1
  • 163
    • 0031824618 scopus 로고    scopus 로고
    • Increased immune activation precedes the inflection point of CD4 T cells and the increased serum virus load in human immunodeficiency virus infection
    • Salazar-Gonzalez JF, et al. Increased immune activation precedes the inflection point of CD4 T cells and the increased serum virus load in human immunodeficiency virus infection. J Infect Dis 1998;178:423-430.
    • (1998) J Infect Dis , vol.178 , pp. 423-430
    • Salazar-Gonzalez, J.F.1
  • 164
    • 0032955651 scopus 로고    scopus 로고
    • Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage
    • Giorgi JV, et al. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis 1999;179:859-870.
    • (1999) J Infect Dis , vol.179 , pp. 859-870
    • Giorgi, J.V.1
  • 165
    • 78049246978 scopus 로고    scopus 로고
    • Biomarkers and HIV-associated cardiovascular disease
    • Baker JV, Duprez D. Biomarkers and HIV-associated cardiovascular disease. Curr Opin HIV AIDS 2010;5:511-516.
    • (2010) Curr Opin HIV AIDS , vol.5 , pp. 511-516
    • Baker, J.V.1    Duprez, D.2
  • 166
    • 78449279351 scopus 로고    scopus 로고
    • Cardiovascular complications of AIDS
    • Lekakis J, Ikonomidis I. Cardiovascular complications of AIDS. Curr Opin Crit Care 2010;16:408-412.
    • (2010) Curr Opin Crit Care , vol.16 , pp. 408-412
    • Lekakis, J.1    Ikonomidis, I.2
  • 167
    • 77954758999 scopus 로고    scopus 로고
    • Initiation of antiretroviral therapy at higher nadir CD4+ T-cell counts is associated with reduced arterial stiffness in HIV-infected individuals
    • Ho JE, et al. Initiation of antiretroviral therapy at higher nadir CD4+ T-cell counts is associated with reduced arterial stiffness in HIV-infected individuals. AIDS 2010;24:1897-1905.
    • (2010) AIDS , vol.24 , pp. 1897-1905
    • Ho, J.E.1
  • 168
    • 77955705895 scopus 로고    scopus 로고
    • Low CD4+ T cell count is a risk factor for cardiovascular disease events in the HIV outpatient study
    • Lichtenstein KA, et al. Low CD4+ T cell count is a risk factor for cardiovascular disease events in the HIV outpatient study. Clin Infect Dis 2010;51:435-447.
    • (2010) Clin Infect Dis , vol.51 , pp. 435-447
    • Lichtenstein, K.A.1
  • 169
    • 33751515147 scopus 로고    scopus 로고
    • CD4+ count-guided interruption of antiretroviral treatment
    • El-Sadr WM, et al. CD4+ count-guided interruption of antiretroviral treatment. N Engl J Med 2006;355:2283-2296.
    • (2006) N Engl J Med , vol.355 , pp. 2283-2296
    • El-Sadr, W.M.1
  • 170
    • 79955028940 scopus 로고    scopus 로고
    • Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapy
    • Hunt PW, et al. Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapy. J Infect Dis 2011;203:1474-1483.
    • (2011) J Infect Dis , vol.203 , pp. 1474-1483
    • Hunt, P.W.1
  • 171
    • 84880246969 scopus 로고    scopus 로고
    • Aspirin attenuates platelet activation and immune activation in HIV-infected subjects on antiretroviral therapy: a pilot study
    • doi: 10.1097/QAI.0b013e31828a292c.
    • O'Brien M, et al. Aspirin attenuates platelet activation and immune activation in HIV-infected subjects on antiretroviral therapy: a pilot study. J Acquir Immune Defic Syndr 2013; doi: 10.1097/QAI.0b013e31828a292c.
    • (2013) J Acquir Immune Defic Syndr
    • O'Brien, M.1
  • 172
    • 33646468496 scopus 로고    scopus 로고
    • Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients
    • Herbeuval JP, et al. Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients. Proc Natl Acad Sci USA 2006;103:7000-7005.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7000-7005
    • Herbeuval, J.P.1
  • 173
    • 0025823898 scopus 로고
    • Interferon-alpha and tumor necrosis factor-alpha in serum of patients in various stages of HIV-1 infection
    • von Sydow M, Sonnerborg A, Gaines H, Strannegard O. Interferon-alpha and tumor necrosis factor-alpha in serum of patients in various stages of HIV-1 infection. AIDS Res Hum Retroviruses 1991;7:375-380.
    • (1991) AIDS Res Hum Retroviruses , vol.7 , pp. 375-380
    • von Sydow, M.1    Sonnerborg, A.2    Gaines, H.3    Strannegard, O.4
  • 174
    • 72849136282 scopus 로고    scopus 로고
    • Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response
    • Jacquelin B, et al. Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response. J Clin Invest 2009;119:3544-3555.
    • (2009) J Clin Invest , vol.119 , pp. 3544-3555
    • Jacquelin, B.1
  • 175
    • 84856183595 scopus 로고    scopus 로고
    • Interferon-alpha administration enhances CD8+ T cell activation in HIV infection
    • Manion M, et al. Interferon-alpha administration enhances CD8+ T cell activation in HIV infection. PLoS ONE 2012;7:e30306.
    • (2012) PLoS ONE , vol.7
    • Manion, M.1
  • 176
    • 27744560468 scopus 로고    scopus 로고
    • CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis
    • Herbeuval JP, et al. CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis. Blood 2005;106:3524-3531.
    • (2005) Blood , vol.106 , pp. 3524-3531
    • Herbeuval, J.P.1
  • 177
    • 68349131723 scopus 로고    scopus 로고
    • Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1
    • Meier A, et al. Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1. Nat Med 2009;15:955-959.
    • (2009) Nat Med , vol.15 , pp. 955-959
    • Meier, A.1
  • 178
    • 72849132344 scopus 로고    scopus 로고
    • Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys
    • Bosinger SE, et al. Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys. J Clin Invest 2009;119:3556-3572.
    • (2009) J Clin Invest , vol.119 , pp. 3556-3572
    • Bosinger, S.E.1
  • 179
    • 80051798291 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells are recruited to the colorectum and contribute to immune activation during pathogenic SIV infection in rhesus macaques
    • Kwa S, et al. Plasmacytoid dendritic cells are recruited to the colorectum and contribute to immune activation during pathogenic SIV infection in rhesus macaques. Blood 2011;118:2763-2773.
    • (2011) Blood , vol.118 , pp. 2763-2773
    • Kwa, S.1
  • 180
    • 84862491847 scopus 로고    scopus 로고
    • Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation
    • Vanderford TH, et al. Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation. Blood 2012;119:5750-5757.
    • (2012) Blood , vol.119 , pp. 5750-5757
    • Vanderford, T.H.1
  • 181
    • 84860584561 scopus 로고    scopus 로고
    • PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques
    • Dyavar SR, et al. PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques. J Clin Invest 2012;122:1712-1716.
    • (2012) J Clin Invest , vol.122 , pp. 1712-1716
    • Dyavar, S.R.1
  • 182
    • 2142701542 scopus 로고    scopus 로고
    • Dendritic cells exposed to herpes simplex virus in vivo do not produce IFN-alpha after rechallenge with virus in vitro and exhibit decreased T cell alloreactivity
    • Bjorck P. Dendritic cells exposed to herpes simplex virus in vivo do not produce IFN-alpha after rechallenge with virus in vitro and exhibit decreased T cell alloreactivity. J Immunol 2004;172:5396-5404.
    • (2004) J Immunol , vol.172 , pp. 5396-5404
    • Bjorck, P.1
  • 183
    • 33644752743 scopus 로고    scopus 로고
    • Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells
    • Ito T, Kanzler H, Duramad O, Cao W, Liu YJ. Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells. Blood 2006;107:2423-2431.
    • (2006) Blood , vol.107 , pp. 2423-2431
    • Ito, T.1    Kanzler, H.2    Duramad, O.3    Cao, W.4    Liu, Y.J.5
  • 184
    • 41949103790 scopus 로고    scopus 로고
    • Human immunodeficiency virus viremia induces plasmacytoid dendritic cell activation in vivo and diminished alpha interferon production in vitro
    • Tilton JC, et al. Human immunodeficiency virus viremia induces plasmacytoid dendritic cell activation in vivo and diminished alpha interferon production in vitro. J Virol 2008;82:3997-4006.
    • (2008) J Virol , vol.82 , pp. 3997-4006
    • Tilton, J.C.1
  • 185
    • 80054721608 scopus 로고    scopus 로고
    • Dendritic cell dysfunction during primary HIV-1 infection
    • Huang J, et al. Dendritic cell dysfunction during primary HIV-1 infection. J Infect Dis 2011;204:1557-1562.
    • (2011) J Infect Dis , vol.204 , pp. 1557-1562
    • Huang, J.1
  • 186
    • 70449482630 scopus 로고    scopus 로고
    • Defective plasmacytoid dendritic cell-NK cell cross-talk in HIV infection
    • Reitano KN, et al. Defective plasmacytoid dendritic cell-NK cell cross-talk in HIV infection. AIDS Res Hum Retroviruses 2009;25:1029-1037.
    • (2009) AIDS Res Hum Retroviruses , vol.25 , pp. 1029-1037
    • Reitano, K.N.1
  • 187
    • 22244470043 scopus 로고    scopus 로고
    • Type I interferon production is profoundly and transiently impaired in primary HIV-1 infection
    • Kamga I, et al. Type I interferon production is profoundly and transiently impaired in primary HIV-1 infection. J Infect Dis 2005;192:303-310.
    • (2005) J Infect Dis , vol.192 , pp. 303-310
    • Kamga, I.1
  • 188
    • 84876299371 scopus 로고    scopus 로고
    • Blockade of chronic type I interferon signaling to control persistent LCMV infection
    • Wilson EB, et al. Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science 2013;340:202-207.
    • (2013) Science , vol.340 , pp. 202-207
    • Wilson, E.B.1
  • 189
    • 84876311772 scopus 로고    scopus 로고
    • Persistent LCMV infection is controlled by blockade of type I interferon signaling
    • Teijaro JR, et al. Persistent LCMV infection is controlled by blockade of type I interferon signaling. Science 2013;340:207-211.
    • (2013) Science , vol.340 , pp. 207-211
    • Teijaro, J.R.1
  • 190
    • 33144476838 scopus 로고    scopus 로고
    • Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection
    • Estes JD, et al. Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection. J Infect Dis 2006;193:703-712.
    • (2006) J Infect Dis , vol.193 , pp. 703-712
    • Estes, J.D.1
  • 191
    • 84874234588 scopus 로고    scopus 로고
    • Poor Immune Reconstitution in HIV-Infected Patients Associates with High Percentage of Regulatory CD4(+) T Cells
    • Horta A, et al. Poor Immune Reconstitution in HIV-Infected Patients Associates with High Percentage of Regulatory CD4(+) T Cells. PLoS ONE 2013;8:e57336.
    • (2013) PLoS ONE , vol.8
    • Horta, A.1
  • 192
    • 3543098686 scopus 로고    scopus 로고
    • CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status
    • Kinter AL, et al. CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status. J Exp Med 2004;200:331-343.
    • (2004) J Exp Med , vol.200 , pp. 331-343
    • Kinter, A.L.1
  • 193
    • 15444363618 scopus 로고    scopus 로고
    • Depletion of regulatory T cells in HIV infection is associated with immune activation
    • Eggena MP, et al. Depletion of regulatory T cells in HIV infection is associated with immune activation. J Immunol 2005;174:4407-4414.
    • (2005) J Immunol , vol.174 , pp. 4407-4414
    • Eggena, M.P.1
  • 195
    • 55849140547 scopus 로고    scopus 로고
    • HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism
    • Manches O, et al. HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2, 3-dioxygenase-dependent mechanism. J Clin Invest 2008;118:3431-3439.
    • (2008) J Clin Invest , vol.118 , pp. 3431-3439
    • Manches, O.1
  • 196
    • 77952977625 scopus 로고    scopus 로고
    • Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease
    • Favre D, et al. Tryptophan catabolism by indoleamine 2, 3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci Trans Med 2010;2:32ra36.
    • (2010) Sci Trans Med , vol.2
    • Favre, D.1
  • 197
    • 84865546531 scopus 로고    scopus 로고
    • Activation of the noncanonical NF-kappaB pathway by HIV controls a dendritic cell immunoregulatory phenotype
    • Manches O, Fernandez MV, Plumas J, Chaperot L, Bhardwaj N. Activation of the noncanonical NF-kappaB pathway by HIV controls a dendritic cell immunoregulatory phenotype. Proc Natl Acad Sci USA 2012;109:14122-14127.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 14122-14127
    • Manches, O.1    Fernandez, M.V.2    Plumas, J.3    Chaperot, L.4    Bhardwaj, N.5
  • 198
    • 64249110601 scopus 로고    scopus 로고
    • Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques
    • Boasso A, et al. Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques. J Immunol 2009;182:4313-4320.
    • (2009) J Immunol , vol.182 , pp. 4313-4320
    • Boasso, A.1
  • 199
    • 84872953130 scopus 로고    scopus 로고
    • Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: a pilot study testing inhibition of indoleamine 2,3-dioxygenase
    • Dunham RM, et al. Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: a pilot study testing inhibition of indoleamine 2, 3-dioxygenase. AIDS Res Hum Retroviruses 2013;29:207-214.
    • (2013) AIDS Res Hum Retroviruses , vol.29 , pp. 207-214
    • Dunham, R.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.