메뉴 건너뛰기




Volumn 165, Issue 3, 2000, Pages 1685-1691

CD40 ligand trimer and IL-12 enhance peripheral blood mononuclear cells and CD4+ T cell proliferation and production of IFN-γ in response to p24 antigen in HIV-infected individuals: Potential contribution of anergy to HIV- specific unresponsiveness

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD40 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12;

EID: 0034254205     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.3.1685     Document Type: Article
Times cited : (41)

References (54)
  • 1
    • 0032580479 scopus 로고    scopus 로고
    • HIV-protease inhibitors
    • Flexner, C. 1998. HIV-protease inhibitors. N. Engl. J. Med. 338:1281.
    • (1998) N. Engl. J. Med. , vol.338 , pp. 1281
    • Flexner, C.1
  • 5
    • 0032732511 scopus 로고    scopus 로고
    • HAART in HIV-infected patients: Restoration of antigen-specific CD4 T-cell responses in vitro is correlated with CD4 memory T-cell reconstitution, whereas improvement in delayed type hypersensitivity is related to a decrease in viraemia
    • Wendland, T., H. Furrer, P. L. Vernazza, K. Frutig, A. Christen, L. Matter, R. Malinverni, and W. J. Pichler. 1999. HAART in HIV-infected patients: restoration of antigen-specific CD4 T-cell responses in vitro is correlated with CD4 memory T-cell reconstitution, whereas improvement in delayed type hypersensitivity is related to a decrease in viraemia. AIDS 13:1857.
    • (1999) AIDS , vol.13 , pp. 1857
    • Wendland, T.1    Furrer, H.2    Vernazza, P.L.3    Frutig, K.4    Christen, A.5    Matter, L.6    Malinverni, R.7    Pichler, W.J.8
  • 7
    • 0032480989 scopus 로고    scopus 로고
    • Restored humoral immune response to influenza vaccination in HIV-infected adults treated with highly active antiretroviral therapy
    • Kroon, F. P., G. F. Rimmelzwaan, M. T. Roos, A. D. Osterhaus, D. Hamann, F. Miedema, and J. T. van Dissel. 1998. Restored humoral immune response to influenza vaccination in HIV-infected adults treated with highly active antiretroviral therapy. AIDS 12:F217.
    • (1998) AIDS , vol.12
    • Kroon, F.P.1    Rimmelzwaan, G.F.2    Roos, M.T.3    Osterhaus, A.D.4    Hamann, D.5    Miedema, F.6    Van Dissel, J.T.7
  • 8
    • 0032490305 scopus 로고    scopus 로고
    • Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease
    • Li, T. S., R. Tubiana, C. Katlama, V. Calvez, H. Ait Mohand, and B. Autran. 1998. Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease. Lancet 351:1682.
    • (1998) Lancet , vol.351 , pp. 1682
    • Li, T.S.1    Tubiana, R.2    Katlama, C.3    Calvez, V.4    Ait Mohand, H.5    Autran, B.6
  • 9
    • 0032089064 scopus 로고    scopus 로고
    • Lymphocyte-proliferative responses to HIV antigens as a potential measure of immunological reconstitution in HIV disease
    • Valentine, F. T., A. Paolino, A. Saito, and R. S. Holzman. 1998. Lymphocyte-proliferative responses to HIV antigens as a potential measure of immunological reconstitution in HIV disease. AIDS Res. Hum. Retroviruses 14 (Suppl. 2):S161.
    • (1998) AIDS Res. Hum. Retroviruses , vol.14 , Issue.SUPPL. 2
    • Valentine, F.T.1    Paolino, A.2    Saito, A.3    Holzman, R.S.4
  • 10
    • 0033386086 scopus 로고    scopus 로고
    • Can chemoprophylaxis against opportunistic infections be discontinued after an increase in CD4 cells induced by highly active antiretroviral therapy?
    • Kirk, O., J. D. Lundgren, C. Pedersen, H. Nielsen, and J. Gerstoft. 1999. Can chemoprophylaxis against opportunistic infections be discontinued after an increase in CD4 cells induced by highly active antiretroviral therapy? AIDS 13:1647.
    • (1999) AIDS , vol.13 , pp. 1647
    • Kirk, O.1    Lundgren, J.D.2    Pedersen, C.3    Nielsen, H.4    Gerstoft, J.5
  • 11
    • 0033573787 scopus 로고    scopus 로고
    • Discontinuation of prophylaxis for pneumocystis carinii pneumonia in HIV-1-infected patients treated with highly active antiretroviral therapy
    • Schneider, M. M., J. C. Borleffs, R. P. Stolk, C. A. Jaspers, and A. I. Hoepelman. 1999. Discontinuation of prophylaxis for Pneumocystis carinii pneumonia in HIV-1-infected patients treated with highly active antiretroviral therapy. Lancet 353:201.
    • (1999) Lancet , vol.353 , pp. 201
    • Schneider, M.M.1    Borleffs, J.C.2    Stolk, R.P.3    Jaspers, C.A.4    Hoepelman, A.I.5
  • 12
  • 13
    • 0032435619 scopus 로고    scopus 로고
    • Discontinuing anticytomegalovirus therapy in patients with immune reconstitution after combination antiretroviral therapy
    • Jabs, D. A., S. G. Bolton, J. P. Dunn, and A. G. Palestine. 1998. Discontinuing anticytomegalovirus therapy in patients with immune reconstitution after combination antiretroviral therapy. Am. J. Ophthalmol. 126:817.
    • (1998) Am. J. Ophthalmol. , vol.126 , pp. 817
    • Jabs, D.A.1    Bolton, S.G.2    Dunn, J.P.3    Palestine, A.G.4
  • 15
    • 0032750443 scopus 로고    scopus 로고
    • Highly active anti-retroviral therapy (HAART) prolongs time to treatment failure in Kaposi's sarcoma
    • Bower, M., P. Fox, K. Fife, J. Gill, M. Nelson, and B. Gazzard. 1999. Highly active anti-retroviral therapy (HAART) prolongs time to treatment failure in Kaposi's sarcoma. AIDS 13:2105.
    • (1999) AIDS , vol.13 , pp. 2105
    • Bower, M.1    Fox, P.2    Fife, K.3    Gill, J.4    Nelson, M.5    Gazzard, B.6
  • 18
    • 0033004630 scopus 로고    scopus 로고
    • Rate of HIV-1 RNA rebound upon stopping antiretroviral therapy
    • Harrigan, P. R., M. Whaley, and J. S. Montaner. 1999. Rate of HIV-1 RNA rebound upon stopping antiretroviral therapy. AIDS 13:F59.
    • (1999) AIDS , vol.13
    • Harrigan, P.R.1    Whaley, M.2    Montaner, J.S.3
  • 19
    • 0032991492 scopus 로고    scopus 로고
    • HIV-1 rebound during interruption of highly active antiretroviral therapy has no deleterious effect on reinitiated treatment: Comet Study Group
    • Neumann, A. U., R. Tubiana, V. Calvez, C. Robert, T. S. Li, H. Agut, B. Autran, and C. Katlama. 1999. HIV-1 rebound during interruption of highly active antiretroviral therapy has no deleterious effect on reinitiated treatment: Comet Study Group. AIDS 13:677.
    • (1999) AIDS , vol.13 , pp. 677
    • Neumann, A.U.1    Tubiana, R.2    Calvez, V.3    Robert, C.4    Li, T.S.5    Agut, H.6    Autran, B.7    Katlama, C.8
  • 25
    • 0032987509 scopus 로고    scopus 로고
    • The effects of CD40 ligation on peripheral blood mononuclear cell interleukin-12 and interleukin-15 production and on monocyte CD14 surface antigen expression in human immunodeficiency virus-positive patients
    • Zanussi, S., M. D'Andrea, C. Simonelli, D. Trabattoni, M. T. Bortolin, L. Caggiari, U. Tirelli, M. Clerici, and P. De Paoli. 1999. The effects of CD40 ligation on peripheral blood mononuclear cell interleukin-12 and interleukin-15 production and on monocyte CD14 surface antigen expression in human immunodeficiency virus-positive patients. Scand. J. Immunol. 49:286.
    • (1999) Scand. J. Immunol. , vol.49 , pp. 286
    • Zanussi, S.1    D'Andrea, M.2    Simonelli, C.3    Trabattoni, D.4    Bortolin, M.T.5    Caggiari, L.6    Tirelli, U.7    Clerici, M.8    De Paoli, P.9
  • 28
    • 0029070201 scopus 로고
    • Chronic activation of the immune system in HIV infection: Contribution to T cell apoptosis and Vβ selective T cell anergy
    • Gougeon, M. L. 1995. Chronic activation of the immune system in HIV infection: contribution to T cell apoptosis and Vβ selective T cell anergy. Curr. Top. Microbiol. Immunol. 200:177.
    • (1995) Curr. Top. Microbiol. Immunol. , vol.200 , pp. 177
    • Gougeon, M.L.1
  • 29
    • 0027409391 scopus 로고
    • T-cell dysfunction in HIV infection: Anergy due to defective antigen-presenting cell function?
    • Meyaard, L., H. Schuitemaker, and F. Miedema. 1993. T-cell dysfunction in HIV infection: anergy due to defective antigen-presenting cell function? Immunol. Today 14:161.
    • (1993) Immunol. Today , vol.14 , pp. 161
    • Meyaard, L.1    Schuitemaker, H.2    Miedema, F.3
  • 30
    • 0031569513 scopus 로고    scopus 로고
    • A tumor-associated and self antigen peptide presented by dendritic cells may induce T cell anergy in vivo, but IL-12 can prevent or revert the anergic state
    • Grohmann, U., R. Bianchi, E. Ayroldi, M. L. Belladonna, D. Surace, M. C. Fioretti, and P. Puccetti. 1997. A tumor-associated and self antigen peptide presented by dendritic cells may induce T cell anergy in vivo, but IL-12 can prevent or revert the anergic state. J. Immunol. 158:3593.
    • (1997) J. Immunol. , vol.158 , pp. 3593
    • Grohmann, U.1    Bianchi, R.2    Ayroldi, E.3    Belladonna, M.L.4    Surace, D.5    Fioretti, M.C.6    Puccetti, P.7
  • 31
    • 0031920752 scopus 로고    scopus 로고
    • The role of IL-12 in the induction of an immune response to a tumor/self peptide: Prevention and reversion of anergy
    • Belladonna, M. L., U. Grohmann, R. Bianchi, E. Ayroldi, D. Surace, P. Puccetti, and M. C. Fioretti. 1998. The role of IL-12 in the induction of an immune response to a tumor/self peptide: prevention and reversion of anergy. J. Chemother. 10:157.
    • (1998) J. Chemother. , vol.10 , pp. 157
    • Belladonna, M.L.1    Grohmann, U.2    Bianchi, R.3    Ayroldi, E.4    Surace, D.5    Puccetti, P.6    Fioretti, M.C.7
  • 34
    • 0031725323 scopus 로고    scopus 로고
    • Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy
    • Powell, J. D., J. A. Ragheb, S. Kitagawa-Sakakida, and R. H. Schwartz. 1998. Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy Immunol. Rev. 165:287.
    • (1998) Immunol. Rev. , vol.165 , pp. 287
    • Powell, J.D.1    Ragheb, J.A.2    Kitagawa-Sakakida, S.3    Schwartz, R.H.4
  • 36
    • 0029147357 scopus 로고
    • Cytokine interactions in human immunodeficiency virus-infected individuals: Roles of interleukin (IL)-2, IL-12, and IL-15
    • Seder, R. A., K H. Grabstein, J. A. Berzofsky, and J. F. McDyer. 1995. Cytokine interactions in human immunodeficiency virus-infected individuals: roles of interleukin (IL)-2, IL-12, and IL-15. J. Exp. Med. 182:1067.
    • (1995) J. Exp. Med. , vol.182 , pp. 1067
    • Seder, R.A.1    Grabstein, K.H.2    Berzofsky, J.A.3    McDyer, J.F.4
  • 39
    • 0028858649 scopus 로고
    • Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes
    • Kiener, P. A., P. Moran-Davis, B. M. Rankin, A. F. Wahl, A. Aruffo, and D. Hollenbaugh. 1995. Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes. J. Immunol. 155:4917.
    • (1995) J. Immunol. , vol.155 , pp. 4917
    • Kiener, P.A.1    Moran-Davis, P.2    Rankin, B.M.3    Wahl, A.F.4    Aruffo, A.5    Hollenbaugh, D.6
  • 40
    • 0028289244 scopus 로고
    • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and down-regulated by tumor necrosis factor α
    • Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and down-regulated by tumor necrosis factor α. J. Exp. Med. 179:1109.
    • (1994) J. Exp. Med. , vol.179 , pp. 1109
    • Sallusto, F.1    Lanzavecchia, A.2
  • 41
    • 0029812593 scopus 로고    scopus 로고
    • Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
    • Cella, M., D. Scheidegger, K. Palmer-Lehmann, P. Lane, A. Lanzavecchia, and G. Alber. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747.
    • (1996) J. Exp. Med. , vol.184 , pp. 747
    • Cella, M.1    Scheidegger, D.2    Palmer-Lehmann, K.3    Lane, P.4    Lanzavecchia, A.5    Alber, G.6
  • 43
    • 0033541599 scopus 로고    scopus 로고
    • Dendritic cell secretion of IL-15 is induced by recombinant huCD40LT and augments the stimulation of antigen-specific cytolytic T cells
    • Kuniyoshi, J. S., C. J. Kuniyoshi, A. M. Lim, F. Y. Wang, E. R. Bade, R. Lau, E. K. Thomas, and J. S. Weber. 1999. Dendritic cell secretion of IL-15 is induced by recombinant huCD40LT and augments the stimulation of antigen-specific cytolytic T cells. Cell. Immunol. 193:48.
    • (1999) Cell. Immunol. , vol.193 , pp. 48
    • Kuniyoshi, J.S.1    Kuniyoshi, C.J.2    Lim, A.M.3    Wang, F.Y.4    Bade, E.R.5    Lau, R.6    Thomas, E.K.7    Weber, J.S.8
  • 44
    • 0032519939 scopus 로고    scopus 로고
    • CD40 ligand/CD40 stimulation regulates the production of IFN-γ from human peripheral blood mononuclear cells in an IL-12-and/or CD28-dependent manner
    • McDyer, J. F., T. J. Goletz, E. Thomas, C. H. June, and R. A. Seder. 1998. CD40 ligand/CD40 stimulation regulates the production of IFN-γ from human peripheral blood mononuclear cells in an IL-12-and/or CD28-dependent manner. J. Immunol. 160:1701.
    • (1998) J. Immunol. , vol.160 , pp. 1701
    • McDyer, J.F.1    Goletz, T.J.2    Thomas, E.3    June, C.H.4    Seder, R.A.5
  • 45
    • 0029792922 scopus 로고    scopus 로고
    • Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists
    • Madrenas, J., R. H. Schwartz, and R. N. Germain. 1996. Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists. Proc. Natl. Acad. Sci. USA 93:9736.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9736
    • Madrenas, J.1    Schwartz, R.H.2    Germain, R.N.3
  • 46
    • 0028467949 scopus 로고
    • The role of CD40 and CD80 accessory cell molecules in dendritic cell-dependent HIV-1 infection
    • Pinchuk, L. M., P. S. Polacino, M. B. Agy, S. J. Klaus, and E. A. Clark. 1994. The role of CD40 and CD80 accessory cell molecules in dendritic cell-dependent HIV-1 infection. Immunity 1:317
    • (1994) Immunity , vol.1 , pp. 317
    • Pinchuk, L.M.1    Polacino, P.S.2    Agy, M.B.3    Klaus, S.J.4    Clark, E.A.5
  • 47
    • 0028040126 scopus 로고
    • Induction of interieukin 12 responsiveness is impaired in anergic T lymphocytes
    • Quill, H., A. Bhandoola, G. Trinchieri, J. Haluskey, and D. Peritt. 1994. Induction of interieukin 12 responsiveness is impaired in anergic T lymphocytes. J. Exp. Med. 179:1065.
    • (1994) J. Exp. Med. , vol.179 , pp. 1065
    • Quill, H.1    Bhandoola, A.2    Trinchieri, G.3    Haluskey, J.4    Peritt, D.5
  • 49
    • 0031229823 scopus 로고    scopus 로고
    • CD4 T cell anergy in murine AIDS: Costimulation via CD28 and the addition of IL-12 are not sufficient to rescue anergic CD4 T cells
    • Andrews, C., S. L. Swain, and G. Muralidhar. 1997. CD4 T cell anergy in murine AIDS: costimulation via CD28 and the addition of IL-12 are not sufficient to rescue anergic CD4 T cells J. Immunol. 159:2132.
    • (1997) J. Immunol. , vol.159 , pp. 2132
    • Andrews, C.1    Swain, S.L.2    Muralidhar, G.3
  • 50
    • 0032710328 scopus 로고    scopus 로고
    • Treatment of human immunodeficiency virus infection with hydroxyurea, didanosine, and a protease inhibitor before seroconversion is associated with normalized immune parameters and limited viral reservoir
    • Lori, F., H. Jessen, J. Lieberman, D. Finzi, E. Rosenberg, C. Tinelli, B. Walker, R. F. Siliciano, and J. Lisziewicz. 1999. Treatment of human immunodeficiency virus infection with hydroxyurea, didanosine, and a protease inhibitor before seroconversion is associated with normalized immune parameters and limited viral reservoir. J. Infect. Dis. 180:1827.
    • (1999) J. Infect. Dis. , vol.180 , pp. 1827
    • Lori, F.1    Jessen, H.2    Lieberman, J.3    Finzi, D.4    Rosenberg, E.5    Tinelli, C.6    Walker, B.7    Siliciano, R.F.8    Lisziewicz, J.9
  • 51
    • 0028981432 scopus 로고
    • Allergen-stimulated inlerleukin-4 and interferon-γ production in primary culture: Responses of subjects with allergic rhinitis and normal controls
    • Imada, M., F. E. Simons, F. T. Jay, and K. T. Hayglass. 1995. Allergen-stimulated inlerleukin-4 and interferon-γ production in primary culture: responses of subjects with allergic rhinitis and normal controls. Immunology 85:373.
    • (1995) Immunology , vol.85 , pp. 373
    • Imada, M.1    Simons, F.E.2    Jay, F.T.3    Hayglass, K.T.4
  • 52
    • 0028240682 scopus 로고
    • Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens
    • Surcel, H. M., M. Troye-Blomberg, S. Paulie, G. Andersson, C. Moreno, G. Pasvol, and J. Ivanyi. 1994. Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens. Immunology 81:171.
    • (1994) Immunology , vol.81 , pp. 171
    • Surcel, H.M.1    Troye-Blomberg, M.2    Paulie, S.3    Andersson, G.4    Moreno, C.5    Pasvol, G.6    Ivanyi, J.7
  • 53
    • 0024993203 scopus 로고
    • Production by activated human T cells of intcrleukin 4 but not interferon-γ is associated with elevated levels of serum antibodies to activating malaria antigens
    • Troye-Blomberg, M., E. M. Riley, L. Kabilan, M. Holmberg, H. Perlmann, U. Andersson, C. H. Heusser, and P. Perlmann. 1990. Production by activated human T cells of intcrleukin 4 but not interferon-γ is associated with elevated levels of serum antibodies to activating malaria antigens. Proc. Natl. Acad. Sci. USA 87:5484.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 5484
    • Troye-Blomberg, M.1    Riley, E.M.2    Kabilan, L.3    Holmberg, M.4    Perlmann, H.5    Andersson, U.6    Heusser, C.H.7    Perlmann, P.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.