TRIM5 is an innate immune sensor for the retrovirus capsid lattice

Nature

Volumn 472, Issue 7343, 2011, Pages 361-365

  Pertel, Thomas ^a   Hausmann, Stéphane ^a   Morger, Damien ^b   Züger, Sara ^b   Guerra, Jessica ^a   Lascano, Josefina ^a   Reinhard, Christian ^a   Santoni, Federico A ^a   Uchil, Pradeep D ^c   Chatel, Laurence ^d   Bisiaux, Aurélie ^e   Albert, Matthew L ^e   Strambio De Castillia, Caterina ^a   Mothes, Walther ^c   Pizzato, Massimo ^a   Grütter, Markus G ^b   Luban, Jeremy ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NOVIMMUNE SA   (Switzerland)

^e INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRIPARTITE MOTIF PROTEIN 5; UBIQUITIN CONJUGATING ENZYME 13; UBIQUITIN CONJUGATING ENZYME E2;

CYTOPLASM; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE SYSTEM;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; INNATE IMMUNITY; PRIORITY JOURNAL; RETROVIRUS; RETROVIRUS INFECTION; SIGNAL TRANSDUCTION; VIRUS CAPSID;

CAPSID; CARRIER PROTEINS; CELL LINE; ENZYME ACTIVATION; HEK293 CELLS; HIV-1; HUMANS; IMMUNITY, INNATE; LIPOPOLYSACCHARIDES; MAP KINASE KINASE KINASES; NF-KAPPA B; PROTEIN BINDING; RECEPTORS, PATTERN RECOGNITION; RETROVIRIDAE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES;

HUMAN IMMUNODEFICIENCY VIRUS 1; MIRIDAE;

EID: 79955377543     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09976     Document Type: Article

References (27)

1. Sayah, D. M., Sokolskaja, E., Berthoux, L & Luban, J. Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1. Nature 430, 569-573 (2004). (Pubitemid 38998631)
2. Stremlau, M. et al. Thecytoplasmic bodycomponentTRIM5a restricts HIV-1 Infection in Old World monkeys. Nature 427, 848-853 (2004). (Pubitemid 38297747)
3. Sebastian, S. & Luban, J.TRIM5aselectively bindsa restriction-sensitiveretroviral capsid. Retrovirology 2, 40 (2005).
4. Stremlau, M. et al. Specific recognition and accelerated uncoatingof retrovira capsids by the TRIM5a restriction factor. Proc. Natl Acad. Sci. USA 103, 5514-5519(2006).
5. Berthoux, L et al. As2O3 enhances retroviral reverse transcription and counteracts Ref1 antiviral activity. J. Virol. 77, 3167-3180 (2003). (Pubitemid 36228101)
6. Shi, M. et al. TRIM30a negatively regulates TLR-mediated NF-kB activation by targeting TAB2 and TAB3 for degradation. Nature Immunol. 9, 369-377 (2008). (Pubitemid 351405106)
7. Tareen, S. U. & Emerman, M. Human Trim5a hasadditional activitiesthatare uncoupled from retroviral capsid recognition. Virology409, 113-120 (2011).
8. Luban, J. & Cyclophilin, A. TRIM5, and resistanceto human immunodeficiency virus type 1 infection. J. Virol. 81, 1054-1061 (2007). (Pubitemid 46170755)
9. Panne, D., Maniatis, T. & Harrison, S. C. An atomic model ofthe interferon-b enhanceosome. Cell129, 1111-1123 (2007). (Pubitemid 46891042)
10. Ishii, K. J., Koyama, S., Nakagawa, A., Coban, C. & Akira, S. Host innate immune receptorsand beyond: makingsenseof microbial infections. Cell Host Microbe 3, 352-363 (2008). (Pubitemid 351773099)
11. Xia, Z. P. et al. Directactivation of protein kinases by unanchored polyubiquitin chains. Nature 461, 114-119 (2009).
12. Kornbluth, R. S., Oh, P. S., Munis, J. R., Cleveland, P. H. & Richman, D. D. Interferons and bacterial lipopolysaccharide protect macrophages from productive infection by human immunodeficiency virus in vitro. J. Exp. Med. 169, 1137-1151 (1989). (Pubitemid 19085845)
13. Neagu, M. R. et al. Potent inhibition of HIV-1 byTRIM5-cyclophilin fusion proteins engineered from human components. J. Clin. Invest 119, 3035-3047 (2009).
14. Roe, T, Reynolds, T. C, Yu, G. & Brown, P. O. Integration of murine leukemiavirus DNAdependson mitosis. EMBOJ. 12, 2099-2108(1993). (Pubitemid 23157725)
15. Berthoux, L, Sebastian, S., Sokolskaja, E. & Luban, J. Cyclophilin A is required for TRIM5a-mediated resistance to HIV-1 in Old World monkey cells. Proc. Natl Acad. Sci. USA 102, 14849-14853 (2005). (Pubitemid 41457144)
16. Zeng, W. et al. Reconstitution ofthe RIG-I pathway revealsa signaling roleof unanchored polyubiquitin chains in innate immunity. Cell 141, 315-330(2010).
17. Langelier, C. R. et al. Biochemical characterization of a recombinant TRIM5a protein that restricts human immunodefficiency virus type1 replication. J.Virol. 82, 11682-11694 (2008).
18. Yin, Q., Lamothe, B., Darnay, B. G. & Wu, H. Structural basisforthe lackof E2 Interaction in the RING domain of TRAF2. Biochemistry 48, 10558-10567 (2009).
19. Sokolskaja, E., Berthoux, L & Luban, J. Cyclophilin Aand TRIM5a independently regulate human immunodeficiency virus type 1 infectivity in human cells. J. Virol. 80, 2855-2862 (2006). (Pubitemid 43346380)
20. Yan, N., Regalado-Magdos, A. D., Stiggelbout, B., Lee-Kirsch, M. A. & Lieberman, J The cytosolicexo nuclease TREX1 inhibitsthe innateimmuneresponseto human mmunodeficiency virus type 1. Nature Immunol. 11, 1005-1013(2010).
21. Perron, M. J. et al. TRIM5a mediatesthe postentry blockto N-tropic murine leukemia viruses in human cells. Proc. Natl Acad. Sci. USA 101, 11827-11832 (2004). (Pubitemid 39095379)
22. Ulm, J. W., Perron, M., Sodroski, J. & Mulligan, R. C. Complexdeterminantswithin the Moloney murine leukemia virus capsid modulate susceptibility of the virus to Fv1 and Ref1-mediated restriction. Virology 363, 245-255 (2007). (Pubitemid 46779064)
23. Pornillos, O. et al. X-raystructures ofthe hexameric building blockof the HIV capsid. Cell 137, 1282-1292 (2009).
24. Ganser, B. K., Li, S., Klishko, V. Y., Finch, J. T. & Sundquist, W. I. Assemblyand analysis of conical models for the HIV-1 core. Science 283, 80-83 (1999). (Pubitemid 29044851)
25. Ganser-Pornillos, B. K. et al. Hexagonal assemblyof a restrictingTRIM5a protein. Proc. Natl Acad. Sci. USA 108, 534-539 (2011).
26. Medzhitov, R. & Littman, D. HIV immunology needsa newdirection.Nature455, 591 (2008).
27. Pornillos, O., Ganser-Pornillos, B. K. & Yeager, M.Atomic-level modelling of the HIV capsid. Nature 469, 424-427 (2011).