PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques

Journal of Clinical Investigation

Volumn 122, Issue 5, 2012, Pages 1712-1716

  Shetty, Ravi Dyavar ^a   Velu, Vijayakumar ^a   Titanji, Kehmia ^a   Bosinger, Steven E ^a   Freeman, Gordon J ^b   Silvestri, Guido ^a,c   Amara, Rama Rao ^a,c  

^a EMORY UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; LIPOPOLYSACCHARIDE; PROGRAMMED DEATH 1 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD; CD8+ T LYMPHOCYTE; COLON; CONTROLLED STUDY; DOWN REGULATION; IMMUNITY; INTESTINE; MACACA; NONHUMAN; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; RECTUM; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; VIREMIA;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIVIRAL AGENTS; BACTEREMIA; BACTERIAL TRANSLOCATION; CAMPYLOBACTER; CHRONIC DISEASE; FECES; GENE EXPRESSION PROFILING; HUMANS; INTERFERON TYPE I; INTESTINAL MUCOSA; INTESTINE, LARGE; LIPOPOLYSACCHARIDES; MACACA MULATTA; OPPORTUNISTIC INFECTIONS; PROGRAMMED CELL DEATH 1 RECEPTOR; SALMONELLA; SHIGELLA; SIGNAL TRANSDUCTION; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; TRANSCRIPTION, GENETIC; TRICHURIS;

EID: 84860584561     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI60612     Document Type: Article

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