Persistent immune activation in HIV-1 infection is associated with progression to AIDS

AIDS

Volumn 17, Issue 13, 2003, Pages 1881-1888

  Hazenberg, Mette D ^a,b   Otto, Sigrid A ^a,b   Van Benthem, Birgit H B ^e   Roos, Marijke Th L ^a,b   Coutinho, Roel A ^e   Lange, Joep M A ^c,d   Hamann, Dörte ^a,b   Prins, Maria ^e   Miedema, Frank ^a,b,d,f  

^a SANQUIN RESEARCH   (Netherlands)

^b Landsteiner Laboratory   (Netherlands)

^c Natl AIDS Therapy Evaluation Centre   (Netherlands)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e MUNICIPAL HEALTH SERVICE   (Netherlands)

^f CENTRAL LABORATORY   (Netherlands)

Author keywords

Immune activation; Naive T cell depletion; Preseroconversion; T cell turnover

Indexed keywords

CD4 ANTIGEN; CD70 ANTIGEN; CD8 ANTIGEN; HLA DR ANTIGEN; KI 67 ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; COHORT ANALYSIS; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE SYSTEM; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; SEROCONVERSION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TURNOVER TIME;

ACQUIRED IMMUNODEFICIENCY SYNDROME; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; DISEASE PROGRESSION; FOLLOW-UP STUDIES; HIV INFECTIONS; HIV SEROPOSITIVITY; HIV-1; HUMANS; KI-67 ANTIGEN; LYMPHOCYTE ACTIVATION; PROGNOSIS; PROSPECTIVE STUDIES; RNA, VIRAL;

EID: 0041327667     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200309050-00006     Document Type: Article

References (35)

1. Fahey JL, Taylor JMG, Detels R, Hofmann B, Melmed R, Nishanian P, et al. The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1. N Engl J Med 1990, 322:166-172.
2. Fahey JL, Taylor JGM, Manna B, Nishanian P, Aziz N, Giorgi JV, et al. Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements. AIDS 1998, 12:1581-1590.
3. Carbone J, Gil J, Benito JM, Navarro J, Muñóz-Ferná ndez A, Bartolomé J, et al. Increased levels of activated subsets of CD4 T cells add to the prognostic value of low CD4 T cell counts in a cohort of HIV-infected drug users. AIDS 2000, 14:2823-2829.
4. +, long-term surviving injecting drug users distinguishes those who will progress to AIDS from those who will remain stable. Clin Exp Immunol 2000, 122:72-78.
5. Plaeger S, Bass HZ, Nishanian P, Thomas J, Aziz N, Detels R, et al. The prognostic significance in HIV infection of immune activation represented by cell surface antigen and plasma activation marker changes. Clin Immunol 1999, 90:238-246.
6. +cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression. J Acquir Immune Defic Syndr 1997, 16:83-92.
7. +T lymphocyte activation in HIV-1 disease reflects an aspect of pathogenesis distinct from viral burden and immunodeficiency. J Acquir Immune Defic Syndr 1998, 18:332-340.
8. + T cell levels: results of 6 years of follow-up. The Los Angeles Center, Multicenter AIDS Cohort Study. J Acquir Immune Defic Syndr 1993, 6:904-912.
9. + T cells is a marker of poor prognosis in HIV infection: results of 6 years of follow-up. Cytometry 1996, 26:1-7.
10. + T cells go out of stock. Nat Immunol 2000, 1:285-289.
11. Lens SMA, Tesselaar NA, van Oers MHJ, van Lier RAW. Control of lymphocyte function through CD27-CD70 interactions. Semin Immunol 1998, 10:491-499.
12. + T cells. Eur J Immunol 1996, 26:1700-1706.
13. Gerdes J, Lemke H, Baisch H, Wacker H-H, Schwab U, Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 1984, 133:1710-1715.
14. Kovacs JA, Lempicki RA, Sidorov IA, Adelsberger JW, Herpin B, Metcalf JA, et al. Identification of dynamically distinct subpopulations of T lymphocytes that are differentially affected by HIV. J Exp Med 2001, 194:1731-1741.
15. Mohri H, Perelson AS, Tung K, Ribeiro RM, Ramratnam B, Markowitz M, et al. Increased turnover of T lymphocytes in HIV-1 infection and its reduction by anti-retroviral therapy. J Exp Med 2001, 194:1277-1287.
16. Hazenberg MD, Cohen Stuart JWT, Otto SA, Borleffs JCC, Boucher CA, de Boer RJ, et al. T cell division in human immunodeficiency virus (HIV-1)-infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active anti-retroviral therapy. Blood 2000, 95:249-255.
17. Norusis MJ SPSS 7.5 for Windows. User's Guide. Chicago, IL: Statistical Package for Social Sciences Inc.; 1997
18. Anonymous. EGRET Users's Manual. Seattle, WA: Statistics and Epidemiology Research, Corp.; 1992.
19. + lymphocytes. Proc Natl Acad Sci USA 1994, 91:1104-1108.
20. + lymphocytes as prognostic markers of HIV-1 infection. Ann Intern Med 1997, 126:946-954.
21. Gupta P, Kingsley L, Armstrong J, Ming Ding, Cottrill M, Rinaldo C. Enhanced expression of human immunodeficiency virus type 1 correlates with development of AIDS. Virology 1993, 196:586-595.
22. +T cell count and function: Markers with reciprocal predictive value over time after seroconversion. AIDS 1997, 11:1799-1806.
23. Meyaard L, Otto SA, Jonker RR, Mijnster MJ, Keet RPM, Miedema F. Programmed death of T cells in HIV-1 infection. Science 1992, 257:217-219.
24. Grossman Z, Herberman RB, Dimitrov DS. T cell turnover in SIV infection. Science 1999, 284:555a-555b.
25. Grossman Z, Meier-Schellersheim M, Sousa AE, Victorino RMM, Paul WE. CD4 T-cell depletion in HIV infection: are we closer to understanding the cause? Nat Med 2002, 8:319-323.
26. + T cell demographics and dynamics in lymphatic tissues. Annu Rev Immunol 1999, 17:625-656.
27. Roederer M, Gregson Dubs J, Anderson MT, Raju PA, Herzenberg LA, Herzenberg L. CD8 naive T cell counts decrease progressively in HIV. infected adults. J Clin Invest 1995, 95:2061-2066.
28. Steel CM, Ludlam CA, Beatson D, Peutherer JF, Cuthbert RJ, Simmonds P, et al. HLA haplotype A1 B8 DR3 as a risk factor for HIV-related disease. Lancet 1988, 1:1185-1188.
29. Hazenberg MD, Otto SA, Hamann D, Roos MT, Schuitemaker H, De Boer RJ, et al. Depletion of naive CD4 T cells by CXCR4-using HIV-1 variants occurs mainly through increased T-cell death and activation. AIDS 2003, 17:1419-1424.
30. Embretson J, Zupancic M, Beneke J, Till M, Wolinsky S, Ribas JL, et al. Analysis of human immunodeficiency virus-infected tissues by amplification and in situ hybridization reveals latent and permissive infections at single-cell resolution. Proc Natl Acad Sci USA 1993, 90:357-361.
31. Chun T-W, Carruth L, Finzi D, Shen X, DiGiuseppe JA, Taylor H, et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 1997, 387:183-187.
32. Clark DR, de Boer RJ, Wolthers KC, Miedema F. T cell dynamics in HIV-1 infection. Adv Immunol 1999, 73:301-327.
33. + T-cell memory. Nat Med 2001, 7:913-919.
34. + T cell turnover. Science 1996, 274:1543-1547.
35. + T cells in HIV-1 infection: a mathematical interpretation. AIDS Res Hum Retroviruses 1999, 15:1053-1062.