Increased immune activation precedes the inflection point of CD4 T cells and the increased serum virus load in human immunodeficiency virus infection

Journal of Infectious Diseases

Volumn 178, Issue 2, 1998, Pages 423-430

  Salazar Gonzalez, Jesus F ^a   Martinez Maza, Otoniel ^b   Nishanian, Parunag ^b   Aziz, Najib ^b   Shen, Lu Ping ^b   Grosser, Stella ^b   Taylor, Jeremy ^b   Detels, Roger ^b   Fahcy, John L ^b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR; NEOPTERIN; TUMOR NECROSIS FACTOR ALPHA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CASE CONTROL STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOPATHOGENESIS; IMMUNOREGULATION; LYMPHOCYTE COUNT; PRIORITY JOURNAL; PROGNOSIS; SEROCONVERSION; T LYMPHOCYTE ACTIVATION; VIRUS CELL INTERACTION; VIRUS LOAD; VIRUS TRANSMISSION;

EID: 0031824618     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/515629     Document Type: Article

References (19)

1. Fauci AS. Multifactorial nature of human immunodeficiency virus disease: implications for therapy. Science 1993;262:1011-8.
2. Levy JA. Pathogenesis of human immunodeficiency virus infection. Microbiol Rev 1993;57:183-9.
3. Fauci AS. Host factors and the pathogenesis of HIV-induced disease. Nature 1996;384:529-34.
4. Tsoukas CM, Bernard NF. Markers predicting progression of human immunodeficiency virus-related disease. Clin Microbiol Rev 1994;7:14-28.
5. Fahey JL, Taylor JMG, Detels R, et al. The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1. N Engl J Med 1990;322:166-72.
6. + T cell levels: results of 6 years of follow-up. J Acquir Immune Defic Syndr 1993;6:904-12.
7. de Wolf, Goudsmit J, Paul DA, et al. Risk of AIDS related complex and AIDS in homosexual men with persistent HIV antigenaemia. Br Med J 1987;295:569-72.
8. Allain JP, Laurian Y, Paul DA, et al. Long-term evaluation of HIV antigen and antibodies to p24 and gp41 in patients with hemophilia: potential clinical importance. N Engl J Med 1987;317:1114-21.
9. Nishanian P, Huskins R, Stehn S, Detels R, Fahey JL. A simple method for improved assay demonstrates that HIV p24 antigen is present as immune complexes in most sera from HIV-infected individuals. J Infect Dis 1990;162:21-8.
10. + lymphocytes as prognostic markers of HIV-1 infection. Ann Intern Med 1997;126:946-54.
11. Mellors JW, Rinaldo CR, Gupta P, et al. Prognosis in HIV infection predicted by the quantity of virus in plasma. Science 1996;272:1167-71.
12. + lymphocytes. Proc Natl Acad Sci USA 1994;91:1104-8.
13. Wong MT, Dolan MJ, Kozlow E, et al. Patterns of virus burden and T cell phenotype are established early and are correlated with the rate of disease progression in human immunodeficiency virus type 1-infected persons. J Infect Dis 1996;173:877-87.
14. Jurriaans S, Van Gemen B, Weverling GJ, et al. The natural history of HIV-1 infection: virus load and virus phenotype independent determinants of clinical course? Virology 1994;204:223-33.
15. Katzenstein TL, Pedersen C, Nielsen C, et al. Longitudinal serum HIV RNA quantification: correlation to viral phenotype at seroconversion and clinical outcome. AIDS 1996;10:167-73.
16. + cell depletion and progression to AIDS. Ann Intern Med 1993;118:681-8.
17. Verhofstede C, Reniers S, Wanzeele FV, Plum J. Evaluation of proviral copy number and plasma RNA levels as early indicators of progression of HIV infection: correlation with virological and immunological markers of disease. AIDS 1994;8:1421-7.
18. Furtado MR, Kingsley LA, Wolinsky SM. Changes in the viral mRNA expression pattern correlate with a rapid rate of CD4+ T cell number decline in human immunodeficiency virus type 1-infected individuals. J Virol 1995;69:2092-100.
19. Bagnarelli P, Valenza A, Menzo S, et al. Dynamics and modulation of human immunodeficiency virus type 1 transcripts in vitro and in vivo. J Virol 1996;70:7603-13.