Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication

Nature Immunology

Volumn 8, Issue 6, 2007, Pages 569-577

  Hodges, Ashleigh ^a   Sharrocks, Katherine ^a   Edelmann, Mariola ^b   Baban, Dilair ^c   Moris, Arnaud ^d   Schwartz, Olivier ^d   Drakesmith, Hal ^a   Davies, Kay ^c   Kessler, Benedikt ^b   McMichael, Andrew ^a   Simmons, Alison ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; DENDRITIC CELL SPECIFIC LECTIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INTERFERON; JAGGED1; LECTIN; LEUKEMIA ASSOCIATED RHO GUANINE NUCLEOTIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ANIMAL CELL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; DOWN REGULATION; ENZYME ACTIVITY; GENE ACTIVATION; GENE EXPRESSION PROFILING; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEOMICS; SIGNAL TRANSDUCTION; SYNAPSE; T LYMPHOCYTE; UPREGULATION; VIRUS REPLICATION;

AMINO ACID SEQUENCE; CELL ADHESION MOLECULES; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; ENZYME ACTIVATION; GENE EXPRESSION PROFILING; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HIV-1; HUMANS; LECTINS, C-TYPE; MOLECULAR SEQUENCE DATA; PHENOTYPE; PHOSPHOSERINE; RECEPTORS, CELL SURFACE; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC; VIRUS REPLICATION;

EID: 34249088361     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1470     Document Type: Article

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