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Volumn 61, Issue 5, 2012, Pages 535-544

Plasma factors during chronic HIV-1 infection impair IL-12 secretion by myeloid dendritic cells via a virus-independent pathway

Author keywords

HIV 1; I kappaB kinase; IL 12; Innate immunity; Myeloid dendritic cell; Tolllike receptor

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; TOLL LIKE RECEPTOR; I KAPPA B KINASE;

EID: 84873120085     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0b013e31826afbce     Document Type: Conference Paper
Times cited : (29)

References (58)
  • 1
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM Dendritic cells and the control of immunity. Nature. 1998;392:245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 2
    • 15444368103 scopus 로고    scopus 로고
    • Different subsets of peripheral blood dendritic cells show distinct phenotypic and functional abnormalities in HIV-1 infection
    • Almeida M, Cordero M, Almeida J., et al Different subsets of peripheral blood dendritic cells show distinct phenotypic and functional abnormalities in HIV-1 infection. AIDS. 2005;19:261-271.
    • (2005) AIDS , vol.19 , pp. 261-271
    • Almeida, M.1    Cordero, M.2    Almeida, J.3
  • 3
    • 33646799484 scopus 로고    scopus 로고
    • Persistent abnormalities in peripheral blood dendritic cells and monocytes from HIV-1-positive patients after 1 year of antiretroviral therapy
    • Almeida M, Cordero M, Almeida J., et al Persistent abnormalities in peripheral blood dendritic cells and monocytes from HIV-1-positive patients after 1 year of antiretroviral therapy. J Acquir Immune Defic Syndr. 2006;41:405-415.
    • (2006) J Acquir Immune Defic Syndr. , vol.41 , pp. 405-415
    • Almeida, M.1    Cordero, M.2    Almeida, J.3
  • 4
    • 34249043294 scopus 로고    scopus 로고
    • Abnormal cytokine production by circulating monocytes and dendritic cells of myeloid origin in ART-treated HIV-1+ patients relates to CD4+ T-cell recovery and HCV co-infection
    • Almeida M, Cordero M, Almeida J., et al Abnormal cytokine production by circulating monocytes and dendritic cells of myeloid origin in ART-treated HIV-1+ patients relates to CD4+ T-cell recovery and HCV co-infection. Curr HIV Res. 2007;5:325-336.
    • (2007) Curr HIV Res. , vol.5 , pp. 325-336
    • Almeida, M.1    Cordero, M.2    Almeida, J.3
  • 5
    • 67650446501 scopus 로고    scopus 로고
    • Monocyte-derived dendritic cells from HIV type 1-infected individuals show reduced ability to stimulate T cells and have altered production of interleukin (IL)-12 and IL-10
    • Buisson S, Benlahrech A, Gazzard B., et al Monocyte-derived dendritic cells from HIV type 1-infected individuals show reduced ability to stimulate T cells and have altered production of interleukin (IL)-12 and IL-10. J Infect Dis. 2009;199:1862-1871.
    • (2009) J Infect Dis. , vol.199 , pp. 1862-1871
    • Buisson, S.1    Benlahrech, A.2    Gazzard, B.3
  • 6
    • 84855172914 scopus 로고    scopus 로고
    • Differential regulation of TLR pathways in acute and chronic HIV-1 infection
    • Chang JJ, Lacas A, Lindsay R.J., et al Differential regulation of TLR pathways in acute and chronic HIV-1 infection. AIDS. 2012;26:533-541.
    • (2012) AIDS , vol.26 , pp. 533-541
    • Chang, J.J.1    Lacas, A.2    Lindsay, R.J.3
  • 7
    • 34948822417 scopus 로고    scopus 로고
    • Dendritic cell function during chronic hepatitis C virus and human immunodeficiency virus type 1 infection
    • Fan Z, Huang XL, Kalinski P, et al Dendritic cell function during chronic hepatitis C virus and human immunodeficiency virus type 1 infection. Clin Vaccine Immunol. 2007;14:1127-1137.
    • (2007) Clin Vaccine Immunol. , vol.14 , pp. 1127-1137
    • Fan, Z.1    Huang, X.L.2    Kalinski, P.3
  • 8
    • 2442684197 scopus 로고    scopus 로고
    • HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
    • Granelli-Piperno A., Golebiowska A, Trumpfheller C., et al HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation. Proc Natl Acad Sci USA. 2004; 101:7669-7674.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 7669-7674
    • Granelli-Piperno, A.1    Golebiowska, A.2    Trumpfheller, C.3
  • 9
    • 34249088361 scopus 로고    scopus 로고
    • Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering rho-GTPase activity required for HIV-1 replication
    • Hodges A, Sharrocks K, Edelmann M., et al Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication. Nat Immunol. 2007;8:569-577.
    • (2007) Nat Immunol. , vol.8 , pp. 569-577
    • Hodges, A.1    Sharrocks, K.2    Edelmann, M.3
  • 10
    • 41349107635 scopus 로고    scopus 로고
    • Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection
    • Lester RT, Yao XD, Ball T.B., et al Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection. AIDS. 2008; 22:685-694.
    • (2008) AIDS , vol.22 , pp. 685-694
    • Lester, R.T.1    Yao, X.D.2    Ball, T.B.3
  • 11
    • 20744435124 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 vpr impairs dendritic cell maturation and T-cell activation: Implications for viral immune escape
    • Majumder B, Janket ML, Schafer E.A., et al Human immunodeficiency virus type 1 Vpr impairs dendritic cell maturation and T-cell activation: implications for viral immune escape. J Virol. 2005;79:7990-8003.
    • (2005) J Virol. , vol.79 , pp. 7990-8003
    • Majumder, B.1    Janket, M.L.2    Schafer, E.A.3
  • 12
    • 78149442321 scopus 로고    scopus 로고
    • Evidence of dysregulation of dendritic cells in primary HIV infection
    • Sabado RL, O'Brien M, Subedi A, et al Evidence of dysregulation of dendritic cells in primary HIV infection. Blood. 2010;116:3839-3852.
    • (2010) Blood , vol.116 , pp. 3839-3852
    • Sabado, R.L.1    O'Brien, M.2    Subedi, A.3
  • 13
    • 37349066496 scopus 로고    scopus 로고
    • HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells
    • Shan M, Klasse PJ, Banerjee K, et al HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells. PLoS Pathog. 2007; 3:e169.
    • (2007) PLoS Pathog. , vol.3
    • Shan, M.1    Klasse, P.J.2    Banerjee, K.3
  • 14
    • 7244240713 scopus 로고    scopus 로고
    • HIV-1-infected dendritic cells up-regulate cell surface markers but fail to produce IL-12 p70 in response to CD40 ligand stimulation
    • Smed-Sorensen A., Lore K, Walther-Jallow L, et al HIV-1-infected dendritic cells up-regulate cell surface markers but fail to produce IL-12 p70 in response to CD40 ligand stimulation. Blood. 2004;104:2810-2817.
    • (2004) Blood , vol.104 , pp. 2810-2817
    • Smed-Sorensen, A.1    Lore, K.2    Walther-Jallow, L.3
  • 15
    • 80052379842 scopus 로고    scopus 로고
    • Systemic immune activation in HIV infection is associated with decreased MDC responsiveness to TLR ligand and inability to activate naive CD4 T-cells
    • Yonkers NL, Rodriguez B, Asaad R., et al Systemic immune activation in HIV infection is associated with decreased MDC responsiveness to TLR ligand and inability to activate naive CD4 T-cells. PLoS One. 2011; 6:e23884.
    • (2011) PLoS One , vol.6
    • Yonkers, N.L.1    Rodriguez, B.2    Asaad, R.3
  • 16
    • 0033179535 scopus 로고    scopus 로고
    • Normal immune function of monocyte-derived dendritic cells from HIV-infected individuals: Implications for immunotherapy
    • Chougnet C, Cohen SS, Kawamura T, et al Normal immune function of monocyte-derived dendritic cells from HIV-infected individuals: implications for immunotherapy. J Immunol. 1999;163:1666-1673.
    • (1999) J Immunol. , vol.163 , pp. 1666-1673
    • Chougnet, C.1    Cohen, S.S.2    Kawamura, T.3
  • 17
    • 34248544993 scopus 로고    scopus 로고
    • C-type lectin DC-SIGN modulates toll-like receptor signaling via raf-1 kinase-dependent acet-ylation of transcription factor NF-kappaB
    • Gringhuis SI, den Dunnen J, Litjens M, et al C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acet-ylation of transcription factor NF-kappaB. Immunity. 2007;26:605-616.
    • (2007) Immunity , vol.26 , pp. 605-616
    • Gringhuis, S.I.1    Den Dunnen, J.2    Litjens, M.3
  • 18
    • 0027340164 scopus 로고
    • A TH1->TH2 switch is a critical step in the etiology of HIV infection
    • Clerici M, Shearer GM A TH1->TH2 switch is a critical step in the etiology of HIV infection. Immunol Today. 1993;14:107-111.
    • (1993) Immunol Today , vol.14 , pp. 107-111
    • Clerici, M.1    Shearer, G.M.2
  • 19
    • 0027967164 scopus 로고
    • Ability of HIV to promote a TH1 to TH0 shift and to replicate preferentially in TH2 and TH0 cells
    • Maggi E, Mazzetti M, Ravina A., et al Ability of HIV to promote a TH1 to TH0 shift and to replicate preferentially in TH2 and TH0 cells. Science. 1994;265:244-248.
    • (1994) Science , vol.265 , pp. 244-248
    • Maggi, E.1    Mazzetti, M.2    Ravina, A.3
  • 20
    • 0030042402 scopus 로고    scopus 로고
    • Evidence for type 2 cytokine production and lymphocyte activation in the early phases of HIV-1 infection
    • Meroni L, Trabattoni D, Balotta C., et al Evidence for type 2 cytokine production and lymphocyte activation in the early phases of HIV-1 infection. AIDS. 1996;10:23-30.
    • (1996) AIDS , vol.10 , pp. 23-30
    • Meroni, L.1    Trabattoni, D.2    Balotta, C.3
  • 21
    • 0033490502 scopus 로고    scopus 로고
    • Interleukin-12: A cytokine at the interface of inflammation and immunity
    • Trinchieri G Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv Immunol. 1998;70:83-243.
    • (1998) Adv Immunol. , vol.70 , pp. 83-243
    • Trinchieri, G.1
  • 22
    • 0027240219 scopus 로고
    • Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
    • D'Andrea A., Aste-Amezaga M, Valiante N.M., et al Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med. 1993;178:1041-1048.
    • (1993) J Exp Med. , vol.178 , pp. 1041-1048
    • D'Andrea, A.1    Aste-Amezaga, M.2    Valiante, N.M.3
  • 23
    • 0025875022 scopus 로고
    • Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
    • Wolf SF, Temple PA, Kobayashi M, et al Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol. 1991;146: 3074-3081.
    • (1991) J Immunol. , vol.146 , pp. 3074-3081
    • Wolf, S.F.1    Temple, P.A.2    Kobayashi, M.3
  • 24
    • 40949099876 scopus 로고    scopus 로고
    • Dendritic cells from HIV-1 infected individuals are less responsive to toll-like receptor (TLR) ligands
    • Martinson JA, Roman-Gonzalez A, Tenorio A.R., et al Dendritic cells from HIV-1 infected individuals are less responsive to toll-like receptor (TLR) ligands. Cell Immunol. 2007;250:75-84.
    • (2007) Cell Immunol. , vol.250 , pp. 75-84
    • Martinson, J.A.1    Roman-Gonzalez, A.2    Tenorio, A.R.3
  • 25
    • 0028262475 scopus 로고
    • Impaired interleukin 12 production in human immunodeficiency virus-infected patients
    • Chehimi J, Starr SE, Frank I, et al Impaired interleukin 12 production in human immunodeficiency virus-infected patients. J Exp Med. 1994;179: 1361-1366.
    • (1994) J Exp Med. , vol.179 , pp. 1361-1366
    • Chehimi, J.1    Starr, S.E.2    Frank, I.3
  • 26
    • 0030055867 scopus 로고    scopus 로고
    • Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus
    • Chougnet C, Wynn TA, Clerici M, et al Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus. J Infect Dis. 1996;174:46-53.
    • (1996) J Infect Dis. , vol.174 , pp. 46-53
    • Chougnet, C.1    Wynn, T.A.2    Clerici, M.3
  • 27
    • 0030010968 scopus 로고    scopus 로고
    • Role of IL-12 in peripheral blood mononuclear cell responses to fungi in persons with and without HIV infection
    • Harrison TS, Levitz SM Role of IL-12 in peripheral blood mononuclear cell responses to fungi in persons with and without HIV infection. J Immunol. 1996;156:4492-4497.
    • (1996) J Immunol. , vol.156 , pp. 4492-4497
    • Harrison, T.S.1    Levitz, S.M.2
  • 28
    • 0030641331 scopus 로고    scopus 로고
    • Priming with IFN-gamma restores deficient IL-12 production by peripheral blood mononuclear cells from HIV-seropositive donors
    • Harrison TS, Levitz SM Priming with IFN-gamma restores deficient IL-12 production by peripheral blood mononuclear cells from HIV-seropositive donors. J Immunol. 1997;158:459-463.
    • (1997) J Immunol. , vol.158 , pp. 459-463
    • Harrison, T.S.1    Levitz, S.M.2
  • 29
    • 0033179165 scopus 로고    scopus 로고
    • The interleukin-12-mediated pathway of immune events is dysfunctional in human immunodeficiency virus-infected individuals
    • Marshall JD, Chehimi J, Gri G., et al The interleukin-12-mediated pathway of immune events is dysfunctional in human immunodeficiency virus-infected individuals. Blood. 1999;94:1003-1011.
    • (1999) Blood , vol.94 , pp. 1003-1011
    • Marshall, J.D.1    Chehimi, J.2    Gri, G.3
  • 30
    • 0031029278 scopus 로고    scopus 로고
    • Interleukin-12 (IL-12) production in whole blood cultures from human immunodeficiency virus-infected individuals studied in relation to IL-10 and prostaglandin E2 production
    • Meyaard L, Hovenkamp E, Pakker N., et al Interleukin-12 (IL-12) production in whole blood cultures from human immunodeficiency virus-infected individuals studied in relation to IL-10 and prostaglandin E2 production. Blood. 1997;89:570-576.
    • (1997) Blood , vol.89 , pp. 570-576
    • Meyaard, L.1    Hovenkamp, E.2    Pakker, N.3
  • 31
    • 0028978632 scopus 로고
    • Priming for high interferon-gamma production induced by interleukin-12 in both CD4+ and CD8+ T cell clones from HIV-infected patients
    • Paganin C, Frank I, Trinchieri G. Priming for high interferon-gamma production induced by interleukin-12 in both CD4+ and CD8+ T cell clones from HIV-infected patients. J Clin Invest. 1995;96:1677-1682.
    • (1995) J Clin Invest. , vol.96 , pp. 1677-1682
    • Paganin, C.1    Frank, I.2    Trinchieri, G.3
  • 32
    • 0034653914 scopus 로고    scopus 로고
    • HIV-associated dysfunction of in vitro IL-12 production depends on the nature of the stimulus and on the CD4 T-cell count of the patient
    • Vanham G, Penne L, Fransen K., et al HIV-associated dysfunction of in vitro IL-12 production depends on the nature of the stimulus and on the CD4 T-cell count of the patient. Blood. 2000;95:2185-2187.
    • (2000) Blood , vol.95 , pp. 2185-2187
    • Vanham, G.1    Penne, L.2    Fransen, K.3
  • 33
    • 0036885129 scopus 로고    scopus 로고
    • HIV-1 protein vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: Potential implications of vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection
    • Mirani M, Elenkov I, Volpi S., et al HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection. J Immunol. 2002; 169:6361-6368.
    • (2002) J Immunol. , vol.169 , pp. 6361-6368
    • Mirani, M.1    Elenkov, I.2    Volpi, S.3
  • 34
    • 0030894793 scopus 로고    scopus 로고
    • Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: An indirect interleukin-10-mediated effect
    • Taoufik Y, Lantz O, Wallon C., et al Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect. Blood. 1997;89:2842-2848.
    • (1997) Blood , vol.89 , pp. 2842-2848
    • Taoufik, Y.1    Lantz, O.2    Wallon, C.3
  • 35
    • 40649097299 scopus 로고    scopus 로고
    • The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine
    • Trumpfheller C, Caskey M, Nchinda G., et al The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine. Proc Natl Acad Sci U S A. 2008;105: 2574-2579.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 2574-2579
    • Trumpfheller, C.1    Caskey, M.2    Nchinda, G.3
  • 36
    • 77958464026 scopus 로고    scopus 로고
    • A tonsillar PolyICLC/AT-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessation
    • Vagenas P, Aravantinou M, Williams V.G., et al A tonsillar PolyICLC/AT-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessation. PLoS One. 2010;5:e12891.
    • (2010) PLoS One , vol.5
    • Vagenas, P.1    Aravantinou, M.2    Williams, V.G.3
  • 37
    • 80051706186 scopus 로고    scopus 로고
    • TLR4 engagement during TLR3-induced proinflammatory signaling in dendritic cells promotes IL-10-mediated suppression of antitumor immunity
    • Bogunovic D, Manches O, Godefroy E., et al TLR4 engagement during TLR3-induced proinflammatory signaling in dendritic cells promotes IL-10-mediated suppression of antitumor immunity. Cancer Res. 2011; 71:5467-5476.
    • (2011) Cancer Res. , vol.71 , pp. 5467-5476
    • Bogunovic, D.1    Manches, O.2    Godefroy, E.3
  • 38
    • 2442509079 scopus 로고    scopus 로고
    • Poly (I: C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12
    • Rouas R, Lewalle P, El Ouriaghli F, et al Poly (I: C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12. Int Immunol. 2004;16:767-773.
    • (2004) Int Immunol. , vol.16 , pp. 767-773
    • Rouas, R.1    Lewalle, P.2    El Ouriaghli, F.3
  • 39
    • 34248162935 scopus 로고    scopus 로고
    • Generation of clinical grade dendritic cells with capacity to produce biologically active IL-12p70
    • Zobywalski A, Javorovic M, Frankenberger B., et al Generation of clinical grade dendritic cells with capacity to produce biologically active IL-12p70. J Transl Med. 2007;5:18.
    • (2007) J Transl Med. , vol.5 , pp. 18
    • Zobywalski, A.1    Javorovic, M.2    Frankenberger, B.3
  • 40
    • 0027410369 scopus 로고
    • High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR
    • Piatak M Jr, Saag M.S., Yang LC, et al High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science. 1993;259:1749-1754.
    • (1993) Science , vol.259 , pp. 1749-1754
    • Piatak Jr., M.1    Saag, M.S.2    Yang, L.C.3
  • 41
    • 84863337769 scopus 로고    scopus 로고
    • Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation
    • Shan L, Deng K, Shroff N.S., et al Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation. Immunity. 2012;36:491-501.
    • (2012) Immunity , vol.36 , pp. 491-501
    • Shan, L.1    Deng, K.2    Shroff, N.S.3
  • 42
    • 0027743305 scopus 로고
    • Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro
    • Clerici M, Lucey DR, Berzofsky J.A., et al Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science. 1993;262:1721-1724.
    • (1993) Science , vol.262 , pp. 1721-1724
    • Clerici, M.1    Lucey, D.R.2    Berzofsky, J.A.3
  • 43
    • 0034254205 scopus 로고    scopus 로고
    • CD40 ligand trimer and IL-12 enhance peripheral blood mononuclear cells and CD4+ T cell proliferation and production of IFN-gamma in response to p24 antigen in HIV-infected individuals: Potential contribution of anergy to HIV-specific unresponsiveness
    • Dybul M, Mercier G, Belson M., et al CD40 ligand trimer and IL-12 enhance peripheral blood mononuclear cells and CD4+ T cell proliferation and production of IFN-gamma in response to p24 antigen in HIV-infected individuals: potential contribution of anergy to HIV-specific unresponsiveness. J Immunol. 2000;165:1685-1691.
    • (2000) J Immunol. , vol.165 , pp. 1685-1691
    • Dybul, M.1    Mercier, G.2    Belson, M.3
  • 44
    • 0029899102 scopus 로고    scopus 로고
    • In vitro restoration of T cell immune function in human immunodeficiency virus-positive persons: Effects of interleukin (IL)-12 and anti-IL-10
    • Landay AL, Clerici M, Hashemi F., et al In vitro restoration of T cell immune function in human immunodeficiency virus-positive persons: effects of interleukin (IL)-12 and anti-IL-10. J Infect Dis. 1996;173: 1085-1091.
    • (1996) J Infect Dis. , vol.173 , pp. 1085-1091
    • Landay, A.L.1    Clerici, M.2    Hashemi, F.3
  • 45
    • 0028839280 scopus 로고
    • T helper type 1/T helper type 2 cytokines and T cell death: Preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons
    • Estaquier J, Idziorek T, Zou W., et al T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons. J Exp Med. 1995;182: 1759-1767.
    • (1995) J Exp Med. , vol.182 , pp. 1759-1767
    • Estaquier, J.1    Idziorek, T.2    Zou, W.3
  • 46
    • 0034690620 scopus 로고    scopus 로고
    • In vitro and in vivo responses to interleukin 12 are maintained until the late SIV infection stage but lost during AIDS
    • Villinger F, Bucur S, Chikkala N.F., et al In vitro and in vivo responses to interleukin 12 are maintained until the late SIV infection stage but lost during AIDS. AIDS Res Hum Retroviruses. 2000;16:751-763.
    • (2000) AIDS Res Hum Retroviruses , vol.16 , pp. 751-763
    • Villinger, F.1    Bucur, S.2    Chikkala, N.F.3
  • 47
    • 0032549621 scopus 로고    scopus 로고
    • Administration of recombinant human interleukin 12 to chronically SIVmac-infected rhesus monkeys
    • Watanabe N, Sypek JP, Mittler S, et al Administration of recombinant human interleukin 12 to chronically SIVmac-infected rhesus monkeys. AIDS Res Hum Retroviruses. 1998;14:393-399.
    • (1998) AIDS Res Hum Retroviruses , vol.14 , pp. 393-399
    • Watanabe, N.1    Sypek, J.P.2    Mittler, S.3
  • 48
    • 0036148075 scopus 로고    scopus 로고
    • Administration of recombinant rhesus interleukin-12 during acute simian immunodeficiency virus (SIV) infection leads to decreased viral loads associated with prolonged survival in SIVmac251-infected rhesus macaques
    • Ansari AA, Mayne AE, Sundstrom J.B., et al Administration of recombinant rhesus interleukin-12 during acute simian immunodeficiency virus (SIV) infection leads to decreased viral loads associated with prolonged survival in SIVmac251-infected rhesus macaques. J Virol. 2002;76: 1731-1743.
    • (2002) J Virol. , vol.76 , pp. 1731-1743
    • Ansari, A.A.1    Mayne, A.E.2    Sundstrom, J.B.3
  • 49
    • 0032526338 scopus 로고    scopus 로고
    • Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10
    • Aste-Amezaga M., Ma X, Sartori A., et al Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10. J Immunol. 1998;160: 5936-5944.
    • (1998) J Immunol. , vol.160 , pp. 5936-5944
    • Aste-Amezaga, M.1    Ma, X.2    Sartori, A.3
  • 50
    • 0024408824 scopus 로고
    • Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by th1 clones
    • Fiorentino DF, Bond MW, Mosmann TR Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med. 1989;170:2081-2095.
    • (1989) J Exp Med. , vol.170 , pp. 2081-2095
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 51
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley JM, Price DA, Schacker T.W., et al Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006;12:1365-1371.
    • (2006) Nat Med. , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1    Price, D.A.2    Schacker, T.W.3
  • 52
    • 39349088126 scopus 로고    scopus 로고
    • Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy
    • Hunt PW, Brenchley J, Sinclair E., et al Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J Infect Dis. 2008;197:126-133.
    • (2008) J Infect Dis. , vol.197 , pp. 126-133
    • Hunt, P.W.1    Brenchley, J.2    Sinclair, E.3
  • 53
    • 65649102237 scopus 로고    scopus 로고
    • Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection
    • Jiang W, Lederman MM, Hunt P, et al Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection. J Infect Dis. 2009;199:1177-1185.
    • (2009) J Infect Dis. , vol.199 , pp. 1177-1185
    • Jiang, W.1    Lederman, M.M.2    Hunt, P.3
  • 54
    • 58149177783 scopus 로고    scopus 로고
    • Cutting edge: Experimentally induced immune activation in natural hosts of simian immunodeficiency virus induces significant increases in viral replication and CD4+ T cell depletion
    • Pandrea I, Gaufin T, Brenchley J.M., et al Cutting edge: experimentally induced immune activation in natural hosts of simian immunodeficiency virus induces significant increases in viral replication and CD4+ T cell depletion. J Immunol. 2008;181:6687-6691.
    • (2008) J Immunol. , vol.181 , pp. 6687-6691
    • Pandrea, I.1    Gaufin, T.2    Brenchley, J.M.3
  • 55
    • 0021165018 scopus 로고
    • Circulating immune complexes in AIDS
    • Gupta S, Licorish K. Circulating immune complexes in AIDS. N Engl J Med. 1984;310:1530-1531.
    • (1984) N Engl J Med. , vol.310 , pp. 1530-1531
    • Gupta, S.1    Licorish, K.2
  • 56
    • 77954060985 scopus 로고    scopus 로고
    • Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection
    • Kramer HB, Lavender KJ, Qin L, et al Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection. PLoS Pathog. 2010;6:e1000893.
    • (2010) PLoS Pathog. , vol.6
    • Kramer, H.B.1    Lavender, K.J.2    Qin, L.3
  • 57
    • 0030613551 scopus 로고    scopus 로고
    • The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
    • Zandi E, Rothwarf DM, Delhase M, et al The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell. 1997;91: 243-252.
    • (1997) Cell. , vol.91 , pp. 243-252
    • Zandi, E.1    Rothwarf, D.M.2    Delhase, M.3
  • 58
    • 2342522110 scopus 로고    scopus 로고
    • Shaping the nuclear action of NF-kappaB
    • Chen LF, Greene WC Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol. 2004;5:392-401.
    • (2004) Nat Rev Mol Cell Biol. , vol.5 , pp. 392-401
    • Chen, L.F.1    Greene, W.C.2


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