Discovery of a new class of natural product-inspired quinazolinone hybrid as potent antileishmanial agents

Journal of Medicinal Chemistry

Volumn 56, Issue 11, 2013, Pages 4374-4392

  Sharma, Moni ^a,b   Chauhan, Kuldeep ^a   Shivahare, Rahul ^a   Vishwakarma, Preeti ^a   Suthar, Manish K ^a   Sharma, Abhisheak ^a   Gupta, Suman ^a   Saxena, Jitendra K ^a   Lal, Jawahar ^a   Chandra, Preeti ^a   Kumar, Brijesh ^a   Chauhan, Prem M S ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b Bhagwant University   (India)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 [4,6 DI(PIPERIDIN 1 YL) 1,3,5 TRIAZIN 2 YLAMINO]PHENYL] 2 METHYL 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; ANTILEISHMANIAL AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; MILTEFOSINE; NITRIC OXIDE; QUINAZOLINONE DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

AMASTIGOTE; ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG SYNTHESIS; IC 50; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; LEISHMANIA DONOVANI; MACROPHAGE; MALE; MAXIMUM PLASMA CONCENTRATION; MOLECULAR HYBRIDIZATION; NONHUMAN; PARASITE SURVIVAL; PROTEIN EXPRESSION; RAT; TH1 CELL; TH2 CELL; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; ANTIPARASITIC AGENTS; BIOLOGICAL AGENTS; CATTLE; CELL LINE; CERCOPITHECUS AETHIOPS; CRICETINAE; CYTOKINES; FEMALE; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; MACROPHAGES; MALE; MESOCRICETUS; MICE; NITRIC OXIDE; PARASITIC SENSITIVITY TESTS; QUINAZOLINONES; RATS; RATS, SPRAGUE-DAWLEY; SERUM ALBUMIN, BOVINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84879054143     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400053v     Document Type: Article

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