Synthesis and biological evaluation of new [1,2,4]triazino[5,6-b]indol-3-ylthio-1,3,5-triazines and [1,2,4]triazino[5,6-b]indol-3-ylthio-pyrimidines against Leishmania donovani

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2359-2365

  Gupta, Leena ^a   Sunduru, Naresh ^a   Verma, Aditya ^a   Srivastava, Saumya ^a   Gupta, Suman ^a   Goyal, Neena ^a   Chauhan, Prem M S ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

1,3,5 Triazine; Leishmaniasis; Pyrimidine; Triazino 5,6 b indole

Indexed keywords

3 [2 (4 ETHYLPIPERAZIN 1 YL) 6 METHYLPYRIMIDIN 4 YLTHIO] 5 METHYL 5H [1,2,4]TRIAZINO[5,6 B]INDOLE; 3 [4,6 BIS(4 ETHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLTHIO] 5 METHYL 5H [1,2,4]TRIAZINO[5,6 B]INDOLE; 3 [4,6 DI(PIPERIDIN 1 YL) 1,3,5 TRIAZIN 2 YLTHIO] 5 METHYL 5H [1,2,4]TRIAZINO[5,6 B]INDOLE; 4 METHYL 6 (5 METHYL 5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YLTHIO) N (3 MORPHOLINOPROPYL)PYRIMIDIN 2 AMINE; 5 METHYL 3 (6 METHYL 2 (PIPERIDIN 1 YL)PYRIMIDIN 4 YLTHIO) 5H [1,2,4]TRIAZINO[5,6 B]INDOLE; ANTILEISHMANIAL AGENT; INDOLE DERIVATIVE; N BUTYL 4 METHYL 6 (5 METHYL 5H [1,2,4]TRIAZINO[5,6 B] INDOL 3 YLTHIO)PYRIMIDIN 2 AMINE; N ISOPROPYL 4 METHYL 6 (5 METHYL 5H[1,2,4]TRIAZINO[5,6 B] INDOL 3 YLTHIO)PYRIMIDIN 2 AMINE; N1, N1 DIMETHYL N2 (4 METHYL 6 (5 METHYL 5H [1,2,4] TRIAZINO[5,6 B]INDOL 3 YLTHIO)PYRIMIDIN 2 YL)ETHANE 1,2 DIAMINE; N2, N4 DIBUTYL 6 (5 METHYL 5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YLTHIO) 1,3,5 TRIAZINE 2,4 DIAMINE; N2, N4 DIISOPROPYL 6 (5 METHYL 5H [1,2,4]TRIAZINO[5,6 B] INDOL 3 YLTHIO) 1,3,5 TRIAZINE 2,4 DIAMINE; PENTAMIDINE; STIBOGLUCONATE SODIUM; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

AMASTIGOTE; ARTICLE; CELL LINE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; INFRARED SPECTROSCOPY; LEISHMANIA DONOVANI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROMASTIGOTE;

ANIMALS; ANTIPROTOZOAL AGENTS; CELL LINE; CELL SURVIVAL; DRUG EVALUATION, PRECLINICAL; INHIBITORY CONCENTRATION 50; LEISHMANIA DONOVANI; LIFE CYCLE STAGES; MICE; PYRIMIDINES; TRIAZINES;

EID: 77950860253     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.015     Document Type: Article

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