Small molecule natural products in the discovery of therapeutic agents: The synthesis connection

Journal of Organic Chemistry

Volumn 71, Issue 22, 2006, Pages 8329-8351

  Wilson, Rebecca M ^a   Danishefsky, Samuel J ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Howard Hughes Medical Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DERIVATIVES; DRUG PRODUCTS; INTERNATIONAL TRADE; PRODUCT DEVELOPMENT; SYNTHESIS (CHEMICAL);

NATURAL PRODUCTS; PHARMACEUTICAL IMPORTS; THERAPEUTIC AGENTS;

DRUG THERAPY;

ACONITINE; AJMALINE; ATORVASTATIN; BIOTIN; CANTHARIDIN; COCAINE; COMPACTIN; DISODIUM HYDROGEN PHOSPHATE; DOCETAXEL; E 7389; ENDIANDRIC ACID A; EPOTHILONE B; EPOTHILONE D; EQUILENIN; ESTRONE; GIBBERELLIC ACID; GINKGOLIDE B; HALICHONDRIN B; INDOLIZOMYCIN; IXABEPILONE; KOS 1584; KOS 1591; LONGIFOLENE; LYCOPODINE; MEVINOLIN; MORPHINE; NATURAL PRODUCT; PACLITAXEL; PENICILLIN V; PHOMOIDRIDE B; PRAVASTATIN; PROGESTERONE; PROSTAGLANDIN F2 ALPHA; QUININE; RAPAMYCIN; RESERPINE; SIMVASTATIN; STREPTOMYCIN; STRYCHNINE; TRABECTEDIN; TSUKUBAENOLIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

CHEMICAL MODIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ESTERIFICATION; REVIEW; RING CLOSING METATHESIS;

BIOLOGICAL FACTORS; DRUG DESIGN; HUMANS; MOLECULAR STRUCTURE; ORGANIC CHEMICALS;

EID: 33750464876     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0610053     Document Type: Review

References (312)

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130. Synthesis: (d) Nicolaou, K. C.; Chakraborty, T. K.; Piscopio, A. D.; Minowa, N.; Bertinato, P. J. Am. Chem. Soc. 1993, 115, 4419.
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