Triazine-based vanilloid 1 receptor open channel blockers: Design, synthesis, evaluation, and SAR analysis

Journal of Medicinal Chemistry

Volumn 54, Issue 21, 2011, Pages 7441-7452

  Vidal Mosquera, Miquel ^a   Fernández Carvajal, Asia ^b   Moure, Alejandra ^a   Valente, Pierluigi ^b   Planells Cases, Rosa ^c   González Ros, José M ^b   Bujons, Jordi ^a   Ferrer Montiel, Antonio ^b   Messeguer, Angel ^a  

^a INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

^b MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^c CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 BIS(4' CHLOROPHENETHYLAMINO) 6 [3' (N,N DIMETHYLAMINO)PROPYLAMINO] 1,3,5 TRIAZINE; 2,4 BIS(4' FLUOROPHENETHYLAMINO) 6 [3' (N,N DIMETHYLAMINO)PROPYLAMINO] 1,3,5 TRIAZINE; 2,4 BIS(PHENETHYLAMINO) 6 [3' (N,N DIMETHYLAMINO)PROPYLAMINO] 1,3,5 TRIAZINE; ANALGESIC AGENT; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST;

ARTICLE; DRUG BINDING SITE; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ELECTRIC POTENTIAL; NONHUMAN; PAIN; PHARMACOPHORE; RECEPTOR UPREGULATION; STRUCTURE ACTIVITY RELATION; TISSUE INJURY;

ANALGESICS; ANIMALS; BINDING SITES; DRUG DESIGN; FEMALE; OOCYTES; PATCH-CLAMP TECHNIQUES; RATS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES; TRPV CATION CHANNELS; XENOPUS;

EID: 80455140518     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200981s     Document Type: Article

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