Design and synthesis of novel 7-aminoquinazoline derivatives: Antitumor and anticonvulsant activities

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 5, 2012, Pages 1879-1885

  El Azab, Adel S ^a,b   Eltahir, Kamal E H ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b Cairo University   (Egypt)

Author keywords

Anticonvulsant; Antitumor; Chimney test; NCI; Neurotoxicity; Quinazolinone; Synthesis

Indexed keywords

4 AMINOBUTYRIC ACID; METHAQUALONE; PENTETRAZOLE; PICROTOXIN; QUINAZOLINE DERIVATIVE; STRYCHNINE; VALPROIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; ATAXIA; CANCER INHIBITION; COGNITIVE DEFECT; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; ELECTRIC SHOCK; ELECTRON TRANSPORT; HUMAN; HUMAN CELL; LD 50; MOTOR DYSFUNCTION; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; SEDATION; SEIZURE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

AMINES; ANIMALS; ANTICONVULSANTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; NEOPLASMS; QUINAZOLINES; SEIZURES;

EID: 84857356050     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.071     Document Type: Article

References (37)

1. S. Eckhardt Curr. Med. Chem. Anti-Cancer Agents 2 2002 419
2. C.W. Lee, D.H. Hong, S.B. Han, S.H. Jong, H.C. Kim, R.L. Fine, S.H. Lee, and H.M. Kim Biochem. Pharmacol. 64 2002 473
3. E. Honkanen, A. Pippuri, P. Kairisalo, P. Nore, H. Karppanen, and I. Paakkari J. Med. Chem. 26 1983 1433
4. Y. Zhou, D.E. Murphy, Z. Sun, and V.E. Gregor Tetrahedron Lett. 45 2004 8049
5. M.A. Aziza, M.W. Nassar, S.G. Abdel-Hamide, A.E. El-Hakim, and A.S. El-Azab Indian J. Heterocycl. Chem. 6 1996 25
6. A.S. El-Azab Phosphorus, Sulfur Silicon Relat. Elem. 183 2007 333
7. F.M. Refaie, A.Y. Esmat, S.M.A. Gawad, A.M. Ibrahim, and M.A. Mohamed Lipids Health Dis. 4 2005 22
8. N.S. Habib, K.A. Ismail, A.A. El-Tombary, and T. Abdel-Aziem Pharmazie 55 2000 495
9. M.A. Al-Omar, A.S. El-Azab, H.A. El-Obeid, and S.G. Abdel Hamide J. Saudi Chem. Soc. 10 2006 113
10. A.M. Alafeefy, A.A. Kadi, A.S. El-Azab, S.G. Abdel-Hamide, and M.H. Daba Arch. Pharm. (Weinheim) 341 2008 377
11. A. Kumar, S. Sharma, A. Archana, K. Bajaj, S. Sharma, H. Panwar, T. Singh, and V.K. Srivastava Bioorg. Med. Chem. 11 2003 5293
12. V. Alagarsamy, V.R. Solomon, and K. Dhanabal Bioorg. Med. Chem. 15 2007 235
13. A.S. El-Azab, E.H. Kamal, and S.M. Attia Monatsh. Chem. 142 2011 837
14. S.K. Kashaw, V. Kashaw, P. Mishra, N.K. Jain, and J.P. Stables Eur. J. Med. Chem. 44 2009 4335
15. V. Archana, K. Srivastava, and A. Kumar Bioorg. Med. Chem. 12 2004 1257
16. A.S. El-Azab, and E.H. ElTahir Bioorg. Med. Chem. Lett 22 2012 327
17. F.A. Al-Omary, L.A. Abou-Zeid, M.N. Nagi, El-S.E. Habib, A.A. Abdel-Aziz, A.S. El-Azab, S.G. Abdel-Hamide, M.A. Al-Omar, A.M. Al-Obaid, and H.I. El-Subbagh Bioorg. Med. Chem. 18 2010 2849
18. A.M. Al-Obaid, S.G. Abdel-Hamide, H.A. El-Kashef, A.A. Abdel-Aziz, A.S. El-Azab, H.A. Al-Khamees, and H.I. El-Subbagh Eur. J. Med. Chem. 4 2009 2379
19. A.S. El-Azab, M.A. Al-Omar, A.A. Abdel-Aziz, N.I. Abdel-Aziz, M.A. El-Sayed, A.M. Aleisa, M.M. Sayed-Ahmed, and S.G. Abdel-Hamid Eur. J. Med. Chem. 45 2010 4188
20. V. Bavetsias, J.H. Marriott, C. Melin, R. Kimbell, Z.S. Matusiak, F.T. Boyle, and A.L. Jackman J. Med. Chem. 43 2000 1910
21. J.B. Smaill, G.W. Rewcastle, J.A. Loo, K.D. Greis, O.H. Chan, E.L. Reyner, E. Lipka, H.D. Showalter, P.W. Vincent, W.L. Elliott, and W.A. Denny J. Med. Chem. 43 2000 1380
22. A. Wissner, D.M. Berger, D.H. Boschelli, M.B. Floyd Jr., L.M. Greenberger, B.C. Gruber, B.D. Johnson, N. Mamuya, R. Nilakantan, M.F. Reich, R. Shen, H.R. Tsou, E. Upeslacis, Y.F. Wang, B. Wu, F. Ye, and N. Zhang J. Med. Chem. 43 2000 3244
23. S.T. Al-Rashood, I.A. Aboldahab, M.N. Nagi, L.A. Abouzeid, A.A.M. Abdel-Aziz, S.G. Abdel-Hamide, K.M. Youssef, A.M. Al-Obaid, and H.I. El-Subbagh Bioorg. Med. Chem. 14 2006 8608
24. H. Stefan, and T. Feuerstein Pharmacol. Ther. 113 2007 165
25. E.J. Donner, and O.C. Snead NeuroRX 3 2006 170
26. R.S. Greenwood Epilepsia 41 2000 S42
27. M. Namara, G.J. Hardman, L.E. Limbird, and A.G. Gilman Drugs Effective in the Therapy of the Epilepsies 2001 McGraw-Hill New York pp 521-548
28. W. Löscher, and D. Schmidt Epilepsy Res. 50 2002 3
29. M. Bialer, S.I. Johannessen, H.J. Kupferberg, R.H. Levy, E. Perucca, and T. Tomson Epilepsy Res. 61 2004 1
30. S.K. Kashaw, V. Kashaw, P. Mishra, N.K. Jain, and J.P. Stables Eur. J. Med. Chem. 44 2009 4335
31. R.L. Krall, J.K. Penry, B.G. White, H.J. Kupferberg, and E.A. Swinyard Epilepsia 19 1978 409
32. R.J. Potr, J.J. Cereghino, G.D. Gladding, B.J. Hessie, H.J. Kupferberg, and B. Scoville Cleve. Clin. Q 51 1984 293
33. W. Löscher, and B. Nolting Epilepsy Res. 9 1991 1
34. J.F. Wolfe, T.L. Rathman, M.C. Sleevi, J.A. Campbell, and T.D. Greenwood J. Med. Chem. 33 1990 161
35. R.W. Olsen J. Neurochem. 27 1981 1
36. L. Lacoste, S. Bartolucci, and J. Lapointey J. Physiol. Pharmacol. 66 1988 1135
37. R. Okada, and H. Negishi Brain Res. 480 1989 383