Characterization of pentamidine excretion in the isolated perfused rat kidney

Journal of Antimicrobial Chemotherapy

Volumn 52, Issue 3, 2003, Pages 397-404

  Poola, Nagaraju R ^a,c   Kalis, Michelle ^b   Plakogiannis, Fotios M ^a   Taft, David R ^a  

^a LONG ISLAND UNIVERSITY   (United States)

^b MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^c BAYER PHARMA AG   (Germany)

Author keywords

Kidney accumulation; Nephrotoxicity; Pentamidine; Renal excretion; Renal transport

Indexed keywords

DIDANOSINE; INULIN; PENTAMIDINE; SODIUM; TETRYLAMMONIUM;

ANIMAL TISSUE; ARTICLE; COLORIMETRY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACCUMULATION; DRUG DISPOSITION; DRUG EXCRETION; DRUG TRANSPORT; DRUG URINE LEVEL; GLOMERULUS FILTRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY CLEARANCE; KIDNEY FUNCTION TEST; KIDNEY PERFUSION; MALE; NEPHROTOXICITY; NONHUMAN; RAT; SODIUM ABSORPTION; STATISTICAL SIGNIFICANCE; URINARY EXCRETION;

ALGORITHMS; ANIMALS; ANTIPROTOZOAL AGENTS; BIOLOGICAL TRANSPORT, ACTIVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIDANOSINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLOMERULAR FILTRATION RATE; KIDNEY; KIDNEY FUNCTION TESTS; MALE; PENTAMIDINE; PERFUSION; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; TETRAETHYLAMMONIUM COMPOUNDS;

EID: 0141518142     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkg341     Document Type: Article

References (42)

1. Blagburn, B. L., Sundermann, C. A., Lindsay, D. S. et al. (1991). Inhibition of Cryptosporidium parvum in neonatal Hsd (ICR) BR Swiss mice by polyether ionophores and aromatic amidines. Antimicrobial Agents and Chemotherapy 35, 1520-3.
2. Bell, C. A., Cory, M., Fairley, T. A. et al. (1991). Structure-activity relationships of pentamidine analogs against Giardia lamblia and correlation of antigiardial activity with DNA binding affinity. Antimicrobial Agents and Chemotherapy 35, 1099-107.
3. Lindsay, D. S., Blagburn, B. L., Hall, J. E. et al. (1991). Activity of pentamidine and pentamidine analogs against Toxoplasma gondii in cell cultures. Antimicrobial Agents and Chemotherapy 35, 1914-6.
4. Bryceson, A. D., Chulay, J. D., Mugambi, M. et al. (1985). Visceral leishmaniasis unresponsive to antimonial drugs: II. Response to high dosage sodium stibogluconate or prolonged treatment with pentamidine. Transactions of the Royal Society of Tropical Medicine and Hygiene 79, 705-14.
5. Apted, F. L. (1980). Present status of chemotherapy and chemophylaxis of human trypanosomiasis in the Eastern Hemisphere. Pharmacology and Therapeutics 11, 391-413.
6. Ivady, G. & Paldy, L. (1958). A new form of treatment of interstitial plasma cell pneumonia in premature infants with pentavalent antimony and aromatic diamines. Monatsschrift Fur Kinderheilkunde 106, 10-4.
7. Walzer, P. D., Perl, D. P., Krogstad, D. J. et al. (1974). Pneumocystis carinii pneumonia in the United States: epidemiologic, diagnostic, and clinical features. Annals of Internal Medicine 80, 83-93.
8. Sands, M., Kron, M. A. & Brown, R. B. (1985). Pentamidine: a review. Review of Infectious Diseases 7, 625-34.
9. Briceland, L. L. & Bailie, G. R. (1991). Pentamidine-associated nephrotoxicity and hyperkalemia in patients with AIDS. DICP, The Annals of Pharmacotherapy 25, 1171-4.
10. Lachaal, M. & Venuto, R. C. (1989). Nephrotoxicity and hyperkalemia in patients with acquired immunodeficiency syndrome treated with pentamidine. American Journal of Medicine 87, 260-3.
11. Vohringer, H. F. & Arasteh, K. (1993). Pharmacokinetic optimization in the treatment of pneumocystis carinii pneumonia. Clinical Pharmacokinetics 24, 388-412.
12. Conte, J. E. (1991). Pharmacokinetics of intravenous pentamidine in patients with normal renal function or receiving hemodialysis. Journal of Infectious Diseases 163, 169-75.
13. Bronner, U., Gustafsson, L. L., Doua, F. et al. (1995). Pharmacokinetics and adverse reactions after a single dose of pentamidine in patients with Trypanosoma gambiense sleeping sickness. British Journal of Clinical Pharmacology 39, 289-95.
14. Lidman, C., Bronner, U., Gustafsson, L. L. et al. (1994). Plasma pentamidine concentrations vary between individuals with Pneumocystis carinii pneumonia and the drug is actively secreted by the kidney. Journal of Antimicrobial Chemotherapy 33, 803-10.
15. Masereeuw, R. & Russel, F. G. (2001). Mechanisms and clinical implications of renal drug excretion. Drug Metabolism Reviews 33, 299-351.
16. Feddersen, A. & Sack, K. (1991). Experimental studies on the nephrotoxicity of pentamidine in rats. Journal of Antimicrobial Chemotherapy 28, 437-46.
17. Yeh, T. K., Kang, H. J., Wientjes, M. G. et al. (1996). Pharmacokinetic interaction between intravenous 2′,3′-dideoxyinosine and pentamidine in rats. Pharmaceutical Research 13, 628-32.
18. Bekersky, I. & Colburn, W. A. (1981). Renal clearance of carprofen in the isolated perfused rat kidney. Drug Metabolism and Disposition 9, 25-9.
19. Taft, D. R., Chapron, D. J., Fournier, D. J. et al. (1996). Concentration dependent tubular secretion of acetazolamide and its inhibition by salicylic acid in the isolated perfused rat kidney. Drug Metabolism and Disposition 24, 456-61.
20. Cox, P. G., Moons, M. M., Slegers, J. F. et al. (1990). Isolated perfused rat kidney as a tool in the investigation of renal handling and effects of nonsteroidal antiinflammatory drugs. Journal of Pharmacological Methods 24, 89-103.
21. Bekersky, I., Poynor, W. J. & Colburn, W. A. (1980). Pharmacokinetics of saccharin in the rat: renal clearance in vivo and in the isolated perfused kidney. Drug Metabolism and Disposition 8, 64-7.
22. Poola, N. R., Bhuiyan, D., Ortiz, S. et al. (2002). A novel HPLC assay for pentamidine: comparative effects of creatinine and inulin on GFR estimation and pentamidine renal excretion in the isolated perfused rat kidney. Journal of Pharmacy and Pharmaceutical Science 5, 135-45.
23. Bowman, R. H. (1975). The perfused rat kidney. Methods in Enzymology 39, 3-11.
24. Nishiitsutsuji-Uwo, J. M., Ross, B. D. & Krebs, H. A. (1967). Metabolic activities of the isolated perfused rat kidney. Biochemical Journal 103, 852-62.
25. Bowman, R. H. (1978). Methodology for study of isolated perfused rat kidney in vitro. In Methods in Pharmacology, Vol. 4B, Renal Pharmacology, pp. 50-7. Plenum Press, New York, NY, USA.
26. Epstein, F. H., Brosnan, J. T., Tange, J. D. et al. (1982). Amino acids improve viability of the perfused rat kidney. American Journal of Physiology 243, F284-92.
27. Hall, S. D. & Rowland, M. (1984). A simple system for the investigation of protein binding effects on the renal handling of drugs in an isolated perfused rat kidney preparation. Journal of Pharmacological Methods 12, 85-9.
28. Sweeney, K. R., Hsyu, P.-H., Statkevich, P. et al. (1995). Renal disposition and drug interaction screening of (-)-2′-deoxy-3′-thiacytidine (3TC) in the isolated perfused rat kidney. Pharmaceutical Research 12, 1958-63.
29. Statkevich, P., Fournier, D. J. & Sweeney, K. R. (1993). Characterization of methotrexate elimination and interaction with indomethacin and flurbiprofen in the isolated perfused rat kidney. Journal of Pharmacology and Experimental Therapeutics 265, 1118-24.
30. Kugler, A. R., Olson, S. C. & Smith, D. E. (1996). Tubular transport mechanisms of quinapril and quinaprilat in the isolated perfused rat kidney: effect of organic anions and cations. Journal of Pharmacokinetics and Biopharmaceutics 24, 349-68.
31. Savant, I. A., Kalis, M., Almoazen, H. et al. (2001). Alternative high-performance liquid chromatographic assay for p-aminohippuric acid (PAH): effect of aging on PAH excretion in the isolated perfused rat kidney. Journal of Pharmaceutical and Biomedical Analysis 26, 687-99.
32. Gabrielsson, J. & Weiner, D. (2000). Pharmacokinetic and Pharmacodynamic Data Analysis, 3rd edn, pp. 185-90. Swedish Pharmaceutical Press, Stockholm, Sweden.
33. Koepsell, H. (1998). Organic cation transporters in intestine, kidney, liver, and brain. Annual Review of Physiology 60, 243-66.
34. Pritchard, J. B. & Miller, D. S. (1997). Renal secretion of organic cations: a multi-step process. Advanced Drug Delivery Reviews 25, 231-42.
35. Urakami, Y., Okuda, M., Masuda, S. et al. (2001). Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharmaceutical Research 18, 1528-34.
36. Pietig, G., Mehrens, T., Hirsch, J. R. et al. (2001). Properties and regulation of organic cation transport in freshly isolated human proximal tubules. Journal of Biological Chemistry 276, 33741-6.
37. Silverblatt, F. J. & Kuehn, C. (1979). Autoradiography of gentamicin uptake by the rat proximal tubule cell. Kidney International 15, 335-45.
38. Ghosh, P. & Chatterjee, S. (1987). Effect of gentamicin on sphingomyelinase activity in cultured human renal proximal tubule cells. Journal of Biological Chemistry 262, 12550-6.
39. Kleyman, T. R., Roberts, C. & Ling, B. N. (1995). A mechanism for pentamidine-induced hyperkalemia: inhibition of distal nephron sodium transport. Annals of Internal Medicine 122, 103-6.
40. Shu, Y., Bello, C. L., Mangravite, L. M. et al. (2001). Functional characteristics and steroid hormone-mediated regulation of an organic cation transporter in Madin-Darby canine kidney cells. Journal of Pharmacology and Experimental Therapeutics 299, 392-8.
41. Yabuuchi, H., Tamai, I., Nezu, J. et al. (1999). Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. Journal of Pharmacology and Experimental Therapeutics 289, 768-73.
42. Dutt, A., Heath, L. A. & Nelson, J. A. (1994). P-glycoprotein and organic cation secretion by the mammalian kidney. Journal of Pharmacology and Experimental Therapeutics 269, 1254-60.