Synthesis and antileishmanial activity of novel 2,4,6-trisubstituted pyrimidines and 1,3,5-triazines

European Journal of Medicinal Chemistry

Volumn 44, Issue 6, 2009, Pages 2473-2481

  Sunduru, Naresh ^a   Nishi, ^a   Palne, Shraddha ^a   Chauhan, Prem M S ^a   Gupta, Suman ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

1,3,5 Triazine; Leishmaniasis; Pyrimidine

Indexed keywords

(4,6 DICHLORO[1,3,5]TRIAZIN 2 YL) [4 (3,4 DIMETHOXYPHENYL) 6 METHYLSULFANYLPYRIMIDIN 2 YL] AMINE; (4,6 DICHLORO[1,3,5]TRIAZIN 2 YL) [4 METHYLSULFANYL 6 (3,4,5 TRIMETHOXYPHENYL) PYRIMIDIN 2 YL] AMINE; 1 (3,4 DIMETHOXYPHENYL) 3,3 BIS METHYLSULFANYLPROPENON; 3,3 BIS METHYLSULFANYL 1 (3,4,5 TRIMETHOXYPHENYL)PROPENONE; 4 (3,4 DIMETHOXYPHENYL) 6 METHYLSULFANYLPYRIMIDIN 2 YLAMINE; 4 METHYLSULFANYL 6 (3,4,5 TRIMETHOXYPHENYL) PYRIMIDIN 2 YLAMINE; 4,6 BIS(4 ETHYLPIPERAZIN 1 YL) N (4 (METHYLTHIO) 6 (3,4,5 TRIMETHOXYPHENYL)PYRIMIDIN 2 YL) 1,3,5 TRIAZIN 2 AMINE; 4,6 BIS(4 METHYLPIPERAZIN 1 YL) N (4 (METHYLTHIO) 6 (3,4,5 TRIMETHOXYPHENYL)PYRIMIDIN 2 YL) 1,3,5 TRIAZIN 2 AMINE; N (4 (3,4 DIMETHOXYPHENYL) 6 (METHYLTHIO)PYRIMIDIN 2 YL) 4, 6 DIMORPHOLINO 1,3,5 TRIAZIN 2 AMINE; N (4 (3,4 DIMETHOXYPHENYL) 6 (METHYLTHIO)PYRIMIDIN 2 YL) 4,6 BIS (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 AMINE; N (4 (3,4 DIMETHOXYPHENYL) 6 (METHYLTHIO)PYRIMIDIN 2 YL) 4,6 DI(PIPERIDIN 1 YL) 1,3,5 TRIAZIN 2 AMINE; N (4 (3,4 DIMETHOXYPHENYL) 6 (METHYLTHIO)PYRIMIDIN 2 YL) N 4,N 6 DIPROPYL 1,3,5 TRIAZINE 2,4,6 TRIAMINE; N (4 (METHYLTHIO) 6 (3,4,5 TRIMETHOXYPHENYL)PYRIMIDIN 2 YL) 4,6 DI(PIPERIDIN 1 YL) 1,3,5 TRIAZIN 2 AMINE; N (4 (METHYLTHIO) 6 (3,4,5 TRIMETHOXYPHENYL)PYRIMIDIN 2 YL) 4,6 DIMORPHOLINO 1,3,5 TRIAZIN 2 AMINE; N 2 (4 (3,4 DIMETHOXYPHENYL) 6 (METHYLTHIO)PYRIMIDIN 2 YL) N 4,N 6 BIS (2 MORPHOLINOETHYL) 1,3,5 TRIAZINE 2,4,6 TRIAMINE; N 2 (4 (3,4 DIMETHOXYPHENYL) 6 (METHYLTHIO)PYRIMIDIN 2 YL) N 4,N 6 BIS (3 MORPHOLINOPROPYL) 1,3,5 TRIAZINE 2,4,6 TRIAMINE; N 2 (4 (METHYLTHIO) 6 (3,4,5 TRIMETHOXYPHENYL)PYRIMIDIN 2 YL) N 4,N 6 BIS (2 MORPHOLINOPROPYL) 1,3,5 TRIAZINE 2,4,6 TRIAMINE; N 2 (4 (METHYLTHIO) 6 (3,4,5 TRIMETHOXYPHENYL)PYRIMIDIN 2 YL) N 4,N 6 DIPROPYL 1,3,5 TRIAZINE 2,4,6 TRIAMINE; N 2 N 4 (4 (METHYLTHIO) 6 (3,4,5 TRIMETHOXYPHENYL)PYRIMIDIN 2 YL) N 4,N 6 BIS (2 MORPHOLINOETHYL) 1,3,5 TRIAZINE 2,4,6 TRIAMINE; N 2,N 4 BIS(2 (DIETHYLAMINO)ETHYL) N 6 (4 (3,4 DIMETHOXYPHENYL) 6 (METHYLTHIO)PYRIMIDIN 2 YL) 1,3,5 TRIAZINE 2,4,6 TRIAMINE; N 2,N 4 BIS(2 (DIETHYLAMINO)ETHYL) N 6 (4 (METHYLTHIO) 6 (3,4,5 TRIMETHOXYPHENYL)PYRIMIDIN 2 YL) 1,3,5 TRIAZINE 2,4,6 TRIAMINE; N 2,N 4 DI TERT BUTYL N 6 (4 (3,4 DIMETHOXYPHENYL) 6 (METHYLTHIO)PYRIMIDIN 2 YL) 1,3,5 TRIAZINE 2,4,6 TRIAMINE; N 2,N 4 DI TERT BUTYL N 6 (4 (METHYLTHIO) 6 (3,4,5 TRIMETHOXYPHENYL)PYRIMIDIN 2 YL) 1,3,5 TRIAZINE 2,4,6 TRIAMINE; N 2,N 4 DIBUTYL N 6 (4 (3,4 DIMETHOXYPHENYL) 6 (METHYLTHIO)PYRIMIDIN 2 YL) 1,3,5 TRIAZINE 2,4,6 TRIAMINE; N 2,N 4 DIBUTYL N 6 (4 (METHYLTHIO) 6 (3,4,5 TRIMETHOXYPHENYL)PYRIMIDIN 2 YL) 1,3,5 TRIAZINE 2,4,6 TRIAMINE; N 2,N 4 DIISOPROPYL N 6 (4 (METHYLTHIO) 6 (3,4,5 TRIMETHOXYPHENYL)PYRIMIDIN 2 YL) 1,3,5 TRIAZINE 2,4,6 TRIAMINE; PENTAMIDINE; PYRIMIDINE DERIVATIVE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; DRUG SCREENING; DRUG SYNTHESIS; HAMSTER; IN VITRO STUDY; IN VIVO STUDY; LEISHMANIA DONOVANI; NONHUMAN;

ANIMALS; ANTIPROTOZOAL AGENTS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; MESOCRICETUS; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PYRIMIDINES; TRIAZINES;

EID: 64249139717     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.01.016     Document Type: Article

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