Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 28, 2006, Pages 10606-10611

  Nören Müller, Andrea ^a,b   Reis Corrêa Jr , Ivan ^a,b   Prinz, Heino ^a,b   Rosenbaum, Claudia ^a,b   Saxena, Krishna ^c   Schwalbe, Harald J ^c   Vestweber, Dietmar ^d   Cagna, Guiseppe ^d   Schunk, Stefan ^e   Schwarz, Oliver ^e   Schiewe, Hajo ^e   Waldmann, Herbert ^a,b  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b TU DORTMUND UNIVERSITY   (Germany)

^c GOETHE UNIVERSITY   (Germany)

^d MAX PLANCK INSTITUTE FOR MOLECULAR BIOMEDICINE   (Germany)

^e ANALYTICON DISCOVERY GMBH   (Germany)

Author keywords

Chemical biology; Medicinal chemistry; Phosphatase inhibition

Indexed keywords

AJMALICINE; INDOLE DERIVATIVE; NATURAL PRODUCT; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE CDC25A; PROTEIN TYROSINE PHOSPHATASE MPTPA; PROTEIN TYROSINE PHOSPHATASE MPTPB; PROTEIN TYROSINE PHOSPHATASE PTP1B; PROTEIN TYROSINE PHOSPHATASE SHP 2; PROTEIN TYROSINE PHOSPHATASE VE PTP; PROTEIN TYROSINE PHOSPHATASE VHR; QUINOLIZIDINE DERIVATIVE; RESERPINE; UNCLASSIFIED DRUG; YOHIMBINE DERIVATIVE;

ARTICLE; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; MOLECULAR SIZE; PRIORITY JOURNAL; VALIDATION PROCESS;

BIOLOGICAL PRODUCTS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; PHOSPHOPROTEIN PHOSPHATASE;

EID: 33746047675     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0601490103     Document Type: Article

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