Urea/thiourea derivatives of quinazolinone-lysine conjugates: Synthesis and structure-activity relationships of a new series of antimicrobials

European Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2011, Pages 2530-2540

  Suresha, G P ^a   Suhas, R ^a   Kapfo, Wethroe ^a   Channe Gowda, D ^a  

^a UNIVERSITY OF MYSORE   (India)

Author keywords

Potent microbe inhibitors; Quinazolinone lysine conjugates; Thiourea; Urea

Indexed keywords

3 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANOIC ACID; 4 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)BUTANOIC ACID; 6 (TERT BUTOXYCARBONYLAMINO) 2 [3 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOIC ACID; 6 (TERT BUTOXYCARBONYLAMINO) 2 [4 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOIC ACID; 6 [3 (3 FLUOROPHENYL)UREIDO] 2 [3 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOIC ACID; 6 [3 (3 FLUOROPHENYL)UREIDO] 2 [4 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOIC ACID; 6 [3 (4 CHLOROPHENYL)UREIDO] 2 [3 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOIC ACID; 6 [3 (4 CHLOROPHENYL)UREIDO] 2 [4 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOIC ACID; 6 [3 (4 FLUORO 2 METHYLPHENYL)THIOUREIDO] 2 [3 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOATE; 6 [3 (4 METHOXYPHENYL)UREIDO] 2 [3 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOIC ACID; 6 [3 (4 METHOXYPHENYL)UREIDO] 2 [4 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOIC ACID; 6 AMINO 2 [3 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOIC ACID TRIFLUORO ACETIC ACID SALT; 6 AMINO 2 [4 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOIC ACID TRIFLUORO ACETIC ACID SALT; ANTIBIOTIC AGENT; METHYL 6 (TERT BUTOXYCARBONYLAMINO) 2 [3 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOATE; METHYL 6 (TERT BUTOXYCARBONYLAMINO) 2 [4 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOATE; METHYL 6 [3 (3 FLUOROPHENYL)UREIDO] 2 [3 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOATE; METHYL 6 [3 (3 FLUOROPHENYL)UREIDO] 2 [4 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)BUTANAMIDO]HEXANOATE; METHYL 6 [3 (4 CHLOROPHENYL)UREIDO] 2 [3 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOATE; METHYL 6 [3 (4 CHLOROPHENYL)UREIDO] 2 [4 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOATE; METHYL 6 [3 (4 METHOXYPHENYL)UREIDO] 2 [3 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOATE; METHYL 6 [3 (4 METHOXYPHENYL)UREIDO] 2 [4 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)BUTANAMIDO]HEXANOATE; METHYL 6 AMINO 2 [3 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOATE TRIFLUORO ACETIC ACID SALT; METHYL 6 AMINO 2 [4 (4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)PROPANAMIDO]HEXANOATE TRIFLUORO ACETIC ACID SALT; QUINAZOLINONE DERIVATIVE; STREPTOMYCIN; TETRACYCLINE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS;

AMIDES; ANTI-BACTERIAL AGENTS; BACTERIA; DOSE-RESPONSE RELATIONSHIP, DRUG; LYSINE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; QUINAZOLINONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 79955627409     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.03.041     Document Type: Article

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