Synthesis and cytotoxicity of 2-phenylquinazolin-4(3H)-one derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 3900-3908

  Rhee, Hee Kyung ^a   Yoo, Ji Hye ^a   Lee, Eunyoung ^a   Kwon, Young Joo ^a   Seo, Hang Rhan ^b   Lee, Yun Sil ^a   Choo, Hea Young Park ^a  

^a Ewha Womans University   (South Korea)

^b Korea Institute of Radiation and Medical Science   (South Korea)

Author keywords

2 Phenylquinazolin 4(3H) one; Cell cycle arrest; Cytotoxicity

Indexed keywords

2 (4 (4 (2 (TRIFLUOROMETHYL)PHENYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL) QUINAZOLIN 4(3H) ONE; 2 (4 (4 (3 (TRIFLUOROMETHYL)PHENYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (4 (TRIFLUOROMETHYL)PHENYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (4 CHLOROBENZYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (4 CHLOROPHENYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (4 FLUOROPHENYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (4 ISOPROPYLPHENYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (4 METHOXYPHENYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (4 METHYLBENZYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (4 NITROPHENYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (BENZYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (BUTYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (CYCLOPENTYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (CYCLOPROPYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (ISOPROPYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (METHYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (NAPHTHALEN 1 YLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (NAPHTHALEN 2 YLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (PHENYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (QUINOLIN 8 YLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 (THIOPHEN 2 YLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 2 (4 (4 TOSYLPIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 3 BENZYL 2 (4 (4 (4 METHOXYPHENYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 3 BENZYL 2 (4 (4 (PHENYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 3 METHYL 2 (4 (4 (4 METHOXYPHENYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; 3 METHYL 2 (4 (4 (PHENYLSULFONYL)PIPERAZINE 1 CARBONYL)PHENYL)QUINAZOLIN 4(3H) ONE; CYTOTOXIC AGENT; DOXORUBICIN; QUINAZOLINE DERIVATIVE; TERT BUTYL 4 (4 (3 METHYL 4 OXO 3,4 DIHYDROQUINAZOLIN 2 YL)BENZOYL)PIPERAZINE 1 CARBOXYLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; QUINAZOLINES; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80052923470     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.05.061     Document Type: Article

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