Synthesis and structure-activity relationships of antitubercular 2-nitroimidazooxazines bearing heterocyclic side chains

Journal of Medicinal Chemistry

Volumn 53, Issue 2, 2010, Pages 855-866

  Sutherland, Hamish S ^a   Blaser, Adrian ^a   Kmentova, Iveta ^a   Franzblau, Scott G ^b   Wan, Baojie ^b   Wang, Yuehong ^b   Ma, Zhenkun ^c   Palmer, Brian D ^a   Denny, William A ^a   Thompson, Andrew M ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 NITROIMIDAZOOXAZINE DERIVATIVE; 2,3 DIHYDRO 2 METHYL 6 NITRO 2 [4 [4 (4 TRIFLUOROMETHOXYPHENOXY) 1 PIPERIDINYL]PHENOXYMETHYL]IMIDAZO[2,1 B]OXAZOLE; OXAZINE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; LIVER MICROSOME METABOLISM; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; MICE; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; OXAZINES; PYRAZOLES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77249095085     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901378u     Document Type: Article

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