Synthesis, biological evaluation and molecular docking of novel series of spiro [(2H,3H) quinazoline-2,1′- cyclohexan]-4(1H)- one derivatives as anti-inflammatory and analgesic agents

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2117-2131

  Amin, K M ^a   Kamel, M M ^b   Anwar, M M ^b   Khedr, M ^c   Syam, Y M ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b NATIONAL RESEARCH CENTRE   (Egypt)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Analgesic; Antiinflammatory; Cyclooxygenase 2; Molecular docking; Spiro (2H,3H) quinazoline 2,1 cyclohexan 4(1H) one; Ulcerogenic effect

Indexed keywords

4 [SPIRO[(2H,3H)QUINAZOLINE 2,1' CYCLOHEXAN] 4 (1H) ONE 3 YL] N (CYCLOHEXYL) THIOAMIDO BENZOIC ACID HYDRAZIDE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; INDOMETACIN; QUINAZOLINONE DERIVATIVE; SPIRO [(2H, 3H) 3 (4 (5 P N,N DIMETHYLAMINOPHENYL) 4,5 DIHYDRO 1 PHENYL 1H PYRAZOL 3 YL PHENYL)QUINAZOLINE 2,1' CYCLOCYCLOHEXAN] 4(1H) ONE; SPIRO [(2H,3H) 3(4 (2' DIAZINE)AMINOSULFONYLPHENYL) QUINAZOLINE 2,1' CYCLOHEXAN] 4(1H) ONE; SPIRO [(2H,3H) QUINAZOLINE 2,1' CYCLOHEXAN] 4(1H) ONE DERIVATIVE; SPIRO[(2H,3H) 3 (4 (4 HYDROXYPHENYL) 1,2 DIHYDRO 3 CYANO 2 IMINOPYRIDIN 6 YL PHENYL)QUINAZOLINE 2,10 CYCLOHEXAN] 4(1H) ONE; SPIRO[(2H,3H) 3 (4 (4 O HYDROXYPHENYL) 1,2 DIHYDRO 3 CYANO 2 OXO PYRIDIN 6 YL PHENYL)QUINAZOLINE 2,1' CYCLOHEXAN] 4(1H) ONE; SPIRO[(2H,3H) 3 (4 (4 P FLOROPHENYL) 1,2 DIHYDRO 3 CYANO 2 IMINO PYRIDIN 6 YL PHENYL) QUINAZOLINE 2,1' CYCLOHEXAN] 4(1H) ONE; TRAMADOL; UNCLASSIFIED DRUG;

AMINOLYSIS; ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; MOLECULAR DOCKING; ULCEROGENESIS;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CYCLOHEXANES; CYCLOHEXANONES; CYCLOOXYGENASE 2; EDEMA; FEMALE; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUINAZOLINES; RATS; ULCER;

EID: 77950857463     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.12.078     Document Type: Article

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